kpna5
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  • Official Full Name
  • karyopherin alpha 5 (importin alpha 6)
  • Background
  • The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus.
  • Synonyms
  • KPNA5; karyopherin alpha 5 (importin alpha 6); importin subunit alpha-6; IPOA6; SRP6; IMA5_HUMAN; Importin alpha 6; Importin subunit alpha 6; IPOA 6; Karyopherin alpha 5; Karyopherin alpha 5 importin alpha 6; Karyopherin subunit alpha 5; Karyopherin subunit alpha-5; KPNA 5; SRP 6; OTTHUMP00000017076
Cat.#:KPNA5-4893HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human KPNA5 Protein, GST-tagged
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Cat.#:KPNA5-29811THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human KPNA5
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Cat.#:KPNA5-86HTag:T7|His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human KPNA5 protein, T7/His-tagged
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Cat.#:KPNA5-3303RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat KPNA5 Protein
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Cat.#:KPNA5-2661ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish KPNA5
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Cat.#:KPNA5-4888HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human KPNA5 293 Cell Lysate
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Involved Pathway

KPNA5 involved in several pathways and played different roles in them. We selected most pathways KPNA5 participated on our site, such as Antiviral mechanism by IFN-stimulated genes, Cytokine Signaling in Immune system, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antiviral mechanism by IFN-stimulated genes
DPF1; EIF4EB; EIF4G2A; NUPL2; IFIT14; EIF4G2; KPNA3; IFIT12; EIF4A1; ARIH1
Cytokine Signaling in Immune system
CSHL1; TRIM45; EIF4A2; PAQR3B; TAB1; MAP3K8; IFI27; PEA15A; IL17RD; HLA-DQB2
Disease
DERL2; AP1S1; MMAA; APOBEC3G; ELL; SFTPC; DOCK2; PSTPIP2; gag; AP1M2
Host Interactions with Influenza Factors
KPNA4; KPNA5; CPSF4; KPNA3
ISG15 antiviral mechanism
KPNA4; MX2; EIF4E3; ARIH1; KPNA3; IFIT12; IFIT10; IFIT8; KPNA5; UBE2L6
Immune System
DYNLL2; B2ML; BFB; TCIRG1; CYLD; GRAP2A; TRIM5; FBXO3; CASP4; TIRAP
Infectious disease
KPNA3; VPS37A; PDCD6IP; CPSF4; CHMP4C; ANTXR1; LTF; NMT1; APOBEC3G; RCC1
Influenza Infection
IPO5; CPSF4; KPNA5; KPNA3; KPNA4

Protein Function

KPNA5 has several biochemical functions, for example, nuclear localization sequence binding, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNA5 itself. We selected most functions KPNA5 had, and list some proteins which have the same functions with KPNA5. You can find most of the proteins on our site.
Function
Related Protein
Function nuclear localization sequence binding
Related Protein RANBP6; IPO4; KPNA5; KPNA1; KPNA3; TNPO2; IPO13; KPNA2; NUP214; KPNB3
Function protein binding
Related Protein PARL; DOK1; ST6GAL1; RAD23B; FBXO17; NUMB; EOMESA; WWOX; PRPF3; NIPSNAP1
Function protein transporter activity
Related Protein IPO8; SEC61G; KPNA7; MLC1; KPNA2; AP1G1; COX18; XPO5; RANBP6; TNPO3

Interacting Protein

KPNA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNA5.
CDKN1B; SPOPL; ANP32B; NUP50; csp_playo; SKP2; ANP32A; SF1; q5nem9_fratt

KPNA5 Related Articles

Chaudhary, SC; Cho, MG; et al. A putative pH-dependent nuclear localization signal in the juxtamembrane region of c-Met. EXPERIMENTAL AND MOLECULAR MEDICINE 46:-(2014).
Byrum, CA; Smith, J; et al. Restricted expression of karyopherin alpha mRNA in the sea urchin suggests a role in neurogenesis. GENE EXPRESSION PATTERNS 16:51-60(2014).