Recombinant Human MAPK8, GST-tagged

• Cat.No.: MAPK8-9382H
• Product Overview: Recombinant Human MAPK8 was expressed as gst-tagged fusion protein by E.Coli and puri?ed by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: True
• Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.
• AA Sequence: 1-427aa
• Storage: The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: MAPK8 mitogen-activated protein kinase 8 [ Homo sapiens (human) ]
• Official Symbol: MAPK8
• Synonyms: MAPK8; JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2; mitogen-activated protein kinase 8; mitogen-activated protein kinase 8; MAP kinase 8; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; stress-activated protein kinase 1c; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; NP_001265476.1; EC 2.7.11.24; NP_001265477.1; NP_002741.1; NP_620634.1; NP_620637.1
• Gene ID: 5599
• mRNA Refseq: NM_001278547
• Protein Refseq: NP_001265476
• MIM: 601158
• UniProt ID: P45983
• Chromosome Location: 10q11.22
• Pathway: AGE/RAGE pathway; Activated TLR4 signalling; B Cell Receptor Signaling Pathway
• Function: ATP binding; JUN kinase activity; histone deacetylase binding