mapk3
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  • Official Full Name
  • MAPK3 mitogen-activated protein kinase 3
  • Synonyms
  • MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk; MAPK 1; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; mitogen-activated protein kinase 1; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; ERT2; ERK-1; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; MGC20180;
Cat.#:MAPK3-1031MTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein
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Cat.#:MAPK3-1517HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human MAPK3 protein
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Cat.#:MAPK3-2787HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3, His-tagged
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Cat.#:MAPK3-28694THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-28699THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-286HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-287HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-288HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-28HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated ERK1, His-tagged
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Cat.#:MAPK3-34HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-36HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-9534MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK3 Protein
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Cat.#:MAPK3-3574RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK3 Protein
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Cat.#:MAPK3-11551ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK3
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Cat.#:MAPK3-307HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 3, Active
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Cat.#:MAPK3-1048HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Active), GST-Tagged
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Cat.#:MAPK3-1049HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Unactive), GST-Tagged
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Cat.#:MAPK3-4494HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK3 293 Cell Lysate
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Involved Pathway

MAPK3 involved in several pathways and played different roles in them. We selected most pathways MAPK3 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNA1C; MEF2CB; ZAK; FGF8A; RAP1AB; FGF6B; AKT2L; PRKACBB; FGF20; PPM1BA
ErbB signaling pathway
RAF1B; HBEGFB; MAP2K4B; CAMK2G; PAK2; HRASA; NRAS; PLCG2; PTK2AB; MAP2K4A
Ras signaling pathway
Pdgfa&Pdgfb; PLA2G4A; STK4; FGF18; PIK3CD; MAP2K1; PAK6; ABL1; RAF1; PLCG1
Rap signaling pathway
NRAS; PDGFB; FGF20; NGFR; MET; RASGRP3; PRKD3; LPAR2; PIK3CD; LPAR4
cGMP-PKG signaling pathway
CALM2; PIK3CD; ATP1A2; GNAI3; SLC25A5; BDKRB2; PPP3CB; NPR1; PLCB2; INS
cAMP signaling pathway
VAV1; NFATC1; GNAI2; PIK3R2; GABBR2; MLLT4; PPARA; OXTR; PLCE1; CAMK2B
Chemokine signaling pathway
CXCL14; GNG7; STAT2; CCL21; GNAI1; PRKCB; Ccl12; IKBKB; NFKBIB; PIK3CD
HIF- signaling pathway
STAT3; IL6R; RPS6KB1; PGK1; TCEB2; PIK3CA; ERBB2; Il6ra; MTOR; TFRC
FoxO signaling pathway
HOMER1B; GABARAP; MAP2K2B; FOXO3; USP7; HRASA; IGF1; PIK3R5; PRKAB1; PRKAG2A
Sphingolipid signaling pathway
RAC3; SGMS1; RAC2; NSMAF; ASAH1; SMPD2; PIK3CB; NOS3; RAF1; FCER1A
