mapk8
Share
  • Official Full Name
  • mitogen-activated protein kinase 8
  • Background
  • The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain.
  • Synonyms
  • MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC 2.7.11.24; Stress-activated protein kinase JNK1
Cat.#:MAPK8-100HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK8, His-tagged
+Inquiry
Cat.#:MAPK8-156HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK8 protein, His/MBP-tagged
+Inquiry
Cat.#:MAPK8-29668THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK8
+Inquiry
Cat.#:MAPK8-518HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MAPK8
+Inquiry
Cat.#:MAPK8-554HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged
+Inquiry
Cat.#:MAPK8-751HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 8
+Inquiry
Cat.#:MAPK8-781HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK8, GST tagged
+Inquiry
Cat.#:MAPK8-9382HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK8, GST-tagged
+Inquiry
Cat.#:Mapk8-1550MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mapk8 protein, His & T7-tagged
+Inquiry
Cat.#:Mapk8-338M(Mouse)Tag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Mapk8, GST-tagged, Active
+Inquiry
Cat.#:Mapk8-1551RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mapk8 protein, His & T7-tagged
+Inquiry
Cat.#:MAPK8-612HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 8, His-tagged
+Inquiry
Cat.#:Mapk8-689RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mitogen-activated Protein Kinase 8
+Inquiry
Cat.#:Mapk8-1051MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged
+Inquiry
Cat.#:MAPK8-4488HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK8 293 Cell Lysate
+Inquiry
Cat.#:MAPK8-4489HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK8 293 Cell Lysate
+Inquiry

