Recombinant Human NR0B2 Protein (Met1-Arg257), His tagged
Cat.No. : | NR0B2-3606H |
Product Overview : | Recombinant human SHP (Met1-Arg257) protein fused with His tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with which it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1. Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism. Regulates the circadian expression of cytochrome P450 (CYP) enzymes. Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | 29.18 kDa |
Protein Length : | Met1-Arg257 |
Purity : | >90 % as determined by SDS-PAGE. |
Notes : | For research use only. |
Storage : | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt. |
Storage Buffer : | Supplied as solution form in PBS pH 7.5 or lyophilized from PBS pH 7.5. |
Reconstitution : | Reconstitute in sterile water for a stock solution. |
Shipping : | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
Gene Name : | NR0B2 nuclear receptor subfamily 0, group B, member 2 [ Homo sapiens (human) ] |
Official Symbol : | NR0B2 |
Synonyms : | NR0B2; nuclear receptor subfamily 0, group B, member 2; nuclear receptor subfamily 0 group B member 2; SHP; nuclear receptor SHP; small heterodimer partner; orphan nuclear receptor SHP; SHP1; FLJ17090; |
Gene ID : | 8431 |
mRNA Refseq : | NM_021969 |
Protein Refseq : | NP_068804 |
MIM : | 604630 |
UniProt ID : | Q15466 |
Products Types
◆ Recombinant Protein | ||
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NR0B2-3720R | Recombinant Rat NR0B2 Protein, His (Fc)-Avi-tagged | +Inquiry |
NR0B2-473H | Recombinant Human NR0B2 Protein, His-tagged | +Inquiry |
NR0B2-6066H | Recombinant Human NR0B2 Protein, GST-tagged | +Inquiry |
NR0B2-2582C | Recombinant Chicken NR0B2 | +Inquiry |
◆ Lysates | ||
NR0B2-3722HCL | Recombinant Human NR0B2 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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