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Official Full Name nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Background This gene encodes one of the NF-kappaB family of transcription factors which are characterized by a Rel homology domain (RHD) in the N-terminal region. These transcription factors have key roles in regulating immunity, stress responses, apoptosis, and differentiation. The p100 form of this gene is processed in the proteasome to the p52 form. NF-kappaB molecules containing p52 participate in noncanonical NF-kappaB regulatory pathways. Recent reviews of the NF-kappaB signalling pathways include PubMed 17072323, 18267068, 18515173, and 21772278.
Synonyms NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); nuclear factor NF-kappa-B p100 subunit; LYT 10; NF kB2; p52; p105; oncogene Lyt-10; DNA-binding factor KBF2; lymphocyte translocation chromosome 10 protein; nuclear fa
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • T7
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NFKB2-1280H Recombinant Human NFKB2, GST-tagged E.coli GST
    Human NFKB2-306H Recombinant Human NFKB2 protein, His/MBP-tagged E.coli His/MBP
    Human NFKB2-4859 Recombinant Human NFKB2 protein, GST-tagged Insect Cell GST
    Human NFKB2-4859H Recombinant Human NFKB2, GST-tagged Sf9 Insect Cell GST
    Human NFKB2-7052H Recombinant Human NFKB2, GST-tagged Sf9 Insect Cell GST
    Human NFKB2-815H Recombinant Human NFKB2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse Nfkb2-1851M Recombinant Mouse Nfkb2 protein, His & T7-tagged E.coli His/T7
    Chicken NFKB2-1850C Recombinant Chicken NFKB2 protein, His & T7-tagged E.coli His/T7
    Chicken NFKB2-5983C Recombinant Chicken NFKB2 Mammalian Cell His
    Zebrafish NFKB2-249Z Recombinant Zebrafish NFKB2 Mammalian Cell His

    NFKB2 involved in several pathways and played different roles in them. We selected most pathways NFKB2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with NFKB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGF9; RPS6KAL; CACNA1SB; PPM1NB; FGF1A; FGF20; FGF13; RAP1AA; PRKCA; PPP3CA
    NF-kappa B signaling pathway DDX58; CCL4L2; NFKBIA; CFLAR; GM10591; LRDD; SYK; TRAF1; LBP; TRADD
    Osteoclast differentiation SOCS3; LCK; IFNAR1; LILRB1; IL1R1; PPP3CB; CYBB; MAPK9; PIK3CB; SQSTM1
    Legionellosis ITGAM; NFKBIA; CLK1; NFKB1; IL12A; MYD88; CASP8; PYCARD; RAB1A; IL1B
    Epstein-Barr virus infection H2-Q10; PTMA; MAP2K4; SYK; TRAF5; POLR3F; HLA-DQA2; HDAC1; SNW1; YWHAH
    Pathways in cancer RXRB; PRKACA; FGF1; Pdgfa&Pdgfb; SMAD3; PIAS2; TP53; PLEKHG5; RARB; CCNE2
    Viral carcinogenesis SNW1; HIST1H2BL; GRB2; HIST1H2BK; ACTN1; PIK3CG; SP100; HDAC2; BAK1; MRPS18B

    NFKB2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by NFKB2 itself. We selected most functions NFKB2 had, and list some proteins which have the same functions with NFKB2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding JUNBB; RFX1; CEBPB; NR3C1; ZNF713; OTX2; MED1; ZNF543; JDP2; TCF12
    chromatin binding SLC30A9; MBD5; CIC; CEBPB; BARX2; ZFP932; REST; HDAC2; GABPA; OVOL2
    protein binding GPS2; HNRPLL; DIAP1; VASN; TP63; SCMH1; AGFG1; CHDH; Pilrb1; AGXT
    transcription coactivator activity ZEB1; Ankar; HINFP; TAF6L; RIPK3; CITED2; GATA4; DDX5; JMY; ATF2
    transcription factor activity, sequence-specific DNA binding FOXJ1A; ZNF606; SALL4; CEBPA; TAF13; TBX6; NFIL3; FOXK2; ELF1; HIF1AB
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding NKX2; SRF; HOXA5; BARHL2; TFAP2A; NOBOX; DLX5; SP1; PLAG1; ZNF750

    NFKB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NFKB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NFKB2.


    Lee, CE; Fulcher, DA; et al. Autosomal-dominant B-cell deficiency with alopecia due to a mutation in NFKB2 that results in nonprocessable p100. BLOOD 124:2964-2972(2014).
    Chen, K; Coonrod, EM; et al. Germline Mutations in NFKB2 Implicate the Noncanonical NF-kappa B Pathway in the Pathogenesis of Common Variable Immunodeficiency. AMERICAN JOURNAL OF HUMAN GENETICS 93:812-824(2013).

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