mapk3
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  • Official Full Name
  • MAPK3 mitogen-activated protein kinase 3
  • Synonyms
  • MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk; MAPK 1; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; mitogen-activated protein kinase 1; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; ERT2; ERK-1; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; MGC20180;
Cat.#:MAPK3-1031MTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein
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Cat.#:MAPK3-1517HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human MAPK3 protein
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Cat.#:MAPK3-2787HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3, His-tagged
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Cat.#:MAPK3-28694THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-28699THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-286HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-287HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-288HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-28HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated ERK1, His-tagged
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Cat.#:MAPK3-34HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-36HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-9534MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK3 Protein
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Cat.#:MAPK3-3574RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK3 Protein
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Cat.#:MAPK3-11551ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK3
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Cat.#:MAPK3-307HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 3, Active
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Cat.#:MAPK3-1048HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Active), GST-Tagged
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Cat.#:MAPK3-1049HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Unactive), GST-Tagged
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Cat.#:MAPK3-4494HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK3 293 Cell Lysate
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Involved Pathway

MAPK3 involved in several pathways and played different roles in them. We selected most pathways MAPK3 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
FGF12A; PDGFRA; STMN1B; SRFA; HSP70L; CDC42; MAP2K5; FGF18; GADD45B; FGF1
ErbB signaling pathway
MAPK8; MAPK3; RAF1B; AKT2L; PAK2B; PRKCB; PAK7; HBEGFA; ERBB4; GAB1
Ras signaling pathway
SHC1; RASAL1; RASSF5; GNG13; RHOA; FLT4; PIK3CG; RAP1A; CALML5; RALBP1
Rap signaling pathway
PLCE1; MLLT4; ARAP3; ITGB2; RAP1B; CDC42; RALB; IGF1; PLCB4; PIK3R5
cGMP-PKG signaling pathway
PRKG1; ATP1A1; IRS2; NFATC3; SLC25A31; SLC25A6; SLC8A2; MYLK3; SLC8A1; FXYD2
cAMP signaling pathway
FXYD1; PDE4C; HTR4; GLP1R; MAPK10; ATP1B3; MAPK8; CREB5; F2R; ROCK1
Chemokine signaling pathway
GNG10; ITK; STAT3; CCL6; RLN1; CCL21; CCL7; GM10591; CCL8; CCL23
HIF- signaling pathway
PIK3R5; HK1; ERBB2; SLC2A1; NOS2; HIF1A; IGF1; PDK1; VHL; ANGPT2
FoxO signaling pathway
CCND2; FOXO4; BCL6; PIK3R1; TNFSF10; FOXO6; IRS4; SGK2; BRAF; TGFBR2
Sphingolipid signaling pathway
PPP2R5C; AKT1; RAC3; DEGS2; SGMS1; GAB2; GNAI3; NRAS; BDKRB2; SPHK1
