NPR2
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Official Full Name
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
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Overview
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. (aa 288-302) -
Synonyms
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptidereceptor B); NPR-B; ANPRB; EC 4.6.1.2; ANPb; AMDM; GUCY2B; acromesomelic dysplasia, Maroteaux type; Atrial natriuretic peptide receptor type B; GUC2B; Guanylate cyclase B; NPRB; ANP-B; NPRBi; ANPR-B; atrial natriuretic peptide B-type receptor; GC-B; atrial natriuretic peptide receptor 2; OTTHUMP00000021345; NPR2;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- E.Coli or Yeast
- HEK293
- Insect Cell
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- His|SUMO
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
NPR2 involved in several pathways and played different roles in them. We selected most pathways NPR2 participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | NT5M;NUDT2;AK7;POLD2;NT5C2;PRPS1B;POLR2E;ENTPD1;ENPP4 |
| cGMP-PKG signaling pathway | MAP2K2;ATP1A2;MYH7;CREB5;IRS1;PRKG2;ATF4;IRS2;CALM1 |
| Vascular smooth muscle contraction | CACNA1C;PLA2G10;PLA2G4F;RAF1;CALM2B;PLA2G3;GNAS;PRKACAA;MYL9B |
| Oxytocin signaling pathway | PLCB1;CALM3;PRKAB2;CALM1;NFATC4;PPP1CA;SRC;CACNG7;PPP1CC |
NPR2 has several biochemical functions, for example, ATP binding, GTP binding, NOT adenylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NPR2 itself. We selected most functions NPR2 had, and list some proteins which have the same functions with NPR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CSNK2A2;GUK1;TSSK6;ABCG5;NAIP7;IKBKE;ACSS1;PANK2;FES |
| GTP binding | RAB39A;IRGF4;RIT2;NMUR2;RAN;RHOU;RAB3D;SUCLG1;NPR1 |
| NOT adenylate cyclase activity | NPR3;GUCY2F;NPR2;GUCY1B3;NPR1;GC2;GUCY2C;GUCY1A3;GC3 |
| guanylate cyclase activity | GUCY2E;GC2;GUCY2F;GC3;NPR1A;NPR2;GUCY2C;GUCY1A3;GUCY1B3 |
| hormone binding | MTNR1A;GPR30;UCN2;CALR;ADIPOR1A;NPR1;ADIPOR1B;ADIPOR2;MC1R |
| identical protein binding | DAPK2;SORD;ALAD;BAIAP2;CBX3;TTC32;CSK;ADORA2A;SERPINA1A |
| natriuretic peptide receptor activity | NPR2;NPR1A;NPR1;NPR3 |
| peptide hormone binding | GHSR;ACVR1;AVPR1A;INHBA;OXTR;ANXA5;GIPR;AGTR1B;NPR3 |
| protein kinase activity | JAK2;PKN3;CCL8;PRKCBA;TNK2B;KSR1;SLKA;CDKL2;MAPKAPK2A |
| receptor activity | NOTCH1A;ICAM1;NLGN4X;F2RL1.2;NCR3;Siglece;KLRG1;STRA6;ANTXR2B |
| transmembrane signaling receptor activity | TNFRSF8;Cd79a, Cd79b;GPR133;NPR2;GPR113;FZD7B;IL1R1;GHRHRA;LILRB5 |
NPR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPR2.
HSP90AB1; CDC37
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