klhl13
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  • Official Full Name
  • kelch-like 13 (Drosophila)
  • Background
  • This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants.
  • Synonyms
  • KLHL13; kelch-like 13 (Drosophila); BKLHD2, BTB and kelch domain containing 2, KIAA1309 , KIAA1309; kelch-like protein 13; FLJ10262; BKLHD2; BTB and kelch domain containing 2; BTB and kelch domain containing 2 KIAA1309; BTB and kelch domain containing protein 2; Kelch like 13 (Drosophila); Kelch like protein 13; KIAA1309; MGC74791; OTTHUMP00000023881; OTTHUMP00000023882; OTTHUMP00000023883; OTTHUMP00000023885; OTTHUMP00000215715
Cat.#:KLHL13-412HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KLHL13, GST-tagged
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Cat.#:KLHL13-8705MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse KLHL13 Protein
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Cat.#:KLHL13-2788CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken KLHL13
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Cat.#:KLHL13-5734ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KLHL13
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Cat.#:KLHL13-8061ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KLHL13
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Cat.#:KLHL13-4912HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human KLHL13 293 Cell Lysate
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Involved Pathway

KLHL13 involved in several pathways and played different roles in them. We selected most pathways KLHL13 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLHL13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ubiquitin mediated proteolysis
UBE2S; UBE2IA; CDC34; UBE2N; UBE2E1; BIRC3; MGRN1B; PRPF19; BTRC; NHLRC1

Protein Function

KLHL13 has several biochemical functions, for example, contributes_to ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLHL13 itself. We selected most functions KLHL13 had, and list some proteins which have the same functions with KLHL13. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to ubiquitin-protein transferase activity
Related Protein KLHL26; CCIN; KLHL1; KLHL23; KLHL10; KBTBD8; UBE2S; KLHL17; TNFAIP1; KLHL3

Interacting Protein

KLHL13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLHL13 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLHL13.
ZMYM6; HSP90AB1; USP11; COPS2; MAD2L1; KLHL22; ZMYM4; COPS6; NUDCD3; COPS5; COPS4; KLHL9; UBXN7