MSH6
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Official Full Name
mutS homolog 6
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Overview
MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as Hereditary Non-Polyposis Colon Cancer (HNPCC). The anti-M -
Synonyms
MSH6; mutS homolog 6 (E. coli); GTBP, mutS (E. coli) homolog 6; DNA mismatch repair protein Msh6; p160; GTMBP; hMSH6; sperm-associated protein; mutS-alpha 160 kDa subunit; G/T mismatch-binding protein; GTBP; HSAP; HNPCC5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- MSH6 Related Articles
- MSH6 Related Research Area
MSH6 involved in several pathways and played different roles in them. We selected most pathways MSH6 participated on our site, such as Mismatch repair, Pathways in cancer, Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mismatch repair | RPA2;MLH3;RFC2;POLD1;MLH1;LIG1;POLD4;RPA3;RFC5 |
| Pathways in cancer | PML;GNA11;LAMB3;PTEN;SOS1;SMAD4;RXRB;PLCG1;WNT10B |
| Colorectal cancer | TRP53;MAPK8;AXIN2;RHOA;ARAF;BRAF;SMAD3;Casp3;APC |
MSH6 has several biochemical functions, for example, contributes_to ADP binding, contributes_to ATP binding, contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH6 itself. We selected most functions MSH6 had, and list some proteins which have the same functions with MSH6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ADP binding | MSH6;ATP5D;MSH2 |
| contributes_to ATP binding | ABCG8;ATP1A2;MSH2;ATP5D;MSH6;SFRP5;ATP1B1 |
| contributes_to ATPase activity | ATP1B1;ATP5E;RUVBL2;SFRP5;ATP6V1H;ATP5C1;ATP5H;PPP2R4;ATP5J2 |
| DNA-dependent ATPase activity | DHX36;SMARCA2;RAD51B;SMARCA4;RAD51C;MSH3;CHD6;TTF2;RAD51D |
| contributes_to MutLalpha complex binding | MSH2;MSH6 |
| chromatin binding | TRIM37;HESX1;WDHD1;ENY2;ZFP932;NFKB2;TRIM24;ORC1L;UBTFL |
| contributes_to double-stranded DNA binding | MSH2;MSH6;STRA13;APITD1 |
| contributes_to four-way junction DNA binding | XRCC2;XRCC3;RAD51B;MSH6;RAD51C;MSH2;RAD51D;RAD51L1;RAD51L3 |
| contributes_to guanine/thymine mispair binding | MSH6;MSH2 |
| contributes_to magnesium ion binding | MSH2;MSH6 |
| methylated histone binding | CHD1;CCDC101;PHF2;LRWD1;FAM156A;MSL3;ING3;SPIN1;UHRF1 |
| mismatched DNA binding | PMS1;TDG;MSH4;MSH5;MLH1;MSH6;MLH3 |
| contributes_to mismatched DNA binding | MSH6;MSH2;MSH3 |
| contributes_to oxidized purine DNA binding | MSH2;MSH6 |
| protein binding | MAGEA6;CHN1;ARHGEF6;RAD23A;RPL39L;RPL19;OLFM4;TMEM203;ELF2 |
| contributes_to protein binding | MSH6;MSH2;CPSF3L;TGFBR3;PAK1;MEF2A;CRY1A;MLH1;ACVR2A |
| NOT protein homodimerization activity | MYO9B;EXT2;MECOM;MSH6;MLXIPL;KCNA3;MSH3;NUDT16L1;DDIT3 |
| contributes_to single guanine insertion binding | MSH3;MSH2;MSH6 |
| contributes_to single thymine insertion binding | MSH2;MSH6 |
MSH6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH6.
MSH2; MYC; 41_bp_heteroduplex; BRCA1; MCC; CASP4; PSMD4; HRAS; MAP2K1; q5ngv3_fratt; NANS; midostaurin
- Q&As
- Reviews
Q&As (7)
Ask a questionMSH6 modulates cell cycle and apoptosis, ensuring cells with DNA damage do not proliferate.
Mutations in MSH6 increase the risk of various cancers, due to impaired DNA repair mechanisms.
MSH6 deficiency can lead to HNPCC by allowing accumulation of DNA replication errors.
MSH6 is crucial in DNA mismatch repair, helping correct replication errors to maintain DNA integrity.
MSH6 plays a vital role in preventing mutations and maintaining genomic stability.
Alterations in MSH6 can affect the response to chemotherapy, potentially impacting treatment outcomes.
MSH6 is involved in the cellular response to DNA damage, facilitating repair to prevent mutations.
Customer Reviews (3)
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