Involved Pathway

MAPK8 involved in several pathways and played different roles in them. We selected most pathways MAPK8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
ELK1; DUSP8A; TGFBR1B; IL1R2; PRKCBB; MAPKAPK2A; CASP3A; KCNA3; PAK1; MAPK8A
ErbB signaling pathway
PIK3CB; AKT2; PRKCA; HRASB; GRB2B; EGFRA; MAPK8A; PAK1; PAK7; SHC3
Ras signaling pathway
NGF; RRAS; BAD; PTPN11; IKBKG; PDGFD; ETS1; PAK2; PLA2G4A; SOS1
cAMP signaling pathway
ATP1A2; GRIN2C; MAPK9; CALML3; CREB3L1; HHIP; VAV1; PRKACG; PLN; GRIN2B
FoxO signaling pathway
CCND2; FOXO1A; PDPK1B; GRM1; PIK3R1; FOXO3; FOXG1; CCNG2; FOXO6; S1PR1
Sphingolipid signaling pathway
OPRD1; RELA; PLCB3; FYN; DEGS2; TRADD; PPP2R5E; S1PR2; SPTLC1; MAP2K2
Protein processing in endoplasmic reticulum
STT3B; FBXO2; UBE2E3; HSPA1A; SEL1L; UBXN6; HSPA4L; DNAJC5GA; HSP90AB1; UBQLN4
Wnt signaling pathway
PRKACBB; WNT7AA; PPP3CCA; FOSL1A; PRKACA; NFATC3; SFRP2; PRICKLE2B; PORCN; CCND2A
Osteoclast differentiation
ACP5; LILRB2; FCGR3; PIK3CA; LILRA2; FOSL1; SIRPG; NFKBIA; TGFBR1; LILRA4
Focal adhesion
MAPK8A; AKT3A; MYLK; ITGB6; MYL12.1; MYLK3; MAPK3; VAV3; PIK3R1; COL1A1A
Toll-like receptor signaling pathway
PIK3CB; STAT1B; RIPK1L; TLR4; IL1B; MAP2K2A; MAPK14B; TRAF6; AKT3A; IFNAR2
NOD-like receptor signaling pathway
TNF; NAIP6; MAPK9; MAPK13; PSTPIP1B; IKBKB; TAB3; TRAF6; CXCL2; MAPK11
RIG-I-like receptor signaling pathway
ATG5; CXCL8B.3; TNF; IFNA16; IFNA4; IFIH1; PL10; ATG12; IL12B; IL12BA
Fc epsilon RI signaling pathway
GRB2; SYK; PLCG2; PIK3R5; BTK; MAPK11; MAP2K2; VAV1; VAV3; MAPK13
TNF signaling pathway
MAP2K6; CCL2; LIF; DNM1L; MAPK9; PIK3CB; ATF4; BCL3; TNFAIP3; NFKBIA
Neurotrophin signaling pathway
MAP3K5; AKT2; KIDINS220; SOS1; RELA; IRAK4; RAC1; RPS6KA2; RIPK2; CAMK4
Retrograde endocannabinoid signaling
ITPR3; GNAQ; GABRB3; GRIA3; MAPK11; MAPK13; GNG4; GABRG2; GNAI3; GRIA4
Dopaminergic synapse
PLCB3; PPP1CB; MAOA; PLCB1; KIF5B; PPP1CC; DDC; PLCB2; CAMK2G; CLOCK
Inflammatory mediator regulation of TRP channels
BDKRB2; HRH1; CYP4A14; TRPV3; PTGER2; PLA2G4A; MAPK8; CYP2C70; PLCB4; PTGER4
Insulin signaling pathway
PPP1CAA; TSC2; INPPL1; SOCS4; RPS6; PIK3CB; MKNK2A; SHC2; PIK3R3A; SHC3
GnRH signaling pathway
GNA15.1; PLD1A; PTK2BB; HRAS; PLA2G4A; CAMK2G; GNRHR2; PRKACAA; PLD2; MAP3K4
Progesterone-mediated oocyte maturation
PRKACBB; CDC23; INS1; PDE3B; PIK3CB; MAPK12B; RPS6KA3; MAPK8A; PKMYT1; PIK3CG
Prolactin signaling pathway
CSH; SOCS5; PIK3R3; ELF5; KRAS; STAT1; SRC; RELA; SHC4; SOCS2
Adipocytokine signaling pathway
CPT1A; G6PC2; ACSL3B; ACSL1A; ACSL3A; PCK2; RXRAA; MAPK8B; PTPN11B; G6PCA.2
Type II diabetes mellitus
MAFA; PRKCZ; PIK3CD; IRS1; SOCS1; INS1; PKM; IRS2; PIK3CB; INS2
Insulin resistance
AKT2; AKT1; AKT3A; SLC27A2; PDPK1; MLXIPL; RPS6KB2; PCK2; PRKCBB; RPS6KAL
Non-alcoholic fatty liver disease (NAFLD)
NDUFB2; CYCS; UQCR11; COX7A2L; GSK3A; PRKAG3; NDUFS7; INS; NDUFS2; NDUFA4L2
Epithelial cell signaling in Helicobacter pylori infection
TCIRG1; RELA; MAP2K4; CXCR1; ATP6V0E1; IL-8; MAP3K14; NFKBIA; ATP6V0C; ATP6V1E1
Shigellosis
WAS; ELMO2; U2AF1L4; VCL; ITGA5; MAPK8; MAPK9; RIPK2; HCLS1; WASL
Salmonella infection
TLR5B; ARPC5B; ARPC4L; IL1A; CXCL2; KLC1; RELA; RILP; IL8L2; IL6
Pertussis
C1RA; FOS; ITGAM; CASP7; Hc; CALM1; MAPK11; MYD88; IL1B; IL1A
Chagas disease (American trypanosomiasis)
GNAL; PLCB1; CCL3L1; IL-8; CD247; CFLAR; PPP2R2A; GNAQ; GNAI3; PPP2R1B
Toxoplasmosis
TAB2; TGFB2; PDPK1; LDLR; NOS2; IRGM1; Toxoplasma Gondii Profilin Family Protein; NFKBIB; LAMB3; HLA-DOB
Tuberculosis
IFNA21; MAPK3; IFNA13; LBP; BAX; IFNA10; TRADD; IL10RA; IFNA6; CAMK2D
Hepatitis C
STAT2; TNF; LDLR; PPP2R2A; PPP2CB; IFNA5; PDPK1; DDX58; TRAF2; AKT1
Hepatitis B
BIRC5; ATF4; IFNA7; TGFBR1; CASP9; TLR3; IFNA6; PTEN; CASP10; PRKCG
Influenza A
RNASEL; HLA-DOA; TMPRSS13; EIF2AK4; IRF9; HSPA8; OAS3; NXF1; MAP2K2; NUP98
HTLV-I infection
FZD6; PIK3CB; XPO1; ANAPC1; WNT8A; DVL1; ITGAL; MAP3K3; FDPS; STAT5B
Herpes simplex infection
TRAF6; HLA-DRB5; EEF1DA; SRSF2B; HLA-DQA1; CCL5; CUL1B; USP7; FADD; PPP1CAB
Epstein-Barr virus infection
PSMD6; MAP2K7; POLR1D; PSMC2; SYK; IKBKG; PSMD3; TRAF5; SFPI1; PSMD8
Pathways in cancer
ROCK2; BMP2; BID; FZD6; PLCG1; STAT5A; PTGER1; PPARD; SOS1; MMP9
Colorectal cancer
APC; PIK3R5; BAD; TRP53; PIK3CG; MAPK1; BAX; CASP9; CYCS; SMAD3
Pancreatic cancer
PIK3CB; IKBKG; RAC2; TRP53; ARAF; RALBP1; PIK3CD; RAD51; TGFA; MAPK3
Choline metabolism in cancer
PLA2G4B; GRB2; RAC2; SLC22A2; MAPK8; RHEB; PIK3CB; RAC3; DGKA; PIP5K1A

Protein Function

MAPK8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8 itself. We selected most functions MAPK8 had, and list some proteins which have the same functions with MAPK8. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ATP1A1A.2; C22orf28; Aatk; ATP2B1; IARS2; HUNK; MCMDC2; MARK4; IPMK; FDXACB1
Function JUN kinase activity
Related Protein MAPK10; ALPK2; MAPK9; MAPK8
Function enzyme binding
Related Protein CDC20; ADORA2A; CBX3; CYP3A4; EIF2AK3; YWHAH; KIAA1967; KDM4C; ZNF346; CD4
Function histone deacetylase binding
Related Protein KAT2B; CRY1; TOP2A; HDAC6; HDAC10; PARK2; RAD9A; MYOCD; ZMYND15; CEBPB
Function histone deacetylase regulator activity
Related Protein MAPK8; TRP53; TP53; NCOR1
Function protein binding
Related Protein EDAR; HIF1AN; KCNJ10; MT2A; TNS3; AP1M2; RGS3; UBB; KIAA1274; F2
Function protein serine/threonine kinase activity
Related Protein TAF1L; STK24; SBK1; NUAK2; BMPR1B; OXSR1A; PRKACBB; ACVR2AA; RPS6KA4; ARAF

Interacting Protein

MAPK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8.
JUN; PIK3R1; MAPK8IP1; CRK; MAP2K7

MAPK8 Related Articles

Yabu, T; Shiba, H; et al. Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. CELL DEATH AND DIFFERENTIATION 22:258-273(2015).
Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).