mapk3
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  • Official Full Name
  • MAPK3 mitogen-activated protein kinase 3
  • Synonyms
  • MAPK3; mitogen-activated protein kinase 3; PRKM3; ERK1; p44erk1; p44mapk; MAPK 1; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; insulin-stimulated MAP2 kinase; mitogen-activated protein kinase 1; extracellular signal-related kinase 1; extracellular signal-regulated kinase 1; microtubule-associated protein 2 kinase; ERT2; ERK-1; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; MGC20180;
Cat.#:MAPK3-1031MTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein
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Cat.#:MAPK3-1517HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human MAPK3 protein
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Cat.#:MAPK3-2787HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3, His-tagged
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Cat.#:MAPK3-28694THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-28699THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-286HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-287HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-288HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3 protein, His/MBP-tagged
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Cat.#:MAPK3-28HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant human biotinylated ERK1, His-tagged
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Cat.#:MAPK3-34HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-36HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK3
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Cat.#:MAPK3-9534MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAPK3 Protein
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Cat.#:MAPK3-3574RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAPK3 Protein
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Cat.#:MAPK3-11551ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MAPK3
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Cat.#:MAPK3-307HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 3, Active
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Cat.#:MAPK3-1048HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Active), GST-Tagged
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Cat.#:MAPK3-1049HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 3 (Unactive), GST-Tagged
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Cat.#:MAPK3-4494HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK3 293 Cell Lysate
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Involved Pathway

