ncstn
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  • Official Full Name
  • nicastrin
  • Background
  • This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimers disease; however, the nature of the encoded proteins role in Alzheimers disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
  • Synonyms
  • NCSTN; nicastrin; ATAG1874; anterior pharynx-defective 2;
Cat.#:NCSTN-469HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NCSTN Protein, MYC/DDK-tagged
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Cat.#:NCSTN-1217HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NCSTN, His-tagged
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Cat.#:NCSTN-2316HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human NCSTN, His tagged
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Cat.#:Ncstn-7406MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ncstn, His tagged
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Cat.#:Ncstn-8687MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ncstn, Fc tagged
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Cat.#:NCSTN-3925RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NCSTN Protein
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Cat.#:Ncstn-7993RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ncstn protein, His & T7-tagged
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Cat.#:NCSTN-2962RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NCSTN Protein, His-tagged
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Cat.#:NCSTN-1231CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NCSTN
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Cat.#:NCSTN-1946ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NCSTN
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Cat.#:NCSTN-2528HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human NCSTN cell lysate
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Cat.#:NCSTN-1380MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse NCSTN cell lysate
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Involved Pathway

NCSTN involved in several pathways and played different roles in them. We selected most pathways NCSTN participated on our site, such as Notch signaling pathway, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCSTN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Notch signaling pathway
NUMBL; KAT2B; DLC; DTX3; JAG2B; EP300; DLK1; CTBP2; NOTCH1; CIR1
Alzheimers disease
UQCRB; NDUFB1; COX6B2; APP; ITPR1; PLCB3; CAPN1; IDE; ATP5B; CALM3

Protein Function

NCSTN has several biochemical functions, for example, endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCSTN itself. We selected most functions NCSTN had, and list some proteins which have the same functions with NCSTN. You can find most of the proteins on our site.
Function
Related Protein
Function endopeptidase activity
Related Protein TMEM59; KLK1B22; Ren1; TRAPPC12; FAP; KLK1B24; ECE1; CTSH; PSMA8; PSMB9
Function protein binding
Related Protein CDX1; IFIT2; RHOBTB3; PLD1; RARG; CEP57; HIST1H3D; NKX2-5; GABARAPL2; KCNA5

Interacting Protein

NCSTN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCSTN here. Most of them are supplied by our site. Hope this information will be useful for your research of NCSTN.
APH1A; PSEN1; PSENEN; TMED10; TMED2; CALR; PSEN1; PSEN2

NCSTN Related Articles

Filipovic, A; Lombardo, Y; et al. Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells. BREAST CANCER RESEARCH AND TREATMENT 148:455-462(2014).