Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 3, GST-tagged MAP3K3-1259H

Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 3, GST-tagged

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Cat.No. : MAP3K3-1259H Optional Service: Optional requirements on this protein
Product Overview : Recombinanthuman full length MAP3K2 with N-terminal GST tag is expressed in Insect cells.
Description : MAP3K3directly regulates MAPK8 and extracellular signal-regulated protein kinase(ERK) pathways by phosphorylating multiple MAP2Ks.
Source : Insect cells
Species : Human
Form : Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT+ 50% glycerol.
Molecular Weight : 99.8 kDa
Purity : ≥ 90% as determinedby SDS-PAGE analysis.
Specific Activity : 20 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 8.33μg/ml.
Concentration : 0.22mg/ml
Storage : Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : MAP3K3
nullValue_other :
FunctionATP binding; MAPkinase kinase kinase activity; metal ion binding; protein kinase activity; nucleotidebinding; protein serine/tyreonine kinase activity
PDB rendering basedon 2c60. :

Gene Name : MAP3K3 mitogen-activated proteinkinase kinase kinase 3 [ Homo sapiens ]
Synonyms : MAP3K3; mitogen-activatedprotein kinase kinase kinase 3; MEKK3; MAPKKK3; MAPK/ERKkinase kinase 3; EC 2.7.11.25; MEK kinase 3; MAP/ERK kinasekinase 3
Gene ID : 4215
mRNA Refseq : NM_002401
Protein Refseq : NP_002392
MIM : 609487
UniProt ID : Q99759
Chromosome Location : 17q23.3
Pathway : Cytokine Signalingin Immune system; EGFR1 Signaling Pathway; ErbB1 downstream signaling; Gapjunction; GnRH signaling pathway; HTLV-I infection; IL1-mediatedsignaling events; Immune System; Interleukin-1signaling;Neurotrophinsignaling pathway; Regulation of p38-alpha and p38-beta; Signalingby Interleukins; Insulin Signaling; TNF receptorsignaling pathway; MAPK Cascade; MAPK signaling pathway; TNF-alpha/NF-kBSignaling Pathway; Trk receptor signaling mediated by the MAPK pathway
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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