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Official Full Name mitogen-activated protein kinase 8
Background The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain.
Synonyms MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC; Stress-activated protein kinase JNK1
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK8-1729H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Mapk8-3945M Recombinant Mouse Mapk8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human MAPK8-5523H Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAPK8-100H Recombinant Human MAPK8, His-tagged E.coli His
    Human MAPK8-156H Recombinant Human MAPK8 protein, His/MBP-tagged E.coli His/MBP
    Human MAPK8-29668TH Recombinant Human MAPK8 E.coli N/A
    Human MAPK8-4488HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
    Human MAPK8-4489HCL Recombinant Human MAPK8 293 Cell Lysate HEK293 N/A
    Human MAPK8-518H Recombinant Human MAPK8 Mammalian Cell His
    Human MAPK8-554H Recombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged E.coli GST
    Human MAPK8-612H Recombinant Human Mitogen-activated Protein Kinase 8, His-tagged Insect Cell His
    Human MAPK8-751H Recombinant Human Mitogen-activated Protein Kinase 8 E.coli N/A
    Human MAPK8-781H Recombinant Human MAPK8, GST tagged Insect Cell GST
    Human MAPK8-9382H Recombinant Human MAPK8, GST-tagged E.coli GST
    Mouse Mapk8-1051M Recombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged E.coli GST
    Mouse Mapk8-1550M Recombinant Mouse Mapk8 protein, His & T7-tagged E.coli His/T7
    Mouse Mapk8-338M(Mouse) Recombinant Mouse Mapk8, GST-tagged, Active Sf9 Insect Cell GST
    Rat Mapk8-1551R Recombinant Rat Mapk8 protein, His & T7-tagged E.coli His/T7
    Rat Mapk8-689R Recombinant Rat Mitogen-activated Protein Kinase 8 E.coli N/A

