Recombinant Human MAP3K3
| Cat.No. : | MAP3K3-30192TH |
| Product Overview : | Recombinant full-length Human MEKK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal proprietary tag. |
- Specification
- Gene Information
- Related Products
| Description : | This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
| Biological activity : | Specific activity: 20nmol/min/mg. |
| Form : | Liquid |
| Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5 |
| Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequence Similarities : | Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Contains 1 OPR domain.Contains 1 protein kinase domain. |
| Gene Name : | MAP3K3 mitogen-activated protein kinase kinase kinase 3 [ Homo sapiens ] |
| Official Symbol : | MAP3K3 |
| Synonyms : | MAP3K3; mitogen-activated protein kinase kinase kinase 3; MEKK3; MAP/ERK kinase kinase 3; MAPK/ERK kinase kinase 3; MAPKKK3; |
| Gene ID : | 4215 |
| mRNA Refseq : | NM_002401 |
| Protein Refseq : | NP_002392 |
| MIM : | 602539 |
| Uniprot ID : | Q99759 |
| Chromosome Location : | 17q |
| Pathway : | Cytokine Signaling in Immune system, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; GnRH signaling pathway, organism-specific biosystem; GnRH signaling pathway, conserved biosystem; HTLV-I infection, organism-specific biosystem; |
| Function : | ATP binding; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; |
Products Types
| ◆ Recombinant Protein | ||
| MAP3K3-2489R | Recombinant Rhesus Macaque MAP3K3 Protein, His (Fc)-Avi-tagged | +Inquiry |
| MAP3K3-2669R | Recombinant Rhesus monkey MAP3K3 Protein, His-tagged | +Inquiry |
| MAP3K3-735H | Recombinant Human MAP3K3 Protein, His-tagged | +Inquiry |
| MAP3K3-352H | Recombinant Human MAP3K3, GST-tagged, Active | +Inquiry |
| MAP3K3-2492H | Recombinant Human MAP3K3 protein, His-tagged | +Inquiry |
| ◆ Lysates | ||
| MAP3K3-4505HCL | Recombinant Human MAP3K3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Ask a Question for All MAP3K3 Products
Required fields are marked with *
My Review for All MAP3K3 Products
Required fields are marked with *
0
Inquiry Basket
