mapk3
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  • Official Full Name
  • MAPK3 mitogen-activated protein kinase 3
  • Synonyms
  • MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk; MAPK 1; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; mitogen-activated protein kinase 1; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; ERT2; ERK-1; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; MGC20180;
Cat.#:MAPK3-1031MTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein
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Cat.#:MAPK3-1517HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human MAPK3 protein
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Cat.#:MAPK3-2787HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3, His-tagged
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Cat.#:MAPK3-28694THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-28699THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-286HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-287HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-288HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-28HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated ERK1, His-tagged
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Cat.#:MAPK3-34HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-36HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-9534MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK3 Protein
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Cat.#:MAPK3-3574RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK3 Protein
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Cat.#:MAPK3-11551ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK3
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Cat.#:MAPK3-307HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 3, Active
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Cat.#:MAPK3-1048HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Active), GST-Tagged
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Cat.#:MAPK3-1049HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Unactive), GST-Tagged
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Cat.#:MAPK3-4494HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK3 293 Cell Lysate
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Involved Pathway

MAPK3 involved in several pathways and played different roles in them. We selected most pathways MAPK3 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
NR4A1; LAMTOR3; C11orf52; MEF2CA; ZAK; CACNA2D1; CACNG6A; MAPKAPK2A; RAF1B; KCNA3
ErbB signaling pathway
PIK3R3; CAMK2D2; ERBB3B; MAP2K4A; MTOR; SHC3; MAPK1; TGFA; PRKCG; ARAF
Ras signaling pathway
PLD1; CDC42; RALBP1; NF1; FGF3; PRKACG; KIT; KSR2; IKBKG; FGF9
Rap signaling pathway
FGF22; PLCB1; MAP2K2; FGF1; PFN3; RALGDS; CDC42; RAF1; PRKCG; FGF18
cGMP-PKG signaling pathway
PIK3R2; MAPK3; VDAC1; NFATC2; Adcy4; RHOA; PDE3A; PPP3R1; MYLK3; GNAI2
cAMP signaling pathway
HCN4; CAMK2G; HTR1A; GNAI2; ATP2B4; VAV1; RAC1; BDNF; MLLT4; MAP2K1
Chemokine signaling pathway
PRKCD; VAV3; CCL4L1; PLCB3; CXCL14; GNG12; PIK3R1; CCL20; VAV1; Cxcl15
HIF- signaling pathway
IL6R; PIK3CG; PLCG2; MAP2K2; TFRC; VHL; VEGFA; TF; TLR4; IFNG
FoxO signaling pathway
GABARAPL2; INSRA; GRB2; BCL6A; HOMER3; PRKAG1; AKT2; PLK4; G6PCA.1; INSRB
Sphingolipid signaling pathway
GNA12; HRAS; BAX; PPP2R2C; PIK3CG; BID; SPTLC3; SGPP1; GAB2; PPP2CB
Phospholipase D signaling pathway
