nfkb2
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  • Official Full Name
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
  • Background
  • This gene encodes one of the NF-kappaB family of transcription factors which are characterized by a Rel homology domain (RHD) in the N-terminal region. These transcription factors have key roles in regulating immunity, stress responses, apoptosis, and differentiation. The p100 form of this gene is processed in the proteasome to the p52 form. NF-kappaB molecules containing p52 participate in noncanonical NF-kappaB regulatory pathways. Recent reviews of the NF-kappaB signalling pathways include PubMed 17072323, 18267068, 18515173, and 21772278.
  • Synonyms
  • NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); nuclear factor NF-kappa-B p100 subunit; LYT 10; NF kB2; p52; p105; oncogene Lyt-10; DNA-binding factor KBF2; lymphocyte translocation chromosome 10 protein; nuclear fa
Cat.#:NFKB2-815HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NFKB2 Protein, MYC/DDK-tagged
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Cat.#:NFKB2-1280HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB2, GST-tagged
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Cat.#:NFKB2-306HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NFKB2 protein, His/MBP-tagged
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Cat.#:NFKB2-4859Tag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human NFKB2 protein, GST-tagged
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Cat.#:NFKB2-4859HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NFKB2, GST-tagged
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Cat.#:NFKB2-7052HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NFKB2, GST-tagged
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Cat.#:Nfkb2-1851MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nfkb2 protein, His & T7-tagged
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Cat.#:NFKB2-1850CTag:His/T7
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken NFKB2 protein, His & T7-tagged
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Cat.#:NFKB2-5983CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NFKB2
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Cat.#:NFKB2-249ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NFKB2
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Involved Pathway

NFKB2 involved in several pathways and played different roles in them. We selected most pathways NFKB2 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKB2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
Casp3; GNA12; FGF6B; ARRB2B; PPP3R2; CACNA2D1A; MAP4K1; RPS6KA3A; MAP4K4; FGF18
NF-kappa B signaling pathway
IKBKG; PRKCB; LTB; BTK; PLAU; CCL4L1; CXCL12; MAP3K7; MYD88; GM1987
Osteoclast differentiation
LILRB5; LCP2; NCF4; IKBKG; IFNGR2; TYROBP; MAP2K1; FCGR4; CYBB; MAP3K14
Legionellosis
RAB1B; VCP; CASP8; BNIP3; IL-8; CLK1; CYCS; EEF1A1; HSPA8; C3
HTLV-I infection
ANAPC7; WNT9A; MAP3K3; TBPL2; SLC25A5; ITGAL; EGR2; PTTG2; ANAPC11; IL15RA
Epstein-Barr virus infection
HDAC1; NFKBIB; PSMC6; GTF2E2; SYK; NEDD4; TRADD; SPN; HLA-DQA2; IL10RB
Pathways in cancer
FAS; STAT1; BDKRB1; F2RL3; Casp3; LAMC1; ITGA2; WNT8A; PPARD; WNT1
Viral carcinogenesis
CDC20; GTF2A1; GRB2; HLA-E; RBL1; MRPS18B; IRF3; ACTN4; HIST1H2BL; MAPKAPK2

Protein Function

NFKB2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKB2 itself. We selected most functions NFKB2 had, and list some proteins which have the same functions with NFKB2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein ETV2; RAX; ZNF100; IFI203; TFE3A; ZNF331; ZNF502; NFYC; TFAP2A; SNAI3
Function chromatin binding
Related Protein CEBPB; PPARG; SMARCA2; YBX1; NCOA5; GATA1A; ATAD2; TADA2B; RUNX2; EBF2
Function protein binding
Related Protein PTRH2; YARS2; CCDC85B; CD93; PDS5B; SERPINA1A; SOCS6; NDUFS2; TBC1D7; TLR6
Function transcription coactivator activity
Related Protein GMEB1; ING4; CTNNB1; GTF2A1L; NCOA2; LPIN1; CARM1; WWTR1; AIP; ECD
Function transcription factor activity, sequence-specific DNA binding
Related Protein TGIF2; RARA; PKNOX1; FOXB1A; ALX3; HES1; PURBA; RUNX2A; ATF5A; BCL6
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein CREB3L1; NKX2; ALS2CR8; MYOG; MEF2B; POU2F2; TTC6; POU2F3; GLI3; FOXC2

Interacting Protein

NFKB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKB2.
NFKB1; MAP3K8; RELB; REL; EPS8

NFKB2 Related Articles

Lee, CE; Fulcher, DA; et al. Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100. BLOOD 124:2964-2972(2014).
Chen, K; Coonrod, EM; et al. Germline Mutations in NFKB2 Implicate the Noncanonical NF-kappa B Pathway in the Pathogenesis of Common Variable Immunodeficiency. AMERICAN JOURNAL OF HUMAN GENETICS 93:812-824(2013).