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KPNA5

Official Full Name

karyopherin alpha 5 (importin alpha 6)
Overview

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus.
Synonyms

KPNA5; karyopherin alpha 5 (importin alpha 6); importin subunit alpha-6; IPOA6; SRP6; IMA5_HUMAN; Importin alpha 6; Importin subunit alpha 6; IPOA 6; Karyopherin alpha 5; Karyopherin alpha 5 importin alpha 6; Karyopherin subunit alpha 5; Karyopherin subunit alpha-5; KPNA 5; SRP 6; OTTHUMP00000017076;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A
N
T7|His

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KPNA5-86H	Recombinant Human KPNA5 protein, T7/His-tagged	E.coli	T7/His		Inquiry
Human	KPNA5-29811TH	Recombinant Human KPNA5	Wheat Germ	N/A	539 amino acids	Inquiry
Human	KPNA5-4888HCL	Recombinant Human KPNA5 293 Cell Lysate	HEK293	N/A		Inquiry
Human	KPNA5-5819HF	Recombinant Full Length Human KPNA5 Protein, GST-tagged	In Vitro Cell Free System	GST	539 amino acids	Inquiry
Human	KPNA5-4893H	Recombinant Human KPNA5 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	KPNA5-2377H	Recombinant Human KPNA5 Protein, His-tagged	E.coli	N-His	Met1-Ser351	Inquiry
Human	KPNA5-274HF	Recombinant Full Length Human KPNA5 Protein	In Vitro Cell Free System		539 amino acids	Inquiry
Rat	KPNA5-3303R	Recombinant Rat KPNA5 Protein	Mammalian Cell	His		Inquiry
Rat	KPNA5-2959R	Recombinant Rat KPNA5 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	KPNA5-2959R-B	Recombinant Rat KPNA5 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Kpna5-1720R	Recombinant Rat Kpna5 Protein, His-tagged	E.coli	N-His	Met1-Asp285	Inquiry
Zebrafish	KPNA5-2661Z	Recombinant Zebrafish KPNA5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
KPNA5 Related Articles

KPNA5 involved in several pathways and played different roles in them. We selected most pathways KPNA5 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Antiviral mechanism by IFN-stimulated genes	KPNA3;EIF4A2;DPF1;EIF4G2A;EIF4E;IFIT12;NUP50;IFIT10;IFIT8
Cytokine Signaling in Immune system	JAK1;ARIH1L;PEA15A;FGFR1B;KBTBD7;LAMTOR2;EIF4A2;IRF4;IFIT10
Disease	DOCK2;MTRR;RBP1;PDCD6IP;ANTXR2;CTBP1;APOBEC3G;AP1M2;GPC5
Host Interactions with Influenza Factors	KPNA4;CPSF4;KPNA3;KPNA5
ISG15 antiviral mechanism	ARIH1;USP18;IFIT14;MX2;IFIT10;EIF4E3;KPNA5;HERC5;KPNA3
Immune System	CYBA;LILRA1;CLEC2G;TXNIPB;DEFA1;DEFB103A;CTSC;IFIT3;NA
Infectious disease	NMT2;KPNA3;PACS1;CHMP4C;SYT2;AP1G1;EEF2;APOBEC3G;AP1M2
Influenza Infection	IPO5;CPSF4;KPNA4;KPNA3;KPNA5

KPNA5 has several biochemical functions, for example, nuclear localization sequence binding, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNA5 itself. We selected most functions KPNA5 had, and list some proteins which have the same functions with KPNA5. You can find most of the proteins on our site.

Function	Related Protein
nuclear localization sequence binding	RANBP6;TNPO2;KPNA6;KPNA7;KPNA1;KPNA5;BRAP;IPO4;KPNA2
protein binding	CLPP;FCN2;MAB21L2;C4orf26;HER5;RPF1;MRPL51;PKIA;EFCAB4B
protein transporter activity	AP3S2;PGAP2;KPNB1;IPO9;KPNA6;DSCR3;TNPO2;RANBP6;KPNA1

KPNA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNA5.

CDKN1B; SPOPL; ANP32B; NUP50; csp_playo; SKP2; ANP32A; SF1; q5nem9_fratt

Chaudhary, SC; Cho, MG; et al. A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met. EXPERIMENTAL AND MOLECULAR MEDICINE 46:-(2014).

Byrum, CA; Smith, J; et al. Restricted expression of karyopherin alpha mRNA in the sea urchin suggests a role in neurogenesis. GENE EXPRESSION PATTERNS 16:51-60(2014).