Recombinant Rat Mitogen-activated Protein Kinase 8

• Cat.No.: Mapk8-689R
• Product Overview: Recombinant rat Mapk8 is expressed inE. coli.

Specification

• Cat. No.: Mapk8-689R
• Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway.
• Source: E. coli.
• Form: Liquid.
• Formulation: In 150 mM NaCl, 50 mM Tris-HCl, 10 mM β-mercaptoethanol, 1 mM imidazole, 1 mM Mg (OAc) 2, 500 nM ATP, 10% glycerol, pH 7.5.
• Molar Mass: 48000Da.
• Specific Activity: ≥30 units/mg protein.
• Unit Definition: One unit is defined as the amount of enzyme that will phosphorylate 1.0 nmol GST-c-Jun (1-79) Substrate per min at 30°C, pH 7.5.
• Purity: ≥90% by SDS-PAGE.
• Storage: ≤ -70oC. Ship: Dry Ice Only.
• Tag: Non

Gene Information

• Gene Name: Mapk8 mitogen-activated protein kinase 8 [ Rattus norvegicus ]
• Synonyms:
  Mapk8; mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; SAPK gamma; c-Jun N-terminal kinase 1; c-jun NH2-terminal kinase; p54 gamma; stress-activated protein kinase JNK1; JNK
• Gene ID: 116554
• mRNA Refseq: XM_341399
• Protein Refseq: XP_341400
• UniProt ID: P49185
• Chromosome Location: 16p16
• Pathway: ErbB signaling pathway; Fc epsilon RI signaling pathway; Focal adhesion; Insulin signaling pathway; NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Progesterone-mediated oocyte maturation; Toll-like receptor signaling pathway; Wnt signaling pathway
• Function: ATP binding; JUN kinase activity; MAP kinase activity; protein serine/threonine kinase activity; transferase activity

Reviews

04/18/2020

I am confident that the MAPK8 protein will unravel crucial insights into molecular mechanisms, greatly enhancing the significance and impact of my scientific investigations.

12/02/2016

By relying on the MAPK8 protein, I can approach my research with unwavering confidence in its quality and the unparalleled support extended by its manufacturer.

02/25/2016

the manufacturer's commitment to providing excellent technical support adds an additional layer of confidence to my choice of the MAPK8 protein.

Q&As

Is MAPK8 involved in inflammatory processes?

Yes, MAPK8 is implicated in regulating inflammation and immune responses, contributing to the pathogenesis of inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.

Can MAPK8 inhibitors potentially be used in treating Alzheimer's disease?

Research suggests that MAPK8 inhibitors might have therapeutic potential in managing Alzheimer's disease by modulating neuronal responses and reducing neuroinflammation.

How is MAPK8 protein expression assessed in clinical research?

MAPK8 protein expression is often assessed using techniques like immunohistochemistry, western blotting, or quantitative PCR in clinical samples to understand its role in diseases.

How does MAPK8 influence neuronal function and neurodegeneration?

MAPK8 activation is associated with neuronal stress responses and plays a role in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases.

How does MAPK8 influence cellular apoptosis?

MAPK8 signaling pathways can either promote or suppress apoptosis depending on the cellular context and stimuli, making it a potential target for regulating cell death in disease settings.