mapk3
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  • Official Full Name
  • MAPK3 mitogen-activated protein kinase 3
  • Synonyms
  • MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk; MAPK 1; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; mitogen-activated protein kinase 1; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; ERT2; ERK-1; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; MGC20180;
Cat.#:MAPK3-1031MTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein
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Cat.#:MAPK3-1517HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human MAPK3 protein
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Cat.#:MAPK3-2787HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3, His-tagged
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Cat.#:MAPK3-28694THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-28699THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-286HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-287HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-288HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-28HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated ERK1, His-tagged
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Cat.#:MAPK3-34HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-36HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-9534MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK3 Protein
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Cat.#:MAPK3-3574RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK3 Protein
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Cat.#:MAPK3-11551ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK3
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Cat.#:MAPK3-307HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 3, Active
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Cat.#:MAPK3-1048HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Active), GST-Tagged
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Cat.#:MAPK3-1049HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Unactive), GST-Tagged
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Cat.#:MAPK3-4494HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK3 293 Cell Lysate
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Involved Pathway

MAPK3 involved in several pathways and played different roles in them. We selected most pathways MAPK3 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RAC3; PRKACBB; PLA2G4C; CACNA1DA; HSPB1; RAC1; MAP2K2; FGF20; AKT2; Fasl
ErbB signaling pathway
PAK2B; PRKCG; PIK3R1; BTC; PAK2; MAP2K4; MAP2K2A; MAPK8; RAF1; CAMK2G
Ras signaling pathway
IGF1R; Kitl; VEGFC; PLA2G4C; CSF1; FGF20; PLA2G4F; RAF1; GNB3; FGF1
Rap signaling pathway
ITGB2; PRKD1; TLN1; PIK3CD; PIK3R3; SIPA1L2; CALM3; VASP; MAP2K2; RAPGEF5
cGMP-PKG signaling pathway
ROCK1; PIK3R2; PRKG1; ATP2B1; PIK3CB; GTF2I; NOS3; CREB3L2; PPP3R2; VDAC3
cAMP signaling pathway
GNAS; ROCK1; PRKACA; PPARA; ATP1B3; GRIA3; GRIA2; GHRL; F2R; PDE3A
Chemokine signaling pathway
GNAI1; GNB3; IKBKG; CCL4; AKT2; IL-8; CXCR3; ADRBK1; XCR1; CXCR1
HIF- signaling pathway
AKT1; ANGPT4; RPS6KB2; TCEB2; RELA; PRKCA; IGF1R; PIK3R3; EPO; MTOR
FoxO signaling pathway
PLK1; PTENB; MAPK14A; TGFBR1A; PRKAB1B; GABARAPL2; G6PC3; CCNB3; INSR; PIK3CB
Sphingolipid signaling pathway
ACER1; ROCK2; BDKRB2; PPP2R5B; BCL2; TRAF2; PIK3CD; CERS4; PPP2R2B; SPHK2
Phospholipase D signaling pathway
