map2k3
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  • Official Full Name
  • mitogen-activated protein kinase kinase 3
  • Background
  • MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5). MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAP
  • Synonyms
  • MAP2K3; mitogen-activated protein kinase kinase 3; PRKMK3; dual specificity mitogen-activated protein kinase kinase 3; dual specificity mitogen activated protein kinase kinase 3; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK3; MEK3; MKK3; MEK 3; MAPKK 3
Cat.#:MAP2K3-29204THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K3, His-tagged
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Cat.#:MAP2K3-303HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K3 protein, His/MBP-tagged
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Cat.#:MAP2K3-9500MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAP2K3 Protein
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Cat.#:MAP2K3-2664RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAP2K3 Protein, His-tagged
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Cat.#:MAP2K3-2016CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAP2K3
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Cat.#:MAP2K3-794HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K3, His-tagged
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Cat.#:MAP2K3-4510HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAP2K3 293 Cell Lysate
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Cat.#:MAP2K3-4511HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAP2K3 293 Cell Lysate
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Involved Pathway

MAP2K3 involved in several pathways and played different roles in them. We selected most pathways MAP2K3 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP3K6; MAP2K1; RAP1AA; TGFBR1B; CACNA1DA; MAP2K7; FGF8A; PRKACAB; GADD45G; MAPK8IP2
Rap signaling pathway
PDGFB; MAGI2; MAP2K2; LPAR2; MAP2K1; RASSF5; ITGAL; TLN1; FGF9; FGFR3
Toll-like receptor signaling pathway
MAP2K1; IFNB; CRFB2; TICAM2; IFNA10; IFNPHI1; TLR3; NFKBIAA; TLR2-1; AKT2L
Fc epsilon RI signaling pathway
PIK3R1; MAP2K7; AKT1; TNF; FCER1G; RAC1; LAT; PIK3R3; MS4A2; PIK3R5
TNF signaling pathway
PIK3CA; ICAM1; PIK3R5; CREB3L3; CREB3L1; SOCS3; MAP2K6; MAGI2; MAP2K7; TRAF2
Inflammatory mediator regulation of TRP channels
CYP2C50; TRPA1; NGF; PLCB4; MAPK13; IL1B; CYP2C70; PRKACG; PRKCB; HTR2B
GnRH signaling pathway
MAP2K2; CACNA1C; GNAS; GNRHR4; MMP14A; MAPK9; PRKCD; PRKACAA; MAP2K4; LHB
Amyotrophic lateral sclerosis (ALS)
SOD1; BID; GRIA2; TOMM40L; DAXX; MAP2K3; TNF; GRIN2A; Casp3; MAP3K5
Toxoplasmosis
HLA-DRB4; LAMA3; STAT1; GNAI1; MAP2K6; PIK3R5; SOCS1; LAMC1; CASP8; HLA-DOB
Influenza A
DDX39B; CPSF4; TRIM25; TNFSF10; TLR4; HSPA1A; PRSS3; HLA-DOA; EIF2AK1; TLR7
Epstein-Barr virus infection
HSPA1A; PIK3R1; TNFAIP3; POLR3GL; POLR1D; ICAM1; POLR2I; NFKBIB; PIK3CA; POLR2B

Protein Function

MAP2K3 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K3 itself. We selected most functions MAP2K3 had, and list some proteins which have the same functions with MAP2K3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein STK38L; RECQL4; MARK1; HIPK3; DYNC1LI1; DAK; HSP70L; THRAP3; DSTYK; PTK2AB
Function MAP kinase kinase activity
Related Protein MAPKAPK5; MAP2K2B; MAPK14; MAP2K1; MAP3K14; MAP3K20; MAP2K6; SBK3; MAP2K7; LRRK2
Function protein binding
Related Protein HOMER1; NPLOC4; EFHA1; DOK1; NACA; PPP1R12B; EXOSC3; HMG20B; RAD50; RBCK1
Function protein kinase binding
Related Protein CENPJ; CDK5; Cd24a; TEX14; XBP1; FAF1; KCNQ3; PTK2; KIF11; CCNB1
Function protein serine/threonine kinase activity
Related Protein MAPK14; RPS6KA3B; IRAK2; ROCK1; MTOR; MAP2K5; LMTK3; SGK3; PIK3R4; TSSK4
Function protein tyrosine kinase activity
Related Protein FGFR4; INSRA; DYRK3; KIAA1804; ERBB4; MAP2K2; NTRK2B; KDR; EPHB4B; ZAP70

Interacting Protein

MAP2K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K3.
LRRK2; MAPK14; DYRK1B; TINF2; MAP3K5; MAP2K6; PKN1; MAPK14; TAOK2; MAP3K4; ALDOC; RPL13

MAP2K3 Related Articles

Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).