myl5
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  • Official Full Name
  • myosin, light chain 5, regulatory
  • Background
  • This gene encodes one of the myosin light chains, a component of the hexameric ATPase cellular motor protein myosin. Myosin is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene product, one of the regulatory light chains, is expressed in fetal muscle and in adult retina, cerebellum, and basal ganglia.
  • Synonyms
  • MYL5; myosin, light chain 5, regulatory; myosin, light polypeptide 5, regulatory; myosin light chain 5; MYL 5; MYL5_HUMAN; MyLC 2; MyLC-2; MYLC2; Myosin light chain 5 regulatory; Myosin light polypeptide 5; Myosin light polypeptide 5 regulatory; Myosin regulatory light chain 5; Superfast myosin regulatory light chain 2; OTTHUMP00000217187; OTTHUMP00000217188; OTTHUMP00000217190; OTTHUMP00000217193
Cat.#:MYL5-5812HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYL5 Protein, GST-tagged
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Cat.#:MYL5-29364THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYL5, His-tagged
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Cat.#:MYL5-3622HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYL5, His-tagged
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Cat.#:MYL5-6875HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Myosin, Light Chain 5, Regulatory, His-tagged
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Cat.#:MYL5-4025HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MYL5 293 Cell Lysate
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Involved Pathway

MYL5 involved in several pathways and played different roles in them. We selected most pathways MYL5 participated on our site, such as Focal adhesion, Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYL5 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Focal adhesion
PAK6; RAC1A; PXNA; ITGA6B; LAMC3; ITGA2; COL6A3; MYL9; VCL; PTK2AA
Tight junction
CLDNE; CLDN20; EPB41L3A; CASKA; CLDN7; MRAS; YBX3; ACTN4; HRAS; CLDN7A
Leukocyte transendothelial migration
CLDN23; ITGB1; MAPK12; CLDN4; CLDN14; CLDN6; NCF2; Itgam&Itgb2; ROCK1; ACTG1
Regulation of actin cytoskeleton
PAK2; ARHGEF7; PPP1CC; GNA12; PIP4K2AA; FGF12A; FGF5; FGF20; PDGFD; Itga10&Itgb1

Protein Function

MYL5 has several biochemical functions, for example, calcium ion binding, structural constituent of muscle. Some of the functions are cooperated with other proteins, some of the functions could acted by MYL5 itself. We selected most functions MYL5 had, and list some proteins which have the same functions with MYL5. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein RGN; FKBP7; CD97; SLC24A5; RHOT1B; MMP13A; FAT1A; DSG1A; STIM2; SPARCL1
Function structural constituent of muscle
Related Protein MYOT; MYL6; MYOM1; SORBS2; NEBL; TCAP; DMD; TTN; TPM2; MYBPC3

MYL5 Related Articles

Kakei, T; Sumiyoshi, H; et al. Characteristics of light chains of Chara myosin revealed by immunological investigation. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES 88:201-211(2012).
Vicente-Manzanares, M; Horwitz, AR; et al. Myosin light chain mono- and di-phosphorylation differentially regulate adhesion and polarity in migrating cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 402:537-542(2010).