Phospholipase D signaling pathway
PPAP2C; PIK3R2; PIK3CG; HRAS; AGTR1A; CYTH1; AVPR1A; PRKCA; PIP5K1B; LPAR5
Oocyte meiosis
CDC20; INS; PPP2R5D; PRKACBA; YWHAH; PRKACB; PGR; PPP3CA; ADCY1A; CCNB2
mTOR signaling pathway
PRKCBB; RPS6KA6; RPS6KB1B; AKT3A; INS; HIF1AB; INSB; DDIT4; RPS6KB1; PRKCG
PIK-Akt signaling pathway
INS; LAMA4; VWF; ITGB7; COL24A1; TCL1A; ITGA2B; IFNA16; INS2; IL7R
Adrenergic signaling in cardiomyocytes
ADCY1A; PPP1CAB; ATP1B2A; PPP2R2A; ATP1B2B; VMHC; PIK3R3; PRKACAA; MAPK11; PPP2R2C
Vascular smooth muscle contraction
MAP2K1; PPP1CAA; PLA2G4D; RHOA; MYL9A; ADRA1BB; CACNA1DA; EDNRAA; PLA2G10; ROCK1
Dorso-ventral axis formation
CPEB2; CPEB4; GRB2; PIWIL1; GRB2B; SPIRE1; ETS1; CPEB3; MAPK3; MAP2K1
TGF-beta signaling pathway
TGFBR1; RHOAB; IFNG1-2; BMP4; BMPR1AB; LEFTY2; ID2; BMP7B; TGFB3; LFT1
Axon guidance
KLB; MET; EFNB3B; PPP3R1; PLXNC1; SEMA4C; EPHA6; ROBO3; RNF8; CSK
VEGF signaling pathway
PPP3CCA; VEGFAB; MAPKAPK2; PPP3R1; PLA2G4A; SRC; MAPK3; PTGS2A; PTK2AB; PIK3R3
Osteoclast differentiation
PIK3R2; IFNB1; MAP2K7; AKT1; SPI1; PPP3CC; LILRA5; IKBKG; RELA; NFKBIA
Focal adhesion
GRB2A; COL27A1; ITGA11A; IGF1RB; COL6A3; AKT3A; SHC3; RHOB; CAPN2A; FYNB
Adherens junction
RHOAB; FGFR1A; PTPRM; MAPK3; LMO7; SNAI1; CSNK2A2; RAC2; TCF7; CSNK2A2A
Gap junction
MAP2K2B; PRKG1A; MAPK7; HTR2CL1; GNAS; GNAQ; ADRB3A; GNAI2; GRB2A; PRKACG
Signaling pathways regulating pluripotency of stem cells
SETDB1; PCGF2; LIFR; DLX5; RAF1; HESX1; FGFR1; ZFHX3; MAP2K2; MAPK1
Platelet activation
ARHGEF12; MAPK3; F2R; GP6; ARHGEF1; P2RY12; ARHGAP35; PPP1R12A; ITPR1; PPP1CC
Toll-like receptor signaling pathway
IL8L1; RAC1B; PIK3CB; PIK3R1; IFNA3; PIK3R3B; TNF; FADD; AKT3A; PIK3R2
NOD-like receptor signaling pathway
MAPK8B; IKBKG; NFKBIAA; CXCL2; NFKBIA; BIRC3; MAPK12B; IL8L2; RELA; CARD18
Natural killer cell mediated cytotoxicity
HLA-C; VAV1; IFNA4; SHC2; KIR3DL2; PPP3R2; KIR2DL1; ICAM1; IFNB1; KIR2DL3
T cell receptor signaling pathway
PAK2; NFATC2; PIK3R2; MAP3K14; PIK3R5; VAV3; PPP3CA; HRAS; SLA1; NFKB1
B cell receptor signaling pathway
RAC2; GRB2; PPP3R1; NFKBIA; NRAS; ITK; LILRB3; ARPC3; ARPC1B; VAV2
Fc epsilon RI signaling pathway
MAPK13; IL4; PLCG1; TNF; RAC2; MAP2K1; INPP5D; GM-CSF; VAV3; RAF1
Fc gamma R-mediated phagocytosis
AKT1; MAPK1; INPP5D; PAK1; WASF2; RAF1; PIP5K1C; PPAP2B; PRKCD; MARCKS
TNF signaling pathway
CASP10; IKBKG; LIF; NFKBIA; MLKL; ATF4; AKT1; IL15; CREB3L2; MMP14
Circadian entrainment
GNGT2; PRKCB; GRIN2A; GNG4; NOS1; GRIA1; CALML3; PRKG2; RASD1; GNG3
Long-term potentiation
CALML3; RAP1B; RPS6KA1; PLCB3; CALM4; CAMK2A; RPS6KA6; RPS6KA3; GRIN2C; CAMK2B
Neurotrophin signaling pathway
PIK3R2; CALM2; NTRK2; MAP2K1; ARHGDIB; PRKCD; Fasl; RPS6KA2; CAMK4; MAPK3
Retrograde endocannabinoid signaling
MAPK3; GABRR3; GABRG2; GNG7; GNG2; PRKCG; MAPK1; GRIA2; GNAI2; DAGLB
Glutamatergic synapse
ADRBK2; PLA2G4C; GNAI3; SLC1A2; GRIA1; GLUL; Adcy4; GLS2; PRKACB; MAPK3
Cholinergic synapse
CHRNA3; CAMK2G; PRKCG; CAMK4; CHRM1; CHRNA6; KCNQ1; BCL2; CHRM2; GNAI2
Serotonergic synapse
Casp3; GNG8; PRKCB; MAPK1; MAOA; MAOB; CYP2C38; BRAF; CYP2C39; HTR3E
Long-term depression
PRKG2; CRHR1; MAP2K2; PLCB1; GRIA2; MAP2K1; RAF1; GRID2; GUCY1B3; GRIA1
Regulation of actin cytoskeleton
INSRR; FGF11; DIAPH1; FGF7; MYLK; ITGA10; SSH3; GNA13A; RAF1B; ITGA2
Insulin signaling pathway
PIK3R3A; CALML3; FOXO1; GRB2A; PHKA1; MKNK2; G6PCA.2; HKDC1; BRAF; MAPK8A
GnRH signaling pathway
MAP3K2; CDC42L2; PLD1A; PRKACAA; CALM3A; CAMK2D1; GNRH3; SRC; Adcy4; MAPK1
