myl12b
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  • Official Full Name
  • myosin, light chain 12B, regulatory
  • Background
  • The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments.
  • Synonyms
  • MLC-B; MRLC2; myosin regulatory light chain 12B; MLC-2; MLC20; MLC-2A; SHUJUN-1; OTTHUMP00000162244; OTTHUMP00000165806; OTTHUMP00000165807; OTTHUMP00000165808; myosin regulatory light chain 2; myosin regulatory light chain MRLC2; myosin regulatory light chain 20 kDa; myosin regulatory light chain 2-B, smooth muscle isoform; MYL12B; myosin, light chain 12B, regulatory
Cat.#:MYL12B-2277HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MYL12B Protein, MYC/DDK-tagged
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Cat.#:MYL12B-5548HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYL12B Protein, GST-tagged
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Cat.#:MYL12B-8046HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYL12B protein, His & T7-tagged
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Cat.#:MYL12B-10313MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MYL12B Protein
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Cat.#:MYL12B-3853RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MYL12B Protein
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Cat.#:MYL12B-2922RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MYL12B Protein, His-tagged
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Cat.#:MYL12B-682HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Myosin, Light Chain 12B, Regulatory
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Cat.#:MYL12B-4029HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MYL12B 293 Cell Lysate
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Involved Pathway

MYL12B involved in several pathways and played different roles in them. We selected most pathways MYL12B participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYL12B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
PAK7; CLASP1; LRRC4; EPHB4A; COL9A1B; EPHA8; LAMTOR2; DLG4; ARHGEF12; DUSP7
Developmental Biology
DUSP4; MED26; DLG3; STX1B; LGI2A; SCN9A; COL4A3; MYOD1; NRG3; KDR
EPH-Ephrin signaling
ARPC5; ARPC3; EPHB4B; ARPC1A; ACTR2B; EFNA4; ARHGEF28; EFNA3B; ARPC1B; EFNA2A
EPHA-mediated growth cone collapse
EPHA2A; EFNA2A; EFNA5; EFNA1; EFNA3B; EFNA1A; EPHA4A; MYL12B; KDR; SHB
Focal adhesion
ITGA8; LAMA4; ERBB2; MYLK4; RAC1B; PTK2AA; PARVAA; ITGA10; CAV2; MYL2B
Leukocyte transendothelial migration
MSN; PIK3CA; PTPN11; CLDN15; ACTN3; F11R; ACTB; PIK3R5; RHOH; CLDN7
Muscle contraction
TNNI1; DESMB; LMOD1; SORBS3; CMLC1; TMOD3; TCAP; VIML; TNNI2A.3; MYL12B
Platelet activation
PLCB3; SYK; P2RY1; FGB; MAPK1; GNAI2; GP5; BTK; PIK3CA; MYLK4

Protein Function

MYL12B has several biochemical functions, for example, calcium ion binding, myosin heavy chain binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYL12B itself. We selected most functions MYL12B had, and list some proteins which have the same functions with MYL12B. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein RPH3A; S100A1; CDH4; KCNIP1B; CDH17; CDH16; ATP2A1; TPD52; ITSN2; LRP1
Function myosin heavy chain binding
Related Protein MYL9; PDLIM2; CORO1A; MYL2; AMPD1; MYL12B; MYBPC3
Function protein binding
Related Protein BSCL2; ZNF652; BCL2L14; CD44; EFEMP2; KLC3; EMP3; SULT4A1; NOP58; BRD9

Interacting Protein

MYL12B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYL12B here. Most of them are supplied by our site. Hope this information will be useful for your research of MYL12B.
ACTB; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; DAPK3; ACTA2; MYH11; USP45; HSPB1; q81ws3_bacan; FN1; VCAM1; ARRB1; GRB2; GTF2B; BECN1