map3k3
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  • Official Full Name
  • mitogen-activated protein kinase kinase kinase 3
  • Background
  • MAP kinase kinase kinase (MEKK3 or MAP3K3) is a serine/threonine protein kinase that activates SAPK and ERK via phosphorylation and activation of their respective MAP kinase kinases, SEK and MEK1/2 (1,2). MEKK3 also stimulates MEK5 via activation of ERK5/
  • Synonyms
  • MAP3K3; mitogen-activated protein kinase kinase kinase 3; MEKK3; MAP/ERK kinase kinase 3; MAPK/ERK kinase kinase 3; MAPKKK3; MEKK 3; MEK kinase 3
Cat.#:MAP3K3-30192THTag:
Source (Host):Species:Human
Product nameRecombinant Human MAP3K3
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Cat.#:MAP3K3-352HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAP3K3, GST-tagged, Active
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Cat.#:MAP3K3-735HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP3K3 Protein, His-tagged
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Cat.#:MAP3K3-2669RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAP3K3 Protein, His-tagged
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Cat.#:MAP3K3-1259HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 3, GST-tagged
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Cat.#:MAP3K3-4505HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAP3K3 293 Cell Lysate
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Involved Pathway

MAP3K3 involved in several pathways and played different roles in them. We selected most pathways MAP3K3 participated on our site, such as MAPK signaling pathway, Neurotrophin signaling pathway, GnRH signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
TGFBR2; PAK2B; Fasl; MAP2K2; HRASA; MOS; FGF4; CACNB3; PRKCA; JIP1
Neurotrophin signaling pathway
BRAF; PTPN11; MAP2K7; AKT1; PSEN1; KRAS; MATK; RPS6KA1; SH2B3; RHOA
GnRH signaling pathway
CALML5; PRKCB; CGNRH-R; PLCB3; CALML3; PRKCA; CALM; GNRH3; PRKACBA; PLD1A
HTLV-I infection
CALR; MAP3K1; CREM; WNT11; NFKB1; SLC25A4; POLE2; SMAD4; WNT9A; MAP3K3

Protein Function

MAP3K3 has several biochemical functions, for example, ATP binding, MAP kinase kinase kinase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K3 itself. We selected most functions MAP3K3 had, and list some proteins which have the same functions with MAP3K3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DNAJA3; EPB42; STK32A; TYK2; SRPK3; MCM8; ATP1A1; LMTK3; CDC34A; TOR1B
Function MAP kinase kinase kinase activity
Related Protein MAP3K13; TAOK2; YSK4; MAP3K14; MAP3K5; ZAK; STK4; MAP3K4; TAOK1; TAOK3
Function metal ion binding
Related Protein S100S; SP2; FTR82; RBM26; ZNF215; SEMG1; CYP2C55; ZNF48; CSGALNACT1; ZNF562
Function protein binding
Related Protein SLC30A8; ARMC2; IMMT; CA8; TNS3; ZNF136; MFN2; GAST; C9orf9; DACH1
Function protein kinase activity
Related Protein PRKCBB; LMTK2; PTK7A; NPR1A; STK24B; ACVR1BA; SYK; RPS6KB1B; ROCK1; ADRBK1

Interacting Protein

MAP3K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K3.
YWHAE; TRAF7; CHUK; FLNA; MAP2K5; YWHAB; YWHAE

MAP3K3 Related Articles

Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).