mapk3
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  • Official Full Name
  • MAPK3 mitogen-activated protein kinase 3
  • Synonyms
  • MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk; MAPK 1; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; mitogen-activated protein kinase 1; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; ERT2; ERK-1; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; MGC20180;
Cat.#:MAPK3-1031MTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein
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Cat.#:MAPK3-1517HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein
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Cat.#:MAPK3-2787HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3, His-tagged
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Cat.#:MAPK3-28694THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-28699THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-286HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-287HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-288HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-28HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated ERK1, His-tagged
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Cat.#:MAPK3-34HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-36HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-9534MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK3 Protein
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Cat.#:MAPK3-3574RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK3 Protein
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Cat.#:MAPK3-11551ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK3
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Cat.#:MAPK3-307HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 3, Active
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Cat.#:MAPK3-1048HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Active), GST-Tagged
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Cat.#:MAPK3-1049HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Unactive), GST-Tagged
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Cat.#:MAPK3-4494HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPK3 293 Cell Lysate
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Involved Pathway

MAPK3 involved in several pathways and played different roles in them. We selected most pathways MAPK3 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PTPN7; ARRB2; HSPB1; ELK4; NLK1; MAP2K3; MAP2K4; FGF13; MAPK8; IL1R1
ErbB signaling pathway
AKT2L; PAK2; PAK6; PRKCB; CAMK2D2; CAMK2D; PTK2AA; HRAS; PRKCBB; PAK6B
Ras signaling pathway
PAK1; SHC1; FGF2; FGF22; GRIN2B; MAPK1; GNG3; GNG5; KRAS; FGF11
Rap signaling pathway
INS; MLLT4; GNAI2; TEK; KRIT1; CALML5; LPAR2; FGF14; ITGAL; Fgf15
cGMP-PKG signaling pathway
SLC25A4; PIK3CG; PRKCE; VDAC3; GNA11; ITPR1; GNAI3; ATP1A3; RAF1; IRS1
cAMP signaling pathway
GHRL; GRIA3; PLCE1; SOX9; PIK3CD; CNGA1; SLC9A1; NFATC1; CALM4; PDE3A
Chemokine signaling pathway
SRC; PRKACA; CCL23; GNG8; PIK3R1; JAK3; FGR; PPBP; GNG12; PXN
HIF- signaling pathway
Il6ra; ENO3; CAMK2B; TIMP1; ANGPT4; PIK3CA; CAMK2G; CAMK2A; SLC2A1; PIK3CD
FoxO signaling pathway
G6PCA.1; CCND2; IKBKB; IGF1; NLK2; GADD45G; CCNB3; SLC2A4; FOXG1; CCND1
Sphingolipid signaling pathway
PLD2; CERS4; ACER1; SPHK1; HRAS; ASAH2; PRKCB; MAPK10; PDPK1; LASS5
Phospholipase D signaling pathway
