NR1H2 Protein, nuclear receptor subfamily 1, group H, member 2


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Official Full Name nuclear receptor subfamily 1, group H, member 2
Background The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
Synonyms NR1H2; nuclear receptor subfamily 1, group H, member 2; NER; UNR; LXRB; LXR-b; NER-I; RIP15; oxysterols receptor LXR-beta; LX receptor beta; nuclear receptor NER; liver X nuclear receptor beta; nuclear orphan receptor LXR-beta; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Nicotiana Benthamiana
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NR1H2-1399B Recombinant Bovine NR1H2 Protein E.coli
    Human NR1H2-1399H Recombinant Human NR1H2 protein, His-tagged E.coli His
    Human NR1H2-010N Recombinant Human Liver X receptor-LBD, His-tagged Nicotiana Benthamiana His
    Human NR1H2-1061H Recombinant Human NR1H2, 211-461aa E.coli N/A
    Human NR1H2-1062H Recombinant Human NR1H2, LB Domain, 211-461aa, GST-tagged E.coli GST
    Human NR1H2-115H Recombinant Human NR1H2, GST-tagged Sf9 Insect Cell GST
    Human NR1H2-1266H Recombinant Human NR1H2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human NR1H2-133H Recombinant Human NR1H2 Nicotiana Benthamiana N/A
    Human NR1H2-1354H Recombinant Human NR1H2, His-tagged E.coli His
    Human NR1H2-2503H Recombinant Human NR1H2, His-tagged E.coli His
    Human NR1H2-27981TH Recombinant Human NR1H2, His-tagged E.coli His
    Human NR1H2-27982TH Recombinant Human NR1H2 E.coli N/A
    Human NR1H2-440HCL Recombinant Human NR1H2 lysate HEK293 N/A
    Human NR1H2-6069H Recombinant Human NR1H2 Protein, GST-tagged Wheat Germ GST
    Mouse NR1H2-10855M Recombinant Mouse NR1H2 Protein Mammalian Cell His
    Mouse Nr1h2-7889M Recombinant Mouse Nr1h2 protein, His & T7-tagged E.coli His/T7
    Rat NR1H2-4063R Recombinant Rat NR1H2 Protein Mammalian Cell His
    Rhesus Macaque NR1H2-3092R Recombinant Rhesus monkey NR1H2 Protein, His-tagged Mammalian Cell His

    NR1H2 involved in several pathways and played different roles in them. We selected most pathways NR1H2 participated on our site, such as Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1H2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Insulin resistance PCK2; MLXIPL; SLC2A4; PRKCDA; IRS2; PRKAG3; PIK3R1; MTOR; OGT.1; GYS2

    NR1H2 has several biochemical functions, for example, ATPase binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1H2 itself. We selected most functions NR1H2 had, and list some proteins which have the same functions with NR1H2. You can find most of the proteins on our site.

    Function Related Protein
    ATPase binding ATPIF1A; S100A1; ATP6V0A1A; FXYD3; BBC3; ANK2; DRD1; TCIRG1; PIH1D1; FXYD4
    DNA binding HIST2H2AC; SOS1; PKNOX1.1; IRX5A; ZNF683; HISTH1L; HMG20B; OLIG1; PARP2; ZBTB6
    RNA polymerase II core promoter proximal region sequence-specific DNA binding MEIS1; CUX2; ELK3; MYBL1; ETV4; TFE3A; CTCFL; MYPOP; FOXA2; NEUROG3
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding RORB; NR2E3; NR5A5; RORAA; RORA; NR5A1A; NR5A2; RORCB; NR5A1; RORAB
    RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding NR1H2
    apolipoprotein A-I receptor binding NR1H2; APOA1; CDC42
    protein binding RAB2B; SPRY2; MAP2K1; CD8B; TTF2; SEPT5; TRP53; TUSC2; NOSTRIN; TIMM21
    retinoid X receptor binding RARB; NCOR1; NRIP1; HMGA1-RS1; HMGA1; NSD1; NR1H4; VDR; NR1H2; NR0B2
    steroid hormone receptor activity NR2C2; NR5A2; RORC; RXRBA; ESRRB; PPARD; NR2F1A; NR2C1; RXRA; ESR2A
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding SOX9; MESP1; TFAM; MEF2A; POU4F1; SMAD2; MAFB; NCOA3; FLI1; NR2E1
    zinc ion binding MUL1B; RNF185; PIAS4; NR1H3; BIRC5; TRIM61; RNFT2; CA12; SF3A2; ZCWPW2

    NR1H2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1H2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1H2.


    Andersen, V; Vogel, U; et al. Interactions between meat intake and genetic variation in relation to colorectal cancer. GENES AND NUTRITION 10:-(2015).
    He, Q; Pu, J; et al. Activation of Liver-X-Receptor alpha But Not Liver-X-Receptor beta Protects Against Myocardial Ischemia/Reperfusion Injury. CIRCULATION-HEART FAILURE 7:1032-U315(2014).

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