mapk8
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  • Official Full Name
  • mitogen-activated protein kinase 8
  • Background
  • The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain.
  • Synonyms
  • MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC 2.7.11.24; Stress-activated protein kinase JNK1
Cat.#:MAPK8-100HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK8, His-tagged
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Cat.#:MAPK8-156HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK8 protein, His/MBP-tagged
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Cat.#:MAPK8-29668THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK8
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Cat.#:MAPK8-518HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MAPK8
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Cat.#:MAPK8-554HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged
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Cat.#:MAPK8-751HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 8
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Cat.#:MAPK8-781HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK8, GST tagged
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Cat.#:MAPK8-9382HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK8, GST-tagged
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Cat.#:Mapk8-1550MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mapk8 protein, His & T7-tagged
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Cat.#:Mapk8-338M(Mouse)Tag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Mapk8, GST-tagged, Active
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Cat.#:Mapk8-1551RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mapk8 protein, His & T7-tagged
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Cat.#:MAPK8-612HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 8, His-tagged
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Cat.#:Mapk8-689RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mitogen-activated Protein Kinase 8
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Cat.#:Mapk8-1051MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged
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Cat.#:MAPK8-4488HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPK8 293 Cell Lysate
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Cat.#:MAPK8-4489HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAPK8 293 Cell Lysate
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Involved Pathway

MAPK8 involved in several pathways and played different roles in them. We selected most pathways MAPK8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PLA2G4F; MAPK14B; FGF12; MRAS; GADD45B; RPS6KAL; GADD45BA; RAC3B; GRB2B; RASA2
ErbB signaling pathway
PIK3R5; SHC2; ABL2; CBLB; HBEGFB; PRKCG; HBEGFA; AKT2L; GRB2A; PIK3R3B
Ras signaling pathway
HTR7; TEK; FGF17; RASA3; PDGFD; IGF1; FGF3; FIGF; ANGPT4; HGF
cAMP signaling pathway
CREB3L1; ATP2B1; RRAS; CALM1; CAMK2G; CREB5; F2R; ATP1B3; CNGA3; GNAI3
FoxO signaling pathway
MAPK8A; PLK4; MAP2K2A; IL6; SGK3; BNIP4; FBXO25; INS1; NRAS; SOD2
Sphingolipid signaling pathway
PDPK1; PRKCA; AKT2; PLCB3; PRKCZ; RELA; PIK3R5; PPP2R5C; TRAF2; LASS2
Protein processing in endoplasmic reticulum
ERN1; SSR3; CALR3B; SKP1; CAPN2L; RPN2; HSP90AA1.1; CALR; DNAJC5; MAPK8
Wnt signaling pathway
CAMK2D2; FBXW11; GSK3AA; MMP7; PPP3R1B; FZD1; PRKCBA; NFATC3; NKD2B; PPP3CB
Osteoclast differentiation
IFNG; MAP3K14; MAPK12; IL1B; NFKB2; IL1R1; FCGR3A; SIRPG; PPP3CC; IKBKB
Focal adhesion
CAPN2A; LAMC2; HRASA; ARHGAP35; FLT1; IGF1; LAMA5; MAPK1; AKT1; PIK3R2
Toll-like receptor signaling pathway
TNF; LY96; IRF5; IFNA10; MAP2K4B; NFKBIA; MAP2K6; MAP2K4; NFKBIAA; IL8L2
NOD-like receptor signaling pathway
IKBKB; CARD8; HSP90AA1.1; NLRP3; MAPK8; HSP90AA1.2; MAPK12; MAPK9; TNFAIP3; IL1B
RIG-I-like receptor signaling pathway
DDX3X; MAPK12; IFNA10; DDX3; CXCL8B.3; DHX58; RNF207B; RIPK1; MAPK9; TRIM25
Fc epsilon RI signaling pathway
FCER1A; IL4; IL13; MAPK10; PIK3R1; MAP2K1; MS4A2; LCP2; MAP2K6; AKT1
TNF signaling pathway
PIK3R5; CX3CL1; PIK3R1; DNM1L; TNFRSF1B; PIK3CB; LTA; MAP3K14; TRADD; MAPK9
Neurotrophin signaling pathway
ZNF274; TRAF6; CALML3; NTF4; PLCG1; TP73; MAPK1; MAPK12; PRDM4; SHC2
Retrograde endocannabinoid signaling
ITPR1; GNG2; SLC17A7; GNB1; NAPEPLD; Adcy4; GNAO1; GNAI1; GNAI3; PTGS2
Dopaminergic synapse
GNAL; PPP2R5C; GNAI1; CALML5; PPP2R5A; SLC18A2; GNB3; PPP2R3C; AKT2; KCNJ6
Inflammatory mediator regulation of TRP channels
PIK3CD; CYP4A10; PIK3CG; MAPK12; PLCB2; MAP2K3; CYP4A14; CYP2C70; ACCN5; MAPK8
Insulin signaling pathway
PRKACG; MAPK1; PTPRF; SOCS4; PRKAG2A; EXOC7; GRB2A; FOXO1A; MKNK2B; MAPK9
GnRH signaling pathway
CALM2B; CALM3; RAF1A; CALM2A; RAF1B; PLD1; GNAQ; CACNA1D; MAPK8B; CACNA1SA
Progesterone-mediated oocyte maturation
PLK1; BUB1; MAPK10; RPS6KAL; RAF1A; RPS6KA2; MAPK14B; PRKACB; AKT2L; PIK3CG
Prolactin signaling pathway
ESR1; PIK3R2; CSN2; MAPK11; NFKB1; CSH; ESR2; NEK3; MAPK1; INS1
Adipocytokine signaling pathway
ACSL1A; RXRAA; ACSL4A; MAPK8A; PRKCQ; PCK1; ACACB; G6PCA.2; CHUK; ADIPOQ
Type II diabetes mellitus
CACNA1G; INSR; PRKCZ; SOCS1; PIK3R2; SOCS4; MTOR; HK2; MAFA; HK1
Insulin resistance
RPS6KA6; GYS1; G6PC3; SLC2A2; INSRB; PTEN; SLC27A4; PRKAG3B; PPP1R3C; NFKBIAB
Non-alcoholic fatty liver disease (NAFLD)
MLXIPL; NFKB1; PIK3R2; TGFB1; IRS2; PIK3CG; NDUFC2-KCTD14; PRKAG2; INS; NDUFV3
Epithelial cell signaling in Helicobacter pylori infection
NFKBIA; MAPK11; IKBKG; MAPK12; ATP6V0D2; ATP6V0C; JAM2; ATP6V1D; MAPK13; CXCR2
Shigellosis
IL-8; FBXW11; ITGA5; PFN1; NFKBIA; ELMO2; WASF1; BTRC; CD44; ROCK1
Salmonella infection
MAPK11; CDC42; PKN1; CXCL8B.3; IL18; ROCK2B; CD14; ARPC5L; KLC1B; RAC1A
Pertussis
ITGB1; CALM1; RHOA; C4A; CALM3; CALM4; TNF; TRAF6; SERPING1; C4BPB
Chagas disease (American trypanosomiasis)
SMAD3; IFNGR1; IFNB1; MAPK12; C3; PLCB2; PLCB1; IL12B; IL6; FAS
Toxoplasmosis
TLR4; LAMB2; STAT3; HLA-DOA; Toxoplasma Gondii Microneme Protein MIC3; NOS2; SOCS1; TGFB2; BIRC3; IRGM
Tuberculosis
PPP3R1; FCGR4; BID; NFKB1; MRC2; TLR2; IRAK1; FCGR1; CASP9; APAF1
Hepatitis C
EIF2AK3; CLDN4; MAPK9; CLDN10; EIF3E; IFNA21; IFNA8; CLDN6; NR1H3; GRB2
Hepatitis B
PIK3R3; HSPG2; IFIH1; BAX; MAPK9; IFNAR1; TGFB1; RELA; OSTN; CREB3L1
Influenza A
DNAJC3; HSPA2; IFNA6; MAPK1; IFNA3; Fasl; FASLG; EP300; IFNA7; MAP2K3
HTLV-I infection
TRP53; ITGB2; PIK3R1; ETS1; CCNB2; Pdgfa&Pdgfb; TP53; HLA-C; RELA; EP300
Herpes simplex infection
IL12A; SRSF6A; C3A.1; IFNGR2; ARNTL; TP53; HLA-DOB; OAS1B; TNFB; STAT1
Epstein-Barr virus infection
CCNA1; PSMC2; TRAF3; BCL2; RIPK1; POLR3G; MAP3K14; HSPA1L; GSK3B; PSMC3
Pathways in cancer
BAX; FGF2; WNT16; RAF1; RAC3; SKP2; BAD; MSH6; BRAF; GNB4
Colorectal cancer
PIK3CG; FOS; PIK3CD; GSK3B; PIK3R5; AXIN1; RAC1; MAPK9; RAC2; APC
Pancreatic cancer
TGFB2; MAPK10; AKT2; TGFBR1; CASP9; PIK3CA; RAF1; TRP53; TGFB1; BRCA2
Choline metabolism in cancer
RALGDS; PDPK1; RAC2; WASF3; PRKCG; PDGFRB; MAP2K1; MAP2K2; PLA2G4A; RAF1

