|Official Full Name||kallikrein-related peptidase 6|
|Background||Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimers disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]|
|Synonyms||KLK6; kallikrein-related peptidase 6; hK6; Bssp; Klk7; SP59; PRSS9; PRSS18; kallikrein-6; zyme; neurosin; protease M; serine protease 9; serine protease 18;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
KLK6 involved in several pathways and played different roles in them. We selected most pathways KLK6 participated on our site, such as Alpha-synuclein signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Alpha-synuclein signaling||BLK; FKBP1A; CSNK2A1; TOR1A; STUB1; PARK7; KLK6|
KLK6 has several biochemical functions, for example, protein binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLK6 itself. We selected most functions KLK6 had, and list some proteins which have the same functions with KLK6. You can find most of the proteins on our site.
|protein binding||TUBGCP2; YWHAH; SPHK1; ZNF227; CLPX; PIH1D2; TCF7L1A; MAPK3; LAT2; HPS1|
|serine-type endopeptidase activity||KLK1B5; HTRA1A; HGF; PRSS42; GZMA; KLK1B16; TMPRSS15; PRSS7; PCSK5; OVCH2|
KLK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLK6.
pheserargamc; COL1A1; COL4A1; COL1A2; FGA; FGB; APP; COL4A2; COL4A5; CSN1S1; COL4A4; COL4A3; COL4A6