MAPK3 involved in several pathways and played different roles in them. We selected most pathways MAPK3 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP3K4; RASGRF2; RRAS; JIP1; NF1; ATF4B1; FGF12A; FGF1B; PRKCA; PAK2A
ErbB signaling pathway
AKT3A; NRG1; ERBB3; PAK7; TGFA; PIK3CD; MAP2K1; NCK2B; AREGB; AREG
Ras signaling pathway
SHC3; PLA2G12B; PRKCA; Kitl; GNGT1; RAB5C; SHC4; GRIN2A; MAPK8; FGF8
Rap signaling pathway
AKT1; ITGB3; GNAI3; MRAS; RAC3; LPAR5; FGF6; GRIN2B; HGF; FGF3
cGMP-PKG signaling pathway
GNAI2; RHOA; Adcy4; VDAC3; MYH7; GUCY1B3; GTF2IRD1; MEF2B; PIK3CD; CREB3L2
cAMP signaling pathway
RAC2; HHIP; MAPK3; BRAF; GPR119; ROCK1; ATP1B3; PTGER2; LOC100328615; CALM4
Chemokine signaling pathway
AMCF-II; Ccl21a; ADRBK2; NFKBIB; SHC1; PXN; GNG3; PIK3CB; GNGT1; IL-8
HIF- signaling pathway
PRKCB; MAP2K2; ENO2; NOS2; EP300; PGK1; HK3; NOX1; CAMK2G; INS1
FoxO signaling pathway
INSB; NRAS; HRASB; MAPK9; USP7; STK4; RAF1; IKBKB; FBXO25; PIK3R3
Sphingolipid signaling pathway
MAPK11; SGPP2; RELA; PLCB2; PPP2R2C; SGPP1; PPP2R2B; ASAH2; KRAS; S1PR2
Phospholipase D signaling pathway
PIK3CB; SOS1; PLCG2; AVPR2; PDGFC; SHC3; INS2; SHC2; MAPK1; RAF1
Oocyte meiosis
CAMK2B1; MAPK3; MOS; RPS6KAL; MAPK12B; ESPL1; YWHAB; IGF1RB; PLK1; IGF1R
mTOR signaling pathway
EIF4E1C; VEGFA; BRAF; MTOR; RPS6KA2; IKBKB; PIK3CG; PRKCBB; EIF4E2RS1; DDIT4
PIK-Akt signaling pathway
GNG11; PDGFRB; FGF21; IFNA8; GNG5; IGF1; INS1; IFNB1; FGF14; THBS2
Adrenergic signaling in cardiomyocytes
PLCB4; CACNB3A; ADCY7; PPP2CB; RYR2; MYL2B; PPP2R5D; CACNA1SB; PRKCA; PPP2R3A
Vascular smooth muscle contraction
CALM3A; PLA2G12B; PRKCE; PLA2G2D; CALM2; PPP1CA; PPP1CB; PLA2G4A; PLCB4; NPR1A
Dorso-ventral axis formation
GRB2; PIWIL1; CPEB1A; NOTCH1B; MAPK1; NOTCH1A; NOTCH2; CPEB4; GRB2B; ETS1
TGF-beta signaling pathway
TGFBR1B; TGFBR1; EP300; ACVR1BA; BMP7B; TGFBR1A; CHD; ID2B; RPS6KB2; PPP2CA
Axon guidance
SEMA3E; RASGRP4; EPHB3; RASGRP1; PLXND1; CRMP1; EPHA4A; UNC5C; SPNA2; PEBP1
VEGF signaling pathway
MAP2K2; MAPK12A; PIK3R1; AKT3A; MAPKAPK3; MAPK1; BAD; RAC3A; VEGFAA; RAF1
Osteoclast differentiation
PIK3CA; SIRPB1; LCK; MAPK3; IL1R1; IFNB1; MAPK8; RELA; CYBB; IFNAR2
Focal adhesion
ITGA3; LAMB3; PARVG; COL1A1B; PIK3R3; ITGA10; PXN; PAK2B; BIRC2; CDC42L2
Adherens junction
NLK2; FARP2; WAS; WASLB; TGFBR1A; CDH1; RAC1A; RAC3; WASB; TCF7
Gap junction
TUBB2A; Pdgfa&Pdgfb; GRB2B; PRKACAB; DRD2L; TUBA1L2; PDGFRA; GNA11B; MAP2K5; TUBB6
Signaling pathways regulating pluripotency of stem cells
SMARCAD1; HNF1A; OTX1; AXIN2; SKIL; HESX1; FGFR4; PAX6; ACVR1B; LEFTY2
Platelet activation
FGB; GP5; PIK3CD; P2RY12; GP1BA; PRKG1; MYLK4; RAP1A; RHOA; ARHGEF12
Toll-like receptor signaling pathway
FOS; NFKBIAB; LY96; IRF3; IFNB1; RAC1A; PIK3R3A; MAP2K2A; IFNB; MAP2K3
NOD-like receptor signaling pathway
NFKBIAB; NFKBIA; MAP3K7; MAPK14B; BIRC2; CASPA; TAB3; IL1B; MAPK12A; BIRC3
Natural killer cell mediated cytotoxicity
FCGR3B; Casp3; IFNA5; PIK3R3; NRAS; KIR2DS2; TNFRSF10B; CD48; LCK; SH2D1A
T cell receptor signaling pathway
MAP3K14; NFATC1; RAF1; NFKBIA; IKBKB; VAV3; MAP2K7; PLCG1; CD3D; CD40LG
B cell receptor signaling pathway
NFATC1; CARD11; NEDD9; VAV1; PLCG2; DUSP4; SLA2; CD81; PPP3CB; PIK3R2
Fc epsilon RI signaling pathway
PIK3CA; PLA2G4A; LAT; FYN; MAPK12; IL13; PIK3CB; VAV3; MAPK3; PLA2G4D
Fc gamma R-mediated phagocytosis
AKT2; VASP; PIK3CB; WASL; GAB2; LAT; PPAP2C; RAF1; MARCKSL1; PIK3R1
TNF signaling pathway
CREB3L2; CREB3L3; PIK3R1; IKBKG; MAP2K1; PIK3R5; TNFRSF1A; MAPK9; MMP9; TRAF3
Circadian entrainment
PRKACG; KCNJ5; GRIA2; PRKG2; GRIN2A; GNG13; CACNA1H; GNG4; PER1; PRKCB
Long-term potentiation
RAF1; HRAS; PRKACG; RAP1B; CALM3; GRM1; PLCB3; GRIA2; CAMK2A; ATF4
Neurotrophin signaling pathway
AKT2; PIK3CD; CAMK2D; AKT1; MAPK13; SHC2; PIK3R1; PTPN11; ARHGDIA; BDNF
Retrograde endocannabinoid signaling
GABRA1; MAPK12; GRIA3; GRIA1; MAPK1; MAPK3; MAPK10; SLC17A7; MAPK13; PLCB4
Glutamatergic synapse
GRIK1; GNGT1; GNB1; TRPC1; SLC17A8; GRIN2A; GRIN2B; HOMER2; GNAI1; GNG2
