- Human(7)
- Rhesus Macaque(1)
Recombinant Human MAP3K3 Protein, His-tagged
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Cat.No. : | MAP3K3-735H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human MAP3K3, transcript variant 2, fused with His tag at N-terminal was expressed in E. coli. |
Description : | This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions. |
Molecular Mass : | 70.7 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Concentration : | >50 ug/mL as determined by microplate BCA method |
Gene Name : | MAP3K3 mitogen-activated protein kinase kinase kinase 3 [ Homo sapiens ] |
Official Symbol : | MAP3K3 |
Synonyms : | MAP3K3; mitogen-activated protein kinase kinase kinase 3; MEKK3; MAP/ERK kinase kinase 3; MAPK/ERK kinase kinase 3; MAPKKK3; MEKK 3; MEK kinase 3; |
Gene ID : | 4215 |
mRNA Refseq : | NM_002401 |
Protein Refseq : | NP_002392 |
MIM : | 602539 |
UniProt ID : | Q99759 |
◆ Recombinant Protein
MAP3K3-2669R | Recombinant Rhesus monkey MAP3K3 Protein, His-tagged | +Inquiry |
MAP3K3-30192TH | Recombinant Human MAP3K3 | +Inquiry |
MAP3K3-352H | Recombinant Human MAP3K3, GST-tagged, Active | +Inquiry |
MAP3K3-2492H | Recombinant Human MAP3K3 protein, His-tagged | +Inquiry |
MAP3K3-1259H | Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 3, GST-tagged | +Inquiry |
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◆ Lysates
MAP3K3-4505HCL | Recombinant Human MAP3K3 293 Cell Lysate | +Inquiry |
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MAP1LC3AMAP1LC3BMAP1LC3B2Map2k1MAP2K2MAP2K3MAP2K6Map3k1MAP3K14MAP3K2MAP3K3MAP3K5MAP3K8MAP4K5MAP2K4MAP3K6MAP2K5MAP2K7MAP3K11MAP4K4MAP4K2MAP4K1MAP1SMap2MAP3K13MAP3K15MAP3K4MAP3K7MAP3K7IP1MAP4MAP3K10MAP3K9MAP1AMAP1BMAP7MAP4K3MAP3K12MAP1LC3CMAP6D1MAP7D1MAP9MAP6MAP2K1IP1MAP7D2MAP7D3
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