    MAPK8 involved in several pathways and played different roles in them. We selected most pathways MAPK8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MEF2CB; FGF1; FLNA; RASGRP3; CACNA2D1A; RAF1B; MAP2K1; CACNA2D4; MAP2K5; RAP1AA
    ErbB signaling pathway PTK2AA; NRG1; BRAF; RAF1B; AREG; MAPK8B; RAF1; CAMK2B1; GSK3AA; PIK3R5
    Ras signaling pathway PIK3CG; GNG11; GNB2; RASA3; FGFR3; IKBKB; KITLG; FGF22; LOC608458; INS1
    cAMP signaling pathway CALM2; GRIN2D; FSHR; ATP1B4; GNAS; MAPK10; BDNF; GNAI1; ATP1A2; PIK3R3
    FoxO signaling pathway FASLG; HRAS; TGFBR1B; FOXO1A; PIK3R1; NLK; KLF2B; RBL2; STK4; INSR
    Sphingolipid signaling pathway PRKCE; NOS3; SPTLC1; PRKCZ; ASAH1; FYN; LASS4; MAPK12; PPP2R2B; PPP2R5C
    Protein processing in endoplasmic reticulum ERLEC1; HSPA1B; CUL1; WFS1; MAPK10; LMAN2; RNF185; DAD1; TRAM1; CAPN2A
    Wnt signaling pathway PRKACBB; Fzd4; WNT8A; NFATC1; PPARD; VANGL2; FZD3A; RHOA; TRP53; SFRP1
    Osteoclast differentiation LCP2; LILRA4; IKBKB; TAB2; MAPK10; NCF4; PIK3CB; LILRB4; MAPK9; GRB2
    Focal adhesion STYK1; MYL10; ITGA10; COL2A1A; PPP1R12C; CAPN2; BCL2A; COL6A3; MAPK8A; COL1A1
    Toll-like receptor signaling pathway TLR5; IL12BA; CCL3L3; AKT1; IFNA5; MAPK14B; IL8L1; MAP3K7; AKT2; IFNPHI1
    NOD-like receptor signaling pathway MAPK3; ERBB2IP; SUGT1; MAPK8B; IL8L1; NFKBIA; CARD18; NLRC4; IKBKG; PSTPIP1A
    RIG-I-like receptor signaling pathway MAPK12B; MAPK11; IFNPHI3; IL8L1; DHX58; IFNA4; IL8L2; IRF3; NLRX1; ATG5
    Fc epsilon RI signaling pathway MAPK1; AKT2; MAPK11; TNF; MAP2K1; PDPK1; PIK3CA; MAP2K3; IL13; RAC2
    TNF signaling pathway PIK3CG; PIK3R5; VEGFC; CXCL1; CCL20; MMP9; NFKB1; LIF; MAP2K1; ATF4
    Neurotrophin signaling pathway MAPK1; SHC4; RAP1B; IKBKB; MAPK12; Fasl; SH2B1; MAPK7; NGF; RELA
    Retrograde endocannabinoid signaling GNAQ; GNG11; MAPK13; GNAO1; MAPK10; GABRB1; GRM5; GNAI3; MAPK1; PLCB1
    Dopaminergic synapse PPP1CB; CAMK2G; CREB3L4; KIF5C; CALML5; COMT; GNG5; PPP2R2A; DRD4; PRKACA
    Inflammatory mediator regulation of TRP channels MAP2K3; F2RL1; PPP1CB; ITPR3; TRPA1; PIK3CD; IGF1; PIK3R1; PPP1CA; ASIC1
    Insulin signaling pathway PRKAB1; HK3; SH2B2; EIF4E1C; PYGM; PTPN1; GSK3B; PIK3R5; LIPE; IRS4
    GnRH signaling pathway MAPK14B; CAMK2D2; CAMK2B; CAMK2D1; MAPK13; CALM3B; GNRH3; GNA11A; CALM3; PRKCBB
    Progesterone-mediated oocyte maturation IGF1RA; CCNA1; CPEB2; KRAS; ANAPC4; MAPK12A; HSP90AA1; CPEB1A; MAPK14B; PGR
    Prolactin signaling pathway MAPK12; TNFRSF11A; KRAS; CCND1; ELF5; SOCS3; SOCS2; PIK3CB; RELA; PIK3R1
    Adipocytokine signaling pathway SOCS3; PRKCQ; PTPN11; CAMKK1; CPT1C; IRS2; PTPN11A; PRKAA1; JAK2; ACSL5
    Type II diabetes mellitus HK2; PRKCD; SLC2A2; PIK3R2; PKM; SOCS2; SOCS3; CACNA1G; SOCS4; TNF
    Non-alcoholic fatty liver disease (NAFLD) UQCRQ; CASP7; NDUFS3; TGFB1; NDUFV1; RELA; NDUFAB1; NDUFB6; IL6R; PRKAG1
    Epithelial cell signaling in Helicobacter pylori infection ATP6V1E2; CCL5; NFKB1; ATP6V1E1; LYN; MAP2K4; ATP6V1B1; CXCL1; ATP6V0A2; ATP6V1C1
    Shigellosis WASL; SRC; MAPK8; ACTB; RAC1; ARPC5L; DIAPH1; MAPK3; U2AF1; WASF1
    Salmonella infection TJP1; RAC1A; RHOGC; RELA; TLR5B; RHOGD; IL1A; FOS; CASP1; FLNA
    Pertussis Il23a; Il12b; Itgam&Itgb2; C2; C1S; MAPK3; RHOA; IRAK4; CALM2; IL12B; C5
    Chagas disease (American trypanosomiasis) MAPK12; C1QB; C1QC; IKBKB; SMAD3; MYD88; IFNGR1; MAPK13; IFNB1; IL12A
    Toxoplasmosis HLA-DPB1; HLA-DRA; MAP2K3; Toxoplasma Gondii Microneme Protein MIC3; MAPK8; PIK3CB; NFKBIB; IRAK1; LAMC1; TLR2
    Tuberculosis MAPK8; CALM2; IL10RA; Itgam&Itgb2; TLR2; IRAK2; EP300; RHOA; TGFB3; PPP3CB
    Hepatitis B RAF1; TP53; NFATC1; CYCS; PIK3R3; ELK1; PIK3R1; IFNA10; IFNA7; IFNA21
    HTLV-I infection HLA-DPA1; CREM; EGR1; MAPK8; WNT2; WNT1; TGFB2; VDAC2; TGFB1; FZD5
    Herpes simplex infection IL1B; OAS3; MAPK9; MHC1UXA2; TAP1; SRSF5A; SRSF5; NFKBIAB; USP7; H2-Q10
    Epstein-Barr virus infection HLA-DRB3; HLA-DPB1; NFKBIE; HSPB2; TBK1; POLR2J3; TRAF6; YWHAG; POLR3K; CD44
    Pathways in cancer FZD2; MAP2K2; ITGB1; FH; LAMA1; VEGFA; GNG7; STAT1; CTBP2; WNT5B
    Colorectal cancer PIK3R2; PIK3R5; ARAF; MLH1; TGFBR1; TGFB1; AKT2; AXIN2; RALGDS; MAPK9
    Pancreatic cancer SMAD4; MAPK8; PIK3R2; MAPK9; PIK3R3; BAD; NFKB1; STAT3; TGFB3; BCL2L1
    Choline metabolism in cancer PRKCG; DGKE; KRAS; RHEB; SLC5A7; PCYT1A; SOS1; PIP5K1C; GPCPD1; PIK3CG

    MAPK8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8 itself. We selected most functions MAPK8 had, and list some proteins which have the same functions with MAPK8. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CLK1; DYRK3; SGK3; EIF4A1A; GTF2F2B; DHX32; NUBP1; TSSK3; SMC1A; IP6K3
    JUN kinase activity ALPK2; MAPK10; MAPK8; MAPK9
    enzyme binding PEBP1; HMGA1-RS1; PCBP2; ANK1; NLRP1; C2orf56; HIST1H2AE; TNKS2; CA; HSPA1A
    histone deacetylase binding HEY2; ZFP932; CCND1; SP1; TOP2B; RAD9A; SP2; HDAC5; MYOCD; NKX3
    histone deacetylase regulator activity MAPK8; TP53; TRP53; NCOR1
    protein binding NEUROG1; TRIM6; MZT1; PSMD6; RASSF9; U2AF2; NEDD9; SMAGP; NCBP1; ARMCX1
    protein serine/threonine kinase activity OBSCN; TGFBR1B; LRRK2; SPEG; ACVR1L; HIPK4; PRKACAA; MAP3K2; PRKCQ; MAP3K9

    MAPK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8.


    Yabu, T; Shiba, H; et al. Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. CELL DEATH AND DIFFERENTIATION 22:258-273(2015).
    Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).

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