mark2
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  • Official Full Name
  • MAP/microtubule affinity-regulating kinase 2
  • Background
  • Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking. The MARK (MAP/microtubule affinity-regulating kinases) family (
  • Synonyms
  • MARK2; MAP/microtubule affinity-regulating kinase 2; ELKL motif kinase , EMK1; serine/threonine-protein kinase MARK2; ELKL motif kinase 1; PAR 1; Par1b; protein serine/threonine kinase; Ser/Thr protein kinase PAR 1B; serine/threonine kinase; PAR1 homolog
Cat.#:MARK2-781HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MARK2 Protein, His-tagged
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Cat.#:MARK2-9568MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MARK2 Protein
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Cat.#:MARK2-3589RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MARK2 Protein
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Cat.#:MARK2-1057HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAP/Microtubule Affinity-Regulating Kinase 2, GST-tagged
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Cat.#:MARK2-1060HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MARK2 cell lysate
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Involved Pathway

MARK2 involved in several pathways and played different roles in them. We selected most pathways MARK2 participated on our site, such as LKB1 signaling events, Notch signaling pathway, Regulation of Microtubule Cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
LKB1 signaling events
MARK2; MARK4; MAP2; SIK3; CTSD; STK11IP; CDC37
Notch signaling pathway
MIB1; RBPJA; LNX1; LFNG; ADAM12; DTX3L; DLL1; CNTN6; CTBP1; MARK2
Regulation of Microtubule Cytoskeleton
MAP1B; DPYSL2; TPPP; MARK1; MARK2; CFL2; TESK2
TNF-alpha/NF-kB Signaling Pathway
TANK; PFDN2; PPP1R13L; COPS3; TXLNA; TNIP1; CSNK2A1P; PDCD2; KTN1; TRPC4AP
Wnt Signaling Pathway NetPath
ROR2; SALL1; BCL9; PAX2; TAX1BP3; SOX1; NR5A1; CRYBB2; TCF4; BRD7

Protein Function

MARK2 has several biochemical functions, for example, ATP binding, lipid binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MARK2 itself. We selected most functions MARK2 had, and list some proteins which have the same functions with MARK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein FPGS; PKN1B; TDRD12; ENTPD2; FARSB; TNIK; DICER1; DDX42; DCLK2; TTLL12
Function lipid binding
Related Protein UNC119B; SNX10A; COQ9; GLTP; RUFY1; PITPNA; APOA4B.1; APODA.1; ALOX15B; STARD13
Function magnesium ion binding
Related Protein PPM1BB; MARK2; ERN1; SNCA; PPM1NB; STK11; CDC42BPA; RRAGC; PGM2; DYRK2
Function poly(A) RNA binding
Related Protein PIGC; SUMO2; ASS1; ATXN2L; KCTD12; TDRD9; TOP1; SNRNP40; SLBP; SART3
Function protein binding
Related Protein ZFYVE16; QARS; PYY; BUC; CTNNBIP1; KIF2C; PTRH2; VAMP1; COBL; Chrng
Function protein kinase activator activity
Related Protein NKX3; MAPK8IP2; PIK3CA; MT3; STRADA; AGAP2; NCKAP1L; CAB39; STK11; DBF4B
Function protein serine/threonine kinase activity
Related Protein AURKA; CAMK2G1; HIPK3; PHKG1A; STK19; CDK16; MLKL; SMOK3B; CSNK2A1; MAP3K11
Function tau-protein kinase activity
Related Protein CSNK1D; PRKAA1; GSK3A; MARK1; CDK5; MARK4; PHKG1; GSK3B; PHKG2; MARK2

Interacting Protein

MARK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARK2.
YWHAH; YWHAZ; MTCL1; MAPT