LPAR5; AKT1; PDGFC; GRM1; RALGDS; PRKCA; KITLG; SYK; RRAS2; GRM3
Oocyte meiosis
PKMYT1; MAPK12B; CCNB2; CDK1; MAPK12; MOS; REC8; PPP2R5B; CAMK2D1; PPP2R5D
mTOR signaling pathway
PDPK1; INS2; STK11; DDIT4; RB1CC1; PTENB; RHEB; PRR5; DEPDC6; RPS6KAL
PIK-Akt signaling pathway
NGF; GNG5; COL4A1; PDGFC; PDPK1; ITGB5; RAC1; EPO; PPP2R5A; CCNE2
Adrenergic signaling in cardiomyocytes
VMHCL; PIK3R2; CACNB3A; CAMK2G1; CACNB4A; PIK3CG; CACNG8; CREB3L3L; AKT2L; ADCY1A
Vascular smooth muscle contraction
PRKACA; CACNA1C; MYL9A; PRKCHA; CYP4A12A; CALM1A; KCNMB2; CALD1B; PLA2G2F; PPP1CBL
Dorso-ventral axis formation
CPEB1A; MAP2K1; MAPK3; NOTCH3; SPIRE1; KRAS; NOTCH1; PIWIL1; CPEB2; ETV7
TGF-beta signaling pathway
SMAD1; FSTA; ACVR2A; GDF5; TNF; SKP1; ID2; RPS6KB1B; BMP6; TGFBR1A
Axon guidance
DPYSL5; RHOGA; FYN; SRGAP1; EVL; RND1L; LRRC4C; EFNB3; RND1; EFNA2
VEGF signaling pathway
HRASB; SHC2; PLA2G4A; PTGS2B; MAPK13; SPHK1; MAPKAPK2A; PTGS2A; PIK3R2; MAPKAPK3
Osteoclast differentiation
NFKB2; LILRB2; PLCG2; FCGR3A; TEC; MAPK3; IL1B; SOCS3; LILRA3; PIK3R2
Focal adhesion
RAC3; ELK1; COL1A1B; THBS4; MYL12B; PAK2A; HRAS; HGF; GRB2A; PDGFRA
Adherens junction
WASF2; TGFBR2; FYNA; MAPK3; RAC3A; NLK1; SNAI1; PTPRJ; MAPK1; CSNK2B
Gap junction
DRD1B; ADCY2B; TUBA8L3; PRKACA; RAF1B; TUBB2A; TUBA4L; TUBA1L; CSNK1DB; TUBA3B
Signaling pathways regulating pluripotency of stem cells
INHBB; AKT1; MYF5; FZD7; WNT16; WNT5A; MAP2K1; KRAS; WNT3A; PIK3R1
Platelet activation
ITGB3; ARHGAP35; PIK3R1; GUCY1B3; FYN; PPP1CB; FERMT3; AKT1; ITGA2B; PPP1CA
Toll-like receptor signaling pathway
TBK1; IFNA4; IFNPHI3; TAB2; PIK3CG; MAPK12B; TLR8; MAP2K3; TLR2-2; IFNA14
NOD-like receptor signaling pathway
BIRC2; MAPK3; IL1B; MAPK12B; CASPA; HSP90AA1; CXCL2; MAPK12A; CARD9; TRAF6
Natural killer cell mediated cytotoxicity
FCGR3B; MAP2K1; SH2D1A; VAV3; H60a; MAPK3; IFNA7; PLCG1; IFNA6; PTPN11
T cell receptor signaling pathway
MAPK12; GRB2; MAP2K1; IKBKB; PPP3R2; IL5; MAP3K7; PPP3R1; PTPN6; PAK1
B cell receptor signaling pathway
KRAS; PPP3R2; CSK; MAP4K1; LCP2A; PDK2B; LAT2; PDK2; PIK3R2; ARPC2
Fc epsilon RI signaling pathway
GRB2; MAPK8; MAPK12; MS4A2; MAP2K7; PIK3CG; IL3; RAF1; MAP2K3; RAC2
Fc gamma R-mediated phagocytosis
PLD2; PIK3CD; MARCKSL1; PAK1; FCGR2A; SPHK1; CFL1; MYO10; RPS6KB2; LIMK2
TNF signaling pathway
TRADD; RPS6KA4; MAP2K1; Casp3; MMP9; PIK3CG; PIK3R1; CXCL5; IL6; MAPK8
Circadian entrainment
GNAQ; PLCB2; AKR1C1; GRIN1; PRKACA; PLCB4; PER3; GNG2; FOS; GRIA4
Long-term potentiation
RPS6KA1; HRAS; ATF4; PRKACG; MAPK1; PRKACB; PRKACA; CAMK4; GRIN2A; PLCB3
Neurotrophin signaling pathway
BAX; MATK; PIK3R1; AKT2; CALM2; PIK3CG; RIPK2; SH2B2; RPS6KA5; MAP2K5
Retrograde endocannabinoid signaling
GNG8; ITPR1; MAPK12; GABRG3; GNB2; GABRP; GABRR3; PRKCB; GNG10; DAGLB
Glutamatergic synapse
GNG11; HOMER3; PRKACA; GNG4; PLCB4; GRIN2A; SLC17A7; PLD2; GRIK5; PPP3CB
Cholinergic synapse
CHRNA3; CHRNA7; KCNQ2; BCL2; PIK3R2; CAMK4; GNG4; AKT1; KCNJ4; SLC5A7
Serotonergic synapse
PLCB1; ARAF; GNB2; GNAO1; GNAI3; PLA2G4F; TPH1; PLCB3; HTR2B; ALOX12
Long-term depression
PLA2G4D; MAPK1; RYR1; KRAS; PLCB4; PRKG1; GNAI3; PPP2CA; PRKCG; CRH
Regulation of actin cytoskeleton
PIK3R2; MAP2K2; FGF12A; VAV1; FGD3; FGF10; FGF1A; ITGB8; PTK2AA; PIK3CG
Insulin signaling pathway
FOXO1B; PPP1CC; G6PC; EIF4E1C; PRKACA; G6PCA.2; PPP1R3D; PIK3R1; PDPK1; PIK3CD
GnRH signaling pathway
MAP3K3; MAPK11; MMP2; MMP14A; PTK2B; GNRHR1; MAP2K4; EGFRA; ADCY1B; GRB2
Progesterone-mediated oocyte maturation
