mapk8
Share
  • Official Full Name
  • mitogen-activated protein kinase 8
  • Background
  • The c-Jun N-terminal protein kinases (JNKs) are a family of serine/threonine protein kinases of the mitogen-activated protein kinase (MAPK) group. JNKs, which are essential regulators of physiological and pathological processes, are involved in several diseases including diabetes, atherosclerosis, stroke, and Parkinson"s and Alzheimer"s diseases. The JNK family consists of three isoforms; JNK1 and JNK2, which are ubiquitous, and JNK3, which is present primarily in the heart, brain and testis. Differential splicing and exon use yield 10 isoforms of JNK. JNK1 is an important mediator of insulin resistance associated with obesity, but it is also indispensable for the intact cytoarchitecture of the brain.
  • Synonyms
  • MAPK8; mitogen-activated protein kinase 8; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; JNK-46; MAP kinase 8; OTTHUMP00000019552; OTTHUMP00000019555; OTTHUMP00000019556; OTTHUMP00000019558; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; EC 2.7.11.24; Stress-activated protein kinase JNK1
Cat.#:MAPK8-100HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK8, His-tagged
+Inquiry
Cat.#:MAPK8-156HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK8 protein, His/MBP-tagged
+Inquiry
Cat.#:MAPK8-29668THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK8
+Inquiry
Cat.#:MAPK8-518HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MAPK8
+Inquiry
Cat.#:MAPK8-554HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged
+Inquiry
Cat.#:MAPK8-751HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 8
+Inquiry
Cat.#:MAPK8-781HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human MAPK8, GST tagged
+Inquiry
Cat.#:MAPK8-9382HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAPK8, GST-tagged
+Inquiry
Cat.#:Mapk8-1550MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mapk8 protein, His & T7-tagged
+Inquiry
Cat.#:Mapk8-338M(Mouse)Tag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Mapk8, GST-tagged, Active
+Inquiry
Cat.#:Mapk8-1551RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mapk8 protein, His & T7-tagged
+Inquiry
Cat.#:MAPK8-612HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Mitogen-activated Protein Kinase 8, His-tagged
+Inquiry
Cat.#:Mapk8-689RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mitogen-activated Protein Kinase 8
+Inquiry
Cat.#:Mapk8-1051MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mitogen-Activated Protein Kinase 8, GST-Tagged
+Inquiry
Cat.#:MAPK8-4488HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK8 293 Cell Lysate
+Inquiry
Cat.#:MAPK8-4489HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MAPK8 293 Cell Lysate
+Inquiry