PDGFB; RHOA; DNM3; GRM7; PIK3R5; CYTH4; PLA2G4F; TSC1; AVPR2; PIK3R3
Oocyte meiosis
CDC26; CPEB3; CCNE1; PPP1CAB; ESPL1; MAD2L1; RBX1; PPP1CB; FBXO43; PRKACAA
mTOR signaling pathway
DEPDC6; PRKCA; RPTOR; PIK3R3; ULK1; TSC2; CAB39L; RPS6KB2; IGF1; PDPK1B
PIK-Akt signaling pathway
RAC1; KRAS; IFNA17; ANGPT2; FLT1; PPP2R5B; CREB3L3; THBS4; PDGFB; FGF21
Adrenergic signaling in cardiomyocytes
ATP1B1A; TNNT2A; TMEM8C; PIK3R2; CREB3L3A; CACNA1C; PPP2R2BB; PIK3CG; TNNI3; CACNA2D2
Vascular smooth muscle contraction
EDNRAA; RHOA; PPP1R12B; PRKACBA; RHOAC; GNA11B; MAP2K2; CALM2B; PPP1CA; ARHGEF1
Dorso-ventral axis formation
GRB2; EGFRA; PPP1R2P9; GRB2B; CPEB1; PIWIL1; ETV6; NOTCH4; ETV7; PIWIL2
TGF-beta signaling pathway
NOG; ACVR2AA; SMAD3A; GDF5; TFDP1A; BMPR1BA; SMAD7B; TFDP1; RBL1; ZFYVE16
Axon guidance
NADL1.1; FGF10B; GNAI2; ACTR2B; COL9A3; EFNA2A; SEMA3AB; SEMA6C; SEMA6A; CAP2
VEGF signaling pathway
SPHK2; VEGFAA; RAF1; MAP2K2A; MAPK3; PTGS2A; NFATC2; PIK3R2; PRKCA; PLA2G4AA
Osteoclast differentiation
LILRB1; NFATC2; SFPI1; PIK3R2; PPP3R1; TAB2; LILRB2; FOSL2; FCGR3A; CYBB
Focal adhesion
RHOAB; LAMC3; TNN; MYL10; PDGFB; ITGA2B; Itga10&Itgb1; PXNA; ITGB6; LAMA5
Adherens junction
CSNK2A2A; FYNA; FARP2; ACP1; LMO7A; SNAI1; TJP1; INSRB; ACTN1; RAC3B
Gap junction
GNA11; PRKACBA; GUCY1A3; GUCY1B3; TUBB5; CX35B; GNAS; TUBA4A; MAP2K2; TUBA8L4
Signaling pathways regulating pluripotency of stem cells
SMAD1; LHX5; PIK3CD; LIF; ZFHX3; ID2; MYF5; IL6ST; KLF4; FZD3
Platelet activation
PIK3CG; PLA2G4D; SYK; AKT1; GP9; ARHGAP35; MYLK2; PIK3R1; PLCB3; ACTG1
Toll-like receptor signaling pathway
IFNA7; CXCL8B.3; NFKBIA; MAPK8; TNF; AKT3A; TLR2-1; MYD88; AKT1; IL1B
NOD-like receptor signaling pathway
MAP3K7IP3; NLRC4; HSP90AA1.1; MAPK14B; TNF; MAPK13; HSP90AA1; NFKBIAA; MAPK12B; IL1B
Natural killer cell mediated cytotoxicity
KIR2DL3; LAT; CD247; SHC1; KIR3DL2; TNFRSF10C; PIK3CB; LCP2; GRB2; NCR1
T cell receptor signaling pathway
IFNG; NFKBIB; CD3D; KRAS; PIK3R2; PTPRC; VAV1; PTPN6; CD40LG; PAK3
B cell receptor signaling pathway
PLCG2; MAP2K1; MAPK4; FOS; NFATC1; PLEKHA2; CMTM3; PIK3R5; CDK2; IKBKB
Fc epsilon RI signaling pathway
RAC2; PLA2G4C; MAP2K3; GAB2; PIK3CA; MAP2K2; GRB2; PLA2G4F; INPP5D; MAPK13
Fc gamma R-mediated phagocytosis
GAB2; SPHK2; AKT2; FCGR1A; PPAP2C; PTPRC; PLD1; MAPK1; PIP5K1C; MAP2K1
TNF signaling pathway
MAP3K7IP3; CREB5; VCAM1; ICAM1; FADD; FAS; RPS6KA4; PIK3R2; TRAF2; CREB3L2
Circadian entrainment
GNG13; GRIA4; CALML5; CAMK2D; GRIA2; GNAS; CALM3; AKR1C1; CALML3; MTNR1B
Long-term potentiation
ITPR1; CALM4; PPP3CC; GRIN1; RPS6KA6; CALML5; CALM3; CAMK2B; PLCB4; RAP1A
Neurotrophin signaling pathway
MAPK9; BCL2; GSK3B; RAPGEF1; IKBKB; PLCG1; Fasl; SH2B1; CALM2; PTPN11
Retrograde endocannabinoid signaling
GNG13; GABRA6; GABRR1; GABRG2; RIMS1; GNAI1; GRIA4; GNG2; PLCB3; GNAI2
Glutamatergic synapse
GRIK4; GRIN3A; GRM5; GRIK2; SLC1A7; TRPC1; PLA2G4D; GNGT2; GLS2; SLC1A6
Cholinergic synapse
ATF4; AKT2; ACHE; PRKACB; GNG12; MAP2K1; CHRM5; GNB4; MAPK1; CHRNA6
Serotonergic synapse
GNAS; MAP2K1; SLC18A2; CYP2C38; HTR4; GNB1; ITPR3; PLCB2; GNG10; GABRB3
Long-term depression
MAPK3; CRHR1; PRKCB; IGF1R; ARAF; GNAI2; PLA2G4C; GRM1; HRAS; PLA2G4D
Regulation of actin cytoskeleton
RAC3; PIP4K2B; ARPC5L; PDGFRA; LIMK1A; ACTN3; MYLK3; ACTN2B; ARPC5A; PDGFA
Insulin signaling pathway
PPP1R3CB; SLC2A4; CALM2A; AKT2L; PRKACG; PDPK1; GRB2A; SOCS9; PPP1CC; FBP2
GnRH signaling pathway
