MARK2

  • Official Full Name

    MAP/microtubule affinity-regulating kinase 2

  • Overview

    Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking. The MARK (MAP/microtubule affinity-regulating kinases) family (

  • Synonyms

    MARK2;MAP/microtubule affinity-regulating kinase 2;ELKL motif kinase , EMK1;serine/threonine-protein kinase MARK2;ELKL motif kinase 1;PAR 1;Par1b;protein serine/threonine kinase;Ser/Thr protein kinase PAR 1B;serine/threonine kinase;PAR1 homolog

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • Sf21 Cells
  • His
  • GST
  • Non
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    MARK2 involved in several pathways and played different roles in them. We selected most pathways MARK2 participated on our site, such as LKB1 signaling events,Notch signaling pathway,Regulation of Microtubule Cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Wnt Signaling Pathway NetPath HIPK2,CRYBB2,BCL9,MTAP1B,BRD7,SOX1,MAP1B,ANKRD6,CSNK2A1P,ROR2
    TNF-alpha/NF-kB Signaling Pathway TRPC4AP,PDCD2,G3BP2,DAP,NR2C2,KIAA1967,DPF2,TNIP1,AKAP8,KTN1
    Notch signaling pathway NCSTN,NCOR2,CTBP2A,NOTCH1A,MFNG,DVL3A,DLC,APH1B,DTX1,HDAC1
    Regulation of Microtubule Cytoskeleton MAP1B,TPPP,MARK1,DPYSL2,TESK2,CFL2
    LKB1 signaling events MARK4,CDC37,MAP2,CTSD,STK11IP,SIK3

    Protein Function

    MARK2 has several biochemical functions, for example, ATP binding,lipid binding,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MARK2 itself. We selected most functions MARK2 had, and list some proteins which have the same functions with MARK2. You can find most of the proteins on our site.

    Function Related Protein
    protein serine/threonine kinase activity SGK1,DSTYK,EIF2AK2,NEK8,PHKG2,PRKCBB,MAP4K6,VRK3,STK19,PSKH2
    protein kinase activator activity MAPK8IP2,EPO,AGAP2,MT3,NKX3,NKX3-1,PIK3CA,DAXX,PRKAG2,STRADA
    protein binding SEMA6A,ADCYAP1,ASXL1,NAPA,EML1,LTBP2,RANBP2,SMARCA5,PIK3CG,VIPAS39
    poly(A) RNA binding ETF1A,TBCA,SREK1,ZYX,KHDRBS1,TBL2,RRP8,MRPL9,ZFP346,RNPS1
    ATP binding LATS1,PTK2BB,IKBKB,HSPA13,CBWD2,DDX55,RPS6KA1,ERBB4,ACVR2A,MYO9B
    lipid binding O3far1,SNX10B,FFAR1,APOL2,INPP4B,BPIFA3,CETP,GLTP,PSAP,CRABP2B
    tau-protein kinase activity PHKG2,CSNK1D,PRKAA1,MARK4,CDK5,PHKG1,GSK3A,GSK3B,MARK1
    magnesium ion binding HPRT1L,STK38L,ATP9A,PGM3,FAN1,RPS6KA1,COMTA,MTHFD2,ENO1B,PPM1NB

    Interacting Protein

    MARK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARK2.

    YWHAH;YWHAZ;MTCL1;MAPT

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