Cholinergic synapse
PLCB4; GNG3; PIK3R2; CAMK2B; PIK3R5; KCNJ14; CAMK4; GNG8; CREB3L1; CHRM2
Serotonergic synapse
HTR1B; GABRB2; HTR1A; CYP2D9; PRKCB; CYP2D26; GNAI2; PLCB3; PLCB4; CYP2D10
Long-term depression
GUCY1B3; PPP2CB; GNAI1; ITPR1; CRHR1; GRM1; MAPK1; GRIA3; GNAI3; IGF1
Regulation of actin cytoskeleton
FGF7; ARHGEF12; RHOAC; FGFR1; FGF20B; RASSF7; TMSB; ABI2B; ARPC5LB; ITGAM
Insulin signaling pathway
FLOT2B; EIF4EA; INPP5K; HRASB; PCK1; CALM3; ARAF; RHOQ; FOXO1B; GSK3AA
GnRH signaling pathway
PLD2; CACNA1DA; PLD1; MMP2; KRAS; PRKACAB; MAPK1; HRAS; PRKCDA; RAF1B
Progesterone-mediated oocyte maturation
Adcy4; MAPK14B; AKT2L; CDC23; MAPK12A; BUB1; PLK1; MAPK14A; ANAPC7; GNAI1
Estrogen signaling pathway
PLCB4; FKBP4; MAP2K2; GNAI3; AKT2; CREB3L3; SOS1; PRKCD; KCNJ9; NRAS
Melanogenesis
CALM4; GNAI3; CAMK2D1; FZD5; CALM3; MC1R; MITF; GNAI2; WNT1; CALM1B
Prolactin signaling pathway
STAT5A; SOCS2; PIK3CG; CCND1; KRAS; SHC2; SOS1; PIK3CD; SOCS4; ESR1
Thyroid hormone signaling pathway
PLCB3; ATP1A3; KRAS; SLC16A10; MED14; PIK3R2; TRP53; ATP2A2; NOTCH4; SIN3A
Oxytocin signaling pathway
PPP1R12B; NOS3; TRPM2; Adcy4; KCNJ14; RHOA; CACNG1; ELK1; PIK3CD; PRKAA1
Type II diabetes mellitus
PKM; PRKCZ; PRKCE; MAFA; PIK3R2; PIK3CD; PRKCD; PDX1; SLC2A2; CACNA1G
Aldosterone-regulated sodium reabsorption
ATP1A3; IRS1; PRKCG; PIK3CA; SGK1; SCNN1G; SLC9A3R2; ATP1A1; PIK3CB; FXYD2
Alzheimers disease
ATP2A1; CALML5; GSK3B; NDUFA5; PPP3CB; COX7A1; UQCR11; SDHA; GRIN2A; ATP2A3
Prion diseases
C5; C9; C1QA; Hc; SOD1; MAPK3; STIP1; C7; PRNP; LAMC1
Alcoholism
CREB3L2; HDAC6; HIST1H2AD; CAMK4; SHC4; KRAS; HIST1H2BG; HIST1H2AE; NTRK2; NRAS
Shigellosis
ELMO3; CD44; WAS; IKBKG; PFN1; SRC; ARPC5L; ACTG1; RELA; CDC42
Salmonella infection
RAC1; ARPC5L; ARPC5LA; ACTB1; ROCK2; ROCK2B; FLNC; MAPK10; PFN1; MAPK12A
Pertussis
LY96; GM5077; C1S; C2; RHOA; MAPK9; Casp3; C5; IL6; TLR4
Leishmaniasis
IL1A; H2-AA; FCGR3B; TGFB3; ITGB2L; CR1; TLR2; HLA-DOB; FCGR4; NCF4
Chagas disease (American trypanosomiasis)
TLR4; IL1B2; TNFRSF1A; CCL2; IFNGR2; IL6; CFLAR; IL1B; PLCB2; PIK3CA
Toxoplasmosis
HSPA8; HLA-DPA1; LAMB1; CASP9; TRAF6; XIAP; LAMB4; HSPA1B; HLA-DRB5; IL10RA
Tuberculosis
TLR1; HLA-DQB1; HLA-DRB1; RFXANK; ITGAX; FCGR4; FADD; PPP3CC; IFNB1; IRAK2
Hepatitis C
NFKB1; PIK3R2; OAS1B; IFNA21; EIF3E; CLDN1; IFNA2; PPARA; MAPK11; MAPK12
Hepatitis B
STAT5B; BIRC5; HSPG2; TICAM2; TLR3; SMAD4; ELK1; PIK3CD; IL-8; IFNAR1
Influenza A
TNFRSF10D; XPO1; EP300; MAPK10; CCL5; PIK3CA; PRSS1; TNFSF10; PIK3R5; ICAM1
Pathways in cancer
TPR; Pdgfa&Pdgfb; PTGS2; Casp3; PTEN; FGF6; LPAR4; RASSF5; LAMA1; SLC2A1
Viral carcinogenesis
HIST1H2BD; PIK3R3; HIST1H4H; GTF2H3; HIST1H2BC; CCND3; NRAS; MAD1L1; HRAS; PIK3R1
Proteoglycans in cancer
SMAD2; WNT3A; CD63; CAV3; PTPN6; IGF1R; HSPG2; MAPK12; PPP1CB; WNT9A
Colorectal cancer
PIK3R1; Casp3; TRP53; RAC3; MAP2K1; CCND1; TP53; BIRC5; TCF7L2; TGFBR1
Renal cell carcinoma
ARAF; PIK3CB; VHL; PIK3CG; PAK7; VEGFA; PAK1; TCEB2; PAK6; HRAS
Pancreatic cancer
MAPK10; PIK3CA; PIK3CG; IKBKB; MAPK8; CCND1; RAC2; PIK3R1; BCL2L1; RAC1
Endometrial cancer
APC2; HRAS; KRAS; AXIN1; PIK3R2; PIK3CD; BAD; BRAF; LEF1; PIK3R1
Glioma
CALML5; TRP53; KRAS; CALM4; PDGFRB; CALML3; PRKCB; SHC3; SHC2; PIK3CB
Prostate cancer
CCNE2; ERBB2; Ar; BRAF; PDGFB; LEF1; CREB3L3; PDPK1; PIK3CG; MAPK3
Thyroid cancer
NCOA4; RXRA; TPM3; MAPK1; TP53; LEF1; TFG; KRAS; MAP2K2; TPR
Melanoma
BAD; PDGFRA; PIK3CA; PIK3R3; TRP53; BRAF; FGF21; CDH1; RB1; FGF18
Bladder cancer
MMP1A; CDK4; UPK3A; HRAS; VEGFA; TYMP; ARAF; CDH1; RPS6KA5; FGFR3
Chronic myeloid leukemia
CBLB; SMAD3; PIK3R2; PIK3CD; CBL; RUNX1; NFKBIA; PIK3R3; PIK3R5; SMAD4
Acute myeloid leukemia
SFPI1; ARAF; LEF1; AKT3; PIK3R3; SOS1; PML; MAP2K1; NRAS; PIM2
Non-small cell lung cancer
GRB2; PIK3R1; ARAF; PIK3CB; RARB; PIK3CA; FHIT; RXRA; BAD; PLCG1
Central carbon metabolism in cancer
NTRK1; HIF1A; HKDC1; FLT3; FGFR2; MET; PGAM2; PIK3R1; ERBB2; PIK3CG
Choline metabolism in cancer
MAP2K2; RAC2; MAPK8; DGKG; PDPK1; TSC2; RPS6KB1; DGKA; GRB2; SLC22A2

