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MAPK8

  • Official Full Name

    mitogen-activated protein kinase 8

  • Overview

    The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain.
  • Synonyms

    MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC 2.7.11.24; Stress-activated protein kinase JNK1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPK8-9382H Recombinant Human MAPK8, GST-tagged E.coli GST True
Human MAPK8-29668TH Recombinant Human MAPK8 E.coli N/A
Human MAPK8-751H Recombinant Human Mitogen-activated Protein Kinase 8 E.coli N/A
Human MAPK8-554H Recombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged E.coli GST
Human MAPK8-781H Recombinant Human MAPK8 protein(Met1-Arg427), GST-tagged Insect Cells N-GST Met1-Arg427
Human MAPK8-612H Recombinant Human Mitogen-activated Protein Kinase 8, His-tagged Insect Cell His
Human MAPK8-100H Recombinant Human MAPK8, His-tagged E.coli His
Human MAPK8-518H Recombinant Human MAPK8 Mammalian Cell His
Human MAPK8-156H Recombinant Human MAPK8 protein, His/MBP-tagged E.coli His/MBP 1-72 aa
Human MAPK8-4488HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
Human MAPK8-4489HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
Human MAPK8-1729H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPK8-1137H Recombinant Human MAPK8 Protein (S2-E364), His tagged E.coli His S2-E364
Human MAPK8-5523H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPK8-3435H Recombinant Human MAPK8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAPK8-2242H Recombinant Human MAPK8 protein, His-tagged Insect Cell His 4-422aa
Human MAPK8-1136H Recombinant Human MAPK8 Protein (S2-E364), Tag Free E.coli No tag S2-E364
Human MAPK8-2420H Recombinant Human MAPK8 Protein, His-tagged E.coli N-His Tyr26-Ile321
Human MAPK8-3435H-B Recombinant Human MAPK8 Protein Pre-coupled Magnetic Beads HEK293
Human MAPK8-3168H Recombinant Human MAPK8 Protein (Tyr26-Ile321), His tagged E.coli His Tyr26-Ile321
Mouse Mapk8-338M(Mouse) Recombinant Mouse Mapk8, GST-tagged, Active Sf9 Insect Cell GST
Mouse Mapk8-1550M Recombinant Mouse Mapk8 protein, His & T7-tagged E.coli His/T7 Gly138~Val382 (Accession # Q91Y86)
Mouse Mapk8-1051M Recombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged E.coli GST
Mouse Mapk8-3945M Recombinant Mouse Mapk8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Mapk8-689R Recombinant Rat Mitogen-activated Protein Kinase 8 E.coli N/A
Rat Mapk8-1551R Recombinant Rat Mapk8 protein, His & T7-tagged E.coli His/T7 Gly138~Gly370 (Accession # P49185)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAPK8 Related Articles
  • MAPK8 Related Research Area
  • MAPK8 Related Signal Pathway

