MARK2

  • Official Full Name

    MAP/microtubule affinity-regulating kinase 2

  • Overview

    Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking. The MARK (MAP/microtubule affinity-regulating kinases) family (

  • Synonyms

    MARK2;MAP/microtubule affinity-regulating kinase 2;ELKL motif kinase , EMK1;serine/threonine-protein kinase MARK2;ELKL motif kinase 1;PAR 1;Par1b;protein serine/threonine kinase;Ser/Thr protein kinase PAR 1B;serine/threonine kinase;PAR1 homolog

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • Sf21 Cells
  • His
  • GST
  • Non
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    MARK2 involved in several pathways and played different roles in them. We selected most pathways MARK2 participated on our site, such as LKB1 signaling events,Notch signaling pathway,Regulation of Microtubule Cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TNF-alpha/NF-kB Signaling Pathway SMARCE1,KPNA6,ZFAND5,DAP,NKIRAS2,LRPPRC,G3BP2,CSNK2A1P,SMARCB1,TANK
    Regulation of Microtubule Cytoskeleton TPPP,CFL2,MAP1B,DPYSL2,MARK1,TESK2
    Notch signaling pathway DTX2,DTX3L,NOTCH1,JAG1A,PTCRA,NOTCH2,RBPJ,NOTCH1A,TLE3A,DVL3A
    LKB1 signaling events CTSD,MAP2,MARK4,CDC37,SIK3,STK11IP
    Wnt Signaling Pathway NetPath HIPK2,NR5A1,SOX1,TFAP2A,TCF4,MAP1B,ROR2,TAX1BP3,CRYBB2,PAX2

    Protein Function

    MARK2 has several biochemical functions, for example, ATP binding,lipid binding,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MARK2 itself. We selected most functions MARK2 had, and list some proteins which have the same functions with MARK2. You can find most of the proteins on our site.

    Function Related Protein
    protein kinase activator activity PIK3CA,AGAP2,MT3,MAPK8IP2,PRKAG2,TOM1L1,DUSP19,NKX3-1,CAB39,WNT11
    tau-protein kinase activity PHKG1,GSK3B,CSNK1D,GSK3A,MARK1,MARK4,PHKG2,CDK5,PRKAA1
    lipid binding SH3GL1,PITPNM2,ACBD5,BPIFB4,PCYT1A,RBP7B,PTGS2,UNC119,NME4,STARD10
    poly(A) RNA binding ALKBH5,CHTOP,RRP9,ARL6IP4,PARN,SNIP1,PRRC2A,RPL27,SART3,C1orf53
    magnesium ion binding PGM3,FARS2,WEE1,TSSK4,ATP11A,MAPK12,NLK,AASDHPPT,S100P,NT5C1AA
    ATP binding KIF6,MYH6,XRCC2,ARAF,SIK2,MAPK4,RIOK2,SGK3,CMPK2,MAP2K4A
    protein serine/threonine kinase activity CDK14,ZAK,RPS6KAL,GM711,PSKH2,CDK11B,MAPK1,ALPK2,STK4,PRKACAA
    protein binding Unc5b,MBD3,PLEK,USP17L2,SH2D2A,TDP2,PRDM13,BFAR,DAXX,TBC1D15

    Interacting Protein

    MARK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARK2.

    YWHAH;YWHAZ;MTCL1;MAPT

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