Recombinant Rat Mitogen-activated Protein Kinase 8

Cat.No. : Mapk8-689R
Product Overview : Recombinant rat Mapk8 is expressed inE. coli.
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Cat. No. : Mapk8-689R
Description : The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway.
Source : E. coli.
Form : Liquid.
Formulation : In 150 mM NaCl, 50 mM Tris-HCl, 10 mM β-mercaptoethanol, 1 mM imidazole, 1 mM Mg (OAc) 2, 500 nM ATP, 10% glycerol, pH 7.5.
Molar Mass : 48000Da.
Specific Activity : ≥30 units/mg protein.
Unit Definition : One unit is defined as the amount of enzyme that will phosphorylate 1.0 nmol GST-c-Jun (1-79) Substrate per min at 30°C, pH 7.5.
Purity : ≥90% by SDS-PAGE.
Storage : ≤ -70oC. Ship: Dry Ice Only.
Gene Name : Mapk8 mitogen-activated protein kinase 8 [ Rattus norvegicus ]
Synonyms :
Mapk8; mitogen-activated protein kinase 8; MAP kinase 8; MAPK 8; SAPK gamma; c-Jun N-terminal kinase 1; c-jun NH2-terminal kinase; p54 gamma; stress-activated protein kinase JNK1; JNK
Gene ID : 116554
mRNA Refseq : XM_341399
Protein Refseq : XP_341400
UniProt ID : P49185
Chromosome Location : 16p16
Pathway : ErbB signaling pathway; Fc epsilon RI signaling pathway; Focal adhesion; Insulin signaling pathway; NOD-like receptor signaling pathway; Neurotrophin signaling pathway; Progesterone-mediated oocyte maturation; Toll-like receptor signaling pathway; Wnt signaling pathway
Function : ATP binding; JUN kinase activity; MAP kinase activity; protein serine/threonine kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Is MAPK8 involved in inflammatory processes? 02/23/2023

Yes, MAPK8 is implicated in regulating inflammation and immune responses, contributing to the pathogenesis of inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.

Can MAPK8 inhibitors potentially be used in treating Alzheimer's disease? 05/18/2022

Research suggests that MAPK8 inhibitors might have therapeutic potential in managing Alzheimer's disease by modulating neuronal responses and reducing neuroinflammation.

How is MAPK8 protein expression assessed in clinical research? 07/21/2020

MAPK8 protein expression is often assessed using techniques like immunohistochemistry, western blotting, or quantitative PCR in clinical samples to understand its role in diseases.

How does MAPK8 influence neuronal function and neurodegeneration? 08/01/2019

MAPK8 activation is associated with neuronal stress responses and plays a role in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases.

How does MAPK8 influence cellular apoptosis? 06/09/2016

MAPK8 signaling pathways can either promote or suppress apoptosis depending on the cellular context and stimuli, making it a potential target for regulating cell death in disease settings.

Customer Reviews (3)

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Reviews
04/18/2020

    I am confident that the MAPK8 protein will unravel crucial insights into molecular mechanisms, greatly enhancing the significance and impact of my scientific investigations.

    12/02/2016

      By relying on the MAPK8 protein, I can approach my research with unwavering confidence in its quality and the unparalleled support extended by its manufacturer.

      02/25/2016

        the manufacturer's commitment to providing excellent technical support adds an additional layer of confidence to my choice of the MAPK8 protein.

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