mark2
Share
  • Official Full Name
  • MAP/microtubule affinity-regulating kinase 2
  • Background
  • Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking. The MARK (MAP/microtubule affinity-regulating kinases) family (
  • Synonyms
  • MARK2; MAP/microtubule affinity-regulating kinase 2; ELKL motif kinase , EMK1; serine/threonine-protein kinase MARK2; ELKL motif kinase 1; PAR 1; Par1b; protein serine/threonine kinase; Ser/Thr protein kinase PAR 1B; serine/threonine kinase; PAR1 homolog
Cat.#:MARK2-781HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MARK2 Protein, His-tagged
+Inquiry
Cat.#:MARK2-9568MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MARK2 Protein
+Inquiry
Cat.#:MARK2-3589RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MARK2 Protein
+Inquiry
Cat.#:MARK2-1057HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAP/Microtubule Affinity-Regulating Kinase 2, GST-tagged
+Inquiry
Cat.#:MARK2-1060HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MARK2 cell lysate
+Inquiry

Involved Pathway

MARK2 involved in several pathways and played different roles in them. We selected most pathways MARK2 participated on our site, such as LKB1 signaling events, Notch signaling pathway, Regulation of Microtubule Cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARK2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
LKB1 signaling events
MAP2; CDC37; CTSD; MARK4; STK11IP; SIK3; MARK2
Notch signaling pathway
CIR1; NOTCH3; HER15.1; KAT2B; HER9; LFNG; ADAM17; DLL1; DNER; DVL3A
Regulation of Microtubule Cytoskeleton
MAP1B; MARK2; TESK2; TPPP; CFL2; DPYSL2; MARK1
TNF-alpha/NF-kB Signaling Pathway
USP2; MCC; DDX3X; CSNK2A1P; KPNA6; SMARCB1; PFDN2; NR2C2; TANK; G3BP2
Wnt Signaling Pathway NetPath
BCL9; SOX1; TAX1BP3; CSNK2A1P; MARK2; TFAP2A; BRD7; PAX2; CRYBB2; ROR2

Protein Function

MARK2 has several biochemical functions, for example, ATP binding, lipid binding, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MARK2 itself. We selected most functions MARK2 had, and list some proteins which have the same functions with MARK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein AKT2L; MSH5; PRKCD; TTK; PLK1; MAPK1; NIM1K; DDX42; ABCG2C; MAPK14A
Function lipid binding
Related Protein RASGRP2; APOA5; SNX10B; APOL6; FNBP1; OSBPL9; BPIFB4; BPIFB1; STARD8; AMER2
Function magnesium ion binding
Related Protein PRPS1B; PKMA; STK38; NUDT18; ADSS; RPS6KAL; DXO; PKMB; PDXP; SERPINB1A
Function poly(A) RNA binding
Related Protein FAM98C; CEBPZ; MRPS5; DDX52; RBPMS; CDC42EP4; HSPD1; RPS27.2; CORO1A; G3BP2
Function protein binding
Related Protein DCUN1D1; CDK10; NAPA; BCL2L11; KLF12; EMP3; IFRD2; AKT1; FANCL; PACS1
Function protein kinase activator activity
Related Protein DBF4B; DAXX; MARK2; NKX3-1; DUSP19; WNT11; STK11; TOM1L1; MT3; AGAP2
Function protein serine/threonine kinase activity
Related Protein MARK3; BMPR2B; HIPK1; BMPR1A; DYRK4; CAMK2D; MASTL; CDK1; CDK11A; CSNK1G2A
Function tau-protein kinase activity
Related Protein MARK1; PHKG2; GSK3B; MARK2; CDK5; GSK3A; PHKG1; PRKAA1; CSNK1D; MARK4

Interacting Protein

MARK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARK2.
YWHAH; YWHAZ; MTCL1; MAPT