Phospholipase D signaling pathway
TSC2; LPAR4; RALGDS; PLA2G4A; AVPR1A; FCER1A; PDGFB; HRAS; GRM1; MAP2K2
Oocyte meiosis
PPP3CB; ANAPC2; CALML3; MAPK1; STAG3; CDC20; YWHAE2; CALM2B; PPP2R5C; CALM
mTOR signaling pathway
INSB; CAB39L1; IRS1; RPS6KAL; PRKCBA; ULK1; CAB39; AKT2; VEGFAB; PRKCG
PIK-Akt signaling pathway
COL6A4; GNB2; ATF4; COL27A1; PPP2R1B; FGF19; PPP2R2A; LPAR4; SGK1; ITGA9
Adrenergic signaling in cardiomyocytes
MYL4; SCN1BB; TMEM8C; CREB3L3; CACNG1A; ATP2B4; VMHCL; ATP1A1A.1; PPP2R5C; GNAI2B
Vascular smooth muscle contraction
CACNA1SB; CALD1B; PRKACG; PPP1CB; MAPK3; BRAF; RHOAC; CALM4; ROCK2A; PLA2G5
Dorso-ventral axis formation
NOTCH4; NOTCH1B; MAPK1; NOTCH2; PIWIL2; CPEB4; CPEB1B; FMN2; ETV7; EGFRA
TGF-beta signaling pathway
TGIF1; TGIF2; SPAW; PPP2R1A; ROCK2B; BMP7A; CUL1; E2F5; SMAD3; LTBP1
Axon guidance
SRGAP2; CRMP1; SEMA5A; EZRA; RANBP9; DCC; EFNA2A; AGRN; RASGRP4; GFRA4
VEGF signaling pathway
PXN; PRKCG; NFATC2; PLCG2; MAP2K2; PIK3CB; RAF1B; VEGFAA; PIK3CG; SH2D2A
Osteoclast differentiation
SIRP-BETA; MAPK8; FYN; PIK3CB; MAP2K6; FCGR2B; CALCR; LILRA3; FOSB; IL1A
Focal adhesion
COL27A1A; MAPK9; LAMC1; PDGFD; COL11A1A; IGF1; MYL12B; MAPK6; BIRC2; AKT2L
Adherens junction
ACTN4; CTNNA3; CTNND1; CSNK2A2; VCL; PTPN6; PTPRFB; SNAI1; RAC1B; NLK2
Gap junction
TUBB2; PRKCB; HRAS; GNA15.4; CSNK1DA; Adcy4; TUBA2; PRKACG; PRKACA; HTR2CL1
Signaling pathways regulating pluripotency of stem cells
KRAS; Fzd4; SETDB1; PIK3CD; REST; MAPK3; WNT8B; ACVR1B; JARID2; IGF1
Platelet activation
ITGB1; PLA2G4F; PIK3CG; GNAI3; ITGA2B; ITGA2; MAPK11; GP1BA; NOS3; F2RL3
Toll-like receptor signaling pathway
CASP8; TLR2-2; IFNA1; IFNA2; TNF; RIPK1L; CCL4L2; IL12BA; IFNB1; RAC1
NOD-like receptor signaling pathway
SUGT1; IL18; MAPK11; MAP3K7IP3; CXCL2; CCL5; CASPA; PYDC1; MAPK12; MAPK8B
Natural killer cell mediated cytotoxicity
HLA-G; HCST; ICAM2; MAP2K2; IFNB1; Casp3; IFNA10; RAF1; RAET1D; NFATC2
T cell receptor signaling pathway
MAPK12; PIK3R2; PPP3CC; NFATC2; MAPK1; PIK3R5; NRAS; RHOA; NCK1; RELA
B cell receptor signaling pathway
RAP2A; PIK3CB; BCL10; BCL2L11; GSK3AB; HDAC5; ARPC3; CARD11; NFATC3; FCGR2B
Fc epsilon RI signaling pathway
BTK; FCER1A; TNF; PIK3CA; NRAS; PRKCA; GAB2; PIK3CG; GRB2; MAPK13
Fc gamma R-mediated phagocytosis
RAF1; MARCKS; LAT; AKT1; PRKCB; LIMK2; WASF2; DOCK2; ASAP3; WASF3
TNF signaling pathway
TRADD; AKT2; MAPK13; FOS; TNF; AKT1; PIK3R1; IKBKG; PIK3CB; TRAF2
Circadian entrainment
PER2; GNG11; CALM4; PRKG2; MAPK1; NOS1AP; GNG2; ITPR1; GNAO1; GNB3
Long-term potentiation
RPS6KA1; PPP3CB; PPP1CA; ITPR3; MAPK3; CAMK2B; PPP3R2; NRAS; CALM2; PPP1CB
Neurotrophin signaling pathway
NTRK1; BRAF; PIK3CD; YWHAE; MAPK7; MAGED1; SH2B3; MAP3K1; PIK3CA; GSK3B
Retrograde endocannabinoid signaling
MAPK12; GRM1; GABRA2; GABRA4; GABRG2; GABRA1; PRKACG; GNB2; PRKCB; GABRA3
Glutamatergic synapse
GNB2; PRKCA; HOMER2; SHANK3; PLCB2; SLC1A2; SHANK1; SLC1A6; GLUL; SLC1A3
Cholinergic synapse
KCNJ2; PLCB4; GNB2; HRAS; CAMK2A; CHRNA4; CHRNB4; GNGT1; CREB3L4; GNA11
Serotonergic synapse
ITPR3; KRAS; GNG12; HTR3A; APP; ARAF; PLA2G4A; SLC18A1; HTR2C; CYP2D9
Long-term depression
MAP2K2; GRID2; PLA2G4C; LYN; PLA2G4F; GNA12; PLCB3; GNAS; ITPR1; PRKG1
Regulation of actin cytoskeleton
MYH10; FGF20; PIP5K1BA; PFN4; WASL; MYL5; RAC1A; ITGA2; GSN; GSNA
Insulin signaling pathway
CALM2; RPTOR; MKNK1; CALM1; PRKACAB; PHKG1B; PRKAG2; GRB2; PPP1CB; EIF4EA
GnRH signaling pathway
PRKACB; CALM3B; CACNA1SA; PRKCBB; SRC; GRB2B; CAMK2D2; PRKACBA; MAPK8; MMP14
