klk6
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  • Official Full Name
  • kallikrein-related peptidase 6
  • Background
  • Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimers disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • KLK6; kallikrein-related peptidase 6; hK6; Bssp; Klk7; SP59; PRSS9; PRSS18; kallikrein-6; zyme; neurosin; protease M; serine protease 9; serine protease 18;
Cat.#:KLK6-9483HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KLK6 Protein, His-tagged
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Cat.#:KLK6-4932HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human KLK6 Protein, GST-tagged
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Cat.#:KLK6-690HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human KLK6 Protein, MYC/DDK-tagged
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Cat.#:KLK6-26891THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KLK6
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Cat.#:klk6-3928HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human KLK6, His-tagged
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Cat.#:KLK6-3929HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human KLK6
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Cat.#:KLK6-605HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human KLK6
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Cat.#:KLK6-800HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KLK6 protein, His & GST-tagged
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Cat.#:Klk6-801MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Klk6 protein, His & GST-tagged
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Cat.#:Klk6-802RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Klk6 protein, His & GST-tagged
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Cat.#:KLK6-2434RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KLK6 Protein, His-tagged
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Cat.#:KLK6-1559HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human KLK6 cell lysate
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Involved Pathway

KLK6 involved in several pathways and played different roles in them. We selected most pathways KLK6 participated on our site, such as Alpha-synuclein signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alpha-synuclein signaling
CSNK2A1; PARK7; TOR1A; STUB1; KLK6; FKBP1A; BLK

Protein Function

KLK6 has several biochemical functions, for example, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLK6 itself. We selected most functions KLK6 had, and list some proteins which have the same functions with KLK6. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein RBFOX1; RHOXF2; SFPI1; NFYC; VTN; CLIC5; HOXD12; SIX3; PRMT8; KARS
Function serine-type endopeptidase activity
Related Protein MCPT8; TMPRSS11F; KLK12; PREP; ELA2L; C1S; KLK1B4; PRSS48; KLK1B24; DPP4

Interacting Protein

KLK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK6.
pheserargamc; COL1A1; COL4A1; COL1A2; FGA; FGB; APP; COL4A2; COL4A5; CSN1S1; COL4A4; COL4A3; COL4A6

KLK6 Related Articles

Ott, C; Ainciburu, M; et al. Development of monoclonal antibodies to human kallikrein-related peptidase 6 (KLK6) and their use in an immunofluorometric assay for free KLK6. BIOLOGICAL CHEMISTRY 395:1119-1126(2014).
Sotiropoulou, G; Pampalakis, G; et al. Development and immunochemical evaluation of a novel chicken IgY antibody specific for KLK6. CHEMISTRY CENTRAL JOURNAL 6:-(2012).