MAPK3 Protein, MAPK3 mitogen-activated protein kinase 3

MAPK3

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MAPK3

Official Full Name MAPK3 mitogen-activated protein kinase 3
Synonyms MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk; MAPK 1; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; mitogen-activated protein kinase 1; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; ERT2; ERK-1; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; MGC20180;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • His&GST
    • MBP
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK3-1050H Recombinant Human MAPK3 Protein, His/GST-Tagged E. coli His&GST
    Human ERK1-125H Recombinant Human MAPK3 protein, His-tagged E.coli His
    Human MAPK3-061H Recombinant Human MAPK3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human MAPK3-1031M Recombinant Human MAPK3 protein E.coli N/A
    Human MAPK3-1048H Recombinant Human Mitogen-Activated Protein Kinase 3 (Active), GST-Tagged E.coli GST
    Human MAPK3-1049H Recombinant Human Mitogen-Activated Protein Kinase 3 (Unactive), GST-Tagged E.coli GST
    Human MAPK3-1517H Recombinant Human MAPK3 protein E.coli N/A
    Human MAPK3-2787H Recombinant Human MAPK3, His-tagged E.coli His
    Human MAPK3-28694TH Recombinant Human MAPK3 E.coli N/A
    Human MAPK3-28699TH Recombinant Human MAPK3 E.coli N/A
    Human MAPK3-286H Recombinant Human MAPK3 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK3-287H Recombinant Human MAPK3 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK3-288H Recombinant Human MAPK3 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK3-28H Recombinant human biotinylated ERK1, His-tagged E.coli His
    Human MAPK3-307H Recombinant Human Mitogen-activated Protein Kinase 3, Active Sf9 Insect Cell N/A
    Human MAPK3-34H Recombinant Human MAPK3 E.coli N/A
    Human MAPK3-36H Recombinant Human MAPK3 E.coli N/A
    Human MAPK3-4494HCL Recombinant Human MAPK3 293 Cell Lysate HEK293 N/A
    Mouse MAPK3-9534M Recombinant Mouse MAPK3 Protein Mammalian Cell His
    Rat MAPK3-3574R Recombinant Rat MAPK3 Protein Mammalian Cell His
    Zebrafish MAPK3-11551Z Recombinant Zebrafish MAPK3 Mammalian Cell His

