NDUFA2 Protein, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa


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Official Full Name NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
Background The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.
Synonyms NDUFA2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 (8kD, B8); NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; B8; complex I B8 subunit; CD 14; CD14; CI B8; Complex I B8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2 8kDa; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 2; NADH ubiquinone oxidoreductase B8 subunit; NDUFA 2; OTTHUMP00000159890; OTTHUMP00000223709; NADH-ubiquinone oxidoreductase subunit CI-B8; CIB8
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NDUFA2-1222H Recombinant Human NDUFA2, GST-tagged E.coli GST
    Human NDUFA2-3921HCL Recombinant Human NDUFA2 293 Cell Lysate HEK293 N/A
    Human NDUFA2-7202H Recombinant Human NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa, His-tagged E.coli His
    Mouse NDUFA2-10515M Recombinant Mouse NDUFA2 Protein Mammalian Cell His
    Cynomolgus Monkey NDUFA2-733C Recombinant Cynomolgus NDUFA2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque NDUFA2-2974R Recombinant Rhesus monkey NDUFA2 Protein, His-tagged Mammalian Cell His
    Chicken NDUFA2-5620C Recombinant Chicken NDUFA2 Mammalian Cell His
    Zebrafish NDUFA2-3021Z Recombinant Zebrafish NDUFA2 Mammalian Cell His

    NDUFA2 involved in several pathways and played different roles in them. We selected most pathways NDUFA2 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Oxidative phosphorylation PPA1B; NDUFAB1; COX11; NDUFS6; COX7A1; COX7A3; NDUFS4; SDHD; ATP6V0A1; UQCRC2
    Metabolic pathways NDUFB8; ACSL1A; CKM; MVD; EARS2; NDUFA2; SDSL; NDUFA13; EXTL1; IPMK
    Non-alcoholic fatty liver disease (NAFLD) PIK3CD; NDUFS4; COX5A; COX6A2; COX7A2L; IRS1; EIF2AK3; NDUFA11; PRKAB2; CDC42
    Alzheimers disease NDUFA9; NDUFS7; COX5A; SDHC; CHP; COX7A1; UQCR10; ITPR3; NCSTN; BACE2
    Parkinsons disease NDUFA13; UQCR11; ATP5A1; NDUFV1; mt-Atp8; NDUFA7; NDUFC2-KCTD14; SDHB; UCHL1; NDUFA2
    Huntingtons disease NDUFS7; APAF1; BAX; DCTN2; COX7B; NDUFA7; COX7A2; ATP5B; HDAC2; COX5B

    NDUFA2 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFA2 itself. We selected most functions NDUFA2 had, and list some proteins which have the same functions with NDUFA2. You can find most of the proteins on our site.

    Function Related Protein
    NADH dehydrogenase (ubiquinone) activity NDUFS7; NDUFB4; NDUFA10; NDUFA12; NDUFC2; NDUFB10; NDUFS1; NDUFB5; NDUFA9; NDUFS6

    NDUFA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFA2.


    Han, SJ; Zhu, Y; et al. The differently expressed proteins in MSCs of degenerative scoliosis. JOURNAL OF ORTHOPAEDIC SCIENCE 18:885-892(2013).
    Li, YG; Zhu, W; et al. Resveratrol protects cardiomyocytes from oxidative stress through SIRT1 and mitochondrial biogenesis signaling pathways. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 438:270-276(2013).

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