MAPK8 involved in several pathways and played different roles in them. We selected most pathways MAPK8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayIKBKB;CACNA1DA;FGF13B;ARRB2;IL1B;STMN1;PLA2G4C;CACNA2D1;GRB2B
ErbB signaling pathwayTGFA;BTC;MAPK8B;CBLB;ERBB4;KRAS;BRAF;CAMK2G;PIK3R2
Ras signaling pathwayHTR7;PIK3CB;GAB1;FGF10;IGF1;Fgf15;FGF17;GNG2;GNB2
cAMP signaling pathwayGLI3;PDE4A;MAP2K1;ATP1B1;SOX9;PPP1CB;AKT1;PPARA;ATP1A1
FoxO signaling pathwayG6PC2;BNIP3;STK11;GRB2B;PRKAG3;SGK2;IGF1RA;MAPK12B;STK4
Sphingolipid signaling pathwayPPP2R1A;MAP2K2;ABCC1;NRAS;S1PR4;BAX;PIK3CG;GAB2;MS4A2
Protein processing in endoplasmic reticulumEDEM3;CRYABA;YOD1;UBE2D2;MARCH6;PDIA3;DNAJC10;SEC23B;BAG2
Wnt signaling pathwayCCND1;SENP2;PRKACG;WIF1;RAC3B;WNT7B;FZD7A;WNT2BB;WNT11
Osteoclast differentiationIFNGR2;IL1A;BLNK;LILRB1;cgr2b;TGFB1;CYLD;FOSL2;FOS
Focal adhesionPAK4;IGF1RB;PRKCBA;ACTN1;BADB;FYNB;ACTN2B;ITGB1A;COL4A2
Toll-like receptor signaling pathwayIFNA17;MAP2K3;IFNA1;RELA;TLR4BB;IFNAR2;IL-8;MAPK14B;MAP2K6
NOD-like receptor signaling pathwayPYDC1;TAB3;RELA;IKBKB;NLRC4;TRIP6;MAP3K7IP3;MAPK1;MAPK13
RIG-I-like receptor signaling pathwayATG12;MAPK14B;DHX58;IL12BA;IFNE;RIPK1L;IFNK;AZI2;Ifna15
Fc epsilon RI signaling pathwayPIK3R1;IL4;MAPK11;MAPK9;PIK3CG;AKT1;MAP2K4;FYN;GRB2
TNF signaling pathwayNFKBIA;BCL3;MAP3K5;MAPK9;LTA;MAP3K7;MAPK12;MAP2K3;CX3CL1
Neurotrophin signaling pathwayMAPK10;MAPK1;MAP2K1;ARHGDIA;PIK3R5;KRAS;MAPK9;CAMK2B;KIDINS220
Retrograde endocannabinoid signalingPLCB1;ABHD6;GNAQ;GNG3;MAPK8;NAPEPLD;MAPK3;PTGS2;GABRR1
Dopaminergic synapseGRIN2B;GNB4;ITPR3;GNG5;AKT1;SLC18A2;MAOA;GNAI3;MAPK11
Inflammatory mediator regulation of TRP channelsHTR2B;TRPV3;PIK3R2;MAPK8;MAPK10;PLA2G6;PRKCD;ACCN5;CYP2J5
Insulin signaling pathwayTSC1A;PPP1CAB;FLOT1;CALM3A;G6PCA.1;CALM4;INPP5K;CBLB;PDPK1
GnRH signaling pathwayMAPK12B;MAP2K2A;MAP2K6;MMP2;RAF1B;Adcy4;CAMK2D;GNRHR4;PLCB1
Progesterone-mediated oocyte maturationAKT2;MAPK12B;MAPK8A;CDC25A;CPEB3;MAPK8B;FZR1A;MAPK8;CCNB3
Prolactin signaling pathwayTH;SIRPA;STAT5B;PIK3R2;PIK3CG;MAPK10;MAP2K1;PIK3R3;SOCS5
Adipocytokine signaling pathwayAGRP;ACSL4B;IRS1;TNFRSF1A;NFKBIE;PRKAA2;MAPK9;LEPR;JAK2A
Type II diabetes mellitusHK1;INS;SOCS3;HK2;MAPK1;PIK3R5;IKBKB;PIK3CA;INS2
Insulin resistancePRKCD;PPARAB;MAPK8B;MTOR;CD36;CREB3L2;PPARGC1B;G6PC3;PIK3CG
Non-alcoholic fatty liver disease (NAFLD)NDUFA5;NFKB1;IRS1;UQCRFS1;NDUFA13;NDUFC1;AKT2;UQCRQ;NDUFS4
Epithelial cell signaling in Helicobacter pylori infectionATP6V1A;CXCR2;IKBKG;RAC1;MET;TCIRG1;MAPK8;GIT1;ATP6V1C1
ShigellosisACTB;NFKBIA;SRC;U2AF1L4;NFKB1;ITGA5;ITGB1;IL-8;MAPK10
Salmonella infectionPFN2;DYNC1LI1;PFN3;WASLB;RAC1;IL1B;MAPK8B;FOS;RHOGB
PertussisC1QC;C5;GNAI1;IL6;ITGAM;C4BP;Il23a;IL1B;CALML5
Chagas disease (American trypanosomiasis)PPP2R2C;PPP2R1B;CCL3;IL1B2;MAPK1;MYD88;TNFRSF1A;TLR4;SERPINE1
ToxoplasmosisPIK3CG;MAPK11;HLA-DRB1;Toxoplasma Gondii Major Surface Antigen P30;TGFB1;HSPA1A;GNAI3;HLA-DOB;BIRC3
TuberculosisCASP9;IRAK4;RFXAP;ATP6V0A1;IFNGR2;CALM1;NFYC;PIK3C3;IL1A
Hepatitis CCLDN14;EIF2AK1;IFIT1;MAPK9;PIK3CA;IFNA6;IFNA14;MAPK3;BRAF
Hepatitis BTGFB3;IRF3;PRKCG;STAT5A;TP53;MAVS;PCNA;CCNA2;CREB3L2
Influenza ASLC25A6;TNFRSF10C;IKBKE;STAT2;IFNA14;BLB1;OAS1B;HLA-DRB1;MAVS
HTLV-I infectionANAPC1;ATF4;ETS1;HRAS;EP300;ZFP36;ATF1;RANBP1;POLB
Herpes simplex infectionIFNA16;HLA-DRB3;TBK1;TAF10;CLOCKA;PPP1CBL;SRSF5;HCFC2;TAF6L
Epstein-Barr virus infectionPOLR3E;HSPA1A;HSPA6;PSMD7;PRKACB;TYK2;MAPK8;HDAC4;AKT2
Pathways in cancerGNG10;FH1;LPAR2;LAMA3;MAPK3;FADD;ROCK1;GNG3;RAD51
Colorectal cancerMAPK8;CYCS;MLH1;TCF7;APC;AXIN2;SMAD3;TGFBR2;AXIN1
Pancreatic cancerNFKB1;RB1;RAC1;AKT1;CCND1;AKT2;RAC2;MAPK9;MAPK8
Choline metabolism in cancerDGKQ;PCYT1A;SLC44A1;SLC22A5;RAC2;SLC44A2;PLA2G4D;KRAS;PDGFD

