mapk3
Share
  • Official Full Name
  • MAPK3 mitogen-activated protein kinase 3
  • Synonyms
  • MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk; MAPK 1; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; mitogen-activated protein kinase 1; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; ERT2; ERK-1; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; MGC20180;
Cat.#:MAPK3-1031MTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein
+Inquiry
Cat.#:MAPK3-1517HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human MAPK3 protein
+Inquiry
Cat.#:MAPK3-2787HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3, His-tagged
+Inquiry
Cat.#:MAPK3-28694THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
+Inquiry
Cat.#:MAPK3-28699THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
+Inquiry
Cat.#:MAPK3-286HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
+Inquiry
Cat.#:MAPK3-287HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
+Inquiry
Cat.#:MAPK3-288HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
+Inquiry
Cat.#:MAPK3-28HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated ERK1, His-tagged
+Inquiry
Cat.#:MAPK3-34HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
+Inquiry
Cat.#:MAPK3-36HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
+Inquiry
Cat.#:MAPK3-9534MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK3 Protein
+Inquiry
Cat.#:MAPK3-3574RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK3 Protein
+Inquiry
Cat.#:MAPK3-11551ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK3
+Inquiry
Cat.#:MAPK3-307HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 3, Active
+Inquiry
Cat.#:MAPK3-1048HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Active), GST-Tagged
+Inquiry
Cat.#:MAPK3-1049HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Unactive), GST-Tagged
+Inquiry
Cat.#:MAPK3-4494HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK3 293 Cell Lysate
+Inquiry

