myl12b
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  • Official Full Name
  • myosin, light chain 12B, regulatory
  • Background
  • The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments.
  • Synonyms
  • MLC-B; MRLC2; myosin regulatory light chain 12B; MLC-2; MLC20; MLC-2A; SHUJUN-1; OTTHUMP00000162244; OTTHUMP00000165806; OTTHUMP00000165807; OTTHUMP00000165808; myosin regulatory light chain 2; myosin regulatory light chain MRLC2; myosin regulatory light chain 20 kDa; myosin regulatory light chain 2-B, smooth muscle isoform; MYL12B; myosin, light chain 12B, regulatory
Cat.#:MYL12B-2277HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MYL12B Protein, MYC/DDK-tagged
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Cat.#:MYL12B-5548HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYL12B Protein, GST-tagged
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Cat.#:MYL12B-8046HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYL12B protein, His & T7-tagged
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Cat.#:MYL12B-10313MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MYL12B Protein
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Cat.#:MYL12B-3853RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MYL12B Protein
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Cat.#:MYL12B-2922RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MYL12B Protein, His-tagged
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Cat.#:MYL12B-682HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Myosin, Light Chain 12B, Regulatory
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Cat.#:MYL12B-4029HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MYL12B 293 Cell Lysate
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Involved Pathway

MYL12B involved in several pathways and played different roles in them. We selected most pathways MYL12B participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYL12B were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
PLXNA3; CDC42; ITGB1; SEMA5A; SIAH2; COL9A1; PEBP1; ABLIM2; CHL1; ARPC3
Developmental Biology
SDCBP; NKX2.2A; DPYSL5A; MYL12B; MED8; DLG3; GFRA4; COL9A1; FOXH1; MED7
EPH-Ephrin signaling
EFNA4; ARHGEF28; EFNA1A; ARPC2; ARPC1A; ITSN1; ARPC4; CFL1; DNM1; ACTR3
EPHA-mediated growth cone collapse
EFNA3; EFNA1B; EPHA10; EFNA5; MYL9; EFNA2A; MYL12B; EFNA2; EFNA4; EPHA2
Focal adhesion
AKT2; RAC3; VEGFC; BAD; RAF1A; CAPN2; ITGA9; THBS4A; PDGFAA; MAPK10
Leukocyte transendothelial migration
NCF4; ACTN4; MYL10; CD99; OCLN; PLCG2; PIK3CA; PTK2; F11R; CLDN23
Muscle contraction
TNNT1; MYBPC2B; TMOD1; SORBS3; VIML; TMOD3; TNNI2A.1; TNNT3B; TNNI2A.4; SMYHC3
Platelet activation
PRKCZ; ARHGAP35; PIK3R5; F2RL3; PIK3CG; PLCB2; PLCB3; PLA2G4C; ACTG1; MYLK4

Protein Function

MYL12B has several biochemical functions, for example, calcium ion binding, myosin heavy chain binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYL12B itself. We selected most functions MYL12B had, and list some proteins which have the same functions with MYL12B. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein SWAP70; DSG1A; SULF2A; F2; SLC25A13; PCDH1G18; CALRL2; Shh; ALOX15B; SLIT1
Function myosin heavy chain binding
Related Protein MYL2; PDLIM2; CORO1A; AMPD1; MYL12B; MYBPC3; MYL9
Function protein binding
Related Protein CENPT; OSTB; DNASE1; MEX3C; CAND2; NKX3-1; RPL10A; ACMSD; BBS9; PTK2B

Interacting Protein

MYL12B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYL12B here. Most of them are supplied by our site. Hope this information will be useful for your research of MYL12B.
ACTB; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; DAPK3; ACTA2; MYH11; USP45; HSPB1; q81ws3_bacan; FN1; VCAM1; ARRB1; GRB2; GTF2B; BECN1