Protein Function

MAPK3 has several biochemical functions, for example, ATP binding, MAP kinase activity, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK3 itself. We selected most functions MAPK3 had, and list some proteins which have the same functions with MAPK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein EPHB4B; MAPK14; PRKACBA; MYO1F; TYK2; DYRK3; CSNK1G2; PKN1B; MAP4K1; FANCM
Function MAP kinase activity
Related Protein MAPK6; MAPK8B; MAPK11; MAPK14B; MAPK12; MAPK12B; MAPK3; NLK1; MAPK1; MAPK14A
Function phosphatase binding
Related Protein TRPC4AP; DLG1L; PPP1R21; KLRAQ1; MAST2; PPP1R32; CHCHD3; DLG3; SMAD2; PPP1R36
Function phosphotyrosine binding
Related Protein CBLB; ZAP70; FGR; CBL; PTPN3; MAPK1; STAP1; LDLRAP1; CBLC; ACP2
Function protein binding
Related Protein PRKDC; PKN3; HSPA2; FAP; SPON1; VPS33A; CLIC5; DAP3; IL13RA1; CHMP4A
Function scaffold protein binding
Related Protein MAP2K2; DLG4; SHANK1; GRIN2A; CHRNA7; MAPK3; ADCY6; KRT8; P2RY1; PDE4D

Interacting Protein

MAPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK3.
DUSP1; PTPRJ; MAPK14; DHPS; Ptprr

MAPK3 Related Articles

Blaha, M; Nemcova, L; et al. Cyclic guanosine monophosphate does not inhibit gonadotropin-induced activation of mitogen-activated protein kinase 3/1 in pig cumulus-oocyte complexes. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 13:-(2015).
Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).