lifr
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  • Official Full Name
  • Leukemia Inhibitory Factor Receptor
  • Background
  • LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.
  • Synonyms
  • LIFR; Interferon α Receptor β Chain; leukemia inhibitory factor receptor alpha; SWS; SJS2; STWS; CD118; LIF-R; FLJ98106; FLJ99923; leukemia inhibitory factor receptor; CD118 antigen; LIF receptor
Cat.#:LIFR-044HTag:Fc
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human LIFR Protein, Fc-tagged
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Cat.#:LIFR-2817HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LIFR protein, His-tagged
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Cat.#:LIFR-2818HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LIFR protein, His-tagged
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Cat.#:LIFR-2819HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human LIFR protein, His-tagged
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Cat.#:LIFR-28855THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human LIFR
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Cat.#:LIFR-30HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human LIFR protein, His-tagged
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Cat.#:LIFR-611HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human LIFR, His tagged
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Cat.#:LIFR-612HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human LIFR Protein, Fc-tagged
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Cat.#:LIFR-687HTag:
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human LIFR
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Cat.#:Lifr-2820MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lifr protein, His-tagged
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Cat.#:Lifr-2821MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lifr protein, His-tagged
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Cat.#:Lifr-2822MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Lifr protein, His-tagged
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Cat.#:Lifr-3295MTag:GST
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Lifr, His-tagged
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Cat.#:LIFR-868MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse LIFR Protein, His-tagged
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Cat.#:Lifr-2823RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lifr protein, His-tagged
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Cat.#:Lifr-2824RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lifr protein, His-tagged
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Cat.#:Lifr-2825RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Lifr protein, His-tagged
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Cat.#:LIFR-3408RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat LIFR Protein
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Cat.#:Lifr-8774RTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Lifr, His tagged
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Cat.#:LIFR-6144CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken LIFR
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Cat.#:LIFR-1663HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Leukemia Inhibitory Factor Receptor Alpha
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Cat.#:LIFR-2778HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human LIFR cell lysate
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Cat.#:LIFR-2285MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse LIFR cell lysate
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Cat.#:LIFR-1200RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat LIFR cell lysate
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Involved Pathway

LIFR involved in several pathways and played different roles in them. We selected most pathways LIFR participated on our site, such as Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CSH; TGFBR1B; EDAR; KITLGA; IL1R2; CCL3L1; TNFRSF11A; ACVR2B; TNFSF9; CX3CR1
Signaling pathways regulating pluripotency of stem cells
NODAL; PIK3CG; REST; WNT1; ACVR1B; MAPK3; WNT9B; MAPK13; WNT7A; APC
Jak-STAT signaling pathway
IL6R; STAT2; IL2RGA; CRFB4; IL20RB; IL12B; GHRA; PIAS4B; AOX1; TYK2

Protein Function

LIFR has several biochemical functions, for example, contributes_to ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, cytokine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIFR itself. We selected most functions LIFR had, and list some proteins which have the same functions with LIFR. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to ciliary neurotrophic factor receptor activity
Related Protein Il6ra; LIFR; CNTFR; IL6R
Function ciliary neurotrophic factor receptor binding
Related Protein IL6ST; LIFR; CNTF; Ctf2; CLCF1
Function cytokine binding
Related Protein KITA; LIFR; CHRD; NRP1; NOG; GBP1; Fzd4; CSF1RA; CSF1R; IL17F
Function growth factor binding
Related Protein GHRHR; IL6ST; IGFBP2B; A2M; REG3B; HTRA1A; ACVR2B; RHBDF2; NRP1; NKD2
Function leukemia inhibitory factor receptor activity
Related Protein LIFR
Function contributes_to leukemia inhibitory factor receptor activity
Related Protein LIFR; IL6ST
Function contributes_to oncostatin-M receptor activity
Related Protein IL6ST; OSMR; LIFR
Function protein heterodimerization activity
Related Protein ALG2; RBP4; H2AFY2; CD3G; AOC3; TIMELESS; CASP8; TAP1; ADRa1A; UGT1A2

Interacting Protein

LIFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIFR here. Most of them are supplied by our site. Hope this information will be useful for your research of LIFR.
OSM; LIF; CNTF; PRPF4; BAG3; Bmpr1a; GOLT1B

LIFR Related Articles

Sommer, J; Engelowski, E; et al. Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:651-660(2014).
Larrea, E; Echeverria, I; et al. Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection. JOURNAL OF HEPATOLOGY 60:482-489(2014).

LIFR Related Gene Family

IL