Recombinant Human NEFH protein, MYC/DDK-tagged

• Cat.No.: NEFH-25H
• Product Overview: Recombinant Human NEFH fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 111.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: NEFH neurofilament, heavy polypeptide [ Homo sapiens ]
• Official Symbol: NEFH
• Synonyms: NEFH; neurofilament, heavy polypeptide; neurofilament, heavy polypeptide 200kDa; neurofilament heavy polypeptide; NF-H; 200 kDa neurofilament protein; neurofilament triplet H protein; NFH
• Gene ID: 4744
• mRNA Refseq: NM_021076
• Protein Refseq: NP_066554
• MIM: 162230
• UniProt ID: P12036
• Chromosome Location: 22q12.2
• Pathway: Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem
• Function: molecular_function