myl7
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  • Official Full Name
  • myosin, light chain 7, regulatory
  • Background
  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin bindingand potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domainthat binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interactswith cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatorymyosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It isinvolved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating acontractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and byintracellular Ca2+ concentrations.Gene Wiki entry for MYL7.
  • Synonyms
  • MYL7; myosin, light chain 7, regulatory; myosin, light polypeptide 7, regulatory; myosin regulatory light chain 2, atrial isoform; MYL2A; MYLC2A; atrial isoform; MLC-2a; MLC2a; MLRA_HUMAN; Myosin light chain 2a; Myosin regulatory light chain 2; Myosin regulatory light chain 7
Cat.#:MYL7-5816HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYL7 Protein, GST-tagged
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Cat.#:MYL7-6780HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Myosin, Light Chain 7, Regulatory, His-tagged
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Cat.#:MYL7-8916ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MYL7
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Cat.#:MYL7-4021HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MYL7 293 Cell Lysate
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Involved Pathway

MYL7 involved in several pathways and played different roles in them. We selected most pathways MYL7 participated on our site, such as Focal adhesion, Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYL7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Focal adhesion
LAMA2; RAF1; AASS; PAK2B; SEPP1; COL1A1B; ITGB7; PDGFA; COL6A1; COL27A1B
Tight junction
PRKCQ; CLDN3; CLDN16; CLDN14; CLDN10; PPP2R2D; HCLS1; ACTN3A; LLGL2; MPDZ
Leukocyte transendothelial migration
VAV3; AASS; CLDN9; MSN; CLDN16; MYL5; CXCR4; PIK3CB; CDC42; PIK3CG
Regulation of actin cytoskeleton
MAP2K1; FGF11A; GNA12A; KRAS; IQGAP2; ABI2; ITGB3B; ITGA6; FGF8A; PDGFRB

Protein Function

MYL7 has several biochemical functions, for example, calcium ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYL7 itself. We selected most functions MYL7 had, and list some proteins which have the same functions with MYL7. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PCDH2G8; SYTL2; CABP7; PCDH2AB1; TLL1; CHP1; PROS1; S100A3; LCP1; SCUBE2
Function protein binding
Related Protein TESC; FAM46C; PTPN12; SCP2; ASF1B; C19orf73; NR5A1; NDUFB9; RAB3B; STOX1

Interacting Protein

MYL7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYL7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYL7.
TOX4

MYL7 Related Articles

Sheykhani, R; Shirodkar, PV; et al. The role of myosin phosphorylation in anaphase chromosome movement. EUROPEAN JOURNAL OF CELL BIOLOGY 92:175-186(2013).
Kakei, T; Sumiyoshi, H; et al. Characteristics of light chains of Chara myosin revealed by immunological investigation. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES 88:201-211(2012).