ndufs6
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  • Official Full Name
  • NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
  • Background
  • This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.
  • Synonyms
  • NDUFS6; NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase); NADH dehydrogenase (ubiquinone) Fe S protein 6 (13kD) (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; CI 13kA; complex I 13kDa subunit A; NADH dehydrogenase [ubiquinone] iron sulfur protein 6; mitochondrial; CI 13kD A; CI-13kD-A; Complex I 13kD A; Complex I-13kD-A; NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron sulfur protein 6, mitochondrial; NADH ubiquinone oxidoreductase 13 kDa A subunit; NADH-ubiquinone oxidoreductase 13 kDa-A subunit; NDUS6_HUMAN; NADH:ubiquinone oxidoreductase NDUFS6 subunit; complex I, mitochondrial respiratory chain, 13-kD subunit; CI-13kA; CI13KDA
Cat.#:NDUFS6-1242HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NDUFS6, GST-tagged
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Cat.#:NDUFS6-10546MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NDUFS6 Protein
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Cat.#:NDUFS6-3945RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NDUFS6 Protein
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Cat.#:NDUFS6-740CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus NDUFS6 Protein, His-tagged
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Cat.#:NDUFS6-2990RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NDUFS6 Protein, His-tagged
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Cat.#:NDUFS6-1365ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NDUFS6
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Cat.#:NDUFS6-1179HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NDUFS6 cell lysate
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Involved Pathway

NDUFS6 involved in several pathways and played different roles in them. We selected most pathways NDUFS6 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with NDUFS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oxidative phosphorylation
UQCRFS1; NDUFA9A; NDUFV2; MT-ND1; SDHA; ATP4A; ATP6V0C; PPA1; SDHDB; ATP6V1C1
Metabolic pathways
UGT1A2; UGT1A6; ST6GAL2A; ENPP3; POLR2J3; PRDX6; CYP2P7; PAPSS2; LPIN1; IPMKB
Non-alcoholic fatty liver disease (NAFLD)
NDUFC2; NDUFB11; NDUFB5; PRKAA1; RXRA; NDUFA5; CASP8; NDUFA9; MLXIPL; MAPK9
Alzheimers disease
COX7B2; IL1B2; NDUFA6; TNFRSF1A; GRIN2D; NDUFS6; NDUFAB1; NDUFA4; COX6A1; ATP5A1
Parkinsons disease
PINK1; NDUFS4; NDUFS7; NDUFB3; VDAC3; UQCRFS1; COX5A; NDUFB11; ATP5E; Casp3
Huntingtons disease
POLR2J3; ATP5D; POLR2B; IFT57; ATP5E; NDUFB9; DNAH14; ATP5G3; COX7C; NDUFB10

Protein Function

NDUFS6 has several biochemical functions, for example, NADH dehydrogenase (ubiquinone) activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NDUFS6 itself. We selected most functions NDUFS6 had, and list some proteins which have the same functions with NDUFS6. You can find most of the proteins on our site.
Function
Related Protein
Function NADH dehydrogenase (ubiquinone) activity
Related Protein NDUFAF2; NDUFB5; NDUFA1; NDUFS2; NDUFA7; NDUFS5; NDUFS4; NDUFC2-KCTD14; NDUFC2; NDUFA4
Function electron carrier activity
Related Protein NOX4; MAOB; ADH5; NDUFS6; POR; SRD5A1; NCF2; IDH3B; COX5A; NDUFV2

Interacting Protein

NDUFS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NDUFS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of NDUFS6.
NDUFA2; GDNF; MAP3K7; FGFR3; KCNH2; MAPK8IP2; MAPK6; NDUFS8; NDUFS5; NDUFS2; NDUFS3; NDUFA7; MT-ND4; NDUFV2; NDUFS1; Rab5c; NDUFV1; RAB7A; NDUFV3

NDUFS6 Related Articles

Luo, Z; Zeng, W; et al. CD147 Interacts with NDUFS6 in Regulating Mitochondrial Complex I Activity and the Mitochondrial Apoptotic Pathway in Human Malignant Melanoma Cells. CURRENT MOLECULAR MEDICINE 14:1252-1264(2014).
Forbes, JM; Ke, BX; et al. Deficiency in Mitochondrial Complex I Activity Due to Ndufs6 Gene Trap Insertion Induces Renal Disease. ANTIOXIDANTS & REDOX SIGNALING 19:331-343(2013).