nae1
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  • Official Full Name
  • NEDD8 activating enzyme E1 subunit 1
  • Background
  • The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimers disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • NAE1; NEDD8 activating enzyme E1 subunit 1; amyloid beta precursor protein binding protein 1 , amyloid beta precursor protein binding protein 1, 59kDa , amyloid beta precursor protein binding protein 1, 59kD , APPBP1; NEDD8-activating enzyme E1 regulato
Cat.#:NAE1-417HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NAE1 Protein, His-tagged
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Cat.#:NAE1-1570HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NEDD8 Activating Enzyme E1 Subunit 1, His-tagged
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Cat.#:APPBP1-722HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human APPBP1 protein, GST-tagged
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Cat.#:NAE1-103HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human APPBP1/Uba3, His-tagged
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Cat.#:NAE1-168HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human NAE1/UBA3
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Cat.#:NAE1-26749THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NAE1, His-tagged
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Cat.#:NAE1-3889RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NAE1 Protein
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Cat.#:NAE1-724CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus NAE1 Protein, His-tagged
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Cat.#:NAE1-2941RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NAE1 Protein, His-tagged
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Cat.#:NAE1-1281CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NAE1
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Cat.#:NAE1-10794ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NAE1
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Cat.#:NAE1-3984HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human NAE1 293 Cell Lysate
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Involved Pathway

NAE1 involved in several pathways and played different roles in them. We selected most pathways NAE1 participated on our site, such as Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with NAE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alzheimers disease
UQCR11; COX6B2; GRIN2C; NDUFV3; CASP8; ATP5J; PPP3CB; NDUFS1; NDUFB10; NDUFA13

Protein Function

NAE1 has several biochemical functions, for example, contributes_to NEDD8 activating enzyme activity, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NAE1 itself. We selected most functions NAE1 had, and list some proteins which have the same functions with NAE1. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to NEDD8 activating enzyme activity
Related Protein NAE1
Function protein binding
Related Protein DGKQ; NDUFAF1; TTPA; BCAS2; SIGLEC8; PSMC6; QRICH1; SRSF1; VPS36; FZD8
Function protein heterodimerization activity
Related Protein HIST1H2A9; HIST2H2AC; KCNK9; PBX1; CREB3L3; BMP2B; SLC51B; BCL11A; CHRNA5; IRAK2
Function ubiquitin protein ligase binding
Related Protein ANKRD32; UBE2NB; CALR; TOLLIP; GABARAP; UBE2J1; ABI2; MAP1LC3C; CUL4A; CDC34B

Interacting Protein

NAE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NAE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NAE1.
NEDD8; FBXO11; UBE2M; UIMC1; SREBF2; ALG8; UBQLN4