klk4
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  • Official Full Name
  • kallikrein-related peptidase 4
  • Background
  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
  • Synonyms
  • KLK4; kallikrein-related peptidase 4; ARM1; EMSP; PSTS; AI2A1; EMSP1; KLK-L1; PRSS17; kallikrein; kallikrein-4; prostase; serine protease 17; kallikrein-like protein 1; androgen-regulated message 1; enamel matrix serine protease 1; enamel matrix serine proteinase 1; ESMP1
Cat.#:KLK4-4936HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human KLK4 Protein, GST-tagged
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Cat.#:KLK4-1358HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Kallikrein-Related Peptidase 4
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Cat.#:KLK4-1169HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human KLK4, His tagged
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Cat.#:KLK4-555HTag:His
Source (Host):NSO CellsSpecies:Human
Product nameRecombinant Human KLK4 Protein, His-tagged
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Cat.#:KLK4-685HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KLK4 Protein, His-tagged
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Cat.#:Klk4-686MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Klk4 Protein, His/GST-tagged
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Cat.#:Klk4-687RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Klk4 Protein, His-tagged
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Cat.#:KLK4-238HTag:
Source (Host):Species:Human
Product nameNative Human Kallikrein
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Cat.#:KLK4-239RTag:
Source (Host):Species:Rat
Product nameNative Rat Kallikrein
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Cat.#:KLK4-2044HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human KLK4 cell lysate
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Protein Function

KLK4 has several biochemical functions, for example, metal ion binding, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLK4 itself. We selected most functions KLK4 had, and list some proteins which have the same functions with KLK4. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein ZBTB7A; TRP53; RNF11B; ZFP106; ZFP41; CHSY1; SEMG1; ATP11A; RNF34A; SP5A
Function protein binding
Related Protein DAAM1; NUSAP1; MAPK4; CEP55; NRIP1; NME4; RPL7; RPL23A; SUGP1; CDKL3
Function serine-type endopeptidase activity
Related Protein PRSS42; TMPRSS3; KLK1B9; TPSB2; PLAU; LTF; C1S; CTRL; GZMB; PROCA
Function serine-type peptidase activity
Related Protein PRSS8; F9A; MCPT8; FAP; HGFA; KLK1B1; GM5077; PRSS48; SLC38A8; GZMK

Interacting Protein

KLK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK4.
TYRO3

KLK4 Related Articles

Yang, F; Chen, YZ; et al. Stromal TGF-beta signaling induces AR activation in prostate cancer. ONCOTARGET 5:10854-10869(2014).
Debelec-Butuner, B; Alapinar, C; et al. Inflammation-Mediated Abrogation of Androgen Signaling: An In Vitro Model of Prostate Cell Inflammation. MOLECULAR CARCINOGENESIS 53:85-97(2014).