Progesterone-mediated oocyte maturation
PGR; PIK3CD; RAF1B; CDC16; PRKACBB; BRAF; PIK3R3A; MAD2L2; AKT2; PRKACG
Estrogen signaling pathway
PRKACB; Adcy4; SOS1; HSPA8; HSPA1A; PIK3CB; HSPA1B; PLCB3; PRKACG; CREB3L3
Melanogenesis
EDNRB2; WNT2BB; RAF1A; KITLG; CALM; FZD2; GSK3B; FZD8A; WNT6; WNT5B
Prolactin signaling pathway
LHCGR; SIRPA; NEK3; PIK3CA; KRAS; SOCS5; CSH; MAPK8; SLC2A2; ELF5
Thyroid hormone signaling pathway
ATP1A3; RHEB; PIK3R1; BMP4; MED24; PLCD1; HIF1A; PLCG1; ACTG1; NCOA1
Oxytocin signaling pathway
GNAI1; SRC; PIK3R1; MEF2C; CALML3; MYLK2; PIK3R5; CACNA2D3; PRKACG; PTGS2
Type II diabetes mellitus
PRKCZ; INS1; PIK3R3; SLC2A2; TNF; PKLR; PRKCD; MAPK3; MAFA; PIK3CD
Aldosterone-regulated sodium reabsorption
PRKCA; ATP1B4; PIK3R1; SGK1; ATP1B3; ATP1A2; KCNJ1; ATP1B2; PIK3R5; ALPHA-ENAC
Alzheimers disease
SDHD; NDUFS1; UQCR11; BACE1; SDHB; COX4I1; COX7C; LPL; NDUFB6; CHP
Prion diseases
PRKACA; C1QC; IL1A; C9; IL1B; HSPA1A; LAMC1; CASP12; STIP1; SOD1
Alcoholism
SOS1; TH; PDYN; HDAC5; HIST1H2AO; CREB3L1; GRIN2B; HIST1H2BH; GNG5; H2AFY2
Shigellosis
MAPK10; MAPK13; MAPK12; MAD2L2; RIPK2; MAPK1; CD44; PFN3; ACTG1; DIAPH1
Salmonella infection
ARPC4L; RHOGD; ROCK2; ROCK2B; WASL; MAPK12B; WASB; CDC42; RAB7; CXCL3
Pertussis
Casp3; SERPING1; IL12B; LY96; CALML3; TLR4; NOS2; GM5077; CASP7; IRF3
Leishmaniasis
FCGR2A; NFKB1; MAPK11; H2-AA; TLR4; HLA-DOB; CYBA; H2-AB1; HLA-DMB; NFKBIB
Chagas disease (American trypanosomiasis)
PPP2R2A; PIK3CA; IKBKB; C1QC; C1QA; CCL5; Ccl12; TNFRSF1A; CCL3; IL1B
Toxoplasmosis
IL10RA; MAPK10; CYCS; HLA-DRB3; MAPK1; IL12A; PDPK1; HLA-DMA; ALOX5; TGFB2
Tuberculosis
FCGR3; Il23a; CD14; IFNA13; CALM2; MYD88; RIPK2; NFYA; FCGR1A; ITGAM
Hepatitis C
PPP2R2D; OCLN; OAS3; OSTN; RNASEL; SOS1; CLDN3; IFNA1; IFNAR2; KRAS
Hepatitis B
NFKB1; CASP8; IFN-a; KRAS; IKBKB; IL-8; MAP2K1; MAPK3; IFNA8; TLR4
Influenza A
IFNA1; EIF2AK4; NXF2; PABPN1; BLB1; HLA-DOA; CASP1; IFNGR2; IRF7; PML
Pathways in cancer
RUNX1; CYCS; PIK3CA; PPARD; GLI3; AKT2; TCEB1; CXCR4; MAPK9; CCDC6
Viral carcinogenesis
ACTN3; CCND2; GTF2A1L; STAT5B; ACTN2; PSMC1; GTF2E2; CCND3; HDAC4; EP300
Proteoglycans in cancer
ARHGEF12; ELK1; TRP53; FN1; MRAS; TGFB1; ITGB5; WNT2B; WNT9A; PLAU
Colorectal cancer
MAP2K1; PIK3R1; RAC3; PIK3R5; MAPK9; RHOA; PIK3CD; AXIN2; RALGDS; PIK3CA
Renal cell carcinoma
CUL2; PAK1; ARAF; PAK6; PTPN11; ETS1; VHL; EGLN1; RAF1; RAP1B
Pancreatic cancer
ARAF; RAD51; PIK3CA; BCL2L1; MAPK8; MAP2K1; STAT3; BRCA2; TGFBR1; MAPK9
Endometrial cancer
ILK; PIK3R5; PDPK1; PIK3CB; CASP9; AKT2; TP53; PTEN; ARAF; MAPK3
Glioma
PIK3R5; CALML3; RB1; MAPK3; CAMK2D; PIK3CD; TGFA; RAF1; PDGFA; PIK3CA
Prostate cancer
SPRY1; RELA; Ar; NRAS; BAD; SMARCA4; SOS1; TRP53; IKBKG; GRB2
Thyroid cancer
NTRK1; CCND1; NRAS; RXRG; MAP2K1; MAP2K2; LEF1; TPR; RXRA; MAPK3
Melanoma
FGF7; MAP2K1; PIK3R2; FGF21; PIK3R3; MITF; MDM2; PIK3CG; AKT2; FGF19
Bladder cancer
RAF1; TRP53; RASSF1; MDM2; BRAF; CCND1; TP53; MAP2K1; CDKN2A; MYC
Chronic myeloid leukemia
PTPN11; HDAC2; SHC3; RAF1; PIK3CB; PIK3R1; STAT5A; CRK; IKBKG; BCL2L1
Acute myeloid leukemia
NRAS; CEBPA; AKT1; MAPK3; PML; TCF7L2; LEF1; KIT; STAT5B; STAT3
Non-small cell lung cancer
RB1; FOXO3; PRKCA; STK4; FHIT; MAPK1; EML4; PIK3R2; GRB2; PIK3CD
Central carbon metabolism in cancer
SLC1A5; PIK3R3; C12orf5; LDHA; PIK3R5; SIRT6; G6PD; SLC7A5; PGAM2; KRAS
Choline metabolism in cancer
PPAP2B; SLC22A1; WASL; NRAS; SLC5A7; DGKG; MAP2K2; PIK3CA; DGKQ; RPS6KB1

