mapk3
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  • Official Full Name
  • MAPK3 mitogen-activated protein kinase 3
  • Synonyms
  • MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk; MAPK 1; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; mitogen-activated protein kinase 1; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; ERT2; ERK-1; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; MGC20180;
Cat.#:MAPK3-1031MTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein
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Cat.#:MAPK3-1517HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human MAPK3 protein
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Cat.#:MAPK3-2787HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3, His-tagged
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Cat.#:MAPK3-28694THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-28699THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-286HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-287HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-288HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-28HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated ERK1, His-tagged
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Cat.#:MAPK3-34HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-36HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-9534MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK3 Protein
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Cat.#:MAPK3-3574RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK3 Protein
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Cat.#:MAPK3-11551ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK3
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Cat.#:MAPK3-307HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 3, Active
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Cat.#:MAPK3-1048HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Active), GST-Tagged
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Cat.#:MAPK3-1049HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Unactive), GST-Tagged
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Cat.#:MAPK3-4494HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK3 293 Cell Lysate
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Involved Pathway

MAPK3 involved in several pathways and played different roles in them. We selected most pathways MAPK3 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
GNA12; MAP3K14; NFKB2; SOS1; NLK1; ATF4B1; CACNG1A; MAP2K4; MAPK8A; FGF8A
ErbB signaling pathway
PAK6B; PRKCBA; NCK1; EREG; PAK1; PAK6; CAMK2A; AKT3A; ARAF; PTK2AA
Ras signaling pathway
PLA1A; PLCE1; HRAS; TEK; GRB2; ELK1; RASAL1; GNG12; PIK3R3; GRIN1
Rap signaling pathway
CALM3; MAGI1; PLCB3; FARP2; PRKCG; FGFR3; FLT4; RHOA; PGF; ITGB2
cGMP-PKG signaling pathway
PIK3R3; ATP2A1; LOC100328615; NPPB; CREB5; NPR2; GNA11; CREB3L3; PPP3R2; MYLK4
cAMP signaling pathway
PIK3CG; HCN4; PPP1R12A; GRIA2; HTR1E; CNGA3; PLN; GRIA1; PDE3A; VAV2
Chemokine signaling pathway
CXCL11; DOCK2; CCL1; JAK2; CCR1; GSK3A; SHC1; CCL20; BCAR1; IL-8
HIF- signaling pathway
EGLN1; NPPA; NOX3; HK1; BCL2; TLR4; MAPK1; PLCG2; PIK3CD; NOS3
FoxO signaling pathway
MAP2K2; TGFB3; G6PC2; BCL6A; FOXG1A; NLK2; INSRB; CCNB1; AKT1; FOXO3A
Sphingolipid signaling pathway
PPP2R5C; OPRD1; RAF1; PTEN; PPP2R5E; SGMS2; PIK3CD; NSMAF; FYN; KRAS
Phospholipase D signaling pathway
PLCB4; SOS1; LPAR4; INS2; F2R; PIP5K1B; AKT2; INS1; PDGFB; Kitl
Oocyte meiosis
REC8B; PPP2R5C; CAMK2G1; CALM3B; MAPK12B; IGF1R; CAMK2D1; SMC1AL; PPP2R5E; FBXW11
mTOR signaling pathway
RPS6KA6; RRAGCB; PIK3R1; RRAGCA; RPS6KA1; RPS6KA3A; PDPK1; EIF4E2; POLDIP3; INSB
PIK-Akt signaling pathway
ITGA7; GHR; HSP90B1; CREB3L2; THBS2; TCL1B4; IFNA5; RELA; TCL1B; IFNAR2
Adrenergic signaling in cardiomyocytes
CACNB3; CAMK2A; ATP2A2; GNAS; KCNQ1; ATP2B4; CREB5; CALM2B; ADCY1A; PPP2R3A
Vascular smooth muscle contraction
PRKACBB; PLA2G4D; PLA2G12A; MAP2K1; NPR2; PRKG1; ROCK2B; GNA12; CALD1B; CALM1
Dorso-ventral axis formation
ETV6; MAPK1; GRB2B; SPIRE2; CPEB2; MAP2K1; NOTCH4; GRB2A; KRAS; ETS2
TGF-beta signaling pathway
EP300; NOG3; NOG; CUL1A; INHBA; TFDP1A; GDF6A; RPS6KB1B; SMAD1; LFT1
Axon guidance
CLTA; ITGB1; DPYSL3; CFL1; EPHB1; DUSP9; ACTR2B; AP2A1; ARPC1A; PAQR3B
VEGF signaling pathway
SPHK1; SPHK2; MAP2K2B; PLA2G4D; PLCG2; PIK3R1; PTK2; MAPKAPK2; PRKCB; PIK3R2
Osteoclast differentiation
SOCS1; AKT1; FCGR1; TNF; NFATC1; FCGR2B; RELB; PPARG; PIK3R1; IKBKB
Focal adhesion
MYL12B; AASS; PTK2; LAMB2; PAK7; VEGFA; ELK1; ITGA8; CCND2; PDGFRA
Adherens junction
LMO7A; MAPK3; PTPRB; RHOA; TCF7L2; SNAI2; INSRB; ACTB1; TGFBR2; VCLA
Gap junction
ITPR3; GRB2; Adcy4; PRKACBB; PRKACG; DRD1A; PRKCA; GRB2A; HTR2A; GRM5
Signaling pathways regulating pluripotency of stem cells
BMP2; ACVR2B; STAT3; WNT16; FGFR2; AXIN2; HAND1; KLF4; LHX5; ACVR1C
Platelet activation
PRKCZ; COL27A1; PIK3R3; PLCG2; TBXA2R; SYK; MYLK; PLA2G4F; GP1BB; PLA2G4A
Toll-like receptor signaling pathway
MAPK13; TLR4BA; IRF5; CD40; CXCL11; IRF3; RIPK1L; IFNA16; IFNA12; IFNB
NOD-like receptor signaling pathway
CASP5; MAPK12B; NAIP7; CARD8; NFKBIB; MAPK14B; RELA; MAPK8B; MAPK14A; CXCL1
Natural killer cell mediated cytotoxicity
RAET1D; HLA-C; TNFRSF10D; TNFRSF10A; IFNA12; IFNA5; FAS; SAMD3; RAC2; ICAM2
T cell receptor signaling pathway
MAPK3; GRB2; PTPRC; MAPK13; CD8A; SHB; PPP3CC; PIK3R5; PPP3CA; LCP2
B cell receptor signaling pathway
CD19; LCP2A; ARPC3; CTNNB2; PIK3R3; BLK; PLEKHA2; PIK3CG; CD79B; ACTR2
Fc epsilon RI signaling pathway
PLA2G4A; PIK3R3; IL4; VAV2; PLA2G4F; VAV3; PIK3CG; MAP2K7; GAB2; MAPK3
Fc gamma R-mediated phagocytosis
PLD1; SCIN; HCK; PLD2; DOCK2; RPS6KB1; MAPK3; CFL1; FCGR1A; INPPL1
TNF signaling pathway
PIK3CD; PIK3CG; PIK3CA; PIK3R5; IL15; NFKB1; PIK3R1; AKT2; CXCL1; MAP2K7
Circadian entrainment
GNAI2; CAMK2D; GNB3; PLCB1; ITPR3; GNAQ; GUCY1B3; GNG13; CAMK2A; GNB1
Long-term potentiation
GNAQ; PPP1CA; PLCB3; GRIA2; CALM3; PPP3R1; CALM4; GRIN1; RAF1; GRIN2A
Neurotrophin signaling pathway
BCL2; PLCG1; RPS6KA2; SHC1; MAPK9; PIK3CA; RPS6KA1; MAPK10; RAF1; HRAS
Retrograde endocannabinoid signaling
GNG13; MAPK8; GNAQ; GNG5; GABRG1; PLCB4; SLC17A8; DAGLB; PRKCA; GABRB3
Glutamatergic synapse
GRM5; MAPK3; PRKCA; ADRBK2; MAPK1; GRIA3; GLUL; SHANK1; PLA2G4A; GNAS
Cholinergic synapse
CAMK2G; PIK3R3; KCNQ1; PLCB1; GNAO1; CHRM5; GNGT1; PIK3CB; GNG3; GNG8
Serotonergic synapse
PRKCG; GNG13; GNG8; APP; GNAI1; ITPR1; PLA2G4F; HTR2A; HTR2C; HTR3B
Long-term depression
PRKCA; CRH; PLCB3; GNA13; PLCB1; PPP2CB; PLCB4; IGF1R; NOS1; HRAS
Regulation of actin cytoskeleton
PIP5K1BA; PIP5K1A; PDGFAB; FGF13; PIK3R2; ACTN3A; HRASA; FGF8; KRAS; ITGA1
Insulin signaling pathway
SOCS3B; SHC1; ACACB; RPS6KB1B; SHC4; PRKCZ; SHC2; AKT3A; PHKG2; PDE3B
GnRH signaling pathway
MAPK3; MAPK12; LHBETA1; CGNRH-R; GRB2; CALM1; NRAS; HBEGFA; MMP14; CACNA1DA
Progesterone-mediated oocyte maturation
PRKACAB; PIK3R3B; INSB; FZR1; CDC23; RAF1A; PIK3CG; RPS6KA1; GNAI2; GNAI2A
Estrogen signaling pathway
PRKCD; HSPA2; AKT2; PIK3R5; HSPA1A; RAF1; FKBP5; MMP9; PIK3CB; PLCB4
Melanogenesis
WNT10B; MAPK1; FZD3; CALM3; CALML3; GSK3AA; CALM1A; KRAS; MITF; PLCB3
Prolactin signaling pathway
STAT3; RAF1; SOCS3; SIRPA; PIK3CD; ESR1; CSN2; SLC2A2; MAP2K2; SHC4
Thyroid hormone signaling pathway
BMP4; ACTG1; NCOA3; NRAS; AKT2; TSC2; MED4; ATP1B1; ESR1; EP300
Oxytocin signaling pathway
PLA2G4F; ROCK2; PTGS2; CAMK2A; CACNB1; FOS; PRKAG3; CACNA2D1; ACTB; CACNG4
Type II diabetes mellitus
SLC2A4; SLC2A2; PIK3R3; HK1; MAPK10; PKM; HKDC1; HK2; MAPK3; TNF
Aldosterone-regulated sodium reabsorption
MAPK1; KRAS; ATP1B2; ATP1B1; KCNJ1; PIK3R2; PIK3R5; MAPK3; ATP1A1; IRS1
Alzheimers disease
CAPN2; ATP5H; NDUFB4; CALML3; NDUFA5; UQCRC2; ITPR3; IL1B; NDUFA1; mt-Atp8
Prion diseases
MAPK3; C1QB; CASP12; MAP2K1; C8G; HSPA5; C8A; PRKACB; C7; NCAM2
Alcoholism
HIST1H3G; HIST3H3; HIST1H4I; HIST1H2BG; NRAS; MAOA; HIST2H3C; H3F3B; HIST1H3E; HDAC4
Shigellosis
CDC42; ARPC5L; PFN3; RAC1; MAPK10; ELMO3; IL-8; UBE2D2; ROCK1; MAPK11
Salmonella infection
CCL4L1; CDC42L; RELA; ARPC5LB; LBP; NLRC4; PFN1; MAPK3; PFN3; IFNGR2
Pertussis
TICAM2; C1QA; CASP7; C4BPB; GM5077; PYCARD; IL6; MAPK1; CALML5; CALM1
Leishmaniasis
FCGR2C; CR1; HLA-DOA; NCF4; TGFB3; HLA-DQA1; FCGR4; IL4; Itgam&Itgb2; TAB2
Chagas disease (American trypanosomiasis)
AKT1; PPP2R2A; IKBKB; IFNB1; SERPINE1; CASP8; RELA; GNAI3; PPP2R2B; PPP2R1B
Toxoplasmosis
HLA-DOA; CASP9; LAMB3; IRGM1; TLR4; PIK3R1; HLA-DRB3; LAMA1; GNAO1; PIK3CD
Tuberculosis
CALM4; FADD; APAF1; RAB5C; TGFB2; VDR; ATP6AP1; CAP18; CYCS; KSR1
Hepatitis C
RIPK1; DDX58; IFNA7; CXCL8; IFNA13; PIAS1; PIK3R5; IFNAR2; CLDN11; IFIT1
Hepatitis B
BAD; CCNA1; Ifna11; HRAS; IFNB1; VDAC3; CREB3L1; NFATC1; NFKBIA; IFN-a
Influenza A
MAP2K7; TRIM25; FAS; IFNA16; H2-AA; CASP1; GSK3B; NFKBIB; NLRX1; PRKCA
Pathways in cancer
HDAC1; BCL2; PTEN; MSH2; RAC2; PDGFA; IKBKG; GNG7; NRAS; WNT4
Viral carcinogenesis
TRP53; HIST2H2BB; GTF2A1; YWHAH; BAK1; CCNE2; PIK3CD; HIST1H2BH; GTF2E1; PIK3R5
Proteoglycans in cancer
LUM; ARHGEF1; FZD1; PIK3R5; THBS1; TGFB2; ITGB5; Ctsl; PLAUR; Fasl
Colorectal cancer
CASP9; MAPK9; ARAF; MAPK1; MSH2; APPL1; BAD; PIK3R3; TGFBR1; MAP2K1
Renal cell carcinoma
FLCN; TGFB1; ARAF; AKT2; CUL2; ARNT; PIK3R2; AKT1; TCEB2; MAPK1
Pancreatic cancer
ARHGEF6; PLD1; RAC2; RAD51; TRP53; TGFB3; ARAF; RB1; TGFB2; MAPK1
Endometrial cancer
PIK3CA; MAP2K1; CCND1; FOXO3; CASP9; PIK3R3; MAPK3; SOS1; PIK3R2; ILK
Glioma
PIK3CA; NRAS; PIK3R1; PDGFA; MAPK3; AKT2; ARAF; TP53; PIK3CG; CALML3
Prostate cancer
RB1; CREB5; NFKB1; IGF1; CREB3L1; BAD; HSP90AA1; Ar; PDPK1; CCNE1
Thyroid cancer
LEF1; TCF7L2; TPM3; CCDC6; NRAS; MAPK3; TP53; MAPK1; TFG; HRAS
Melanoma
FGF16; FGF17; KRAS; NRAS; PIK3R2; PIK3R3; PDGFC; FGF22; FGFR1; MAPK3
Bladder cancer
ARAF; CDK4; FGFR3; DAPK2; MDM2; TP53; TRP53; CDKN2A; MYC; CDH1
Chronic myeloid leukemia
PIK3CA; NFKB1; SHC1; PIK3CG; TGFBR1; CTBP2; PIK3R5; MECOM; SHC2; ARAF
Acute myeloid leukemia
PIM2; KIT; AKT2; KRAS; RPS6KB1; EIF4EBP1; CCNA1; MYC; PIK3CG; ZBTB16
Non-small cell lung cancer
BAD; PIK3R5; RASSF5; MAP2K1; CCND1; PIK3R1; KRAS; PIK3R2; PIK3CB; PRKCG
Central carbon metabolism in cancer
PDGFRA; MAPK1; SLC16A3; MAPK3; PIK3CA; HIF1A; FLT3; PIK3CD; PIK3R3; SLC7A5
Choline metabolism in cancer
GRB2; HIF1A; RALGDS; PLA2G4B; MAPK3; PIP5K1B; EGF; PIK3R1; SLC22A3; HRAS

