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NAE1

  • Official Full Name

    NEDD8 activating enzyme E1 subunit 1

  • Overview

    The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimers disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    NAE1; NEDD8 activating enzyme E1 subunit 1; amyloid beta precursor protein binding protein 1 , amyloid beta precursor protein binding protein 1, 59kDa , amyloid beta precursor protein binding protein 1, 59kD , APPBP1; NEDD8-activating enzyme E1 regulato;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NAE1-168H Active Recombinant Human NAE1/UBA3 Insect Cell N/A
Human NAE1-103H Active Recombinant Human APPBP1/Uba3, His-tagged E.coli His
Human APPBP1-722H Recombinant Human APPBP1 protein, GST-tagged Wheat Germ GST
Human NAE1-1570H Recombinant Human NEDD8 Activating Enzyme E1 Subunit 1, His-tagged E.coli His
Human NAE1-26749TH Recombinant Human NAE1, His-tagged E.coli His 534 amino acids
Human NAE1-3984HCL Recombinant Human NAE1 293 Cell Lysate HEK293 N/A
Human NAE1-4720H Recombinant Human NAE1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NAE1-417H Recombinant Human NAE1 Protein, His-tagged E.coli His Thr229~Leu534
Human NAE1-32H Recombinant Human NAE1 Protein, His-tagged Insect Cell His
Human NAE1-33H Recombinant Active Human NAE1/UBA3 Complex Protein, His/GST-tagged Insect Cell His/GST
Human NAE1-1072HF Recombinant Full Length Human NAE1 Protein, GST-tagged In Vitro Cell Free System GST 534 amino acids
Mouse Nae1-4281M Recombinant Mouse Nae1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat NAE1-3889R Recombinant Rat NAE1 Protein Mammalian Cell His
Rat NAE1-3548R Recombinant Rat NAE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat NAE1-3548R-B Recombinant Rat NAE1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey NAE1-724C Recombinant Cynomolgus NAE1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey NAE1-469C Recombinant Cynomolgus Monkey NAE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey NAE1-469C-B Recombinant Cynomolgus Monkey NAE1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque NAE1-2941R Recombinant Rhesus monkey NAE1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque NAE1-2761R Recombinant Rhesus Macaque NAE1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NAE1-2761R-B Recombinant Rhesus Macaque NAE1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish NAE1-10794Z Recombinant Zebrafish NAE1 Mammalian Cell His
Chicken NAE1-1281C Recombinant Chicken NAE1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NAE1 Related Research Area

NAE1 involved in several pathways and played different roles in them. We selected most pathways NAE1 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Alzheimers diseaseCOX7A1;TNF;APH1C;RYR3;MAPK3;mt-Atp8;BACE1;ATP5B;APOE

NAE1 has several biochemical functions, for example, contributes_to NEDD8 activating enzyme activity, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAE1 itself. We selected most functions NAE1 had, and list some proteins which have the same functions with NAE1. You can find most of the proteins on our site.

Function Related Protein
contributes_to NEDD8 activating enzyme activity
protein bindingJAM3B;ANKS1A;GJD3;KIAA0247;REEP1;NPL;UNC13A;TMEM74;FLOT2
protein heterodimerization activityADIPOR1;SMAD1;IKZF2;HEYL;TIMELESS;USF2;UGT1A4;SUPT5H;ATF2
ubiquitin protein ligase bindingDERL1;BAG4;UCHL1;HDAC6;HSPD1;PER1;ASB4;HSPA9;AURKA

NAE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NAE1.

NEDD8; FBXO11; UBE2M; UIMC1; SREBF2; ALG8; UBQLN4

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