nr1h2
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  • Official Full Name
  • nuclear receptor subfamily 1, group H, member 2
  • Background
  • The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
  • Synonyms
  • NR1H2; nuclear receptor subfamily 1, group H, member 2; NER; UNR; LXRB; LXR-b; NER-I; RIP15; oxysterols receptor LXR-beta; LX receptor beta; nuclear receptor NER; liver X nuclear receptor beta; nuclear orphan receptor LXR-beta; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor;
Cat.#:NR1H2-1266HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human NR1H2 Protein, MYC/DDK-tagged
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Cat.#:NR1H2-6069HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NR1H2 Protein, GST-tagged
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Cat.#:NR1H2-1061HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1H2, 211-461aa
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Cat.#:NR1H2-1062HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1H2, LB Domain, 211-461aa, GST-tagged
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Cat.#:NR1H2-115HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human NR1H2, GST-tagged
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Cat.#:NR1H2-133HTag:
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human NR1H2
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Cat.#:NR1H2-1354HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1H2, His-tagged
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Cat.#:NR1H2-2503HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1H2, His-tagged
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Cat.#:NR1H2-27981THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1H2, His-tagged
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Cat.#:NR1H2-27982THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1H2
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Cat.#:NR1H2-10855MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NR1H2 Protein
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Cat.#:Nr1h2-7889MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nr1h2 protein, His & T7-tagged
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Cat.#:NR1H2-4063RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NR1H2 Protein
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Cat.#:NR1H2-3092RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NR1H2 Protein, His-tagged
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Cat.#:NR1H2-010NTag:His
Source (Host):Nicotiana benthamianaSpecies:Human
Product nameRecombinant Human Liver X receptor-LBD, His-tagged
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Cat.#:NR1H2-440HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human NR1H2 lysate
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Involved Pathway

NR1H2 involved in several pathways and played different roles in them. We selected most pathways NR1H2 participated on our site, such as Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1H2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Insulin resistance
MAPK8A; SOCS3B; AKT2L; SREBF1; PIK3CD; PRKAG3B; PPARAB; RPS6KB2; PRKAG3; PPARGC1A

Protein Function

NR1H2 has several biochemical functions, for example, ATPase binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1H2 itself. We selected most functions NR1H2 had, and list some proteins which have the same functions with NR1H2. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein LCK; ATP1B2; NSFL1C; ATP1B1; TOR1AIP2; SNTA1; NR1H2; FXYD7; DERL1; PTPN3
Function DNA binding
Related Protein ZSCAN18; Rhox5; ZBTB37; LHX6; DNMT3A; RAD51C; POLR2L; ZNF572; SRFB; C1D
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein TCF3A; NEUROD1; NKX3-2; MEOX2; TCF7L2; GRHL1; NFIB; MITFA; FIGLA; POU2F2
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein RXRB; HNF4G; NR2F1B; HNF4A; NR2F5; STAT3; RORAA; NR2F6; RXRA; PPARDB
Function RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
Related Protein NR1H2
Function apolipoprotein A-I receptor binding
Related Protein APOA1; CDC42; NR1H2
Function protein binding
Related Protein MAP1B; RCN2; EIF4E2; SPAG9; MRAS; DOCK2; WBP1; C1S; PRIMPOL; BAZ2A
Function retinoid X receptor binding
Related Protein VDR; RARG; NR1H2; HMGA1-RS1; NSD1; NCOR1; NR0B2; MED25; NR4A2; NRIP1
Function steroid hormone receptor activity
Related Protein ESR1; RORCA; PPARG; RORC; NR2F6A; ESRRA; RXRBA; NR5A1A; NR1H2; RXRAA
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein YBX1; SIX1; HOXD13; CEBPE; PBX1; SOX9; HMGA2; FOS; ONECUT1; NR2E1
Function zinc ion binding
Related Protein MT2; MMP23BB; MEP1A; PTPN1; ZDHHC3; RNPEP; RNF144AA; PPARA; CPA1; ZCCHC6

Interacting Protein

NR1H2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1H2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1H2.
MDFI; ABCA1; CIDEA; KDM1A; SUV39H1; SPRY2; SORBS2; NPY; VIM; SMPD1; YY1; COL4A5; CDKN1A; RXRG; UBE2D1; MPP1; CHD3

NR1H2 Related Articles

Andersen, V; Vogel, U; et al. Interactions between meat intake and genetic variation in relation to colorectal cancer. GENES AND NUTRITION 10:-(2015).
He, Q; Pu, J; et al. Activation of Liver-X-Receptor alpha But Not Liver-X-Receptor beta Protects Against Myocardial Ischemia/Reperfusion Injury. CIRCULATION-HEART FAILURE 7:1032-U315(2014).