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MBD2

Official Full Name

methyl-CpG binding domain protein 2
Overview

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

MBD2; methyl-CpG binding domain protein 2; methyl-CpG-binding domain protein 2; demethylase; DMTase; NY-CO-41; DKFZp586O0821;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MBD2-405H	Recombinant Human MBD2 Protein, His-tagged	E.coli	His	Glu145~Ala411	Inquiry
Zebrafish	MBD2-12037Z	Recombinant Zebrafish MBD2	Mammalian Cell	His		Inquiry
Chicken	MBD2-1893C	Recombinant Chicken MBD2	Mammalian Cell	His		Inquiry
	Kit-0541	MBD2 Binding Activity/Inhibition Assay Kit		N/A		Inquiry

MBD2 Related Articles

MBD2 involved in several pathways and played different roles in them. We selected most pathways MBD2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with MBD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

MBD2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by MBD2 itself. We selected most functions MBD2 had, and list some proteins which have the same functions with MBD2. You can find most of the proteins on our site.

Function	Related Protein

MBD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MBD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MBD2.

Stefanska, B; Suderman, M; et al. Transcription onset of genes critical in liver carcinogenesis is epigenetically regulated by methylated DNA-binding protein MBD2. CARCINOGENESIS 34:2738-2749(2013).

Gopisetty, G; Xu, J; et al. Epigenetic regulation of CD133/PROM1 expression in glioma stem cells by Sp1/myc and promoter methylation. ONCOGENE 32:3119-3129(2013).