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NR3C1

  • Official Full Name

    nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

  • Overview

    This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
  • Synonyms

    NR3C1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); GR; GCR; GRL; GCCR; glucocorticoid receptor; glucocorticoid nuclear receptor variant 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • GST
  • Flag
  • His|GST
  • SUMO
  • Trx
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NR3C1-8490H Active Recombinant Human NR3C1, His-tagged Sf21 Insect Cell His
Human NR3C1-104H Recombinant Human Glucocorticoid receptor LBD/Hsp90 complex, GST-tagged Sf9 Insect Cell GST
Human NR3C1-1044H Recombinant Human NR3C1 protein, His-tagged Insect Cell His
Human NR3C1-28739TH Recombinant Human NR3C1, His-tagged His
Human NR3C1-106H Recombinant Human NR3C1 protein, His-SUMO-tagged E.coli His-SUMO Leu532~Glu730
Human NR3C1-1218HCL Recombinant Human NR3C1 cell lysate N/A
Human NR3C1-2506H Recombinant Human NR3C1 Protein, His-tagged E.coli N-His Leu528-Lys777
Human NR3C1-3291H Recombinant Human NR3C1 protein, His-Trx-tagged E.coli His-Trx 521-777aa
Human NR3C1-3290H Recombinant Human NR3C1 protein, His-GST-tagged E.coli His/GST 521-777aa
Human NR3C1-6090H Recombinant Human NR3C1 Protein, GST-tagged Wheat Germ GST
Human NR3C1-1104HFL Recombinant Human NR3C1 protein, His&Flag-tagged HEK293 His&Flag 1-777 aa
Human NR3C1-2750H Recombinant Human NR3C1 Protein, His-tagged E.coli N-His Val521-Lys777
Human NR3C1-1853H Recombinant Human NR3C1 Protein, His&GST-tagged E.coli N-His&GST Tyr598-Glu755
Human NR3C1-2507H Recombinant Human NR3C1 Protein, His-tagged E.coli N-His Leu528-Ile742
Human NR3C1-6743HF Recombinant Full Length Human NR3C1 Protein, GST-tagged In Vitro Cell Free System GST 777 amino acids
Human NR3C1-4216H Recombinant Human NR3C1 Protein (Val271-Lys777), N-His tagged E.coli N-His Val271-Lys777
Human NR3C1-0611H Recombinant Human NR3C1 Protein (Gln529-Lys779), N-His-tagged Baculovirus-Insect cells N-His Gln529-Lys779
Human NR3C1-0612H Recombinant Human NR3C1 Protein (Met1-Lys777), C-His-tagged Baculovirus-Insect cells C-His Met1-Lys777
Human NR3C1-4217H Recombinant Human NR3C1 Protein (Gln529-Lys779), N-His tagged Mammalian cells N-His Gln529-Lys779
Mouse Nr3c1-7651M Recombinant Mouse Nr3c1 protein, His-tagged E.coli His Ala622~Phe755 (Accession # P06537)
Mouse Nr3c1-1854M Recombinant Mouse Nr3c1 Protein, His-tagged E.coli N-His Lys254-Gly393
Rat Nr3c1-7164R Recombinant Rat Nr3c1 protein, His-tagged E.coli His Ser106~Thr211 (Accession # P06536)
Rat Nr3c1-7165R Recombinant Rat Nr3c1 protein, His & GST-tagged E.coli His/GST Ala564~Phe733 (Accession # P06536)
Zebrafish NR3C1-2867Z Recombinant Zebrafish NR3C1 Mammalian Cell His
Chicken NR3C1-3295C Recombinant Chicken NR3C1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NR3C1 Related Research Area

NR3C1 involved in several pathways and played different roles in them. We selected most pathways NR3C1 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR3C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionGRIN1B;P2RX5;MAS1;CHRM5A;GIPR;GRIN2B;SSTR2;HTR7;GRID2

NR3C1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, glucocorticoid receptor activity, glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NR3C1 itself. We selected most functions NR3C1 had, and list some proteins which have the same functions with NR3C1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingNEUROG3;SIX4;MZF1;MEIS1;NR1D1;ELF1;BATF3;BATF;KLF13
glucocorticoid receptor activity
glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity
protein bindingZDHHC13;PCMT1;NKD2;KLB;ATP5B;C4orf33;RTN4RL1;HSD17B10;GFER
steroid bindingHSD3B5;PAQR5A;NR3C2;ESRRGA;UGT1A1;ESRRB;PAQR8;ESRRGB;ESR2B
steroid hormone bindingESR2A;ATP1A3;ESR2B;GPR30;ATP1A2;ATP1A1;NR3C1
transcription factor activity, sequence-specific DNA bindingGTF2I;SOX11B;GM239;NKX6-1;SIN3A;PBX1;HLFB;CARF;ZNF274
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingRELA;TTC6;CTCFL;ELF4;TFAP2C;PGR;POU4F2;NFATC2;FOXL2
zinc ion bindingNR4A1;UQCRC2A;EHMT2;ADH7;ZNF212;LMO3;KDM1B;PHC2A;RNF144B

NR3C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR3C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR3C1.

HSP90AA1; dexamethasone; HSPA1A; AKT1

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