METTL1

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METTL1

Official Full Name methyltransferase like 1
Background This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X.
Synonyms METTL1; methyltransferase like 1; C12orf1, methyltransferase like 1; tRNA (guanine-N(7)-)-methyltransferase; TRM8; C12orf1; D1075 like gene product; FLJ95748; Methyltransferase like protein 1; tRNA (guanine N(7) ) methyltransferase; tRNA(m7G46) methyltransferase; YDL201w; D1075-like gene product; methyltransferase-like 1; tRNA(m7G46)-methyltransferase; methyltransferase-like protein 1
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human METTL1-1080HCL Recombinant Human METTL1 cell lysate N/A
    Human METTL1-29205TH Recombinant Human METTL1, His-tagged E.coli His
    Human METTL1-4411H Recombinant Human METTL1 Protein, GST-tagged Wheat Germ GST
    Human METTL1-866H Recombinant Human METTL1, His tagged E.coli His
    Human METTL1-946H Recombinant Human METTL1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human METTL1-953H Recombinant Human METTL1, His-tagged, 33.6kDa (296aa) E.coli His
    Mouse METTL1-9745M Recombinant Mouse METTL1 Protein Mammalian Cell His
    Zebrafish METTL1-1482Z Recombinant Zebrafish METTL1 Mammalian Cell His

    METTL1 involved in several pathways and played different roles in them. We selected most pathways METTL1 participated on our site, such as Gene Expression, tRNA modification in the nucleus and cytosol, tRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with METTL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression NSUN2; TRMT11; ZNF484; ZNF383; ZNF287; ZNF100; NR1H3; TNKS1BP1; ZNF556; WHSC2
    tRNA modification in the nucleus and cytosol TRMT6; PUS7; CDKAL1; ALKBH8; OSGEP; LAGE3; NSUN2; PUS1; TPRKB; TRMT44
    tRNA processing LAGE3; TSEN15; TSEN2; POP7; RPP30; C22orf28; TRMT12; TPRKB; TRMT1; TYW1

    METTL1 has several biochemical functions, for example, protein binding, tRNA (guanine-N7-)-methyltransferase activity, contributes_to tRNA (guanine-N7-)-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by METTL1 itself. We selected most functions METTL1 had, and list some proteins which have the same functions with METTL1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding ATP2A2; FGF10; BFSP2; CDCA7L; ERGIC2; SPARC; PRDX3; HSPB6; SULT1C2; SSH1
    tRNA (guanine-N7-)-methyltransferase activity METTL1
    contributes_to tRNA (guanine-N7-)-methyltransferase activity WDR4; METTL1
    tRNA binding TRMT1L; RARS; FARS2; KARS; PSTK; FARSA; CTU1; IGHMBP2; MADD; SEPSECS

    METTL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with METTL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of METTL1.

    WDR4; ssrna_ug

    Gray, SG; et al. Epigenetic-based immune intervention for rheumatic diseases. EPIGENOMICS 6:253-271(2014).
    Ju, JY; Wang, Y; et al. Human fetal globin gene expression is regulated by LYAR. NUCLEIC ACIDS RESEARCH 42:9740-9752(2014).

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