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Recombinant Human Mitogen-activated Protein Kinase 8

Cat.No. : MAPK8-751H
Product Overview : Recombinant Human Human Mitogen-activated Protein Kinase 8 Amino acidsM1-Q384, is expressed inE.coli.
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Cat. No. : MAPK8-751H
Description : Mitogen-activated protein kinase 8 is an enzyme that in humans is encoded by the MAPK8 gene. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development.
Source : E.coli.
Purification : Immobilized Metal Affinity Chromatography.
Product Identity : JNK1 was confirmed as JNK1 by mass spectroscopy LC-ESI-MS/MS.
MW : 44,292 Da.
Storage Buffer : 50 mM Tris-HCl, pH 7.5; 100 mM NaCl, 5 mM DTT, 20% glycerol.
Concentration : 0.513 μg/μl.
Specific Activity : 2514 pmol/μg×min.
Storage : -80°C. Avoid repeated freeze-thaw cycles!
Gene Name : MAPK8 mitogen-activated protein kinase 8 [ Homo sapiens ]
Synonyms :
MAPK8; mitogen-activated protein kinase 8; JNK-46; JNK1 alpha protein kinase; JNK1 beta protein kinase; JUN N-terminal kinase; MAP kinase 8; MAPK 8; OTTHUMP00000019552; c-Jun N-terminal kinase 1; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; protein kinase JNK1; stress-activated protein kinase 1; stress-activated protein kinase JNK1; JNK; JNK1; PRKM8; SAPK1; JNK1A2; JNK21B1/2; EC 2.7.11.24
Gene ID : 5599
mRNA Refseq : NM_002750
Protein Refseq : NP_002741
MIM : 601158
UniProt ID : P45983
Chromosome Location : 10q11.22
Pathway : Colorectal cancer; Epithelial cell signaling in Helicobacter pylori infection; ErbB signaling pathway; Focal adhesion; MAPK signaling pathway; NOD-like receptor signaling pathway; Pathways in cancer; Progesterone-mediated oocyte maturation; Type II diabetes mellitus; Wnt signaling pathway
Function : ATP binding;JUN kinase activity; MAP kinase activity; kinase activity; protein serine/threonine kinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is MAPK8 involved in inflammatory processes? 02/23/2023

Yes, MAPK8 is implicated in regulating inflammation and immune responses, contributing to the pathogenesis of inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.

Can MAPK8 inhibitors potentially be used in treating Alzheimer's disease? 05/18/2022

Research suggests that MAPK8 inhibitors might have therapeutic potential in managing Alzheimer's disease by modulating neuronal responses and reducing neuroinflammation.

How is MAPK8 protein expression assessed in clinical research? 07/21/2020

MAPK8 protein expression is often assessed using techniques like immunohistochemistry, western blotting, or quantitative PCR in clinical samples to understand its role in diseases.

How does MAPK8 influence neuronal function and neurodegeneration? 08/01/2019

MAPK8 activation is associated with neuronal stress responses and plays a role in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases.

How does MAPK8 influence cellular apoptosis? 06/09/2016

MAPK8 signaling pathways can either promote or suppress apoptosis depending on the cellular context and stimuli, making it a potential target for regulating cell death in disease settings.

Customer Reviews (3)

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Reviews
04/18/2020

    I am confident that the MAPK8 protein will unravel crucial insights into molecular mechanisms, greatly enhancing the significance and impact of my scientific investigations.

    12/02/2016

      By relying on the MAPK8 protein, I can approach my research with unwavering confidence in its quality and the unparalleled support extended by its manufacturer.

      02/25/2016

        the manufacturer's commitment to providing excellent technical support adds an additional layer of confidence to my choice of the MAPK8 protein.

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