NR3C1 Protein, nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)


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Official Full Name nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Background This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Synonyms NR3C1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); GR; GCR; GRL; GCCR; glucocorticoid receptor; glucocorticoid nuclear receptor variant 1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NR3C1-1044H Recombinant Human NR3C1 protein, His-tagged Insect Cell His
    Human NR3C1-104H Recombinant Human Glucocorticoid receptor LBD/Hsp90 complex, GST-tagged Sf9 Insect Cell GST
    Human NR3C1-106H Recombinant Human NR3C1 protein, His/GST-tagged E.coli His/GST
    Human NR3C1-1218HCL Recombinant Human NR3C1 cell lysate N/A
    Human NR3C1-28739TH Recombinant Human NR3C1, His-tagged His
    Human NR3C1-6090H Recombinant Human NR3C1 Protein, GST-tagged Wheat Germ GST
    Human NR3C1-8490H Recombinant Human NR3C1, His-tagged Sf21 Insect Cell His
    Mouse Nr3c1-7651M Recombinant Mouse Nr3c1 protein, His-tagged E.coli His
    Rat Nr3c1-7164R Recombinant Rat Nr3c1 protein, His-tagged E.coli His
    Rat Nr3c1-7165R Recombinant Rat Nr3c1 protein, His & GST-tagged E.coli His/GST
    Chicken NR3C1-3295C Recombinant Chicken NR3C1 Mammalian Cell His
    Zebrafish NR3C1-2867Z Recombinant Zebrafish NR3C1 Mammalian Cell His

    NR3C1 involved in several pathways and played different roles in them. We selected most pathways NR3C1 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR3C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction F2RL1; TAAR10C; MTNR1A; CHRM5A; THRB; NPY8BR; HTR1AB; PTGER1B; NMBR; TACR1B

    NR3C1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, glucocorticoid receptor activity, glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NR3C1 itself. We selected most functions NR3C1 had, and list some proteins which have the same functions with NR3C1. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II core promoter proximal region sequence-specific DNA binding NRF1; ETS2; MYF5; HOXC11; BATF; JUNBB; ZNF680; SMAD2; TFE3; H2AFZ
    glucocorticoid receptor activity NR3C1
    glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity NR3C1
    protein binding TBX6; NME1; ZNF274; SPEF2; RWDD1; SNRPE; NOL3; TSPO; PCNA; C10orf18
    steroid binding PAQR7; ESR1; ESRRG; PGRMC2; AKR1D1; PAQR7B; HSD3B4; PGRMC1; GPR30; ESR2
    steroid hormone binding ATP1A2; ATP1A3; NR3C1; ATP1A1; GPR30; ESR2A; ESR2B
    transcription factor activity, sequence-specific DNA binding NFAT5; ZNF83; TP73; FOXB1A; FOXO3A; ZNF571; ZNF323; MYCS; RAB11FIP4A; PAX8
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding CEBPE; SIX1; ZFP292; CAMTA1; ZNF750; MZF1; PHOX2B; ATF4; IRF4; PAX5
    zinc ion binding DPF2L; ADAM28; AGBL2; ZNF385B; MID1; NR6A1A; SERPINB1A; WHSC1; CA2; Car12

    NR3C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR3C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR3C1.

    HSP90AA1; dexamethasone; HSPA1A; AKT1

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