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METTL1

  • Official Full Name

    methyltransferase like 1

  • Overview

    This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X.
  • Synonyms

    METTL1; methyltransferase like 1; C12orf1, methyltransferase like 1; tRNA (guanine-N(7)-)-methyltransferase; TRM8; C12orf1; D1075 like gene product; FLJ95748; Methyltransferase like protein 1; tRNA (guanine N(7) ) methyltransferase; tRNA(m7G46) methyltransferase; YDL201w; D1075-like gene product; methyltransferase-like 1; tRNA(m7G46)-methyltransferase; methyltransferase-like protein 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human METTL1-866H Recombinant Human METTL1 protein, His-tagged E.coli His Asp32-Gln265
Human METTL1-29205TH Recombinant Human METTL1, His-tagged E.coli His 276 amino acids
Human METTL1-953H Recombinant Human METTL1, His-tagged, 33.6kDa (296aa) E.coli His
Human METTL1-1080HCL Recombinant Human METTL1 cell lysate N/A
Human METTL1-946H Recombinant Human METTL1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human METTL1-4411H Recombinant Human METTL1 Protein, GST-tagged Wheat Germ GST
Human METTL1-6157HF Recombinant Full Length Human METTL1 Protein, GST-tagged In Vitro Cell Free System GST 276 amino acids
Mouse METTL1-9745M Recombinant Mouse METTL1 Protein Mammalian Cell His
Mouse METTL1-5487M Recombinant Mouse METTL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse METTL1-5487M-B Recombinant Mouse METTL1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Mettl1-4040M Recombinant Mouse Mettl1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish METTL1-1482Z Recombinant Zebrafish METTL1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • METTL1 Related Articles

METTL1 involved in several pathways and played different roles in them. We selected most pathways METTL1 participated on our site, such as Gene Expression, tRNA modification in the nucleus and cytosol, tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with METTL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionC22orf28;RORAA;ZNF3;MED16;ZNF577;ZNF26;CSTF3;TSEN54;SKIB
tRNA modification in the nucleus and cytosolTRMT112;TRMT11;NSUN2;LCMT2;LBH;ADAT2;WDR4;ADAT3;TP53RK
tRNA processingNSUN2;C2orf49;CCDC76;TSEN34;POP1;TSEN15;TRMT61A;XPOT;TRMT6

METTL1 has several biochemical functions, for example, protein binding, tRNA (guanine-N7-)-methyltransferase activity, contributes_to tRNA (guanine-N7-)-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by METTL1 itself. We selected most functions METTL1 had, and list some proteins which have the same functions with METTL1. You can find most of the proteins on our site.

Function Related Protein
protein bindingPDE1B;MRPS16;NUDT22;PRICKLE1;TMEM11;KLF12;RTN4RL1;SLC1A2;SRI
tRNA (guanine-N7-)-methyltransferase activity
contributes_to tRNA (guanine-N7-)-methyltransferase activityMETTL1;WDR4
tRNA bindingTRMT1L;PTCD1;AARSD1;IGHMBP2;NSUN2;THG1L;METTL1;KARS;EARS2

METTL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with METTL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of METTL1.

WDR4; ssrna_ug

Gray, SG; et al. Epigenetic-based immune intervention for rheumatic diseases. EPIGENOMICS 6:253-271(2014).
Ju, JY; Wang, Y; et al. Human fetal globin gene expression is regulated by LYAR. NUCLEIC ACIDS RESEARCH 42:9740-9752(2014).
  • Q&As
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