- Human(7)
- Rhesus Macaque(1)
Recombinant Human MAP3K3
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Cat.No. : | MAP3K3-30192TH Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant full-length Human MEKK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal proprietary tag. |
Description : | This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. |
Biological activity : | Specific activity: 20nmol/min/mg. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Contains 1 OPR domain.Contains 1 protein kinase domain. |
Gene Name : | MAP3K3 mitogen-activated protein kinase kinase kinase 3 [ Homo sapiens ] |
Official Symbol : | MAP3K3 |
Synonyms : | MAP3K3; mitogen-activated protein kinase kinase kinase 3; MEKK3; MAP/ERK kinase kinase 3; MAPK/ERK kinase kinase 3; MAPKKK3; |
Gene ID : | 4215 |
mRNA Refseq : | NM_002401 |
Protein Refseq : | NP_002392 |
MIM : | 602539 |
Uniprot ID : | Q99759 |
Chromosome Location : | 17q |
Pathway : | Cytokine Signaling in Immune system, organism-specific biosystem; EGFR1 Signaling Pathway, organism-specific biosystem; GnRH signaling pathway, organism-specific biosystem; GnRH signaling pathway, conserved biosystem; HTLV-I infection, organism-specific biosystem; |
Function : | ATP binding; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; |
◆ Recombinant Protein
MAP3K3-2492H | Recombinant Human MAP3K3 protein, His-tagged | +Inquiry |
MAP3K3-735H | Recombinant Human MAP3K3 Protein, His-tagged | +Inquiry |
MAP3K3-352H | Recombinant Human MAP3K3, GST-tagged, Active | +Inquiry |
MAP3K3-2669R | Recombinant Rhesus monkey MAP3K3 Protein, His-tagged | +Inquiry |
MAP3K3-1259H | Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 3, GST-tagged | +Inquiry |
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◆ Lysates
MAP3K3-4505HCL | Recombinant Human MAP3K3 293 Cell Lysate | +Inquiry |
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MAP1LC3AMAP1LC3BMAP1LC3B2Map2k1MAP2K2MAP2K3MAP2K6Map3k1MAP3K14MAP3K2MAP3K3MAP3K5MAP3K8MAP4K5MAP2K4MAP3K6MAP2K5MAP2K7MAP3K11MAP4K4MAP4K2MAP4K1MAP1SMap2MAP3K13MAP3K15MAP3K4MAP3K7MAP3K7IP1MAP4MAP3K10MAP3K9MAP1AMAP1BMAP7MAP4K3MAP3K12MAP1LC3CMAP6D1MAP7D1MAP9MAP6MAP2K1IP1MAP7D2MAP7D3
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