CYTH1; DGKZ; MAPK1; MAP2K2; CYTH4; Pdgfa&Pdgfb; CXCR1; TSC1; KIT; PDGFC
Oocyte meiosis
CUL1; YWHABA; REC8B; SGOL1; ADCY2B; RPS6KA3B; SMC1B; CAMK2D2; CALM2B; CPEB2
mTOR signaling pathway
PRR5; POLDIP3; DDIT4; EIF4BA; VEGFA; INS1; PTENB; RPS6KA6; VEGFAB; VEGFAA
PIK-Akt signaling pathway
VEGFB; IL6; Ifna11; PHLPP1; IFNA1; NRAS; HSP90B1; FGF3; FGF19; YWHAB
Adrenergic signaling in cardiomyocytes
CACNA1D; CACNB2; PIK3R1; ADRA1B; AKT1; ADRB2B; PPP2R5B; CREM; CALM2A; AKT2
Vascular smooth muscle contraction
CALCRLA; CALM; PLA2G10; PPP1CB; MLCK2; PLA2G12B; ROCK2; MYL9A; ROCK1; KCNMB3
Dorso-ventral axis formation
ETV7; MAPK1; PIWIL2; CPEB1A; SPIRE1; CPEB1B; ETV6; MAP2K1; SPIRE1A; NOTCH1
TGF-beta signaling pathway
TGIF1; IFNG1-2; TFDP1; INHBE; NOG3; CUL1A; BAMBIB; RHOA; BMP8A; SMAD6
Axon guidance
SEMA3E; CSK; EFNA1A; PAK3; NCAN; SLIT2; FGF8B; PLXNC1; DPYSL5A; PAK6
VEGF signaling pathway
RAF1; PTGS2A; RAF1A; PLA2G4A; NOS3; MAPKAPK2A; PRKCB; AKT3A; PLCG2; MAP2K2
Osteoclast differentiation
IL1B; MAPK1; TGFBR1; FCGR2B; TGFB1; PPP3CC; ACP5; IFNAR1; FOSL2; FCGR2C
Focal adhesion
FYN; SPP1; THBS2; ITGA5; HGF; COL1A1; CAPN2; HRAS; MET; MYL2
Adherens junction
CTNNB1; PTPRB; ACTN2; PVRL2; EGFR; WASF2; PVRL1; PTPRFB; ACTN3B; RAC3
Gap junction
PLCB2; PRKG2; CX35B; GNA15.4; GNAS; TUBA3B; CDK1; TJP1; SOS1; PDGFD
Signaling pathways regulating pluripotency of stem cells
BMI1; BMPR1B; FZD8; TBX3; ACVR1B; PIK3CG; NANOG; SMAD5; FZD9; ID2
Platelet activation
PLA2G4D; PPP1CC; TBXAS1; PIK3R2; PRKG1; MYLK3; GNAS; GNAI3; GP6; GNAI1
Toll-like receptor signaling pathway
TLR3; IRF7; IFNAR1; TOLLIP; PIK3R3B; TLR1LA; IL-8; TLR5; TLR8; IFNA21
NOD-like receptor signaling pathway
CASPA; MAPK8; RIPK2; CCL5; MAP3K7; NFKBIAA; NAIP7; MAPK14A; PYDC1; NFKBIB
Natural killer cell mediated cytotoxicity
HCST; PTPN11; ICAM1; KIR3DL1; GM-CSF; HLA-G; LCK; IFNA2; PRKCG; KLRC2
T cell receptor signaling pathway
MAPK3; MAPK12; MAPK9; MAP2K2; AKT1; RHOA; PAK1; RELA; PIK3CG; CD4
B cell receptor signaling pathway
STAP1; TTC6; Cd79a, Cd79b; CD72; LAT2; BLK; VAV3; MAP2K2; NFKBIE; SLA2
Fc epsilon RI signaling pathway
MAPK11; PIK3CB; MAP2K3; HRAS; TNF; IL4; PLA2G4C; PRKCA; MAP2K4; PIK3R3
Fc gamma R-mediated phagocytosis
AKT1; RPS6KB1; ARPC1A; FCGR3A; PPAP2C; PIK3CD; PIP5K1A; RPS6KB2; AKT2; FCGR1A
TNF signaling pathway
PIK3R5; IL6; MMP9; CREB3L3; BIRC2; MAPK3; NFKB1; CREB3L2; IKBKG; TAB2
Circadian entrainment
GRIA1; PLCB1; GNG13; RPS6KA5; GRIA3; PER1; GNG12; AKR1C1; MAPK1; GNAQ
Long-term potentiation
PPP1CC; GRIN2A; PRKACB; MAPK1; PLCB2; HRAS; PPP3CB; PPP3CA; GRM1; PPP3R2
Neurotrophin signaling pathway
SHC3; SORT1; CAMK4; NTRK2; IRAK1; IRS1; MAPKAPK2; IKBKB; MAPK9; CAMK2B
Retrograde endocannabinoid signaling
GNAI2; GABRG2; GNG5; GNB2; GABRR1; PLCB4; GNAQ; GABRR2; PRKACA; GRIA1
Glutamatergic synapse
ITPR1; PLCB2; ITPR3; PRKCG; GRM5; GNG13; PRKACA; GNB3; PLD2; GLS2
Cholinergic synapse
FOS; CREB3L3; CREB3L1; KCNQ3; GNAI3; GNGT1; ITPR3; JAK2; CHRNA7; PIK3R2
Serotonergic synapse
GNG2; HTR3C; PLA2G4C; ALOX15; MAPK1; GNAI1; GNG13; PLCB4; GNG12; SLC18A2
Long-term depression
PRKG1; MAPK1; LYN; PLCB4; PPP2R1B; PRKCB; PRKG2; IGF1R; PPP2CA; GNAI2
Regulation of actin cytoskeleton
VAV3B; PDGFC; FGF11A; BRAF; ITGA11A; PDGFRA; INS2; KRAS; CHRM2A; ARPC5B
Insulin signaling pathway
SHC3; CALM1A; FLOT2A; SOCS1A; FOXO1B; RAPGEF1; PIK3CD; FBP2; EIF4E1B; GYS1
GnRH signaling pathway
PLA2G4F; CALM1; CACNA1SB; HRASA; GNA15.4; GNA11A; PLA2G4AA; GNRH1; MAPK7; MMP14B