Progesterone-mediated oocyte maturation
ANAPC5; AKT2L; CDC25C; PRKACBB; PLK1; PRKACAA; FZR1; MAPK8; MAPK9; AKT1
Estrogen signaling pathway
PLCB2; NOS3; GABBR2; MMP9; PIK3R3; PIK3CA; HSPA1B; CREB5; GRM1; CALM3
Melanogenesis
CREB3L2; CAMK2D2; GNAS; CALML3; FZD7; KRAS; MAP2K2; ADCY1B; MITFB; PRKCBB
Prolactin signaling pathway
INS2; IRF1; MAPK12; CCND1; FOS; PIK3CD; PIK3CB; NFKB1; STAT3; SHC1
Thyroid hormone signaling pathway
MED24; PRKACG; MAP2K1; THRB; MED14; ACTB; MED27; ATP1A1; CCND1; ATP1A2
Oxytocin signaling pathway
RCAN1; PRKCG; KRAS; NFATC3; CALM4; GNAI3; CAMK1; PRKAA1; PRKAG1; CALM2
Type II diabetes mellitus
MAPK3; HK3; PIK3CG; INS1; INS; ADIPOQ; SOCS4; INS-IGF2; IRS4; PKM2
Aldosterone-regulated sodium reabsorption
PIK3R2; IGF1; ATP1A2; HSD11B2; SFN; ATP1B4; KCNJ1; SGK1; PDPK1; MAPK3
Alzheimers disease
COX6B2; CASP8; PLCB4; COX7C; NDUFA8; NDUFB9; PSEN2; COX4I2; APH1C; UQCRFS1
Prion diseases
HSPA1A; PRKACB; STIP1; NCAM1; IL1B; MAPK1; IL1A; CCL5; C7; NCAM2
Alcoholism
HIST1H4J; CREB3L1; HIST1H2AF; KRAS; HIST1H3A; H2AFY2; GM14483; DRD1A; GNG3; MAOB
Shigellosis
CTTN; SRC; IKBKG; VCL; MAPK9; RIPK2; MAD2L2; IL-8; MAPK11; RELA
Salmonella infection
IFNGR2; RHOGC; WASL; MAPK12A; CDC42L; DYNC2H1; RHOGB; RILP; CASP1; MYH9
Pertussis
C1QB; ITGB2; Hc; IRF3; C1S; C5; GNAI2; Il23a; ITGB2L; C2
Leishmaniasis
CR1; TGFB2; FCGR1A; RELA; Itgam&Itgb2; HLA-DRB3; HLA-DOA; FCGR1; NOS2; HLA-DRB4
Chagas disease (American trypanosomiasis)
PIK3CA; TLR9; IL12A; AKT1; MAPK13; IRAK1; PIK3R5; TGFBR2; MYD88; IL6
Toxoplasmosis
IRGM1; HLA-DRA; RELA; IL10RA; MAP2K3; LAMA4; BIRC3; HSPA1A; ALOX5; IL10RB
Tuberculosis
IFNA5; CD209B; TRAF6; IFNA16; HLA-DMA; IRAK4; FCGR2B; RFXAP; IL10RB; HLA-DMB
Hepatitis C
TNF; GRB2; CD81; CLDN11; PDPK1; LDLR; EIF2AK1; PIK3CG; PPP2R1A; EIF2AK4
Hepatitis B
IFNA8; IKBKE; CASP9; IFNA21; PIK3CD; DDX3X; GRB2; IFNAR1; IFNB1; CREB5
Influenza A
NUP98; TLR4; HSPA1L; NFKBIB; PLG; PRSS2; TYK2; KPNA2; HLA-DPB1; BLB1
Pathways in cancer
CTNNA3; GNG3; HDAC2; RELA; LPAR2; FZD5; AXIN2; SFPI1; STK36; PAX8
Viral carcinogenesis
C3; ACTN4; HIST2H4; ATP6V0D1; MAD1L1; REL; DNAJA3; HLA-C; TRADD; SND1
Proteoglycans in cancer
WNT3A; GAB1; SDC1; ESR1; RHOA; ARHGEF12; PLCE1; CAMK2B; RRAS; MET
Colorectal cancer
MAPK3; CCND1; FOS; APC2; PIK3CD; RALGDS; MSH3; MLH1; ARAF; APPL1
Renal cell carcinoma
PIK3CA; NRAS; MAP2K1; GRB2; VHL; RAPGEF1; TGFB1; PDGFB; PAK3; VEGFA
Pancreatic cancer
STAT1; SMAD2; PIK3R5; PIK3CB; MAP2K1; PIK3R2; ERBB2; CDC42; RAC1; PIK3CA
Endometrial cancer
TCF7; PIK3CD; PIK3R3; CASP9; ILK; BAD; MAPK1; GSK3B; HRAS; ERBB2
Glioma
PLCG2; SHC2; MAPK1; ARAF; SHC4; BRAF; PTEN; PIK3R1; SOS1; HRAS
Prostate cancer
PDGFD; ATF4; CREB3L1; PDPK1; ERBB2; MAP2K2; SRD5A2; SPINK1; SMARCA4; KRAS
Thyroid cancer
PPARG; TPR; TCF7L2; MAP2K1; KRAS; TPM3; MAP2K2; MAPK1; TFG; HRAS
Melanoma
BAD; FGF12; ARAF; MAP2K2; FGF13; PIK3CA; MDM2; FGF7; IGF1; FGF6
Bladder cancer
HBEGF; VEGFA; MAPK3; KRAS; ERBB2; MDM2; DAPK3; ARAF; MMP1; IL-8
Chronic myeloid leukemia
HDAC2; BRAF; HDAC1; CBLB; TRP53; KRAS; STAT5A; SHC2; TGFB3; TGFBR2
Acute myeloid leukemia
PIK3R3; RPS6KB1; RARA; MAPK3; PIK3CA; ZBTB16; PIK3R1; MAP2K2; TCF7L2; CEBPA
Non-small cell lung cancer
CASP9; STK4; AKT2; BAD; HRAS; ALK; CCND1; RXRA; EML4; FOXO3
Central carbon metabolism in cancer
PDGFRA; PGAM2; PFKP; PIK3R3; SLC1A5; PIK3CB; HKDC1; MTOR; NTRK1; HK1
Choline metabolism in cancer
MAPK1; TSC2; GRB2; PLA2G4A; PCYT1A; RAF1; PDGFB; SLC22A1; RAC2; PIK3CG