    MAPK3 involved in several pathways and played different roles in them. We selected most pathways MAPK3 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FASLG; KCNA3; FLNA; CACNB2; KRAS; MAP3K11; GNG12; CACNG4; CACNA1SB; FGFR1A
    ErbB signaling pathway AKT3A; AKT1; HRASB; PTK2AB; NCK2A; AKT2; PAK6B; PTK2AA; MAP2K2B; EGFRA
    Ras signaling pathway GNG5; PLA2G2A; ARF6; PAK1; RAC3; FGFR4; CALM4; Fgf15; PTPN11; RASA1
    Rap signaling pathway LPAR2; MAP2K1; FGF16; MLLT4; MAPK1; FLT1; RALGDS; ARAP3; GRIN2B; RASSF5
    cGMP-PKG signaling pathway PIK3CB; PPP1CA; GNA12; CALM4; BDKRB2; CREB3L2; RHOA; AGTR1B; PIK3CA; NFATC2
    cAMP signaling pathway HCAR3; PIK3R3; OXTR; ATP1B3; PAK1; TSHR; DRD1A; PLD2; RELA; GNAS
    Chemokine signaling pathway CXCL12; BRAF; CCR9; JAK2; CX3CR1; PIK3CB; PF4; CCL4; Adcy4; KRAS
    HIF- signaling pathway PLCG2; ENO1; INS; PIK3CD; CAMK2B; MKNK2; ARNT; FLT1; Trf; IGF1
    FoxO signaling pathway SMAD3; GABARAP; KLF2B; FOXO1A; MAPK8; G6PC2; HRASA; PLK4; HRAS; CDKN2B
    Sphingolipid signaling pathway MAPK8; PRKCE; MAPK10; AKT2; PRKCG; PIK3R1; SGPP1; PLCB1; SGPL1; LASS4
    Phospholipase D signaling pathway F2R; SHC1; PDGFA; PPAP2C; MRAS; PTPN11; TSC1; LPAR4; MAPK1; SHC2
    Oocyte meiosis YWHAH; PTTG2; SMC1AL; FBXW11B; PPP3CC; SMC1A; PPP1CC; ADCY1A; INS1; CALM2A
    mTOR signaling pathway PIK3R5; HIF1AB; TSC1; DEPDC6; RPS6KB1; PRKCA; CAB39L; PIK3R1; AKT1S1; TSC1A
    PIK-Akt signaling pathway IFNA2; TRP53; MTCP1; FGFR1; TCL1B1; SPP1; CCND1; RXRA; PKN3; MET
    Adrenergic signaling in cardiomyocytes CACNA1SB; PPP2R2D; AGTR2; ADRB2A; AKT2L; PPP1CA; PPP1CAB; SCN5A; CACNB3; TNNC1B
    Vascular smooth muscle contraction NPR1A; RHOA; MAP2K2B; PLA2G12B; PPP1R14A; MYLK4; ITPR1; GNA12A; CALM2A; KCNMB3
    Dorso-ventral axis formation SPIRE2; NOTCH4; NOTCH1B; ETS1; ETV6; MAP2K1; GRB2B; ETV7; SPIRE1; MAPK3
    TGF-beta signaling pathway BMP2; MYCB; BMPR2B; BMP5; RHOA; ACVR1L; GDF5; BMP8A; LFT2; TGFB1A
    Axon guidance ABLIM2; SEMA4D; FRS3; GSK3B; KCNQ2; FRS2A; FGF8B; ACTR3; SPNA2; COL9A1B
    VEGF signaling pathway HSPB1; PLA2G4F; RAF1B; PTK2AA; PPP3CB; AKT3A; MAP2K2B; MAPK3; PIK3R2; MAPK12A
    Osteoclast differentiation SQSTM1; LCP2; NOX1; NFATC1; MAPK10; TYROBP; SIRP-BETA; MAPK3; FCGR4; SYK
    Focal adhesion ITGB6; COL4A2; PRKCBB; VCL; RHOA; PDGFB; PDGFRB; ACTB2; CCND2A; TLN2A
    Adherens junction LMO7; NLK; CDH1; FYN; PVRL1; FGFR1; PTPRB; ACTN4; LEF1; SMAD3
    Gap junction PDGFA; CX43; HRAS; PDGFC; MAPK7; NRAS; ADCY1B; DRD2L; GRB2B; CDK1
    Signaling pathways regulating pluripotency of stem cells PCGF2; INHBA; FGFR2; FZD5; BMP4; ZFHX3; WNT7B; LIF; MAP2K1; WNT11
    Platelet activation PIK3CD; P2RX1; TBXA2R; ACTB; SRC; ARHGEF1; AKT1; MYLK; ARHGAP35; GNAQ
    Toll-like receptor signaling pathway NFKB1; TLR9; CXCL9; TRAF6; CRFB2; MAP2K2A; CD40; PIK3R3A; TLR8; PIK3R2
    NOD-like receptor signaling pathway NLRP1; RIPK2; MAPK8B; MAPK9; RELA; HSP90AA1.2; IL8L1; BIRC3; NFKBIAB; BIRC2
    Natural killer cell mediated cytotoxicity SOS1; MAP2K1; NRAS; HLA-C; TNFRSF10A; ULBP3; Raet1a; IFNA16; SHC4; HLA-B
    T cell receptor signaling pathway CDC42; SHB; PAK7; CBLC; PAK2; MAP3K14; ZAP70; SOS1; VAV2; EVLB
    B cell receptor signaling pathway RAF1; PDK2; PPP3R2; PIK3R1; LIME1; PDK2B; RASGRP3; STAP1; LCP2A; RAC1
    Fc epsilon RI signaling pathway MAPK10; KRAS; AKT1; MAP2K6; PLA2G4B; MAPK8; RAF1; PLA2G4F; GRB2; RAC2
    Fc gamma R-mediated phagocytosis VAV3; PIK3R5; CFL1; WASL; PIK3CD; RPS6KB2; VASP; FCGR2B; MAPK3; INPPL1
    TNF signaling pathway FADD; MAPK9; RPS6KA5; MAP2K3; BIRC2; TAB2; RELA; DNM1L; RIPK1; TNFAIP3
    Circadian entrainment GNG5; GRIN1; PLCB3; AKR1C1; MAPK1; CAMK2A; GNB1; GNAQ; RYR3; GNB3
    Long-term potentiation GRIN2B; PLCB2; CALML3; PPP1CC; CAMK2B; PPP3R2; MAP2K2; MAPK3; ITPR1; GRIN2C
    Neurotrophin signaling pathway MAPK8; CAMK2A; BAD; RPS6KA5; MAPK9; MAPK11; MAPK1; BRAF; NFKB1; MAGED1
    Retrograde endocannabinoid signaling GNB3; PRKCG; GABRG1; GNG8; GABRA2; Adcy4; ABHD6; GNAQ; NAPEPLD; GABRA3
    Glutamatergic synapse PLA2G4A; GNGT1; PLCB3; GRIN3B; GRIN3A; GRIA1; SLC1A6; GRIK5; PPP3CC; GRM4
