mgat1
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  • Official Full Name
  • mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
  • Background
  • There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene.
  • Synonyms
  • MGAT1; mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase; GLYT1, MGAT; alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; GLCNAC TI; GNT 1; glcNAc-T I; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosam
Cat.#:MGAT1-1704HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant MGAT1 Protein, His-tagged
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Cat.#:MGAT1-4371HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MGAT1 Protein, GST-tagged
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Cat.#:MGAT1-1703HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MGAT1 Protein, His-tagged
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Cat.#:MGAT1-29206THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MGAT1
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Cat.#:Mgat1-3294MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Mgat1, His-tagged
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Cat.#:MGAT1-9807MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MGAT1 Protein
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Cat.#:MGAT1-3668RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MGAT1 Protein
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Cat.#:MGAT1-2759RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MGAT1 Protein, His-tagged
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Cat.#:MGAT1-4343HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MGAT1 293 Cell Lysate
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Involved Pathway

MGAT1 involved in several pathways and played different roles in them. We selected most pathways MGAT1 participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
N-Glycan biosynthesis
DPAGT1; DPM1; ALG6; ALG10B; MGAT4B; MAN1A1; MAN1B1; MGAT4C; DOLK; FUT8A
Metabolic pathways
NOS2A; ACOT2; UOX; LALBA; AGK; ATP6V1G1; MVDA; ADC; CDS2; MOGAT3

Protein Function

MGAT1 has several biochemical functions, for example, acetylglucosaminyltransferase activity, alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MGAT1 itself. We selected most functions MGAT1 had, and list some proteins which have the same functions with MGAT1. You can find most of the proteins on our site.
Function
Related Protein
Function acetylglucosaminyltransferase activity
Related Protein GALNT18A; MGAT1B; UGGT1; XYLT1; B3GNT9-PS; A4GNT; PIGB; EXT1; MGAT1; DPY19L1
Function alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
Related Protein MGAT1
Function metal ion binding
Related Protein ANTXRL; KLF12A; CA4B; HBB-Y; C6AST1; KLF17; MOBKL2B; ZNF274; ZFP692; BTR12

Interacting Protein

MGAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MGAT1.
SMAD9; MAPK6; Anapc13; Mus81; Mad2l1

MGAT1 Related Articles

Sealover, NR; Davis, AM; et al. Engineering Chinese Hamster Ovary (CHO) cells for producing recombinant proteins with simple glycoforms by zinc-finger nuclease (ZFN)-mediated gene knockout of mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat1). JOURNAL OF BIOTECHNOLOGY 167:24-32(2013).
Williams, SA; Stanley, P; et al. Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1, SSEA-3, SSEA-4, or Le(Y) in the preimplantation mouse embryo. GLYCOCONJUGATE JOURNAL 26:335-347(2009).