nr0b2
Share
  • Official Full Name
  • nuclear receptor subfamily 0, group B, member 2
  • Background
  • The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
  • Synonyms
  • NR0B2; nuclear receptor subfamily 0, group B, member 2; nuclear receptor subfamily 0 group B member 2; SHP; nuclear receptor SHP; small heterodimer partner; orphan nuclear receptor SHP; SHP1; FLJ17090
Cat.#:NR0B2-473HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR0B2 Protein, His-tagged
+Inquiry
Cat.#:NR0B2-6066HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NR0B2 Protein, GST-tagged
+Inquiry
Cat.#:Nr0b2-474RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nr0b2 Protein, His-tagged
+Inquiry
Cat.#:NR0B2-638HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR0B2 Protein, His-tagged
+Inquiry
Cat.#:NR0B2-4061RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NR0B2 Protein
+Inquiry
Cat.#:NR0B2-2582CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NR0B2
+Inquiry
Cat.#:NR0B2-3722HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NR0B2 293 Cell Lysate
+Inquiry

Involved Pathway

NR0B2 involved in several pathways and played different roles in them. We selected most pathways NR0B2 participated on our site, such as Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR0B2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Bile secretion
ATP1B3; ABCB1; NR1H4; AQP9; SCTR; GNAS; OSTA; ABCB4; Slc4a2; NCEH1

Protein Function

NR0B2 has several biochemical functions, for example, DNA binding, peroxisome proliferator activated receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR0B2 itself. We selected most functions NR0B2 had, and list some proteins which have the same functions with NR0B2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF669; ZC3H3; TERFA; ZFP473; ZNF652; NEUROD6B; ZMAT4; FOXL1; E2F7; SP140
Function peroxisome proliferator activated receptor binding
Related Protein ASXL1; NR0B2; HMGA1-RS1; PPARGC1A; MED1; CREBBP; IKBKG; NFATC4; ASXL2; HMGA1
Function protein binding
Related Protein PCBP2; MNAT1; DYNLL1; PLSCR1; ABI1; TEF; OAS3; RPL37A; C1QTNF6; STON2
Function protein complex binding
Related Protein C8G; KCTD5; VAMP2; MTHFR; RANBP2; TWF1; DAG1; ABI2; TAB1; NCK2
Function protein domain specific binding
Related Protein ATP1A1; TNFAIP1; HIST1H4N; TRP63; PTPN11; TACC1; SLC34A2; DDC; YWHAQ; HIST1H4B
Function protein homodimerization activity
Related Protein HPGD; GDNFA; SRM; DCK; ATIC; CLN6; ANO2; RASGRP1; CCBL1; USH1G
Function retinoid X receptor binding
Related Protein FUS; RARB; NR1H2; NR0B2; MED25; NR4A2; NCOA1; HMGA1; NCOR1; NR1H4
Function steroid hormone receptor activity
Related Protein THRB; NR6A1B; NR1D2A; NR0B2; PGR; NR2F6; NR2F5; PGRMC2; RARGA; NR1H5
Function thyroid hormone receptor binding
Related Protein MED13; TAF11; MED30; MED1; NCOA3; TRIP12; MED17; FUS; PRMT2; THRAP3
Function transcription corepressor activity
Related Protein CREG1; CBFA2T2; EID1; TFCP2L1; E2F7; DNMT3B; ZHX2; HSF4; RLIM; POU1F1
Function transcription factor binding
Related Protein RELA; NFKBIA; TCF7L2; TMEM173; HDAC4; BCOR; EP300; CHCHD2; SOX10; BRD7

Interacting Protein

NR0B2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR0B2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR0B2.
SIRT1; TP53; MDM2; PLSCR1; ESRRG; Traf6; ZMYND10; FN1; HNRNPA1

NR0B2 Related Articles

Fujii, S; Nishikawa-Torikai, S; et al. Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells. SCIENTIFIC REPORTS 5:-(2015).
Nam, YS; Kim, Y; et al. Small Heterodimer Partner Blocks Cardiac Hypertrophy by Interfering With GATA6 Signaling. CIRCULATION RESEARCH 115:493-+(2014).