    Cholinergic synapse PIK3R1; CHRNA6; CHRNA3; PIK3CB; CREB3; GNAO1; KRAS; PIK3R5; GNAQ; GNG10
    Serotonergic synapse CYP4X1; GNAQ; KCNN2; CYP2C37; TRPC1; ALOX15B; GNAI1; MAOA; GABRB2; CYP2J5
    Long-term depression GUCY1A3; GNA12; PLCB4; RAF1; IGF1R; ARAF; GNAI1; ITPR1; GRM1; GNA13
    Regulation of actin cytoskeleton ACTN2; PIP5K1BA; ITGB1A; DIAP1; PIK3R3A; KRAS; PPP1CB; ITGB7; MYL12.1; ARHGEF7
    Insulin signaling pathway PPP1R3D; SOCS4; PYGL; FLOT1A; FLOT1; FASN; CALM1A; PYGM; BADB; SOCS3
    GnRH signaling pathway CACNA1SA; PRKCBA; CALM1A; PRKACBA; PLCB4; GNRHR; RAF1B; CAMK2G; CALM3B; CACNA1D
    Progesterone-mediated oocyte maturation CDC27; CDC23; IGF1R; CCNB1; MAD2L2; CPEB1; IGF1RA; KRAS; INSB; RPS6KA1
    Estrogen signaling pathway SHC4; RAF1; ESR2; FKBP4; ITPR3; MAPK1; KCNJ9; CREB3L1; CREB3L3; GRB2
    Melanogenesis GNAI2A; WNT2BB; CREB3L3L; GNAQ; GNA11A; RAF1; CAMK2D2; WNT2; FZD2; GNAI2B
    Prolactin signaling pathway CCND2; CSH; PRP2; ESR1; SHC2; ELF5; INS2; LHB; MAPK1; PPIB
    Thyroid hormone signaling pathway FOXO1; PRKCG; RCAN2; CASP9; DIO2; PIK3CG; HIF1A; NCOR1; NCOA1; SLC9A1
    Oxytocin signaling pathway PPP1R12A; OXT; CALM4; CACNA2D3; PLCB2; PLA2G4F; RAF1; MAP2K1; PRKAG3; ROCK2
    Type II diabetes mellitus IKBKB; HKDC1; PRKCE; ADIPOQ; PIK3R1; PKM2; SOCS4; INS1; MTOR; PIK3R2
    Aldosterone-regulated sodium reabsorption PRKCA; PIK3R1; PIK3CD; INSR; ATP1B1; MAPK1; NR3C2; PIK3R2; PDPK1; ALPHA-ENAC
    Alzheimers disease GNAQ; NDUFA3; NDUFV1; NDUFS4; CALM4; RYR3; SDHC; COX6C; COX7C; BACE2
    Prion diseases NOTCH1; MAP2K2; IL1B; C9; ELK1; C8A; STIP1; LOC100033925; C7; PRKACG
    Alcoholism HIST1H2BJ; HIST1H4D; ADORA2A; ATF6B; HIST1H2BB; H3F3A; CREB5; GNG3; HIST1H2AO; HIST1H3I
    Shigellosis CDC42; HCLS1; MAPK3; FBXW11; ELMO2; NFKBIB; MAPK1; NFKB1; VCL; ACTG1
    Salmonella infection CCL3L1; IFNGR2; NLRC4; PFN3; MAPK11; NFKB1; PKN1; RHOGD; ARPC4L; ROCK2B
    Pertussis IRF8; GNAI2; IL-8; C4BPB; IRF1; IL23; IL6; C4BP; CASP7; C1QC
    Leishmaniasis IFNG; HLA-DRB3; FCGR2C; MYD88; ITGA4; PRKCB; NCF1; ITGB2L; FCGR2A; IFNGR1
    Chagas disease (American trypanosomiasis) PLCB3; IFNB1; MYD88; PLCB1; GNAQ; MAPK11; SMAD3; IFNGR2; NFKB1; PPP2R2C
    Toxoplasmosis LAMA2; MAPK12; BIRC7; TGFB1; PPIF; IL12A; CASP9; MAPK8; BIRC3; LAMB4
    Tuberculosis CORO1A; HLA-DQA1; HLA-DPB1; IFNA17; IFNA21; ATP6V0B; HLA-DRB3; AKT2; EEA1; Cd209g
    Hepatitis C IRF3; PPP2R2C; CLDN5; PPP2CB; IFNAR1; PIK3R1; BRAF; SOS1; AKT1; MAPK9
    Hepatitis B MAP3K1; IFNA8; BAX; CXCL8; IFNA21; IFNA6; TNF; TICAM2; PCNA; CASP10
    Influenza A IL8L1; MAPK8; IRAK4; PRSS2; IFNA21; MAP2K3; IFN-a; SLC25A6; XPO1; LOC100686744
    Pathways in cancer FGFR2; BIRC7; PIK3CG; WNT11; PTK2; WNT3A; HSP90AA1; GNG3; STAT5B; LAMA4
    Viral carcinogenesis RAC1; HRAS; NFKB2; HLA-A; VAC14; CCNA2; TRAF2; ATP6V0D1; PRKACG; PIK3R3
    Proteoglycans in cancer FASLG; CCND1; HSPB2; ELK1; ARHGEF12; FGF2; LUM; PRKCB; HOXD10; IGF1
    Colorectal cancer PIK3R1; MSH6; TGFB3; AXIN1; RAC3; MAPK9; TP53; LEF1; CASP9; MSH2
    Renal cell carcinoma HIF1A; TGFB2; VEGFA; PAK7; AKT2; PIK3CA; FH; AKT1; RAP1B; NRAS
    Pancreatic cancer BRAF; RAF1; PIK3R3; TGFB3; MAPK3; IKBKG; STAT3; KRAS; SMAD4; ERBB2
    Endometrial cancer MAP2K1; PIK3CB; MLH1; CTNNA3; PTEN; RAF1; PIK3CG; AXIN2; CDH1; ERBB2
    Glioma RB1; RAF1; TP53; AKT2; PDGFA; PIK3CD; BRAF; CALM1; IGF1R; MTOR
    Prostate cancer FGFR2; CCNE1; BAD; EP300; HSP90AA1; MAPK3; RELA; PIK3CB; FOXA1; FOXO1
    Thyroid cancer CCND1; TFG; KRAS; MAPK1; NRAS; CCDC6; TPR; RXRG; HRAS; MAP2K2
    Melanoma FGF18; MAPK1; FGF17; PDGFC; RAF1; MAP2K1; PTEN; PDGFRA; FGFR1; PDGFA
    Bladder cancer THBS1; CDH1; KRAS; ARAF; UPK3A; TYMP; MMP9; CDK4; SRC; IL-8
    Chronic myeloid leukemia RELA; ARAF; BCR; NFKBIA; SHC1; BCL2L1; CTBP2; PIK3CG; SHC2; MECOM
    Acute myeloid leukemia PIM1; EIF4EBP1; NRAS; MYC; CCNA1; ZBTB16; PIK3CB; PIK3R3; SPI1; STAT5B
    Non-small cell lung cancer PLCG1; ERBB2; MAP2K2; BAD; TP53; STK4; FHIT; AKT2; HRAS; SOS1
    Central carbon metabolism in cancer FGFR3; MAP2K2; SLC16A3; KIT; HK2; PIK3CG; PDGFRA; MAPK1; PDHB; NTRK1
    Choline metabolism in cancer PPAP2C; PDPK1; NRAS; TSC1; PDGFA; MAPK8; RAF1; WASF3; CHKA; PLA2G4F

