MSH6 Protein, mutS homolog 6

MSH6

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MSH6

Official Full Name mutS homolog 6
Background MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as Hereditary Non-Polyposis Colon Cancer (HNPCC). The anti-M
Synonyms MSH6; mutS homolog 6 (E. coli); GTBP, mutS (E. coli) homolog 6; DNA mismatch repair protein Msh6; p160; GTMBP; hMSH6; sperm-associated protein; mutS-alpha 160 kDa subunit; G/T mismatch-binding protein; GTBP; HSAP; HNPCC5
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MSH6-2412H Recombinant Human MSH6, GST-tagged E.coli GST
    Human MSH6-2413H Recombinant Human MSH6, His-tagged E.coli His
    Human MSH6-2414H Recombinant Human MSH6, GST-tagged Wheat Germ GST
    Human MSH6-4117HCL Recombinant Human MSH6 293 Cell Lysate HEK293 N/A
    Mouse MSH6-10134M Recombinant Mouse MSH6 Protein Mammalian Cell His
    Rhesus Macaque MSH6-2873R Recombinant Rhesus monkey MSH6 Protein, His-tagged Mammalian Cell His
    Zebrafish MSH6-9649Z Recombinant Zebrafish MSH6 Mammalian Cell His

    MSH6 involved in several pathways and played different roles in them. We selected most pathways MSH6 participated on our site, such as Mismatch repair, Pathways in cancer, Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mismatch repair SSBP1; LIG1; RFC5; POLD4; MSH2; PCNA; RFC2; MLH3; RPA2; RFC3
    Pathways in cancer BDKRB1; GNG13; Fgf15; FZD3; GNB4; RARA; PIK3R3; BCL2L1; EP300; RB1
    Colorectal cancer TGFB1; APC2; Casp3; MAPK8; MAP2K1; SMAD2; BIRC5; AKT1; BAD; AXIN1

    MSH6 has several biochemical functions, for example, contributes_to ADP binding, contributes_to ATP binding, contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH6 itself. We selected most functions MSH6 had, and list some proteins which have the same functions with MSH6. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to ADP binding ATP5D; MSH2; MSH6
    contributes_to ATP binding SFRP5; MSH6; ATP1B1; ATP5D; ATP1A2; MSH2; ABCG8
    contributes_to ATPase activity ATP5D; ATP5L; MSH6; ATP1A2; RFC3; ATP5I; ABCA7; ATP5J2; ATP5J; ABCG8
    DNA-dependent ATPase activity ERCC2; XRCC3; MSH6; RAD51L1; CHD6; RAD51D; RAD51C; SMARCA4; RAD51L3; MSH4
    contributes_to MutLalpha complex binding MSH6; MSH2
    chromatin binding APTX; HMGXB4; ELK4; MSL1A; OST4; PLAC8; PRDM13; PPARGC1A; PHF21A; LHX2
    contributes_to double-stranded DNA binding MSH2; APITD1; STRA13; MSH6
    contributes_to four-way junction DNA binding MSH2; XRCC3; RAD51L3; RAD51D; MSH6; RAD51L1; RAD51C; XRCC2; RAD51B
    contributes_to guanine/thymine mispair binding MSH6; MSH2
    contributes_to magnesium ion binding MSH2; MSH6
    methylated histone binding CBX8; ING3; CBX5; L3MBTL2; SPIN1; MSL3; TDRD3; ING5; CBX7; ZMYND11
    mismatched DNA binding MSH6; MSH4; MLH1; PMS1; TDG; MLH3; MSH5
    contributes_to mismatched DNA binding MSH6; MSH3; MSH2
    contributes_to oxidized purine DNA binding MSH6; MSH2
    protein binding CCKBR; EIF4EBP3L; C4BPB; BLOC1S4; KCND3; EPS15; PPID; DAAM1; UBE2A; a
    contributes_to protein binding MLH1; INTS10; ACVR2A; PAK1; POLR2A; MSH6; CRY1A; MSH2; MEF2A; CPSF3L
    NOT protein homodimerization activity MSH6; EXT2; MSH3; MYO9B; MLXIPL; KCNA3; DDIT3; NUDT16L1; MECOM
    contributes_to single guanine insertion binding MSH2; MSH6; MSH3
    contributes_to single thymine insertion binding MSH2; MSH6

    MSH6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH6.

    MSH2; MYC; 41_bp_heteroduplex; BRCA1; MCC; CASP4; PSMD4; HRAS; MAP2K1; q5ngv3_fratt; NANS; midostaurin

    Stark, AM; Doukas, A; et al. Expression of DNA mismatch repair proteins MLH1, MSH2, and MSH6 in recurrent glioblastoma. NEUROLOGICAL RESEARCH 37:95-105(2015).
    Jentzsch, T; Robl, B; et al. Expression of MSH2 and MSH6 on a Tissue Microarray in Patients with Osteosarcoma. ANTICANCER RESEARCH 34:6961-6972(2014).

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