Recombinant Human MAPK8, GST-tagged
Cat.No. : | MAPK8-9382H |
Product Overview : | Recombinant Human MAPK8 was expressed as gst-tagged fusion protein by E.Coli and puri?ed by GSH-sepharose. |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | True |
AA Sequence : | 1-427aa |
Storage : | The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | MAPK8 mitogen-activated protein kinase 8 [ Homo sapiens (human) ] |
Official Symbol : | MAPK8 |
Synonyms : | MAPK8; JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2; mitogen-activated protein kinase 8; mitogen-activated protein kinase 8; MAP kinase 8; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; stress-activated protein kinase 1c; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; NP_001265476.1; EC 2.7.11.24; NP_001265477.1; NP_002741.1; NP_620634.1; NP_620637.1 |
Gene ID : | 5599 |
mRNA Refseq : | NM_001278547 |
Protein Refseq : | NP_001265476 |
MIM : | 601158 |
UniProt ID : | P45983 |
Chromosome Location : | 10q11.22 |
Pathway : | AGE/RAGE pathway; Activated TLR4 signalling; B Cell Receptor Signaling Pathway |
Function : | ATP binding; JUN kinase activity; histone deacetylase binding |
Products Types
◆ Recombinant Protein | ||
MAPK8-1137H | Recombinant Human MAPK8 Protein (S2-E364), His tagged | +Inquiry |
MAPK8-2420H | Recombinant Human MAPK8 Protein, His-tagged | +Inquiry |
MAPK8-3435H | Recombinant Human MAPK8 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAPK8-1136H | Recombinant Human MAPK8 Protein (S2-E364), Tag Free | +Inquiry |
Mapk8-3945M | Recombinant Mouse Mapk8 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
MAPK8-4489HCL | Recombinant Human MAPK8 293 Cell Lysate | +Inquiry |
MAPK8-4488HCL | Recombinant Human MAPK8 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, MAPK8 is implicated in regulating inflammation and immune responses, contributing to the pathogenesis of inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.
Research suggests that MAPK8 inhibitors might have therapeutic potential in managing Alzheimer's disease by modulating neuronal responses and reducing neuroinflammation.
MAPK8 protein expression is often assessed using techniques like immunohistochemistry, western blotting, or quantitative PCR in clinical samples to understand its role in diseases.
MAPK8 activation is associated with neuronal stress responses and plays a role in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases.
MAPK8 signaling pathways can either promote or suppress apoptosis depending on the cellular context and stimuli, making it a potential target for regulating cell death in disease settings.
Customer Reviews (3)
Write a reviewI am confident that the MAPK8 protein will unravel crucial insights into molecular mechanisms, greatly enhancing the significance and impact of my scientific investigations.
By relying on the MAPK8 protein, I can approach my research with unwavering confidence in its quality and the unparalleled support extended by its manufacturer.
the manufacturer's commitment to providing excellent technical support adds an additional layer of confidence to my choice of the MAPK8 protein.
Ask a Question for All MAPK8 Products
Required fields are marked with *
My Review for All MAPK8 Products
Required fields are marked with *
Inquiry Basket