Progesterone-mediated oocyte maturation
CCNB1; ANAPC13; PRKACAB; ANAPC5; MAPK8A; INS; AKT3A; PRKACA; AKT2; RAF1
Estrogen signaling pathway
SHC3; HRAS; HSP90AB1; HSPA1B; SRC; GNAS; NRAS; SOS1; PIK3CD; CALML3
Melanogenesis
MAP2K1; WNT2BB; POMC; WNT2BA; CALM1A; WNT6; WNT16; CALM3A; WNT7B; WNT8A
Prolactin signaling pathway
STAT1; CSH; ESR1; FOXO3; PRP2; PPIB; RAF1; STAT5A; RELA; INS
Thyroid hormone signaling pathway
PRKCB; PIK3R2; KAT2A; PLCD1; PRKACG; PIK3R3; NCOR1; ATP2A2; PRKCA; FOXO1
Oxytocin signaling pathway
NPR2; ITPR1; KCNJ14; TRPM2; PLA2G4C; PRKAG2; PRKAB1; NFATC3; CACNA2D1; PPP3CC
Type II diabetes mellitus
ADIPOQ; PKM2; MTOR; IRS1; PIK3CB; PIK3R5; PIK3CD; IRS2; PRKCD; INS-IGF2
Aldosterone-regulated sodium reabsorption
PIK3R5; PIK3CB; MAPK3; FXYD4; NR3C2; INS2; ATP1A2; KRAS; SLC9A3R2; PRKCB
Alzheimers disease
CASP12; NDUFC1; NDUFS2; CALML5; UQCRQ; COX4I1; NDUFA4; NDUFB8; COX8A; SDHC
Prion diseases
HSPA5; LOC100033925; LAMC1; ELK1; C8B; BAX; C1QC; C7; NCAM2; FYN
Alcoholism
GNG4; FOSB; H2AFX; HDAC8; GNAI3; GNB4; H2AFZ; H2AFB3; HIST2H3C2; PDYN
Shigellosis
PFN1; ACTG1; IKBKB; ITGB1; MAPK13; DIAPH1; ELMO3; PFN2; PFN3; ELMO2
Salmonella infection
MYH9; MAPK1; MAPK14B; WAS; WASLA; ARPC5A; FLNA; MAPK8B; TLR4BA; CCL4
Pertussis
CASP7; C4BPA; CXCL6; ITGB2L; NLRP3; PYCARD; C3; CXCL5; AMCF-II; TRAF6
Leishmaniasis
FCGR3B; HLA-DQB1; NCF2; PTPN6; HLA-DRB4; IL12A; HLA-DOB; TGFB2; NOS2; MAPK1
Chagas disease (American trypanosomiasis)
NOS2; CCL3L1; NFKBIA; IFNG; MAPK9; GNAI1; IL10; IKBKG; TLR9; Il2
Toxoplasmosis
HSPA8; GNAI3; TRAF6; CD40LG; HLA-DQA2; IL10RA; PIK3R2; MAPK8; MAPK9; BAD
Tuberculosis
CLEC4E; IFNA1; IL18; CD209B; MAPK10; HLA-DQA2; PPP3CC; IRAK2; IFNGR1; FCGR3B
Hepatitis C
DDX58; PPP2R2D; CLDN23; NFKB1; CXCL8; AKT2; IFNA10; PIK3R5; BRAF; EIF2AK3
Hepatitis B
CCNE2; IFNA12; Casp3; MAPK8; EGR2; DDX3X; CCND1; IFNA14; IFNA10; BAD
Influenza A
FAS; IL12B; TNFSF10; GSK3B; HLA-DMB; SOCS3; FASLG; HSPA1A; HLA-DRB1; IL-8
Pathways in cancer
FOXO1; F2RL3; LPAR4; LAMA5; MMP1A; RUNX1T1; XIAP; TGFB1; PRKCA; Fasl
Viral carcinogenesis
HIST1H2BP; HDAC1; GTF2H2; GTF2H3; HLA-B; PSMC1; TRAF2; SCIN; CCND2; PIK3CD
Proteoglycans in cancer
Fasl; PAK1; WNT10B; RPS6KB2; CAV3; RRAS2; ANK2; RPS6KB1; WNT9A; MAP2K1
Colorectal cancer
MSH3; MAPK8; CYCS; MSH6; TGFBR2; BAX; TCF7; MAP2K1; APC; PIK3CA
Renal cell carcinoma
AHA-1; GAB1; FLCN; PIK3CA; TCEB2; PIK3R3; TGFA; AKT1; RAP1B; PIK3CD
Pancreatic cancer
PIK3R2; ERBB2; PIK3R1; PLD1; BRAF; TGFB2; CDC42; RAD51; RAC3; STAT3
Endometrial cancer
ILK; SOS1; CASP9; CTNNA2; CDH1; RAF1; GRB2; KRAS; PIK3CG; BRAF
Glioma
PIK3R2; TRP53; MDM2; AKT2; MAPK1; MAP2K2; PRKCA; CAMK2A; SHC3; PLCG2
Prostate cancer
INSRR; GRB2; AKT2; CCND1; BRAF; BCL2; AKT1; SMARCA4; CASP9; IGF1
Thyroid cancer
NTRK1; MAP2K2; MAPK1; LEF1; RXRA; CDH1; CCND1; NCOA4; CCDC6; NRAS
Melanoma
TP53; MDM2; FGF2; IGF1; RB1; RAF1; FGFR1; KRAS; FGF19; CDH1
Bladder cancer
MDM2; HBEGF; IL-8; RB1; BRAF; KRAS; EGF; CCND1; TRP53; THBS1
Chronic myeloid leukemia
HDAC2; CTBP1; CRKL; PIK3CG; RUNX1; IKBKB; SMAD3; MAPK1; PIK3R5; HRAS
Acute myeloid leukemia
PIK3R5; IKBKG; LEF1; PIK3R3; GRB2; NRAS; SPI1; PIK3CA; STAT5A; MTOR
Non-small cell lung cancer
ALK; PIK3CD; ERBB2; PRKCG; RASSF5; RXRB; RASSF1; HRAS; RARB; PIK3CA
Central carbon metabolism in cancer
SLC2A2; FGFR1; GLS; PDGFRB; SLC1A5; PIK3R5; FGFR3; KIT; TRP53; PKM2
Choline metabolism in cancer
PPAP2A; DGKE; MAPK9; WASL; TSC2; FOS; MTOR; PIK3CB; RPS6KB2; PDGFRB