GNA11; PLD1A; CAMK2G; HRAS; CACNA1SB; PLA2G4D; GNRHR1; ATF4; PLD1; MMP14B
Progesterone-mediated oocyte maturation
FZR1A; AKT1; INS1; MAD2L1; MAPK8B; Adcy4; MAPK14A; HSP90AA1; MAPK1; ANAPC4
Estrogen signaling pathway
PIK3CG; OPRM1; ATF4; PRKACG; CALM4; GRM1; GABBR2; SHC1; PIK3CA; PRKACA
Melanogenesis
MITF; PRKACAA; FZD8B; CALM3; GNAIA; PRKACBA; PRKCG; MC1R; WNT7B; WNT7AA
Prolactin signaling pathway
HRAS; NRAS; TNFSF11; INS2; TH; SOCS2; MAPK13; PIK3CG; LHCGR; STAT1
Thyroid hormone signaling pathway
PLCZ1; DIO2; KRAS; HDAC1; FXYD2; NOTCH4; EP300; PFKP; GSK3B; ATP1B4
Oxytocin signaling pathway
MAPK1; PPP1R12C; MEF2C; PRKCG; ELK1; PIK3R5; ACTB; CACNG8; MAP2K5; MYL9
Type II diabetes mellitus
PKM; PIK3CD; IRS4; PIK3R1; SOCS1; PRKCZ; MTOR; PIK3R5; INS-IGF2; IRS1
Aldosterone-regulated sodium reabsorption
ATP1B4; PIK3CG; IRS1; INS2; INS; SFN; PIK3R2; PRKCA; ATP1B3; IGF1
Alzheimers disease
MAPK3; CASP9; ATP5F1; COX6B2; NDUFS1; COX8A; ITPR1; COX6A2; NDUFA8; NDUFA10
Prion diseases
MAPK3; C5; SOD1; NOTCH1; IL1B; FYN; C8G; C8B; C8A; IL6
Alcoholism
PDYN; H2AFB1; H2AFB3; HIST1H4E; ADORA2A; HDAC6; H2AFB2; GNB1; SHC2; CALML5
Shigellosis
WASF1; PFN3; WASL; UBE2D2; VCL; CDC42; MAPK8; MAPK1; RIPK2; PFN1
Salmonella infection
MAPK10; NOS2A; KLC1A; TLR4BA; KLC4; PKN2; CASPA; NLRC4; FLNB; KLC1B
Pertussis
GNAI3; MAPK12; C4A; Il23a; C1QB; C2; TLR4; NFKB1; NLRP3; ITGAM
Leishmaniasis
FCGR3A; TGFB1; MAPK13; FCGR3; HLA-DOB; HLA-DQA1; IL12B; NCF1; FCGR4; HLA-DRB4
Chagas disease (American trypanosomiasis)
MAPK11; MAPK12; TGFBR1; FOS; MAPK13; PPP2R2B; SMAD2; PPP2R1B; CCL3L3; SERPINE1
Toxoplasmosis
HSPA1L; BIRC3; HLA-DOA; HLA-DOB; TGFB3; IKBKG; LAMB4; HLA-DRA; LAMA4; LDLR
Tuberculosis
Pla2r1; TLR9; NOS2; ATP6V0B; SPHK2; NFYC; ATP6V0A1; CAMK2A; RFXAP; CASP10
Hepatitis C
BRAF; CLDN15; IFNA5; IFNA17; TP53; MAPK11; PIAS1; RIPK1; TNFRSF1A; PPP2R2A
Hepatitis B
NFATC1; MAP2K1; PIK3R3; IFNAR1; VDAC3; TGFBR1; PIK3R2; IFNA4; MAPK9; CASP10
Influenza A
IFNA17; RELA; IFNA7; PABPN1L; IFNAR1; CASP9; IFNA5; LOC100033925; VDAC1; MAP2K6
Pathways in cancer
IL-8; MAPK1; TRP53; PDGFRA; PLCB4; BRAF; ROCK2; PIK3CB; FZD5; RAC3
Viral carcinogenesis
HPN; HIST1H2BC; SRC; PIK3CG; CCND1; HDAC7; NFKB1; PRKACG; HDAC1; RAC1
Proteoglycans in cancer
CTTN; PDCD4; ITGA5; ACTB; PIK3R2; MAPK1; ELK1; ITGB3; TLR4; PRKCB
Colorectal cancer
DCC; AXIN1; CCND1; PIK3R1; BIRC5; ARAF; BAD; MAPK1; CASP9; PIK3CB
Renal cell carcinoma
FH1; RAF1; EGLN2; PAK7; FH; AHA-1; TGFA; SLC2A1; PIK3CG; HIF1A
Pancreatic cancer
MAPK3; TGFB2; ERBB2; PIK3CG; IKBKB; SMAD2; RALB; ARHGEF6; TP53; PIK3R5
Endometrial cancer
FOXO3; AXIN2; PIK3CD; PDPK1; PIK3R5; CCND1; TRP53; PIK3R2; HRAS; BRAF
Glioma
NRAS; MTOR; AKT1; KRAS; TGFA; Pdgfa&Pdgfb; CALM2; CAMK2B; TRP53; PIK3CB
Prostate cancer
GSTP1; PDGFB; AKT1; MAP2K1; CCNE1; PDGFD; TCF7L2; TGFA; PDPK1; BAD
Thyroid cancer
HRAS; KRAS; CCDC6; MAPK3; TPM3; NCOA4; MAP2K2; TFG; BRAF; PAX8
Melanoma
PIK3R1; FGF9; CDH1; PIK3R2; PIK3CB; PDGFA; FGF19; FGF4; CCND1; ARAF
Bladder cancer
MMP1; SRC; ARAF; MAPK1; E2F1; E2F2; MAP2K2; THBS1; MMP9; RAF1
Chronic myeloid leukemia
CDK6; TGFB3; STAT5B; CTBP2; PIK3CB; SHC2; SHC3; MAP2K1; MAPK3; BAD
Acute myeloid leukemia
AKT1; PIK3CG; MAP2K1; IKBKB; LEF1; SOS1; IKBKG; PIK3CD; NRAS; RUNX1T1
Non-small cell lung cancer
PRKCB; NRAS; MAPK1; RXRB; PIK3CG; RARB; AKT1; AKT2; RXRA; PRKCG
Central carbon metabolism in cancer
IDH1; RET; PKM; RAF1; LDHA; HK1; HRAS; PFKM; KIT; AKT2
Choline metabolism in cancer
RAC2; PPAP2C; PPAP2A; SP1; SLC44A2; HIF1A; PRKCB; SLC44A1; RAF1; PIP5K1C

