mtmr14
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  • Official Full Name
  • myotubularin related protein 14
  • Background
  • This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 18.[provided by RefSeq, Apr 2010]
  • Synonyms
  • MTMR14; myotubularin related protein 14; C3orf29; myotubularin-related protein 14; jumpy; NS5ATP4ABP1; egg-derived tyrosine phosphatase homolog; HCV NS5A-transactivated protein 4 splice variant A-binding protein 1;
Cat.#:MTMR14-4274HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MTMR14 Protein, GST-tagged
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Cat.#:MTMR14-1088HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MTMR14, His-tagged
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Cat.#:MTMR14-10205MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MTMR14 Protein
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Cat.#:MTMR14-5409CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MTMR14
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Cat.#:MTMR14-4076HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MTMR14 293 Cell Lysate
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Cat.#:MTMR14-4077HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MTMR14 293 Cell Lysate
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Involved Pathway

MTMR14 involved in several pathways and played different roles in them. We selected most pathways MTMR14 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTMR14 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PTENA; PLCD4; IPPK; MTM1; INPP5KA; PLCH1; INPP5B; PTENB; MTMR4; PI4K2A
Metabolic pathways
CYP7A1; ATP5F1; POLR3G; AGXT2; CSGALNACT2; POLR2G; KLF15; Acsm2a; AK8; PIGK
Phosphatidylinositol signaling system
PIP4K2A; PIK3C2G; INPPL1; PI4KB; MTMR3; CALM3; INPP5E; CALM3B; PIP5K2; PIK3R5

Protein Function

MTMR14 has several biochemical functions, for example, phosphatidylinositol-3-phosphatase activity, protein binding, protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MTMR14 itself. We selected most functions MTMR14 had, and list some proteins which have the same functions with MTMR14. You can find most of the proteins on our site.
Function
Related Protein
Function phosphatidylinositol-3-phosphatase activity
Related Protein FIG4; MTMR8; MTMR1B; MTMR14; SACM1L; PTEN; MTMR2; MTMR3; MTMR1; MTMR1A
Function protein binding
Related Protein NTF3; ASB9; CBLB; KRTAP3-2; POP5; SBNO2; PAPOLA; MYBPH; DKC1; C1QL1
Function protein tyrosine phosphatase activity
Related Protein PTPRZ1; PTPN23A; PTPN20; PTENA; PTPN4B; CDC25D; PTPMT1; PTPRJ; CDC14B; PTPN2B

Interacting Protein

MTMR14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTMR14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MTMR14.
TP53BP2; ENO3; Atg16l1; Atg12; MAP1LC3B

MTMR14 Related Articles

Son, JY; Lee, JU; et al. Expression, purification, crystallization and preliminary crystallographic analysis of human myotubularin-related protein 3. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70:1240-1243(2014).
Nakhro, K; Park, JM; et al. SET binding factor 1 (SBF1) mutation causes Charcot-Marie-Tooth disease type 4B3. NEUROLOGY 81:165-173(2013).