Protein Function

MAPK3 has several biochemical functions, for example, ATP binding, MAP kinase activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK3 itself. We selected most functions MAPK3 had, and list some proteins which have the same functions with MAPK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CCT5; FGFR1A; CAMK2G1; DHX29; NEK12; RFC4; RFK; MKI67; SMARCAD1; CKB
Function MAP kinase activity
Related Protein MAPK3; NLK1; MAPK14B; MAPK14; MAPK12B; MAPK15; MAPK1; MAPK13; MAPK7; NLK
Function phosphatase binding
Related Protein TRPC4AP; MAST2; MAGI2; DZIP3; ELFN2; PPP1R37; SLC9A3R1; PPP1R26; MAPK1; DLG1
Function phosphotyrosine binding
Related Protein STAP1; ACP2; SHC1; FGR; GRB2; CBLC; MAPK1; CBL; MAPK3; ZAP70
Function protein binding
Related Protein GNA12; HTR1B; DEPDC1; BBS12; CCDC24; KLRK1; CREM; KCNIP3; EMP2; CLASP1
Function scaffold protein binding
Related Protein PANX1; MDM2; KRT8; ATP2B4; GRID2; NOS3; SCN5A; NLGN1; NLRP1; CASP8

Interacting Protein

MAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK3.
DUSP1; PTPRJ; MAPK14; DHPS; Ptprr

MAPK3 Related Articles

Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).