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NEFH

  • Official Full Name

    neurofilament, heavy polypeptide

  • Overview

    Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.
  • Synonyms

    NEFH; neurofilament, heavy polypeptide; neurofilament heavy polypeptide; NF-H; 200 kDa neurofilament protein; neurofilament triplet H protein; Nfh;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Human
  • Mouse
  • Pig
  • Rat
  • Baculovirus-Insect cells
  • bovine Spinal Cord
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • GST
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NEFH-25H Recombinant Human NEFH protein, MYC/DDK-tagged HEK293 Myc/DDK
Human NEFH-1254H Recombinant Human NEFH, His-tagged E.coli His C-350aa
Human NEFH-45HFL Recombinant Full Length Human NEFH Protein, C-Flag-tagged Mammalian cells Flag
Human NEFH-3270H Recombinant Human NEFH protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc 1-413aa
Human NEFH-1241H Recombinant Human NEFH protein, His-GST-tagged E.coli His/GST Met1~Gln100
Human NEFH-1255H Recombinant Human NEFH protein, His/SUMO-tagged E.coli His/SUMO Lys671-Lys1020
Human NEFH-0560H Recombinant Human NEFH protein, His-tagged Baculovirus-Insect cells His Met1-Lys1026
Human NEFH-2216H Recombinant Human NEFH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NEFH-1496H-B Recombinant Human NEFH Protein Pre-coupled Magnetic Beads HEK293
Human NEFH-1496H Recombinant Human NEFH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse NEFH-3274M Recombinant Mouse NEFH protein, His-tagged HEK293 His Pro840~Lys1090
Mouse Nefh-4362M Recombinant Mouse Nefh Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse NEFH-3222M Recombinant Mouse NEFH protein, His-tagged E.coli His Pro840~Lys1090
Rat Nefh-1821R Recombinant Rat Nefh Protein, His-tagged E.coli N-His Leu238-Ala354
Bovine NEFH-181B Native Bovine NEFH Protein
Bovine NEFH-180B Native bovine NEFH bovine Spinal Cord N/A
Pig NEFH-01P Native Pig NEFH Protein
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NEFH Related Research Area

NEFH involved in several pathways and played different roles in them. We selected most pathways NEFH participated on our site, such as Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with NEFH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amyotrophic lateral sclerosis (ALS)MAPK13;CCS;GRIN2A;GPX1;RAC1;GRIA2;DERL1;BAD;SOD1

NEFH has several biochemical functions, for example, dynein binding, kinesin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEFH itself. We selected most functions NEFH had, and list some proteins which have the same functions with NEFH. You can find most of the proteins on our site.

Function Related Protein
dynein bindingSMC3;WDR43;PAFAH1B1A;KATNA1;SNCA;NEFH;BICD1;PAFAH1B1B;LRRC50
kinesin bindingARHGEF10;NEK6;AP1AR;KLC2;KLC3;SPAG9;CLSTN1;PPIAL4A;SERPINB1A
microtubule bindingPEX14;NUMA1;GABARAP;TPPP;MAP6D1;NDEL1;PSRC1;JAKMIP2;KCNH2A
protein binding, bridgingFGA;FSCN2A;ADAP2;CAV2;TNNT2A;PPP2R3A;CNKSR1;SPRR1B;FSCN1A
protein heterodimerization activityHER11;P2RY1;HAND1;HNF1A;SMAD4;NFKB1;HIST1H2B5;CHUK;BAX
protein kinase bindingPOLA1;PTPN1;RNF138;SOCS1;PRC1;TBC1D14;FGFR1OP;PARK2;NPM1
structural constituent of cytoskeletonTUBA1C;COX4I2;TPM1;BFSP1;YEATS4;ACTG1;TUBA3E;TUBA1A;ARPC4
structural molecule activityMAP4;NEFH;SYNC;EPB41L2;KRTAP3-2;EVPLA;KRT77;CLDNB;CLDN3
toxic substance bindingH2-AB1;CHRNA7;A4GALT;AZU1;GUCY2C;NEFH;ASS1;Alb;EPHX2

NEFH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEFH here. Most of them are supplied by our site. Hope this information will be useful for your research of NEFH.

UL36; d2cfj1_9flav; M84; NS; k1_vaccw; ICP0; P/V/C; e3_vaccw; polg_den27; RL1; GRB2; VP35; ESR2; P/V/C

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