Recombinant Human NPR2
Cat.No. : | NPR2-30369TH |
Product Overview : | Recombinant fragment corresponding to amino acids 131-230 of Human Natriuretic Peptide Receptor B with an N terminal proprietary tag; Predicted MWt 36.63 kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. |
Protein length : | 100 amino acids |
Molecular Weight : | 36.630kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | AKNDHYRTLVRTGPSAPKLGEFVVT LHGHFNWTARAALLYLDARTDDRPH YFTIEGVFEALQGSNLSVQHQVYAR EPGGPEQATHFIRANGRIVYICGPL |
Sequence Similarities : | Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Contains 1 guanylate cyclase domain.Contains 1 protein kinase domain. |
Gene Name : | NPR2 natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B) [ Homo sapiens ] |
Official Symbol : | NPR2 |
Synonyms : | NPR2; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); acromesomelic dysplasia, Maroteaux type , AMDM, ANPRB, NPRB; atrial natriuretic peptide receptor 2; ANPb; GUCY2B; |
Gene ID : | 4882 |
mRNA Refseq : | NM_003995 |
Protein Refseq : | NP_003986 |
MIM : | 108961 |
Uniprot ID : | P20594 |
Chromosome Location : | 9p21-p12 |
Pathway : | Purine metabolism, organism-specific biosystem; Purine metabolism, conserved biosystem; Vascular smooth muscle contraction, organism-specific biosystem; Vascular smooth muscle contraction, conserved biosystem; |
Function : | ATP binding; GTP binding; guanylate cyclase activity; hormone binding; identical protein binding; |
Products Types
◆ Recombinant Protein | ||
NPR2-691H | Recombinant Human NPR2 Protein (23-458 aa), His-SUMO-tagged | +Inquiry |
NPR2-3709R | Recombinant Rat NPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
NPR2-6172M | Recombinant Mouse NPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
NPR2-2900R | Recombinant Rhesus Macaque NPR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
Npr2-3770R | Recombinant Rat Npr2, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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