Protein Function

MAPK3 has several biochemical functions, for example, ATP binding, MAP kinase activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK3 itself. We selected most functions MAPK3 had, and list some proteins which have the same functions with MAPK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DDX51; CDK18; ALK; GLUL; FLAD1; PDK2; EPHB1; MYHC4; MAT2A; UBE2D2
Function MAP kinase activity
Related Protein MAPK8B; MAPK8A; MAPK12; MAPK1; NLK1; MAPK14A; MAPK12A; MAPK3; MAPK13; MAPK14B
Function phosphatase binding
Related Protein SYTL2; ELL; PPP1R27; PPP1R26; CNST; PPP1R37; CHCHD3; WNK1; SLC9A3R1; TPRN
Function phosphotyrosine binding
Related Protein CBLB; ZAP70; PTPN3; STAP1; MAPK1; CBLC; CBL; SAMSN1; SHC1; MAPK3
Function protein binding
Related Protein THOC2; RABL2A; RNASE1; BLCAP; EPM2A; LIN7A; ADAMTS3; ZNF543; FAM98A; MAP3K9
Function scaffold protein binding
Related Protein TREM2; ATP2B4; KCNH2; SHANK1; IKBKB; CAV2; SRC; MAP2K2; SHANK3; KCNA5

Interacting Protein

MAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK3.
DUSP1; PTPRJ; MAPK14; DHPS; Ptprr

MAPK3 Related Articles

Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).