RPS6KA3; GNAI2; BUB1; CDK1; PPP1R2P9; FZR1A; PDE3B; CDC25B; RPS6KA1; RAF1
Estrogen signaling pathway
GRB2; GNAI1; SHC3; FKBP4; HSPA1L; KCNJ6; PLCB3; PIK3CG; PIK3R5; GABBR1
Melanogenesis
CAMK2B; CALM; GNAS; MITF; WNT2BA; FZD2; POMCA; GNA11A; RAF1B; PRKCBA
Prolactin signaling pathway
SHC4; GSK3B; INS; CCND2; SLC2A2; RAF1; CSN2; GALT; SHC3; PIK3CD
Thyroid hormone signaling pathway
PLCB1; RXRG; AKT2; MAP2K1; PIK3R5; PRKACG; MED13L; HRAS; MAPK1; PRKACB
Oxytocin signaling pathway
CACNA2D2; CAMK2G; PPP1CB; GNAQ; GNAO1; PRKCG; CACNA2D3; SRC; PLCB3; PIK3R5
Type II diabetes mellitus
ADIPOQ; MAPK3; PDX1; IKBKB; MAFA; SOCS4; SOCS3; INS-IGF2; MAPK1; HK1
Aldosterone-regulated sodium reabsorption
KRAS; NR3C2; PRKCB; IGF1; IRS1; KCNJ1; ATP1A3; MAPK1; ATP1B3; MAPK3
Alzheimers disease
PSEN1; NAE1; GRIN2B; APBB1; BID; NDUFA11; CDK5; ATP5H; PLCB1; NOS1
Prion diseases
C6; PRKACB; NOTCH1; IL1B; LOC100033925; NCAM2; PRKACG; MAP2K1; FYN; LAMC1
Alcoholism
H2AFB3; HDAC11; HIST1H2AP; HIST1H3A; HIST1H2AJ; GM14476; GM6026; HIST2H3A; HDAC7A; GM14483
Shigellosis
WASL; UBE2D2; MAPK13; PFN2; SRC; ROCK1; NFKBIA; IKBKB; ITGA5; ELMO1
Salmonella infection
RAC1A; TLR4BA; PFN4; NOS2; PKN1; PFN1; RELA; CCL4L2; TLR5B; ROCK2B
Pertussis
AMCF-II; SERPING1; C4BPA; C1QB; CALM3; IL6; GNAI3; IL1B; GNAI1; IL12B
Leishmaniasis
HLA-DOA; FCGR1A; NOS2; PRKCB; HLA-DPB1; ITGB1; IFNGR1; FCGR3B; FCGR4; TAB2
Chagas disease (American trypanosomiasis)
PPP2R2B; PIK3R2; PIK3CD; C1QC; SERPINE1; IL-8; MAPK12; PPP2R2C; IL12A; C1QA
Toxoplasmosis
H2-AB1; HSPA1L; TGFB2; LAMC1; LAMA3; Toxoplasma Gondii Dense Granule Protein 7; HLA-DMA; PDPK1; H2-AA; Toxoplasma Gondii Microneme Protein MIC3
Tuberculosis
CEBPG; AKT2; FCGR3A; HLA-DQA2; KSR1; PPP3CB; BCL10; ATP6V0C; IL10RB; IL23
Hepatitis C
SCARB1; PPP2R1A; RIPK1; AKT2; IFNAR2; IFNA17; IRF1; CLDN1; AKT1; PPP2R2B
Hepatitis B
STAT6; RB1; VDAC3; CASP8; ATP6AP1; TGFB1; Ifna11; Fasl; FADD; IFNAR1
Influenza A
IFNA17; EIF2AK4; IL12B; FAS; DDX39B; PIK3R3; IFNA1; VDAC1; ACTB; HSPA6
Pathways in cancer
CCNA1; BIRC5; MECOM; PTCH1; Fgf15; MMP2; GNA11; NCOA4; HSP90AA1; AGTR1A
Viral carcinogenesis
ATP6V0D2; ACTN1; HIST1H2BI; ATP6V0D1; HLA-B; HDAC7; HIST3H2BB-PS; TRAF3; PIK3R2; BAX
Proteoglycans in cancer
MAP2K2; CAMK2D; CD44; WNT10B; Fasl; Fzd4; CCND1; WNT7A; KRAS; PLCG2
Colorectal cancer
BRAF; ARAF; MAPK3; BAD; APC2; PIK3CA; TGFBR1; PIK3CB; RAC3; RAC1
Renal cell carcinoma
PIK3CA; RAPGEF1; TCEB1; MAP2K1; CDC42; SOS1; PIK3CB; EPAS1; TCEB2; PAK2
Pancreatic cancer
ERBB2; TGFA; RAF1; KRAS; RAD51; SMAD4; TRP53; SMAD3; AKT2; AKT1
Endometrial cancer
NRAS; APC; AXIN1; MLH1; BRAF; ILK; APC2; PIK3CA; PIK3CB; HRAS
Glioma
PIK3CG; IGF1R; PRKCB; MAPK3; IGF1; RAF1; SOS1; BRAF; RB1; MTOR
Prostate cancer
IKBKG; PIK3CB; BRAF; ARAF; CCNE2; CCNE1; NDRG1; MAP2K2; TCF7; INS1
Thyroid cancer
RXRA; TCF7L2; TFG; RXRB; TPM3; TRP53; CCND1; LEF1; MAPK3; MAPK1
Melanoma
IGF1; PTEN; RB1; FGF6; PIK3R5; HRAS; Pdgfa&Pdgfb; PDGFC; FGF21; PIK3CA
Bladder cancer
RB1; E2F1; CDK4; DAPK3; VEGFA; MAP2K1; CXCL8; ERBB2; EGF; HRAS
Chronic myeloid leukemia
MECOM; TGFB2; PIK3CG; KRAS; TGFB3; HDAC2; ABL1; STAT5A; PIK3R3; RUNX1
Acute myeloid leukemia
AKT2; HRAS; MAP2K2; SOS1; NFKB1; LEF1; AKT3; FLT3; PIM1; PIK3R1
Non-small cell lung cancer
PLCG1; MAPK3; BRAF; PIK3R3; RXRB; AKT1; MAP2K2; ERBB2; RXRG; EML4
Central carbon metabolism in cancer
PFKL; SLC2A1; PDGFRB; RET; SLC1A5; KRAS; MAPK3; PFKM; SLC2A2; AKT2
Choline metabolism in cancer
PIK3R1; PIK3R5; RAC1; GPCPD1; WAS; SLC22A1; RPS6KB2; LYPLA1; PDGFC; MTOR