Involved Pathway

MAPK8 involved in several pathways and played different roles in them. We selected most pathways MAPK8 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PTPRR; TP53; HSP70L; MAP4K1; MAPKAPK3; MAP2K4; MAPK12B; PPM1BB; CDC25B; PLA2G4F
ErbB signaling pathway
MYCB; AKT1; NRG2; SHC4; PRKCG; PIK3CG; GRB2; CDKN1BB; PIK3R3A; SOS1
Ras signaling pathway
MAP2K1; CSF1; IKBKB; PLA2G4C; GNG3; KRAS; RAB5B; FASLG; RASAL3; PLA2G12A
cAMP signaling pathway
FOS; VAV3; FXYD2; HTR1A; BRAF; CNGA4; ATP1B4; MAP2K2; VIPR2; FSHB
FoxO signaling pathway
BCL6; HOMER2; CCNG2; IGF1; S1PR1; PRKAA1; PIK3R2; KLF2; GRB2; PRKAG2A
Sphingolipid signaling pathway
PLD2; BID; PPP2R5B; CERS5; LASS5; PRKCZ; MAPK3; SGPP2; PPP2R5C; GNAI2
Protein processing in endoplasmic reticulum
UBE2G2; HSP70; MAPK8B; ERO1LB; RNF5; CUL1; EIF2AK2; SEC23B; MOGS; DNAJC3
Wnt signaling pathway
LEF1; SOX17; PRKCBA; WNT11; FZD8B; FBXW11; CUL1B; NLK2; PRKACA; DKK4
Osteoclast differentiation
FCGR1; NCF2; TGFBR2; CSF1R; LILRA2; LILRA4; TRAF6; MAP2K1; TEC; MAP2K7
Focal adhesion
LAMB4; ACTB1; PTK2; PAK2A; COL2A1; ITGA9; HGF; BIRC2; SPP1; MYL12A
Toll-like receptor signaling pathway
IFNA4; TLR9; IFNAR2; IFNA21; RAC1A; TLR2-2; MAPK13; TLR5B; CCL3L1; MAP2K4
NOD-like receptor signaling pathway
NLRC4; HSP90AA1; CARD9; HSP90AB1; TNFAIP3; MAPK13; ERBB2IP; CASP5; BIRC2; NAIP7
RIG-I-like receptor signaling pathway
IFNA3; TP-1; OTUD5; MAVS; NFKBIAA; IL-8; TMEM173; TBKBP1; IFNA2; TRAF2
Fc epsilon RI signaling pathway
PIK3R3; GM-CSF; RAF1; RAC1; MAP2K6; AKT2; RAC2; KRAS; MAPK13; PIK3CA
TNF signaling pathway
RELA; IL1B; AKT1; NFKBIA; CFLAR; TRAF5; MAPK9; CREB3L2; MMP14; CXCL2
Neurotrophin signaling pathway
RPS6KA5; CAMK2B; RPS6KA2; RAC1; IRAK4; SHC2; NFKB1; Fasl; AKT1; SH2B2
Retrograde endocannabinoid signaling
PRKCG; MAPK3; DAGLB; GNG5; Adcy4; GABRP; SLC17A7; GNG4; GRIA1; RIMS1
Dopaminergic synapse
PPP2CA; CALM3; CALML3; GNGT2; DRD5; GNAI3; PLCB3; GNB1; GNG3; MAOB
Inflammatory mediator regulation of TRP channels
PLCG2; PTGER2; CYP2C39; PRKCE; CYP2C38; ACCN4; ITPR1; CYP2C50; TRPA1; PRKCQ
Insulin signaling pathway
GRB2B; MAPK9; FBP1A; PPP1R3CA; SREBF1; PPP1R3C; PRKAG1; PYGM; PRKAA2; PIK3R3
GnRH signaling pathway
PRKACAA; LHBETA1; PRKCB; CACNA1D; MAPK14B; MAPK12B; MMP14; MAP2K2A; ADCY2B; MAP2K2B
Progesterone-mediated oocyte maturation
PIK3CB; ANAPC2; PIK3R3; RPS6KA3; PLK1; MAPK8A; CDH1-A; Adcy4; HSP90AB1; IGF1R
Prolactin signaling pathway
RELA; FOXO3; NEK3; MAPK13; MAPK1; PRL; PIK3R2; PIK3CB; KRAS; LHB
Adipocytokine signaling pathway
TRAF2; PPARAB; STAT3; ADIPOQB; RXRBA; RXRAA; PRKAA2; STK11; RXRGB; PPARA
Type II diabetes mellitus
PKM; MAPK1; IRS1; PIK3R5; PIK3CG; SOCS3; HKDC1; PIK3R1; SOCS1; PDX1
Insulin resistance
RPS6KA3A; PTPRFB; PPARA; INSB; CD36; RPS6KA2; CREB3L1; PRKAG3; INS; PRKCQ
Non-alcoholic fatty liver disease (NAFLD)
NDUFA7; SDHB; COX8C; CASP8; SREBF1; GSK3A; SOCS3; MAPK8; RXRA; INSR
Epithelial cell signaling in Helicobacter pylori infection
ADAM17; MAPK12; NFKB1; ATP6V1C1; ATP6V1D; TCIRG1; CCL5; CXCL1; ATP6V0D1; ATP6V1G3
Shigellosis
WAS; WASF1; RELA; ITGB1; MAPK1; SRC; ELMO1; ROCK2; PFN4; WASL
Salmonella infection
ACTG1; CXCL3; IFNG; NOS2A; DYNC2H1; MAPK12B; NFKB1; ARPC5B; CCL4L1; DYNC1LI2
Pertussis
Il23a; Il12b; TLR4; C4BP; CALM4; Itgam&Itgb2; SERPING1; IRF1; MAPK12; ITGAM; MYD88
Chagas disease (American trypanosomiasis)
IL1B; IL6; CCL2; FASLG; RELA; GNAI1; C3; GNA14; TLR9; PIK3CA
Toxoplasmosis
MAPK9; LAMA5; HSPA1A; PIK3R5; HLA-DMA; HLA-DOA; PIK3CB; PIK3R2; GNAO1; H2-AB1
Tuberculosis
APAF1; CORO1A; MRC2; BCL10; MAPK3; CARD9; FCGR4; Cd209g; HLA-DPB1; NOS2
Hepatitis C
MAPK9; RAF1; TRADD; PPP2R2C; PDPK1; ARAF; PPP2CA; MAPK1; IFNA16; RXRA
Hepatitis B
TLR2; STAT3; IKBKB; YWHAB; IKBKE; Casp3; MAPK1; IFNA12; MAPK10; CASP9
Influenza A
MAPK12; HLA-DQA1; IL6; CXCL10; HLA-DRB5; HLA-DOB; NUP98; AKT1; IRF9; IFNA10
HTLV-I infection
APC; MYB; TCF3; PCNA; NFKB1; PDGFRB; ITGAL; ICAM1; IL15RA; HLA-DRB5
Herpes simplex infection
C3; SRSF9; MHC2A; OAS3; DAXX; IFNA16; MAPK8A; IRF7; HLA-C; HMGN1
Epstein-Barr virus infection
YWHAZ; CD40; TAB1; CD44; Fcer2a; PSMD2; MAP2K7; CD19; PSMD6; EP300
Pathways in cancer
HIF1A; ITGAV; RALGDS; FOXO1; WNT1; FGF10; WNT2B; MAP2K1; HSP90B1; GNG4
Colorectal cancer
MAPK3; PIK3R2; AKT2; TGFB2; SMAD2; MAP2K1; SMAD3; MAPK10; AXIN2; Casp3
Pancreatic cancer
RALBP1; RAC2; KRAS; BRAF; AKT1; RAD51; MAPK3; AKT2; CASP9; MAPK1
Choline metabolism in cancer
RAC2; TSC2; RPS6KB2; WAS; RPS6KB1; SOS1; PRKCA; EGF; PIK3R5; PLD1

