LIFR
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Official Full Name
Leukemia Inhibitory Factor Receptor -
Overview
LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. -
Synonyms
LIFR;Interferon α Receptor β Chain;leukemia inhibitory factor receptor alpha;SWS;SJS2;STWS;CD118;LIF-R;FLJ98106;FLJ99923;leukemia inhibitory factor receptor;CD118 antigen;LIF receptor
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- HEK293
- Human Cells
- Sf21 Cells
- E.coli
- Wheat Germ
- Insect Cells
- Mammalian Cells
- Insect cells
- His
- Fc
- GST
- Non
- Avi
Involved Pathway
LIFR involved in several pathways and played different roles in them. We selected most pathways LIFR participated on our site, such as Cytokine-cytokine receptor interaction,Signaling pathways regulating pluripotency of stem cells,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCL5,TNFSF9,CCL21,TNFRSF1B,IFNB,CCL3,LIF,PDGFRA,IL28RA,CSF1RA |
| Jak-STAT signaling pathway | SOCS7,MYCB,Il4ra,PTPN2A,IL12B,CCND2,CCND2A,PIK3R5,GHRA,IFNA13 |
| Signaling pathways regulating pluripotency of stem cells | SOX2,WNT9B,MAPK11,RAF1,FZD8,FZD2,ACVR1B,KLF4,DLX5,WNT3 |
Protein Function
LIFR has several biochemical functions, for example, contributes_to ciliary neurotrophic factor receptor activity,ciliary neurotrophic factor receptor binding,cytokine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIFR itself. We selected most functions LIFR had, and list some proteins which have the same functions with LIFR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to oncostatin-M receptor activity | OSMR,IL6ST |
| growth factor binding | NRP2,RHBDF2,FLT4,REG3B,FGFBP2,ACVR1C,IGFBP2B,LTBP4,GHR,NRP1 |
| cytokine binding | KIT,Fzd4,CSF1R,GBP1,PARK7,CRLF1,NRP1,CNTFR,CSF1RA,KITA |
| protein heterodimerization activity | PKNOX1,DVL3,HIST3H3,MID1,SCGB2A1,UGT1A6B,IRAK1,ZHX2,HAND1,PDSS1 |
| ciliary neurotrophic factor receptor binding | Ctf2,CLCF1,CNTF,IL6ST |
| contributes_to leukemia inhibitory factor receptor activity | IL6ST |
| contributes_to ciliary neurotrophic factor receptor activity | IL6R,CNTFR,Il6ra |
Interacting Protein
LIFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIFR here. Most of them are supplied by our site. Hope this information will be useful for your research of LIFR.
OSM;LIF;CNTF;PRPF4;BAG3;Bmpr1a;GOLT1B
Resources
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References
- Sommer, J; Engelowski, E; et al. Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:651-660(2014).
- Larrea, E; Echeverria, I; et al. Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection. JOURNAL OF HEPATOLOGY 60:482-489(2014).