Protein Function

MAPK3 has several biochemical functions, for example, ATP binding, MAP kinase activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK3 itself. We selected most functions MAPK3 had, and list some proteins which have the same functions with MAPK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NEK1; SRMS; DDX23; BSK146; P2RX6; MTHFS; KIF25; ULK2; FIGNL1; RIPK4
Function MAP kinase activity
Related Protein NLK; MAPK4; MAPK13; MAPK14A; MAPK6; MAPK7; MAPK12B; MAPK8A; MAPK3; MAPK8B
Function phosphatase binding
Related Protein SLC9A3R2; TRPC4AP; SYTL2; PPP1R35; DYSFIP1; SLC9A3R1; ELFN1; SH3RF2; KLRAQ1; DLG1
Function phosphotyrosine binding
Related Protein PTPN3; SHC1; GRB2; CBLC; CBLB; LDLRAP1; MAPK1; CBL; FGR; STAP1
Function protein binding
Related Protein GRAMD3; DCX; GTF2A2; RORA; CDC45; PDXP; ZBTB2; NOC2L; FRS2; RAD52
Function scaffold protein binding
Related Protein ADCY6; CIT; DSP; KRT15; TREM1; NLRP1; CHRNA7; KCNQ1; ATP2B4; GRID2

Interacting Protein

MAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK3.
DUSP1; PTPRJ; MAPK14; DHPS; Ptprr

MAPK3 Related Articles

Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).