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KLF1

Official Full Name

Kruppel-like factor 1 (erythroid)
Overview

This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.
Synonyms

KLF1; Kruppel-like factor 1 (erythroid); Krueppel-like factor 1; EKLF; erythroid Kruppel like factor; monoclonal A3D8; erythroid Kruppel-like factor; erythroid krueppel-like transcription factor; erythroid-specific transcription factor EKLF; INLU; HBFQT;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque
Zebrafish

Source

E. coli
E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
B2M

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KLF1-394H	Recombinant Human KLF1, GST-tagged	E.coli	GST	1-362aa	$319 / 25ug
Human	KLF1-395H	Recombinant Human KLF1 protein, His-B2M-tagged	E. coli	His-B2M	1-362aa	Inquiry
Human	KLF1-01H	Recombinant Human KLF1 Protein, His-tagged	E.coli	His		Inquiry
Rhesus Macaque	KLF1-2411R	Recombinant Rhesus monkey KLF1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	KLF1-2232R	Recombinant Rhesus Macaque KLF1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	KLF1-2232R-B	Recombinant Rhesus Macaque KLF1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	KLF1-8577Z	Recombinant Zebrafish KLF1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

KLF1 involved in several pathways and played different roles in them. We selected most pathways KLF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

KLF1 has several biochemical functions, for example, core promoter proximal region sequence-specific DNA binding, metal ion binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF1 itself. We selected most functions KLF1 had, and list some proteins which have the same functions with KLF1. You can find most of the proteins on our site.

Function	Related Protein
core promoter proximal region sequence-specific DNA binding	DMRT1;TFAP2A;DMRTC2;DMRT3A;SMAD4;SMAD3;CREBBP;SP3;DMRT3
metal ion binding	DPYD;INO80B;CTDSP2;GCM2;PPP1CA;DNMT3L;ADK;ZNF43;ZIK1
transcription factor activity, sequence-specific DNA binding	SCMH1;ZNF238;FOXD3;MYRFL;TBX22;SCML1;INSM1A;ZFP161;ZNF573
transcription regulatory region DNA binding	GLI1;SMAD7;TBL1X;TCF7L1A;SP1;SALL1A;HOXA13;TOMM20A;IKZF1

KLF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF1.

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