Protein Function

MAPK8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8 itself. We selected most functions MAPK8 had, and list some proteins which have the same functions with MAPK8. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UCK2; ABCB1A; RIPK4; NAGK; XRCC5; SLC14A2; PTK7; GRK7B; RECQL; ADCK1
Function JUN kinase activity
Related Protein MAPK9; MAPK8; ALPK2; MAPK10
Function enzyme binding
Related Protein PRTN3; TOP2A; CBS; PUS7; PARP4; Alb; TBP; CTNNBL1; TSPYL1; RARA
Function histone deacetylase binding
Related Protein TOP2A; MEF2D; PKN1; NUDT21; SUDS3; HDAC6; PARK2; ZFP932; HEY2; HIST1H1B
Function histone deacetylase regulator activity
Related Protein TRP53; NCOR1; TP53; MAPK8
Function protein binding
Related Protein SH3PXD2A; CFH; PHF19; PTPN2; C1R; ZC3HC1; SF3B4; CDC14B; DPCD; CCNK
Function protein serine/threonine kinase activity
Related Protein MAP2K2A; RPS6KC1; CDC42BPA; MINK1; MAPK4; PRKCE; OXSR1A; GRK7A; BCKDK; DAPK3

Interacting Protein

MAPK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8.
JUN; PIK3R1; MAPK8IP1; CRK; MAP2K7

MAPK8 Related Articles

Yabu, T; Shiba, H; et al. Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. CELL DEATH AND DIFFERENTIATION 22:258-273(2015).
Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).