MAPK8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8 itself. We selected most functions MAPK8 had, and list some proteins which have the same functions with MAPK8. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDHX33;NAV2;PTK2B;YARS2;STK33;EPHA8;DDX11;DDX52;ATP1A1B
JUN kinase activityMAPK8;ALPK2;MAPK9;MAPK10
enzyme bindingHSPA5;CYP1A1;DYM;CTNNB1;CCND1;HMGA1-RS1;HIST1H2AI;TOP2A;PLSCR4
histone deacetylase bindingPHB;TFAP4;SP2;ANKRA2;MEF2B;NKX3;ZMYND15;PKN1;NR2C1
histone deacetylase regulator activityNCOR1;TRP53;TP53;MAPK8
protein bindingDNAJC28;CRYAB;METAP2;CLNK;OTX2;LIN7A;CREB3L1;DPM1;FAM50B
protein serine/threonine kinase activityDCKL1B;RIPK1;PAK6;SBK1;OXSR1A;CPNE3;IRAK2;RPS6KAL;TAOK3

MAPK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8.

JUN; PIK3R1; MAPK8IP1; CRK; MAP2K7

Yabu, T; Shiba, H; et al. Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. CELL DEATH AND DIFFERENTIATION 22:258-273(2015).
Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Is MAPK8 involved in inflammatory processes? 02/23/2023

Yes, MAPK8 is implicated in regulating inflammation and immune responses, contributing to the pathogenesis of inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.

Can MAPK8 inhibitors potentially be used in treating Alzheimer's disease? 05/18/2022

Research suggests that MAPK8 inhibitors might have therapeutic potential in managing Alzheimer's disease by modulating neuronal responses and reducing neuroinflammation.

How is MAPK8 protein expression assessed in clinical research? 07/21/2020

MAPK8 protein expression is often assessed using techniques like immunohistochemistry, western blotting, or quantitative PCR in clinical samples to understand its role in diseases.

How does MAPK8 influence neuronal function and neurodegeneration? 08/01/2019

MAPK8 activation is associated with neuronal stress responses and plays a role in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases.

How does MAPK8 influence cellular apoptosis? 06/09/2016

MAPK8 signaling pathways can either promote or suppress apoptosis depending on the cellular context and stimuli, making it a potential target for regulating cell death in disease settings.

Customer Reviews (3)

Write a review
Reviews
04/18/2020

    I am confident that the MAPK8 protein will unravel crucial insights into molecular mechanisms, greatly enhancing the significance and impact of my scientific investigations.

    12/02/2016

      By relying on the MAPK8 protein, I can approach my research with unwavering confidence in its quality and the unparalleled support extended by its manufacturer.

      02/25/2016

        the manufacturer's commitment to providing excellent technical support adds an additional layer of confidence to my choice of the MAPK8 protein.

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