Description : |
This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
73.9 kDa |
AA Sequence : |
MPLKWKTSSPAIWKFPVPVLKTSRS TPLSPAYISLVEEEDQHMKLSLGGS EMGLSSHLQSSKAGPTRIFTSNTHS SVVLQGFDQLRLEGLLCDVTLMPGD TDDAFPVHRVMMASASDYFKAMFTG GMKEQDLMCIKLHGVSKVGLRKIID FIYTAKLSLNMDNLQDTLEAASFLQ ILPVLDFCKVFLISGVTLDNCVEVG RIANTYNLTEVDKYVNSFVLKNFPA LLSTGEFLKLPFERLAFVLSSNSLK HCTELELFKATCRWLRLEEPRMDFA AKLMKNIRFPLMTPQELINYVQTVD FMRTDNTCVNLLLEASNYQMMPYMQ PVMQSDRTAIRSDTTHLVTLGGVLR QQLVVSKELRMYDEKAHEWKSLAPM DAPRYQHGIAVIGNFLYVVGGQSNY DTKGKTAVDTVFRFDPRYNKWMQVA SLNEKRTFFHLSALKGYLYAVGGRN AAGELPTVECYNPRTNEWTYVAKMS EPHYGHAGTVYGGVMYISGGITHDT FQKELMCFDPDTDKWIQKAPMTTVR GLHCMCTVGERLYVIGGNHFRGTSD YDDVLSCEYYSPILDQWTPIAAMLR GQSDVGVAVFENKIYVVGGYSWNNR CMVEIVQKYDPDKDEWHKVFDLPES LGGIRACTLTVFPPEETTPSPSRES PLSAPTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |