mapk3
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  • Official Full Name
  • MAPK3 mitogen-activated protein kinase 3
  • Synonyms
  • MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk; MAPK 1; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; mitogen-activated protein kinase 1; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; ERT2; ERK-1; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; MGC20180;
Cat.#:MAPK3-1031MTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein
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Cat.#:MAPK3-1517HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human MAPK3 protein
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Cat.#:MAPK3-2787HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3, His-tagged
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Cat.#:MAPK3-28694THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-28699THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-286HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-287HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-288HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-28HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated ERK1, His-tagged
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Cat.#:MAPK3-34HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-36HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-9534MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK3 Protein
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Cat.#:MAPK3-3574RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK3 Protein
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Cat.#:MAPK3-11551ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK3
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Cat.#:MAPK3-307HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 3, Active
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Cat.#:MAPK3-1048HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Active), GST-Tagged
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Cat.#:MAPK3-1049HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Unactive), GST-Tagged
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Cat.#:MAPK3-4494HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK3 293 Cell Lysate
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Involved Pathway

MAPK3 involved in several pathways and played different roles in them. We selected most pathways MAPK3 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP3K14; RAC1A; FGF3; Fgf15; GNA12A; CACNB2A; MAPKAPK5; PTPRR; PLA2G4A; FGF9
ErbB signaling pathway
PAK4; PAK6B; STAT5B; CAMK2G; NCK2; CAMK2G1; PAK3; CBLC; MAP2K4A; CAMK2D2
Ras signaling pathway
RASAL2; ZAP70; PLA2G2A; LAT; ETS2; RIN1; HGF; PLA2G2E; FGF3; GRB2
Rap signaling pathway
ACTB; KLK1B4; PDGFRB; PLCB4; RAC1; Kitl; MRAS; RAPGEF1; Fgf15; MAPK1
cGMP-PKG signaling pathway
MAPK1; VDAC1; NPR2; VDAC2; PPP1R12A; SRF; ATP2A3; CREB3L1; GTF2IRD1; IRS1
cAMP signaling pathway
LOC100328615; HTR1E; AMH; PTCH1; ATP2B4; PIK3R5; ATP1B1; CNGA3; NPY; ACOX3
Chemokine signaling pathway
GNG11; CXCL10; PTK2; CCL23; Adcy4; ADRBK1; CX3CR1; RAC1; GM13306; CCL2
HIF- signaling pathway
NOX1; LDHA; TCEB2; FLT1; PIK3CD; TF; VHL; AKT1; CAMK2G; IFNGR1
FoxO signaling pathway
TNFSF10; ATM; INS2; INSR; IGF1R; MAPK10; MAPK14A; PRKAB1; PLK4; SMAD3A
Sphingolipid signaling pathway
SGPP2; PPP2R5A; MAPK1; AKT1; SGMS2; SPTLC2; LASS2; ASAH2; MAP2K2; DEGS2
Phospholipase D signaling pathway
AKT2; INSR; MRAS; RHOA; AVPR1B; AVPR2; PIK3CB; CYTH1; GRM3; RHEB
Oocyte meiosis
REC8; CAMK2B1; CDC23; CCNB2; PPP1CA; PPP2R5EB; PRKACAB; FBXO43; ITPR1; CUL1B
mTOR signaling pathway
IRS1; RB1CC1; HIF1A; PIK3CB; DEPDC6; TSC1; PIK3R5; EIF4E2RS1; DDIT4; RRAGD
PIK-Akt signaling pathway
GYS1; VEGFB; PPP2R2D; ITGA5; Il4ra; PPP2CB; AKT1; GNB1; PPP2R3A; MAP2K1
Adrenergic signaling in cardiomyocytes
RAPGEF4; CREB3; VMHC; CAMK2D1; ATP1B1; SLC14A2; CACNG7; ADRA1D; ADRB1; CACNG8
Vascular smooth muscle contraction
PRKACA; KCNMB1; GNA11A; PRKG1; AGTR1A; GNA11B; CALD1; ADORA2AB; PPP1CBL; ADCY1B
Dorso-ventral axis formation
CPEB2; ETS2; GRB2B; CPEB1B; SOS1; EGFRA; GRB2A; CPEB3; PIWIL2; SPIRE1A
TGF-beta signaling pathway
BMP2; PPP2CB; ZFYVE9; RPS6KB2; MYCB; INHBA; CHD; INHBAB; ACVR2AA; ROCK2B
Axon guidance
EPHB4A; MYL12A; MYL9; NRG2A; RHOA; CNKSR1; EFNA4; KALRN; MARK3; NRP1A
VEGF signaling pathway
MAP2K2A; PRKCBB; SPHK1; MAPKAPK3; SHC2; RAC2; BAD; RAC3A; PPP3CCA; PIK3R1
Osteoclast differentiation
IL1R1; FCGR2B; MAPK10; NCF1; IFNAR2; PPP3R2; LILRA5; PIK3R1; TNF; MAP2K6
Focal adhesion
ITGB1A; AKT2L; ACTN2B; MYLK; THBS3A; COL5A1; PARVAA; GRB2A; VTNB; FLNC
Adherens junction
WASF1; RAC3A; LMO7; PARD3; CSNK2A2; PVRL1; RHOA; TCF7L2; CTNNA1; PTPN1
Gap junction
ADCY1B; PRKACAB; ITPR3; ADRB3B; PLCB4; TUBA7L; CX35B; TJP1; PLCB1; TUBA1C
Signaling pathways regulating pluripotency of stem cells
WNT16; PIK3R2; BMP2; MEIS1; PIK3CD; LIF; WNT2B; STAT3; ESX1; SMAD4
Platelet activation
ROCK2; P2RY12; ARHGEF12; GP9; MAPK13; RAP1A; PLA2G4D; ITGA2B; PTGS1; PPP1R12A
Toll-like receptor signaling pathway
IFNPHI3; IL1B; IFNA2; IFNAR1; PIK3CD; NFKBIA; NFKB1; IL8L1; CD86; IFNB
NOD-like receptor signaling pathway
IKBKB; MAP3K7; PSTPIP1A; PYDC1; MAPK1; IL1B; MAPK10; MAPK12; TAB2; IKBKG
Natural killer cell mediated cytotoxicity
FCGR4; H60a; PTPN6; KIR2DS4; RAC3; RAET1E; IFNA10; PPP3CC; SHC1; PIK3CB
T cell receptor signaling pathway
CD40LG; MAPK13; DEF6A; VAV1; CD28; PPP3R1; MAP3K14; ICOS; CD3E; CD3D; MAPK12
B cell receptor signaling pathway
MALT1; SYK; RELA; IGHM; CD79A; NFKBIE; PPP3R1; PIK3CB; PPP3R2; LYN
Fc epsilon RI signaling pathway
MAP2K1; FCER1A; PIK3R3; PIK3CA; IL13; MAP2K7; AKT1; FCER1G; MAPK1; MAPK12
Fc gamma R-mediated phagocytosis
LIMK2; AMPH; WAS; VAV2; PTPRC; PPAP2B; SPHK2; AKT1; CFL2; PLA2G4D
TNF signaling pathway
TRAF2; CXCL1; LIF; VCAM1; MMP3; MAPK3; AKT1; PIK3R1; CXCL10; TAB2
Circadian entrainment
GNAQ; CAMK2A; PER1; CALM2; GNG3; GNAS; NOS1AP; PRKACB; CALM4; GNAI3
Long-term potentiation
GRIA1; NRAS; CAMK2G; RAF1; RPS6KA3; ITPR3; PPP3CC; GRM1; PPP1CB; CAMK2D
Neurotrophin signaling pathway
PLCG2; ABL1; MAGED1; SH2B1; SHC2; PDPK1; BCL2; ZFP110; TRAF6; IRAK2
Retrograde endocannabinoid signaling
GRIA4; GABRP; MAPK3; PRKCB; GNAI3; GABRA2; FAAH; GABRR2; GRIA1; GABRB1
Glutamatergic synapse
ITPR3; SHANK1; GRIK2; PPP3R1; PPP3R2; PLA2G4F; GRM4; GRIK5; GRIN2A; PRKCA
Cholinergic synapse
GNG12; PLCB4; AKT2; PIK3CD; KCNQ3; CHRM2; GNG3; PIK3R1; NRAS; MAP2K1
Serotonergic synapse
CYP2C70; CYP2C39; PLCB4; GNAI2; ALOX12B; CYP2C37; PLA2G4C; SLC6A4; PRKACG; GNG11
Long-term depression
PLA2G4C; PLCB2; RYR1; PPP2CA; MAPK3; GUCY1A3; PLCB4; GNAI2; GNA12; PLCB3
Regulation of actin cytoskeleton
ITGA8; HRAS; MYL12.1; FGF11; DIAP3; PAK6B; ITGA2; ROCK1; WASLB; FGFR3
Insulin signaling pathway
GRB2A; PCK2; AKT1; FLOT1; PYGB; EIF4E1B; PRKAR2AB; CALM1A; PRKAG3; CALM1
GnRH signaling pathway
CAMK2G1; GNA11; PTK2BB; PRKACA; MAP3K1; PLD1; CACNA1DA; MMP14A; EGFRA; PLCB1
Progesterone-mediated oocyte maturation
CCNA1; CDC27; PRKACBA; CDC25B; PRKACA; MAPK13; PIK3R2; MAPK8B; CDC23; IGF1RA
Estrogen signaling pathway
PLCB4; NOS3; KCNJ3; CALM3; PLCB3; FKBP4; HRAS; GPR30; SHC2; ESR1
Melanogenesis
GNA11A; WNT7A; PRKCB; CREB3L3; GSK3AA; GNAIA; CALM2B; WNT16; RAF1B; RAF1
Prolactin signaling pathway
SOCS3; CSN2; CCND2; RAF1; PRL; PPIB; ELF5; MAPK13; PIK3CD; STAT1
Thyroid hormone signaling pathway
TP53; FXYD2; NCOA3; SLC9A1; NOTCH3; ATP1B3; DIO1; PLCD1; CCND1; PIK3CB
Oxytocin signaling pathway
PIK3R3; CACNA2D1; MYLK3; CACNA2D4; NPR1; EEF2K; CACNG7; PIK3CD; PRKACB; MYLK2
Type II diabetes mellitus
PRKCZ; PKLR; MAPK10; MAPK1; IKBKB; PRKCD; PIK3R2; PRKCE; PIK3R5; PKM2
Aldosterone-regulated sodium reabsorption
ATP1B2; ATP1A2; HSD11B2; PIK3CD; KCNJ1; ALPHA-ENAC; KRAS; NEDD4L; FXYD4; MAPK1
Alzheimers disease
ATP5G3; PLCB3; GRIN2D; PSEN1; MT-ATP6; UQCRH; NDUFS2; ATP5A1; NDUFA8; NDUFS4
Prion diseases
C1QB; NOTCH1; MAP2K1; C8B; C6; IL1B; CASP12; PRNP; IL6; PRKACB
Alcoholism
KRAS; HIST2H3A; HIST1H2BH; GRIN2A; CALM3; GRIN2B; CREB3; TH; HIST1H4N; HIST1H4D
Shigellosis
UBE2D2; FBXW11; U2AF1; PFN3; NFKBIB; HCLS1; CDC42; RIPK2; ARPC5L; RAC1
Salmonella infection
IL8L2; MAPK12B; CDC42; WASB; ROCK2B; KLC4; NFKB1; TLR4BA; IL6; KLC2
Pertussis
RHOA; TNF; FOS; MAPK10; IL23; TLR4; Itgam&Itgb2; ITGB2; GM5077; Casp3
Leishmaniasis
PTPN6; H2-AA; IFNG; TGFB3; NOS2; MAPK3; HLA-DPB1; IFNGR2; HLA-DRA; TLR4
Chagas disease (American trypanosomiasis)
Il2; TLR9; GNA11; IL-8; PIK3CB; IL1B2; CCL3; PLCB1; IL12A; CXCL8
Toxoplasmosis
Toxoplasma Gondii Profilin Family Protein; AKT1; IL12A; LAMB1; TLR4; HLA-DMA; CASP8; TNF; TGFB2; GNAO1
Tuberculosis
CARD9; RHOA; IFNA10; CEBPG; CASP10; ATP6V0D2; IFNA17; PPP3R2; FCGR3A; HLA-DRB3
Hepatitis C
IL-8; IFNB1; MAPK10; MAPK9; PPP2R2D; MAPK1; STAT1; PIK3CB; Ifna15; TNF
Hepatitis B
TP53; APAF1; Casp3; YWHAZ; CREB5; IFNA10; IKBKG; CASP12; IFNB1; DDX58
Influenza A
PIK3R3; OAS1A; PABPN1; HLA-DMB; MAPK11; NLRP3; MAP2K7; PIK3CG; IFNA7; GSK3B
Pathways in cancer
RALGDS; PDGFB; ROCK1; WNT5B; Fgf15; RARB; MSH2; ITGB1; MDM2; FGF10
Viral carcinogenesis
PRKACA; CREB3L3; RBPJ; RBL2; IKBKG; GTF2H2C; HIST1H4B; GTF2A1; SP100; SRF
Proteoglycans in cancer
HSPB2; PPP1R12A; PLCE1; FN1; ERBB4; PRKACA; Ctsl; PTK2; WNT16; TWIST2
Colorectal cancer
SMAD3; TP53; GSK3B; MSH6; MLH1; DCC; AKT2; RAC3; SMAD4; PIK3R1
Renal cell carcinoma
RAP1B; BRAF; TCEB1; HGF; KRAS; ARNT; CUL2; TGFB2; PIK3R3; MAP2K2
Pancreatic cancer
KRAS; AKT1; RAC2; IKBKG; PIK3R5; PIK3CB; BRCA2; BAD; STAT1; RALBP1
Endometrial cancer
ARAF; HRAS; GSK3B; PIK3CB; CCND1; TCF7; MAP2K1; KRAS; LEF1; APC
Glioma
ARAF; PIK3CB; SHC4; GRB2; MTOR; RAF1; MAPK3; SOS1; CALM3; TGFA
Prostate cancer
PDGFD; KRAS; CPN1; SPRY1; FGFR2; GRB2; Ar; NFKB1; TP53; PIK3CA
Thyroid cancer
TFG; CCND1; TP53; LEF1; NRAS; BRAF; PAX8; TCF7; RXRA; CCDC6
Melanoma
PDGFC; MAPK1; PTEN; FGF19; PDGFB; ARAF; FGF1; FGF5; FGF14; MAP2K1
Bladder cancer
HBEGF; IL-8; E2F3; E2F1; CCND1; THBS1; NRAS; DAPK2; E2F2; TYMP
Chronic myeloid leukemia
RELA; GAB2; SHC4; NFKB1; CRKL; CBL; CRK; ARAF; PIK3R1; IKBKG
Acute myeloid leukemia
IKBKG; MTOR; STAT5A; SOS1; JUP; SFPI1; GRB2; RAF1; PIK3R3; PPARD
Non-small cell lung cancer
PLCG2; NRAS; TP53; GRB2; MAP2K2; TRP53; PIK3CG; BAD; AKT1; RXRB
Central carbon metabolism in cancer
PDGFRA; RET; PIK3R3; PIK3CA; PIK3R2; AKT1; AKT2; PIK3CB; FLT3; HK2
Choline metabolism in cancer
SLC22A5; KRAS; PCYT1A; RALGDS; PDGFRA; PPAP2A; TAE1; PLD2; PLA2G4C; PIK3R5

Protein Function

MAPK3 has several biochemical functions, for example, ATP binding, MAP kinase activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK3 itself. We selected most functions MAPK3 had, and list some proteins which have the same functions with MAPK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ABCD3A; FYNB; UBE2H; MAP4K5; DYRK1A; NLRP12; HELLS; BMPR1AA; GATB; TIE1
Function MAP kinase activity
Related Protein MAPK8B; MAPK6; MAPK11; MAPK12A; MAPK15; MAPK1; MAPK3; MAPK14A; MAPK13; MAPK12B
Function phosphatase binding
Related Protein SH3RF2; KLRAQ1; MAST2; CRY2; KIAA0649; SLC9A3R1; PPARA; CSRNP2; SH3GL1; TPRN
Function phosphotyrosine binding
Related Protein PTPN3; LDLRAP1; STAP1; MAPK3; GRB2; ACP2; SAMSN1; CBL; CBLB; ZAP70
Function protein binding
Related Protein MKI67IP; CCDC11; LMX1B; PLXNC1; TLR2; ABCB1; SNX15; CSRP2; RASSF4; GSTA4
Function scaffold protein binding
Related Protein KRT15; IKBKB; KRT8; ATP2B4; DLG4; PDE4D; LRP4; NOS1; NLGN4Y; KCNH2

Interacting Protein

MAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK3.
DUSP1; PTPRJ; MAPK14; DHPS; Ptprr

MAPK3 Related Articles

Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).