Involved Pathway

MAPK3 involved in several pathways and played different roles in them. We selected most pathways MAPK3 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPK8IP3; ECSIT; FOS; MAP3K5; ELK4; PLA2G4F; PRKCG; CACNG1A; TGFB1A; RELA
ErbB signaling pathway
PAK2B; ERBB3; SHC2; CAMK2B; PRKCG; PLCG2; SRC; AKT3A; PIK3CB; PIK3R3
Ras signaling pathway
KLK1B4; FGF18; SHC2; RAC3; RALBP1; TBK1; STK4; Kitl; ANGPT1; RAC2
Rap signaling pathway
ITGA2B; F2R; RAC1; Pdgfa&Pdgfb; ITGAL; FGFR4; FGFR2; LPAR5; PIK3R1; FGF9
cGMP-PKG signaling pathway
GTF2I; ATP2B4; BAD; IRS4; INSR; ATP1B2; GNA11; PPP1CC; NOS3; MYH7
cAMP signaling pathway
MAP2K2; MAPK3; PRKACG; GPR81; BRAF; PIK3CG; FFAR2; TNNI3; ATP1A4; HTR1B
Chemokine signaling pathway
AKT1; FOXO3; CCR7; CCL4L1; HRAS; CCL28; Ccl27a; CCL18; GRK4; NFKBIB
HIF- signaling pathway
NOX1; HMOX1; EP300; SERPINE1; IL6; HK3; ERBB2; RPS6KB2; NFKB1; RELA
FoxO signaling pathway
ATM; CDKN1BA; GADD45G; FOXO3B; GRM1; PIK3R1; PTENB; MAPK8B; PIK3R3B; BCL6
Sphingolipid signaling pathway
PIK3R2; PPP2CA; ROCK1; PPP2R5B; ASAH2; BID; SMPD1; PLCB3; BAX; TRADD
Phospholipase D signaling pathway
PPAP2A; GRM5; DGKD; PDGFD; SPHK1; GRM4; NRAS; AVPR1B; AGTR1A; RAF1
Oocyte meiosis
IGF1RA; PPP1CA; CALM2A; PPP2R5A; AURKA; FBXW11A; FBXO43; CTH1; CAMK2B; ADCY1A
mTOR signaling pathway
BRAF; INS1; RRAGCB; TNF; PIK3R3B; TSC1; PIK3CG; EIF4BB; PTENB; RRN3
PIK-Akt signaling pathway
FN1; LPAR5; IL4R; PPP2R5A; CASP9; PCK1; GYS2; Il4ra; VEGFA; KITLG
Adrenergic signaling in cardiomyocytes
Adcy4; GNAI1; CACNG2; ATP1A3; ATP1B3; CAMK2B; CALM2A; TPM1; MAPK13; GNAI2A
Vascular smooth muscle contraction
PRKCDA; PLCB4; GNA11A; PPP1CC; CALM1A; CALM3A; MAP2K2A; GNAQ; RAF1B; CALCRLA
Dorso-ventral axis formation
CPEB4; CPEB1B; GRB2A; KRAS; CPEB2; NOTCH4; PPP1R2P9; ETS2; ETV7; MAPK3
TGF-beta signaling pathway
RPS6KB1B; TFDP1; BMP8B; MAPK3; FSTA; AMHR2; INHBB; GDF7; ID4; SMURF2
Axon guidance
CREB1B; SLIT2; SRGAP1; NRP1A; ABLIM2; ABLIM1; PEA15; Ntng2; KIF4A; ACTR2B
VEGF signaling pathway
CDC42; MAP2K1; PIK3R1; VEGFAA; AKT1; PPP3CC; RAF1B; PPP3CA; RAC1B; VEGFA
Osteoclast differentiation
TEC; ITGB3; LILRB2; CYBB; AKT2; NFKBIA; TAB2; FOSL2; LILRA2; PLCG2
Focal adhesion
PIK3R2; VAV3B; PARVB; CCND1; TNC; PPP1R12B; PRKCB; RAP1B; KDR; ITGB1B.2
Adherens junction
PVRL1B; SNAI2; ACP1; RAC3B; CSNK2A2A; RHOAA; PARD3; CSNK2A2; PTPN6; CTNNB1
Gap junction
GNAS; MAP2K2B; PDGFB; TUBA8L4; DRD1B; ADRB3A; GUCY1A3; GNAI2; PDGFC; PRKG1
Signaling pathways regulating pluripotency of stem cells
SMAD4; Fzd4; PIK3R1; WNT8A; WNT6; SETDB1; MYF5; APC; WNT4; FZD8
Platelet activation
RAP1A; MAPK13; FCER1G; GNAI1; PRKG1; ITGB3; AKT2; ITPR1; PLA2G4D; PLA2G4A
Toll-like receptor signaling pathway
IFNA2; CXCL9; PIK3R5; IRAK1; PIK3R2; TLR1LA; TLR8; IRF3; RIPK1; IFNA14
NOD-like receptor signaling pathway
MAPK12A; HSP90AA1.1; IL8L2; MAPK8; NFKBIA; CASPA; NLRP1; NFKBIAB; NFKBIB; HSP90AA1
Natural killer cell mediated cytotoxicity
FAS; PRKCA; IFNB1; SH2D1B; MAPK1; KIR3DL1; IFNA5; KLRC1; TYROBP; FCGR4
T cell receptor signaling pathway
FYN; MAP3K14; EVLB; MAPK11; DBNLB; PTPN6; PAK6; PDCD1; NFATC3; MAPK12
B cell receptor signaling pathway
FCGR2B; CRK; PIK3CB; CTNNB2; MAP2K2; MAPK4; ACTR3; STAP1; ARPC2; PIK3CD
Fc epsilon RI signaling pathway
MAPK8; PIK3CB; RAC1; PIK3CG; PDPK1; VAV2; PLCG1; MAPK10; LAT; HRAS
Fc gamma R-mediated phagocytosis
ASAP1; FCGR1A; VAV2; SCIN; ASAP2; NCF1; ARPC1A; PRKCG; PPAP2B; PIK3CD
TNF signaling pathway
ICAM1; MAP3K7; PIK3R1; IKBKB; CASP7; MAP3K5; PIK3CB; MAP2K4; PTGS2; CCL2
Circadian entrainment
GNG4; ADCYAP1R1; MAPK1; GNB4; CALML5; PLCB4; GNAI3; PER2; GNG10; PRKACB
Long-term potentiation
CALM3; MAPK1; PPP1CC; GRIN1; GRIA2; MAPK3; PPP3CA; ITPR3; GRM5; PPP3R1
Neurotrophin signaling pathway
SORT1; CAMK2A; SH2B1; NFKBIE; CALM1; ARHGDIG; BDNF; TRAF6; ABL1; MAP2K5
Retrograde endocannabinoid signaling
PRKCB; PRKCG; GNG13; GNG10; GABRG2; GABRA3; PRKACA; SLC17A8; MAPK12; GABRG3
Glutamatergic synapse
GRIA1; GNG8; SLC17A6; TRPC1; GNG11; GRM1; PLCB2; SLC38A2; GRM7; HOMER2
