"NR0B2" Related Products

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Recombinant Human NR0B2 Protein, His-tagged

Cat.No. : NR0B2-473H
Product Overview : Recombinant Human NR0B2(Met1~Arg257) fused with His tag at N-terminal was expressed in E. coli.
Description : The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Source : E. coli
Species : Human
Tag : His
Form : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Molecular Mass : 31.8kDa
Protein length : Met1~Arg257
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : > 90%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
If bio-activity of the protein is needed, please check active protein
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in PBS or others
Gene Name : NR0B2 nuclear receptor subfamily 0, group B, member 2 [ Homo sapiens ]
Official Symbol : NR0B2
Synonyms : NR0B2; nuclear receptor subfamily 0, group B, member 2; nuclear receptor subfamily 0 group B member 2; SHP; nuclear receptor SHP; small heterodimer partner; orphan nuclear receptor SHP; SHP1; FLJ17090;
Gene ID : 8431
mRNA Refseq : NM_021969
Protein Refseq : NP_068804
MIM : 604630
UniProt ID : Q15466

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