MAP2K3 Protein, mitogen-activated protein kinase kinase 3

MAP2K3

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MAP2K3

Official Full Name mitogen-activated protein kinase kinase 3
Background MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5). MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAP
Synonyms MAP2K3; mitogen-activated protein kinase kinase 3; PRKMK3; dual specificity mitogen-activated protein kinase kinase 3; dual specificity mitogen activated protein kinase kinase 3; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK3; MEK3; MKK3; MEK 3; MAPKK 3
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • MBP
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K3-29204TH Recombinant Human MAP2K3, His-tagged E.coli His
    Human MAP2K3-303H Recombinant Human MAP2K3 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K3-4510HCL Recombinant Human MAP2K3 293 Cell Lysate HEK293 N/A
    Human MAP2K3-4511HCL Recombinant Human MAP2K3 293 Cell Lysate HEK293 N/A
    Human MAP2K3-794H Recombinant Human MAP2K3, His-tagged E.coli His
    Mouse MAP2K3-9500M Recombinant Mouse MAP2K3 Protein Mammalian Cell His
    Rhesus Macaque MAP2K3-2664R Recombinant Rhesus monkey MAP2K3 Protein, His-tagged Mammalian Cell His
    Chicken MAP2K3-2016C Recombinant Chicken MAP2K3 Mammalian Cell His

    MAP2K3 involved in several pathways and played different roles in them. We selected most pathways MAP2K3 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway NTRK2; TNF; PRKACBB; Pdgfa&Pdgfb; TGFB3; PPP3CCB; HSPA1B; FGFR2; NTF4; PTPN7
    Rap signaling pathway PIK3CA; PLCB4; FGF9; PGF; LAT; LCP2; HGF; MLLT4; PDGFC; FGFR4
    Toll-like receptor signaling pathway IFNB; CCL4; MAPK12A; CXCL9; IFNA1; CCL5; TRAF3; NFKBIA; STAT1A; MAP2K1
    Fc epsilon RI signaling pathway INPP5D; LYN; PIK3R1; PLA2G4A; MAP2K3; RAF1; KRAS; PDPK1; PLA2G4D; MAPK12
    TNF signaling pathway LIF; IKBKG; RPS6KA4; CCL20; BIRC2; SOCS3; AKT2; SELE; MAPK11; CREB3L2
    Inflammatory mediator regulation of TRP channels TRPM8; PLCB3; PRKACA; CYP2C50; CALML5; PLA2G4A; TRPV4; CAMK2B; CYP2C37; TRPV3
    GnRH signaling pathway GNA11B; PLA2G4AA; CAMK2B1; ATF4; ATF4B1; CACNA1SB; MAPK14B; MAP2K4; MAP2K1; FSHB
    Amyotrophic lateral sclerosis (ALS) TRP53; GRIN1; SLC1A2; TNFRSF1B; PPP3CA; PPP3CC; GRIN2B; DAXX; NEFM; GRIA2
    Toxoplasmosis HLA-DQA2; PIK3R5; HSPA8; HSPA2; LAMA5; HSPA1A; MAP3K7; PIK3R3; TYK2; IL12A
    Influenza A IRF3; CASP9; TNF; IL8L2; RSAD2; FURIN; EIF2AK3; MAP2K3; IFNB1; IL12B
    Epstein-Barr virus infection EIF2AK3; NFKBIE; DDX58; IKBKG; CDK1; GTF2B; POLR2F; NFKBIA; TRAF3; CCNA1

    MAP2K3 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K3 itself. We selected most functions MAP2K3 had, and list some proteins which have the same functions with MAP2K3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ABCB9; NLRP5; MYO1EB; EPHA8; LRGUK; TEX14; CAMK4; PIP5K1A; DYNC1H1; GRK1
    MAP kinase kinase activity MAPK10; MAP3K20; ALPK2; MAPKAPK5; MAP2K6; MAP2K7; MAP2K3; MAPK14; MAP2K2B; MAP2K1
    protein binding RNF170; C2orf65; KIAA1524; TNIP3; MARK3; STX11; KIAA0649; IRF5; AGTR1A; JIP1
    protein kinase binding SV2A; MAVS; CCNL1A; NCS1; CCNL1B; TRP53; DVL1; CAV2; CCNE1; ITGB2
    protein serine/threonine kinase activity PRKCZ; PRKACAB; CDK1; CIT; DYRK1A; MYO3A; OBSCN; MAP4K6; TAF1L; PIK3CA
    protein tyrosine kinase activity IGF1RA; NTRK3A; ROS1; MAP2K2; HCK; MET; PTK2AA; INSRA; FGFR1; DYRK4

    MAP2K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K3.

    LRRK2; MAPK14; DYRK1B; TINF2; MAP3K5; MAP2K6; PKN1; MAPK14; TAOK2; MAP3K4; ALDOC; RPL13

    Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
    Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).

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