Protein Function

MAPK3 has several biochemical functions, for example, ATP binding, MAP kinase activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK3 itself. We selected most functions MAPK3 had, and list some proteins which have the same functions with MAPK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ATP2A2A; TNIKA; EIF2AK3; MCM2; SMC1AL; DGKB; PRKDC; SCYL1; RAD51L1; ACACA
Function MAP kinase activity
Related Protein MAPK11; MAPK8B; MAPK14B; MAPK7; MAPK12B; MAPK12A; NLK; NLK1; MAPK4; MAPK1
Function phosphatase binding
Related Protein DLG1L; TSC2; DLG3; CRY1; ELFN1; SH3YL1; SH3GL1; SPRED1; CTSC; WNK1
Function phosphotyrosine binding
Related Protein GRB2; SHC1; SAMSN1; FGR; MAPK3; ZAP70; CBL; PTPN3; CBLB; MAPK1
Function protein binding
Related Protein INPP5D; BIRC3; PHF17; TMEM147; KCNRG; SYT16; ZFP523; MALT1; NEFL; TRADD
Function scaffold protein binding
Related Protein NLGN4X; MAPK3; DLG4; KCNQ1; ATP2B4; NOS3; SCN5A; CASP8; HOMER1; PDE4D

Interacting Protein

MAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK3.
DUSP1; PTPRJ; MAPK14; DHPS; Ptprr

MAPK3 Related Articles

Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).