KLF4 Protein, Kruppel-like factor 4 (gut)


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Official Full Name Kruppel-like factor 4 (gut)
Background Krueppel-like factor 4 is a protein that in humans is encoded by the KLF4 gene.. In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSC
Synonyms KLF4; Kruppel-like factor 4 (gut); Krueppel-like factor 4; EZF; GKLF; gut-enriched krueppel-like factor; epithelial zinc finger protein EZF; endothelial Kruppel-like zinc finger protein
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • 13-TAT
    • His
    • CaM
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Klf4-1276M Recombinant Mouse Klf4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human KLF4-145H Recombinant Human KLF4 Protein, 13-residue TAT-tagged HEK293 13-TAT
    Human KLF4-29898TH Recombinant Human KLF4, His-tagged E.coli His
    Human KLF4-29901TH Recombinant Human KLF4 N/A
    Human KLF4-3567H Recombinant Human KLF4, His CaM-tagged E.coli His/CaM
    Human KLF4-4927HCL Recombinant Human KLF4 293 Cell Lysate HEK293 N/A
    Human KLF4-72H Recombinant Human KLF4 protein E.coli N/A
    Human KLF4-8466H Recombinant Human KLF4, His-tagged E.coli His
    Mouse Klf4-5856M Recombinant Mouse Klf4 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque KLF4-2415R Recombinant Rhesus monkey KLF4 Protein, His-tagged Mammalian Cell His
    Zebrafish KLF4-6294Z Recombinant Zebrafish KLF4 Mammalian Cell His

    KLF4 involved in several pathways and played different roles in them. We selected most pathways KLF4 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling pathways regulating pluripotency of stem cells FGFR2; ZIC3; PCGF6; MAPK12; SKIL; SMAD3; ONECUT1; FZD5; FZD2; BMP4

    KLF4 has several biochemical functions, for example, RNA polymerase II transcription factor binding, beta-catenin binding, core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF4 itself. We selected most functions KLF4 had, and list some proteins which have the same functions with KLF4. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription factor binding TBX20; DHX9; GATA4; GATA1A; GSK3B; MTDH; ZFPM1; TEAD3; TRP53; TBX3
    beta-catenin binding ASH2L; DACT2; KLF4; PTPRK; CTNNBIP1; TBL1X; AXIN2; C; Ar; BCL9
    core promoter binding GATA1; RELB; SFPI1; E2F3; E2F8; REST; INSM1B; SFPQ; PSPC1; ELK4
    core promoter proximal region sequence-specific DNA binding CREBBP; SP3A; DMRT1; KLF1; SP3; DMRT2A; MEF2C; DMRT2; PAX2; UHRF1
    histone deacetylase binding MEF2A; TCF21; HDAC3; NR2C1; RBBP4; DHX36; SKOR2; RUNX2; PHB; TFAP4
    phosphatidylinositol 3-kinase regulator activity KLF4; PIK3R1; PIK3R3B; AGAP2; PIK3R3A
    protein binding PPP5C; ZNF180; ANKRD24; TRIM28; PSMA5; INTS9; OCLN; SERPINB3C; APEH; EGR2
    transcription cofactor binding CHD6; FOXO3; TRP53; KLF4
    transcription factor activity, sequence-specific DNA binding ZNF192; FOXQ2; NFYC; BLZF1; SIM2; GATA2; TFDP2; ZFP82; PRDM2; MEOX2
    transcription factor activity, sequence-specific DNA binding transcription factor recruiting KLF4
    transcription regulatory region DNA binding THRA; PAX8; CALCOCO1; PRDM5; GABPB1; ASH2L; ZNF335; WNT1; RNF10; FOXA3
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding STK16; MYOCD; CREB3L1; ETV6; ARID3B; JUNB; MYBL1; PBX1; ISL1; LEF1
    transcriptional activator activity, RNA polymerase II transcription factor binding CREB1; WWP2; LMO2; MIXL1; GBX2; KLF14; SOX10; NKX2; JUN; NR1H4
    zinc ion binding TRIM55B; TRIM13; ZNF385D; SRSF7; PAPPA2; DTX4; CPZ; CXXC1B; PMPCB; USP39

    KLF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF4.

    cd14_distal_promoter_probe; CTBP1; Dlg4

    Makanga, JO; Kobayashi, M; et al. Generation of Rat Induced Pluripotent Stem Cells Using a Plasmid Vector and Possible Application of a Keratan Sulfate Glycan Recognizing Antibody in Discriminating Teratoma Formation Phenotypes. BIOLOGICAL & PHARMACEUTICAL BULLETIN 38:127-133(2015).
    Shimamoto, R; Amano, N; et al. Generation and Characterization of Induced Pluripotent Stem Cells from Aid-Deficient Mice. PLOS ONE 9:-(2014).

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