Protein Function

MAPK8 has several biochemical functions, for example, ATP binding, JUN kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK8 itself. We selected most functions MAPK8 had, and list some proteins which have the same functions with MAPK8. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein EPHB4B; ILK; KATNA1; STK40; CKMB; CAMK4; DCAKD; P2RX4; RPS6KB2; INSRA
Function JUN kinase activity
Related Protein ALPK2; MAPK8; MAPK10; MAPK9
Function enzyme binding
Related Protein STC2; BCL10; DAXX; NLRP1; DAOA; RYR2; CAV1; MTA1; LAMP2; DNMT3L
Function histone deacetylase binding
Related Protein SP2; SOD3; NACC2; NIPBL; MAGEA2; HDAC10; TOP2A; DNMT3B; XBP1; RAD9
Function histone deacetylase regulator activity
Related Protein TRP53; TP53; MAPK8; NCOR1
Function protein binding
Related Protein EXOC4; SIRT7; SAMD4A; SIAH1; BSG; CCS; MMP2; SUCLA2; PIN1; GLMN
Function protein serine/threonine kinase activity
Related Protein STK31; MAPK14A; PAK2B; MAPK14; CAMK1GB; PRKCBA; SMOK3A; IRAK2; PRKCE; ADCK4

Interacting Protein

MAPK8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK8.
JUN; PIK3R1; MAPK8IP1; CRK; MAP2K7

MAPK8 Related Articles

Yabu, T; Shiba, H; et al. Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling. CELL DEATH AND DIFFERENTIATION 22:258-273(2015).
Lou, Q; Zhang, W; et al. The C-Type Lectin OCILRP2 Costimulates EL4 T Cell Activation via the DAP12-Raf-MAP Kinase Pathway. PLOS ONE 9:-(2014).