npr2
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  • Official Full Name
  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
  • Background
  • This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. (aa 288-302)
  • Synonyms
  • natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptidereceptor B); NPR-B; ANPRB; EC 4.6.1.2; ANPb; AMDM; GUCY2B; acromesomelic dysplasia, Maroteaux type; Atrial natriuretic peptide receptor type B; GUC2B; Guanylate cyclase B; NPRB; ANP-B; NPRBi; ANPR-B; atrial natriuretic peptide B-type receptor; GC-B; atrial natriuretic peptide receptor 2; OTTHUMP00000021345; NPR2
Cat.#:NPR2-691HTag:His|SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NPR2 Protein (23-458 aa), His-SUMO-tagged
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Cat.#:NPR2-30369THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human NPR2
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Cat.#:NPR2-323HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NPR2 protein, GST-tagged
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Cat.#:NPR2-10834MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NPR2 Protein
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Cat.#:Npr2-3770RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Npr2, His-tagged
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Cat.#:NPR2-4050RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NPR2 Protein
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Cat.#:NPR2-3081RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NPR2 Protein, His-tagged
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Involved Pathway

NPR2 involved in several pathways and played different roles in them. We selected most pathways NPR2 participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
APRT; POLR2J; GDA; NME2B.1; GUK1A; ITPA; PDE4A; AMPD3B; POLR2I; URAH
cGMP-PKG signaling pathway
CALML5; SLC8A2; VDAC2; MYLK; MEF2A; GNAI3; PPP3CA; KCNMB4; RAF1; ATP1A2
Vascular smooth muscle contraction
PLA2G4A; BRAF; PRKCG; ADORA2AB; GNA11; GNAQ; CALM2B; MYL6B; MAPK3; MYL6
Oxytocin signaling pathway
PPP3R2; MAPK1; Adcy4; PIK3CB; CACNG1; PTGS2; MAPK7; PRKAG3; CACNG4; PIK3R5

Protein Function

NPR2 has several biochemical functions, for example, ATP binding, GTP binding, NOT adenylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NPR2 itself. We selected most functions NPR2 had, and list some proteins which have the same functions with NPR2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ATAD1A; SMC3; ORC1L; ITGB1BP3; KIAA1804; MAP3K4; MYO9B; CHD4; TNNI3K; EGFR
Function GTP binding
Related Protein ARL4CB; RTKN; RAB6B; RAP1AB; TUBA4A; ARL15A; IFT22; ARHGAP35; RERGLA; GNA11
Function NOT adenylate cyclase activity
Related Protein GUCY2C; GUCY1B3; NPR3; GUCY2F; NPR1; NPR2; GC2; GC3; NPR1A; GUCY1A3
Function guanylate cyclase activity
Related Protein NPR1A; GUCY2F; GC3; GUCY1B3; GUCY2C; GUCY2E; NPR2; GC2; NPR1; GUCY1A3
Function hormone binding
Related Protein MC5R; UCN2; TTR; CRYM; NPR3; NPR2; LRP2; MC1R; ADIPOR2; ADIPOR1B
Function identical protein binding
Related Protein DYNLT1C; SNX1; PRDX3; TRP63; CLDN16; SNX8; FGFR1; SNX16; CORO1B; EIF2AK3
Function natriuretic peptide receptor activity
Related Protein NPR3; NPR2; NPR1; NPR1A
Function peptide hormone binding
Related Protein MAS1; HCRTR1; NPR3; CRHR2; GALR2; GHRHR; AGTR1A; GCGR; ACVR1; GHR
Function protein kinase activity
Related Protein MAP2K4; TRIM24; RLN1; RAF1B; TBCK; MAPK12B; RPS6KB2; EPHB4B; ACVR1; BMPR1AA
Function receptor activity
Related Protein CLEC4E; FPR1; SLC40A1; APLNR; KRT1; PAQR3B; MED30; MED14; VMN1R43; THBD
Function transmembrane signaling receptor activity
Related Protein IL4R.1; EDAR; TNFRSF10C; OR4C12; CD5; OR2A4; SELE; SLC22A17; FZD7B; CLDN4

Interacting Protein

NPR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPR2.
HSP90AB1; CDC37