MGAT1

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MGAT1

Official Full Name mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Background There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene.
Synonyms MGAT1; mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase; GLYT1, MGAT; alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; GLCNAC TI; GNT 1; glcNAc-T I; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosam
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MGAT1-1703H Recombinant Human MGAT1 Protein, His-tagged E.coli His
    Human MGAT1-1704H Recombinant MGAT1 Protein, His-tagged NS0 His
    Human MGAT1-29206TH Recombinant Human MGAT1 Wheat Germ N/A
    Human MGAT1-4343HCL Recombinant Human MGAT1 293 Cell Lysate HEK293 N/A
    Human MGAT1-4371H Recombinant Human MGAT1 Protein, GST-tagged Wheat Germ GST
    Mouse Mgat1-3294M Recombinant Mouse Mgat1, His-tagged E.Coli or Yeast His
    Mouse MGAT1-9807M Recombinant Mouse MGAT1 Protein Mammalian Cell His
    Rat MGAT1-3668R Recombinant Rat MGAT1 Protein Mammalian Cell His
    Rhesus Macaque MGAT1-2759R Recombinant Rhesus monkey MGAT1 Protein, His-tagged Mammalian Cell His

    MGAT1 involved in several pathways and played different roles in them. We selected most pathways MGAT1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    N-Glycan biosynthesis RPN2; MGAT1A; MGAT5; ALG13; MOGS; MGAT2; ST6GAL1; MGAT1B; ALG5; MAN2A1
    Metabolic pathways ATP5J2; ALOX5A; CYP4F18; AMD1; ATP5IB; OLAH; SAT2B; ALOX8; UROD; HAAO

    MGAT1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by MGAT1 itself. We selected most functions MGAT1 had, and list some proteins which have the same functions with MGAT1. You can find most of the proteins on our site.

    Function Related Protein
    acetylglucosaminyltransferase activity 4931440L10Rik; B3GNTL1; DPY19L1; POMGNT2; HEXB; UGGT1; XYLT1; LARGE; A4GNT; GALNT18A
    alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity MGAT1
    metal ion binding TRIM41; PVALB4; NTNG1; MT2; CYP2D10; ZNF461; SOBP; TRIM35-1; ZNF764; ANGPT2

    MGAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MGAT1.

    SMAD9; MAPK6; Anapc13; Mus81; Mad2l1

    Sealover, NR; Davis, AM; et al. Engineering Chinese Hamster Ovary (CHO) cells for producing recombinant proteins with simple glycoforms by zinc-finger nuclease (ZFN)-mediated gene knockout of mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase (Mgat1). JOURNAL OF BIOTECHNOLOGY 167:24-32(2013).
    Williams, SA; Stanley, P; et al. Complex N-glycans or core 1-derived O-glycans are not required for the expression of stage-specific antigens SSEA-1, SSEA-3, SSEA-4, or Le(Y) in the preimplantation mouse embryo. GLYCOCONJUGATE JOURNAL 26:335-347(2009).

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