Cholinergic synapse
PRKCA; CREB3; CAMK2B; GNG12; GNB4; NRAS; GNAI2; PRKACB; KCNQ5; GNG7
Serotonergic synapse
MAOB; HTR5A; HTR1B; GNB3; KCND2; PLCB2; GNG10; GNAS; NRAS; HTR7
Long-term depression
GNAI2; GNA11; NOS1; PLCB1; LYN; GNAI3; GNAS; GNA13; GNAQ; PPP1R17
Regulation of actin cytoskeleton
HRASA; FN1A; FGF16; PFN3; PPP1CAA; ARHGEF6; RHOAB; PIP5K1BB; MYL12.1; DIAP1
Insulin signaling pathway
TSC1B; SOCS3; CALML3; INS; IKBKB; PRKAA1; RPS6KB1; SOCS1; PHKB; PRKAB2
GnRH signaling pathway
CALML5; ELK1; MAP2K2A; MAPK14A; GNAQ; PRKCBB; HRAS; PLD1A; MAP2K4B; PLA2G4F
Progesterone-mediated oocyte maturation
CDC16; SPDYA; PIK3R3A; CDC26; IGF1R; MAPK3; GNAI1; CPEB4; AKT2; ANAPC5
Estrogen signaling pathway
ITPR1; GABBR2; PIK3R5; PRKACA; MAP2K1; CALM3; SOS1; AKT2; MAPK3; MMP9
Melanogenesis
WNT3A; WNT3; ADCY1B; KIT; EP300; FZD8B; WNT7A; RAF1; MITF; CALM4
Prolactin signaling pathway
INS2; PIK3R3; STAT1; GSK3B; SOS1; PRLR; TNFRSF11A; TH; MAP2K1; PRL
Thyroid hormone signaling pathway
ESR1; SLC16A2; FOXO1; MED14; RAF1; NRAS; PLCB4; HDAC1; ATP1A4; GATA4
Oxytocin signaling pathway
PRKAA2; CAMK1G; NFATC1; PIK3CD; CD38; OXT; GNAS; PIK3CG; RHOA; NFATC4
Type II diabetes mellitus
PRKCZ; MAPK9; HK1; PKM; SLC2A4; PIK3CB; IRS1; HKDC1; MAPK3; SOCS4
Aldosterone-regulated sodium reabsorption
ATP1B2; PDPK1; MAPK1; PIK3R5; NR3C2; SLC9A3R2; NEDD4L; ATP1B3; ATP1B1; PRKCA
Alzheimers disease
PPP3CA; PLCB1; NDUFB2; BID; COX6B1; CASP8; NDUFB11; NAE1; CALML5; NDUFB6
Prion diseases
FYN; C6; C8G; C8B; PRKACG; C5; ELK1; C1QB; MAP2K2; Hc
Alcoholism
PKIA; FOSB; HIST1H4D; GRIN2A; CREB3L1; HIST2H2AA2; HIST2H2AC; HIST1H4J; CRH; CREB5
Shigellosis
NFKBIB; RHOG; CDC42; HCLS1; ABL1; SRC; MAPK13; ELMO1; MAPK11; DIAPH1
Salmonella infection
IL1A; IL8L2; CDC42L2; PKN2; FOS; ACTB2; FLNC; NOS2B; ACTB1; CCL4L1
Pertussis
C1QC; Il23a; Il12b; ITGAM; GNAI3; MAPK3; MAPK12; C3; IL1A; Itgam&Itgb2; IRAK4
Leishmaniasis
HLA-DOB; MARCKSL1; HLA-DQA2; NFKB1; PTGS2; MAPK3; IL1B; HLA-DRB4; TAB2; FCGR2A
Chagas disease (American trypanosomiasis)
TGFB2; IL6; GNAS; GNA15; ACE; PLCB2; Fasl; PPP2CB; IFNGR2; IL12B
Toxoplasmosis
H2-AA; LAMB3; HSPA8; IRGM; MAPK1; ITGB1; PIK3CA; HSPA1B; IKBKG; HSPA1L
Tuberculosis
RIPK2; RFXAP; PPP3CC; RAB5C; ITGB2L; HLA-DRB3; TGFB1; IL12A; IFNA4; FCGR1
Hepatitis C
NFKBIA; IFNAR2; STAT1; Ifna11; DDX58; RAF1; STAT3; PDPK1; CLDN5; PPP2R1B
Hepatitis B
RB1; IKBKB; AKT2; IFNA10; MAP2K2; MAPK1; PIK3CG; TGFB3; MYD88; Casp3
Influenza A
MAVS; HNRNPUL1; IFNGR2; IKBKE; HLA-DQB1; NXF3; IRAK4; PIK3R5; AKT2; IL-8
Pathways in cancer
SKP2; FGF22; AKT2; NOS2; SMAD3; SMO; STAT3; GNG12; FGFR2; LPAR2
Viral carcinogenesis
HDAC1; HLA-B; GTF2E1; CCND2; SKP2; BAK1; GTF2H2C; GTF2A2; YWHAZ; ATF4
Proteoglycans in cancer
HPSE2; NANOG; HIF1A; ITPR3; TLR4; PPP1CB; WNT9A; CBL; ITPR1; WNT6
Colorectal cancer
RAC1; APC; SMAD4; BAX; TGFB3; PIK3CG; MAPK8; Casp3; PIK3R1; AKT1
Renal cell carcinoma
MAPK3; EP300; TGFB2; MET; ARNT2; PIK3CD; PDGFB; PAK7; MAP2K1; AHA-1
Pancreatic cancer
SMAD4; BRCA2; PLD1; MAP2K1; TGFBR2; IKBKB; ARAF; RAC2; MAPK3; ERBB2
Endometrial cancer
MAPK3; BAD; AXIN2; CTNNA3; AKT1; FOXO3; CASP9; APC; CTNNA2; RAF1
Glioma
PTEN; PIK3R2; PIK3CD; TRP53; CALM1; PLCG2; RAF1; BRAF; PIK3CA; HRAS
Prostate cancer
PDGFRB; ATF4; CCNE1; PDGFC; AKT1; BRAF; Pdgfa&Pdgfb; MAP2K2; CPN1; MAP4K1
Thyroid cancer
CDH1; CCND1; BRAF; PPARG; MAP2K2; PAX8; TPM3; RET; TPR; TCF7L2
Melanoma
MAP2K1; CCND1; ARAF; RB1; FGF8; PDGFC; FGF9; PIK3CG; FGF20; BAD
Bladder cancer
EGF; IL-8; CDKN2A; ERBB2; E2F3; MMP2; FGFR3; ARAF; TYMP; SRC
Chronic myeloid leukemia
RAF1; PIK3R1; STAT5B; BCL2L1; CDK6; PIK3CB; MAP2K2; TGFB2; NRAS; PTPN11
Acute myeloid leukemia
TCF7L2; BRAF; RAF1; PIK3R3; NFKB1; EIF4EBP1; STAT5B; AKT1; HRAS; JUP
Non-small cell lung cancer
RAF1; FOXO3; PIK3R5; NRAS; FHIT; HRAS; PIK3R1; SOS1; STK4; AKT2
Central carbon metabolism in cancer
TP53; PDGFRB; C12orf5; RET; RAF1; SLC7A5; FLT3; PIK3CG; G6PDX; NTRK1
Choline metabolism in cancer
MAPK9; SLC44A2; MAP2K2; TSC1; PIK3R2; PLA2G4D; PDGFA; RHEB; SP1; TAE1

