msh6
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  • Official Full Name
  • mutS homolog 6
  • Background
  • MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). This finding is associated with the autosomal dominant condition known as Hereditary Non-Polyposis Colon Cancer (HNPCC). The anti-M
  • Synonyms
  • MSH6; mutS homolog 6 (E. coli); GTBP, mutS (E. coli) homolog 6; DNA mismatch repair protein Msh6; p160; GTMBP; hMSH6; sperm-associated protein; mutS-alpha 160 kDa subunit; G/T mismatch-binding protein; GTBP; HSAP; HNPCC5
Cat.#:MSH6-2412HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MSH6, GST-tagged
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Cat.#:MSH6-2413HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MSH6, His-tagged
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Cat.#:MSH6-2414HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MSH6, GST-tagged
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Cat.#:MSH6-10134MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MSH6 Protein
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Cat.#:MSH6-2873RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MSH6 Protein, His-tagged
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Cat.#:MSH6-9649ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MSH6
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Cat.#:MSH6-4117HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MSH6 293 Cell Lysate
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Involved Pathway

MSH6 involved in several pathways and played different roles in them. We selected most pathways MSH6 participated on our site, such as Mismatch repair, Pathways in cancer, Colorectal cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MSH6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mismatch repair
PMS2; RPA1; MLH1; MSH6; POLD2; RFC4; MSH3; RFC3; MSH2; POLD4
Pathways in cancer
AXIN1; PRKCG; PIK3R5; GNAI2; CCNE2; SMAD3; NRAS; FIGF; GNG2; LPAR6
Colorectal cancer
PIK3R2; APC2; BIRC5; BAD; TGFBR2; RALGDS; CASP9; MSH2; KRAS; MAPK1

Protein Function

MSH6 has several biochemical functions, for example, contributes_to ADP binding, contributes_to ATP binding, contributes_to ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MSH6 itself. We selected most functions MSH6 had, and list some proteins which have the same functions with MSH6. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to ADP binding
Related Protein ATP5D; MSH2; MSH6
Function contributes_to ATP binding
Related Protein MSH2; SFRP5; ABCG8; ATP5D; MSH6; ATP1A2; ATP1B1
Function contributes_to ATPase activity
Related Protein ATP6V1H; ATP5C1; MSH2; ATP5I; ABCA7; ATP1B1; ATP5H; ATP5A1; PPP2R4; ATP5D
Function DNA-dependent ATPase activity
Related Protein CDK7; ERCC2; RAD51B; RAD51L3; SMARCA4; TOP2A; SMARCA2; IGHMBP2; MSH3; RAD51C
Function contributes_to MutLalpha complex binding
Related Protein MSH2; MSH6
Function chromatin binding
Related Protein JUN; NPM2; TCF7L2; TAF2; POLE; HMG20B; GATA4; SETD7; SSRP1A; PRKCB
Function contributes_to double-stranded DNA binding
Related Protein MSH2; STRA13; MSH6; APITD1
Function contributes_to four-way junction DNA binding
Related Protein RAD51L1; RAD51D; XRCC2; XRCC3; RAD51L3; MSH2; MSH6; RAD51C; RAD51B
Function contributes_to guanine/thymine mispair binding
Related Protein MSH6; MSH2
Function contributes_to magnesium ion binding
Related Protein MSH6; MSH2
Function methylated histone binding
Related Protein LRWD1; ATRX; CBX8; MTF2; CBX4; FAM156A; ZMYND11; PHF19; CBX7; PHF13
Function mismatched DNA binding
Related Protein MLH3; MLH1; MSH5; MSH6; PMS1; TDG; MSH4
Function contributes_to mismatched DNA binding
Related Protein MSH6; MSH3; MSH2
Function contributes_to oxidized purine DNA binding
Related Protein MSH2; MSH6
Function protein binding
Related Protein PRPF4B; KCNJ15; DPYSL5; ANXA11; HERC5; GORASP2; OLA1; MX1; KRT7; FGF12
Function contributes_to protein binding
Related Protein MEF2A; CPSF3L; ACVR2A; PAK1; TGFBR3; POLR2A; TAF10; MSH6; MLH1; INHA
Function NOT protein homodimerization activity
Related Protein MECOM; DDIT3; MSH6; KCNA3; MYO9B; MSH3; NUDT16L1; EXT2; MLXIPL
Function contributes_to single guanine insertion binding
Related Protein MSH2; MSH6; MSH3
Function contributes_to single thymine insertion binding
Related Protein MSH6; MSH2

Interacting Protein

MSH6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MSH6 here. Most of them are supplied by our site. Hope this information will be useful for your research of MSH6.
MSH2; MYC; 41_bp_heteroduplex; BRCA1; MCC; CASP4; PSMD4; HRAS; MAP2K1; q5ngv3_fratt; NANS; midostaurin

MSH6 Related Articles

Stark, AM; Doukas, A; et al. Expression of DNA mismatch repair proteins MLH1, MSH2, and MSH6 in recurrent glioblastoma. NEUROLOGICAL RESEARCH 37:95-105(2015).
Jentzsch, T; Robl, B; et al. Expression of MSH2 and MSH6 on a Tissue Microarray in Patients with Osteosarcoma. ANTICANCER RESEARCH 34:6961-6972(2014).