    MAPK3 has several biochemical functions, for example, ATP binding, MAP kinase activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK3 itself. We selected most functions MAPK3 had, and list some proteins which have the same functions with MAPK3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding EHD1; ABCD3A; VPS4A; CSNK1D; SMC1B; DNAHC8; MAST2; ULK1A; ROR1; RIPK2
    MAP kinase activity MAPK6; MAPK14; MAPK11; MAPK15; MAPK12; MAPK12B; MAPK14A; MAPK8B; MAPK13; NLK2
    phosphatase binding SH3RF2; SLC9A3R1; SYTL2; CRY1; CTSC; WNK1; CHCHD3; MAPK3; DZIP3; DLG1
    phosphotyrosine binding FGR; CBL; GRB2; ACP2; MAPK1; LDLRAP1; STAP1; CBLC; PTPN3; CBLB
    protein binding KCNE3; DPH2; VEGFAB; FBXL15; MAPKAP1; MX1; TMEM190; ACTR8; SERPINA1A; CREBZF
    scaffold protein binding MDM2; CASP8; CHRNA7; ATP2B4; KCNA5; GRID2; NLRP1; SHANK1; DLG4; CHUK

    MAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK3.

    DUSP1; PTPRJ; MAPK14; DHPS; Ptprr

    Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
    Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).

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