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Official Full Name neurofilament, heavy polypeptide
Background Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.
Synonyms NEFH; neurofilament, heavy polypeptide; neurofilament heavy polypeptide; NF-H; 200 kDa neurofilament protein; neurofilament triplet H protein; Nfh
    • Species :
    • Bovine
    • Human
    • Source :
    • bovine Spinal Cord
    • E.coli
    • HEK293
    • Tag :
    • His
    • His/SUMO
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NEFH-1255H Recombinant Human NEFH protein, His/SUMO-tagged E.coli His/SUMO
    Human NEFH-1254H Recombinant Human NEFH, His-tagged E.coli His
    Human NEFH-25H Recombinant Human NEFH protein, MYC/DDK-tagged HEK293 Myc/DDK
    Bovine NEFH-180B Native bovine NEFH bovine Spinal Cord N/A

    NEFH involved in several pathways and played different roles in them. We selected most pathways NEFH participated on our site, such as Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with NEFH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amyotrophic lateral sclerosis (ALS) CASP12; TOMM40L; RAC1; BCL2; TNFRSF1A; NEFM; GRIN2A; BAX; TNF; BID

    NEFH has several biochemical functions, for example, dynein binding, kinesin binding, microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEFH itself. We selected most functions NEFH had, and list some proteins which have the same functions with NEFH. You can find most of the proteins on our site.

    Function Related Protein
    kinesin binding PPIAL4A; KIF1B; KIF18B; JIP1; KLC2; NEFH; SYBU; AP1AR; JAKMIP1; ARPC2
    microtubule binding KIF12; MAP1LC3B; CAMSAP1B; GABARAP; PAFAH1B1B; KIF20B; KIF2B; GAS2L2; KIF5AA; KIF3CB
    protein binding, bridging ANXA1; DDX20; LOR; MMS19; PPP2R3A; TRIM22; NEFL; TRIM17; GATAD2A; CBX5
    protein heterodimerization activity Defa-rs7; HIST2H2AC; H2AFB2; TYR; AGTR1; DRD2; BNIP3; VEGFA; MEF2C; IL12B
    protein kinase binding ELAVL1; SPRY2; CCND3; SPRED2; MAPKAP1; CSPG4; RHEB; SV2A; HDAC7A; AP2A2
    structural constituent of cytoskeleton TUBB4B; NEFH; MSN; TUBB4A; CYLC2; TPM1; TUBAL3; PLS1; CYLC1; ACTL6B
    structural molecule activity KRT27; JUP; CLDN5B; LAMC3; KRT83; KRT34; KRT33B; KRT94; OC90; EVPL
    toxic substance binding NEFH; CHRNA7; DSG1; EPHX2; Alb; A4GALT; AZU1; PHAX; ASS1; H2-AB1

    NEFH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEFH here. Most of them are supplied by our site. Hope this information will be useful for your research of NEFH.

    UL36; d2cfj1_9flav; M84; NS; k1_vaccw; ICP0; P/V/C; e3_vaccw; polg_den27; RL1; GRB2; VP35; ESR2; P/V/C

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