Protein Function

MAPK3 has several biochemical functions, for example, ATP binding, MAP kinase activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK3 itself. We selected most functions MAPK3 had, and list some proteins which have the same functions with MAPK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2G2; CHD4; CHTF18; P2RX4; MARK4; CBWD2; DDX11; ABCD3B; POMK; RPS6KA3
Function MAP kinase activity
Related Protein MAPK13; MAPK12A; MAPK15; MAPK8A; MAPK14A; NLK; NLK2; MAPK11; MAPK14; MAPK4
Function phosphatase binding
Related Protein CSRNP2; CNST; CTSC; CRY2; ELL; DYSFIP1; SH3RF2; PPARA; KIAA0649; KLRAQ1
Function phosphotyrosine binding
Related Protein STAP1; SAMSN1; LDLRAP1; ACP2; ZAP70; CBLB; PTPN3; CBLC; FGR; SHC1
Function protein binding
Related Protein GGA2; PALM; ZRANB1; RUFY1; NLRP1; HTR3C; CYBA; SCG5; MED30; DHX36
Function scaffold protein binding
Related Protein DLG4; CACNA1H; SRC; DSP; CRIPT; KCNQ1; CHRNA7; GRIN2A; GRID2; TREM1

Interacting Protein

MAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK3.
DUSP1; PTPRJ; MAPK14; DHPS; Ptprr

MAPK3 Related Articles

Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).