Recombinant Rat Mitogen-activated Protein Kinase 8
Cat.No. : | Mapk8-689R |
Product Overview : | Recombinant rat Mapk8 is expressed inE. coli. |
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Cat. No. : | Mapk8-689R |
Description : | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. |
Source : | E. coli. |
Form : | Liquid. |
Formulation : | In 150 mM NaCl, 50 mM Tris-HCl, 10 mM β-mercaptoethanol, 1 mM imidazole, 1 mM Mg (OAc) 2, 500 nM ATP, 10% glycerol, pH 7.5. |
Molar Mass : | 48000Da. |
Specific Activity : | ≥30 units/mg protein. |
Unit Definition : | One unit is defined as the amount of enzyme that will phosphorylate 1.0 nmol GST-c-Jun (1-79) Substrate per min at 30°C, pH 7.5. |
Purity : | ≥90% by SDS-PAGE. |
Storage : | ≤ -70oC. Ship: Dry Ice Only. |
Tag : | Non |
Gene Name : | Mapk8 mitogen-activated protein kinase 8 [ Rattus norvegicus ] |
Synonyms : | Mapk8; mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; SAPK gamma; c-Jun N-terminal kinase 1; c-jun NH2-terminal kinase; p54 gamma; stress-activated protein kinase JNK1; JNK |
Gene ID : | 116554 |
mRNA Refseq : | XM_341399 |
Protein Refseq : | XP_341400 |
UniProt ID : | P49185 |
Chromosome Location : | 16p16 |
Pathway : | ErbB signaling pathway; Fc epsilon RI signaling pathway; Focal adhesion; Insulin signaling pathway; NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Progesterone-mediated oocyte maturation; Toll-like receptor signaling pathway; Wnt signaling pathway |
Function : | ATP binding; JUN kinase activity; MAP kinase activity; protein serine/threonine kinase activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
MAPK8-1137H | Recombinant Human MAPK8 Protein (S2-E364), His tagged | +Inquiry |
MAPK8-2420H | Recombinant Human MAPK8 Protein, His-tagged | +Inquiry |
Mapk8-3945M | Recombinant Mouse Mapk8 Protein, Myc/DDK-tagged | +Inquiry |
MAPK8-781H | Recombinant Human MAPK8 protein(Met1-Arg427), GST-tagged | +Inquiry |
MAPK8-3435H | Recombinant Human MAPK8 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
MAPK8-4488HCL | Recombinant Human MAPK8 293 Cell Lysate | +Inquiry |
MAPK8-4489HCL | Recombinant Human MAPK8 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewI am confident that the MAPK8 protein will unravel crucial insights into molecular mechanisms, greatly enhancing the significance and impact of my scientific investigations.
By relying on the MAPK8 protein, I can approach my research with unwavering confidence in its quality and the unparalleled support extended by its manufacturer.
the manufacturer's commitment to providing excellent technical support adds an additional layer of confidence to my choice of the MAPK8 protein.
Q&As (5)
Ask a questionYes, MAPK8 is implicated in regulating inflammation and immune responses, contributing to the pathogenesis of inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.
Research suggests that MAPK8 inhibitors might have therapeutic potential in managing Alzheimer's disease by modulating neuronal responses and reducing neuroinflammation.
MAPK8 protein expression is often assessed using techniques like immunohistochemistry, western blotting, or quantitative PCR in clinical samples to understand its role in diseases.
MAPK8 activation is associated with neuronal stress responses and plays a role in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases.
MAPK8 signaling pathways can either promote or suppress apoptosis depending on the cellular context and stimuli, making it a potential target for regulating cell death in disease settings.
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