Protein Function

MAPK3 has several biochemical functions, for example, ATP binding, MAP kinase activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK3 itself. We selected most functions MAPK3 had, and list some proteins which have the same functions with MAPK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein Abcb1b; WEE1; PDXK; MYH9A; KIF3CB; DHX35; ABCD3A; ULK2; PFKMA; PSMC1
Function MAP kinase activity
Related Protein MAPK1; MAPK12A; MAPK12B; MAPK6; MAPK14A; MAPK3; MAPK12; MAPK13; NLK1; NLK2
Function phosphatase binding
Related Protein SH3GL1; DLG1L; SLC9A3R2; DZIP3; DLG3; DLG1; WNK1; SYTL2; CRY2; KLRAQ1
Function phosphotyrosine binding
Related Protein CBLB; FGR; MAPK1; PTPN3; CBL; SHC1; ZAP70; MAPK3; GRB2; SAMSN1
Function protein binding
Related Protein ZKSCAN3; IL17RE; ANXA2; MYBPC3; RG9MTD1; KANK2; SOX10; AXL; PUM2; CTAG1B
Function scaffold protein binding
Related Protein IKBKB; NCK2; NLGN1; LRP4; GRIN2A; KRT15; TREM2; NOS3; NLGN3; TREM1

Interacting Protein

MAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK3.
DUSP1; PTPRJ; MAPK14; DHPS; Ptprr

MAPK3 Related Articles

Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).