klrc3
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  • Official Full Name
  • killer cell lectin-like receptor subfamily C, member 3
  • Background
  • Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms
  • KLRC3; killer cell lectin-like receptor subfamily C, member 3; NKG2-E type II integral membrane protein; NKG2 E; Killer cell lectin like receptor subfamily C member 3; KLRC 3; NK cell receptor E; NKG2 E activating NK receptor; NKG2 E type II integral membrane protein; NKG2-E-activating NK receptor; NKG2E activating NK receptor; NKG2E; NKG2E type II integral membrane protein; NKG2E_HUMAN; OTTHUMP00000235359; OTTHUMP00000235362; NKG2-E
Cat.#:KLRC3-4913HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human KLRC3 Protein, GST-tagged
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Cat.#:KLRC3-29905THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human KLRC3
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Cat.#:KLRC3-7170HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Killer Cell Lectin-Like Receptor Subfamily C, Member 3, His-tagged
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Cat.#:KLRC3-2437RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey KLRC3 Protein, His-tagged
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Involved Pathway

KLRC3 involved in several pathways and played different roles in them. We selected most pathways KLRC3 participated on our site, such as Antigen processing and presentation, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLRC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antigen processing and presentation
CALR; HLA-DRB5; TAPBP; HLA-DMA; H2-AA; PDIA3; HLA-DQA2; PSME2; KIR2DS3; HSP90AB1
Natural killer cell mediated cytotoxicity
KLRC3; KIR2DL3; KIR2DL4; RAET1L; FASLG; IFNAR2; RAET1D; RAET1G; IFNA6; PTPN6

Protein Function

KLRC3 has several biochemical functions, for example, carbohydrate binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLRC3 itself. We selected most functions KLRC3 had, and list some proteins which have the same functions with KLRC3. You can find most of the proteins on our site.
Function
Related Protein
Function carbohydrate binding
Related Protein PKD1L3; LMAN2; SBP; CLEC1B; Clec4n; SI; CD209C; LGALS9C; CLEC7A; PYGB
Function transmembrane signaling receptor activity
Related Protein FZD7A; TLR2-2; CD97; LYVE1; OR4C12; TNFRSF10C; CLEC4A; Fzd4; ENG; SIGLEC8

Interacting Protein

KLRC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLRC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLRC3.
clpB

KLRC3 Related Articles

Lee, YH; Bae, SC; et al. Meta-analysis of gene expression profiles to predict response to biologic agents in rheumatoid arthritis. CLINICAL RHEUMATOLOGY 33:775-782(2014).
Nakata, S; Imagawa, A; et al. Low gene expression levels of activating receptors of natural killer cells (NKG2E and CD94) in patients with fulminant type 1 diabetes. IMMUNOLOGY LETTERS 156:149-155(2013).