Protein Function

MAPK3 has several biochemical functions, for example, ATP binding, MAP kinase activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK3 itself. We selected most functions MAPK3 had, and list some proteins which have the same functions with MAPK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ABCC8; PKMYT1; PRKD2; VMHCL; AK9; UBE2B; AK4; TTLL4; ATP2A1L; UBE2G1A
Function MAP kinase activity
Related Protein MAPK1; NLK1; MAPK14; MAPK8A; MAPK8B; MAPK15; MAPK14A; MAPK14B; NLK2; MAPK11
Function phosphatase binding
Related Protein CTSC; SLC9A3R2; SH3GL1; SMAD2; PPP1R21; MAPK3; PPARA; PPP1R18; PPP1R36; SPRED1
Function phosphotyrosine binding
Related Protein CBL; LDLRAP1; SAMSN1; PTPN3; ZAP70; FGR; GRB2; ACP2; MAPK1; SHC1
Function protein binding
Related Protein DOCK9; GAB1; GABBR2; LRRC8C; PAAF1; FABP1; PLEKHB1; CDKL3; GLE1; HIST1H3D
Function scaffold protein binding
Related Protein NLRP1; PDE4D; NLGN4Y; VIM; HOMER1; MDM2; SRC; CHUK; NOS1; IKBKB

Interacting Protein

MAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK3.
DUSP1; PTPRJ; MAPK14; DHPS; Ptprr

MAPK3 Related Articles

Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).