MSH5 Protein, mutS homolog 5


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Official Full Name mutS homolog 5
Background This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene.
Synonyms MSH5; mutS homolog 5 (E. coli); mutS (E. coli) homolog 5; mutS protein homolog 5; G7; NG23; MUTSH5; MGC2939; DKFZp434C1615
    • Species :
    • Human
    • Rat
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MSH5-4118HCL Recombinant Human MSH5 293 Cell Lysate HEK293 N/A
    Human MSH5-5652H Recombinant Human MSH5 Protein, GST-tagged Wheat Germ GST
    Rat MSH5-3788R Recombinant Rat MSH5 Protein Mammalian Cell His

    MSH5 involved in several pathways and played different roles in them. We selected most pathways MSH5 participated on our site, such as Cell Cycle, Meiosis, Meiotic recombination, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell Cycle PKMYT1; DCTN1; MDM2; ANAPC7; HIST4H4; NDC80; TP53; RB1; BRE; E2F4
    Meiosis DMC1; POT1; TERF2IP; TERF1; TEX15; TEX12; SUN1; SYNE1; MND1; SYCE1
    Meiotic recombination MND1; MSH5; PSMC3IP; SPO11; MSH4; DMC1; TEX15
    Ovarian Infertility Genes DAZL; MSH5; INHA; ZP3; ZP2; DMC1; SYNE2; NRIP1; GJA4; NR5A1

    MSH5 has several biochemical functions, for example, ATP binding, DNA-dependent ATPase activity, NOT damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH5 itself. We selected most functions MSH5 had, and list some proteins which have the same functions with MSH5. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DDR1; NEK8; PKM; FER; AK2; UBE2G2; TRPM4; MYH3; KARS; PRKY
    DNA-dependent ATPase activity SMARCA4; ERCC2; RAD51D; XRCC2; TOP2A; MSH3; SMARCA2; CHD8; RAD51L3; RAD51B
    NOT damaged DNA binding MSH5; MSH4
    mismatched DNA binding MLH1; PMS1; MSH5; MLH3; TDG; MSH4; MSH6
    protein binding CDA; CDC73; THEMIS2; ZSCAN21; RP2; ZNF511; ANKRD17; RNF146; SCAF8; HELZ2

    MSH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH5.

    ABL1; MSH4; XRCC5; Brca1; Tecpr2; LRRK2; SGTB

    Skeldon, SC; Semotiuk, K; et al. Patients with Lynch Syndrome Mismatch Repair Gene Mutations Are at Higher Risk for Not Only Upper Tract Urothelial Cancer but Also Bladder Cancer. EUROPEAN UROLOGY 63:379-385(2013).
    Aceto, GM; De Lellis, L; et al. Nonfluorescent Denaturing HPLC-Based Primer-Extension Method for Allele-Specific Expression: Application to Analysis of Mismatch Repair Genes. CLINICAL CHEMISTRY 55:1711-1718(2009).

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