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Recombinant Human KLC1 protein, GST-tagged

Cat.No. : KLC1-5849H
Product Overview : Recombinant Human KLC1(1-290aa) fused with GST tag at N-terminal was expressed in E. coli.
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Description : Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined.
Source : E. coli
Species : Human
Tag : GST
Form : 1M PBS (58 mM Na2HPO4, 17 mM NaH2PO4, 68 mM NaCl, pH8.0 ), 100 mM GSH and 1% Triton X-100, 15% glycerol.
Protein length : 1-290aa
AA Sequence : MYDNMSTMVYIKEDKLEKLTQDEII SKTKQVIQGLEALKNEHNSILQSLL ETLKCLKKDDESNLVEEKSNMIRKS LEMLELGLSEAQVMMALSNHLNAVE SEKQKLRAQVRRLCQENQWLRDELA NTQQKLQKSEQSVAQLEEEKKHLEF MNQLKKYDDDISPSEDKDTDSTKEP LDDLFPNDEDDPGQGIQQQHSSAAA AAQQGGYEIPARLRTLHNLVIQYAS QGRYEVAVPLCKQALEDLEKTSGHD HPDVATMLNILALVYRDQNKYKDAA NLLNDALAIREKTLG
Storage : Aliquot and store at -20 centigrade to -80 centigrade for up to 6 months. Avoid freeze thaw cycles.
Shipping : The product is shipped with ice packs. Upon receipt, store it immediately at -20 centigrade to -80 centigrade.
Gene Name : KLC1 kinesin light chain 1 [ Homo sapiens ]
Official Symbol : KLC1
Synonyms : KLC1; kinesin light chain 1; kinesin 2 , kinesin 2 60/70kDa , KNS2; hKLC1B; hKLC1G; hKLC1J; hKLC1N; hKLC1P; hKLC1R; hKLC1S; KLC; KNS2A; KLC 1; kinesin 2 60/70kDa; medulloblastoma antigen MU-MB-2.50; KNS2; MGC15245;
Gene ID : 3831
mRNA Refseq : NM_001130107
Protein Refseq : NP_001123579
MIM : 600025
UniProt ID : Q07866
Chromosome Location : 14q32.3
Pathway : Arf6 trafficking events, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem; Kinesins, organism-specific biosystem; Salmonella infection, organism-specific biosystem; Salmonella infection, conserved biosystem;
Function : microtubule motor activity; motor activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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