nr3c1
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  • Official Full Name
  • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
  • Background
  • This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
  • Synonyms
  • NR3C1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); GR; GCR; GRL; GCCR; glucocorticoid receptor; glucocorticoid nuclear receptor variant 1;
Cat.#:NR3C1-6090HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NR3C1 Protein, GST-tagged
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Cat.#:NR3C1-1044HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human NR3C1 protein, His-tagged
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Cat.#:NR3C1-104HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Glucocorticoid receptor LBD/Hsp90 complex, GST-tagged
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Cat.#:NR3C1-106HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR3C1 protein, His/GST-tagged
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Cat.#:NR3C1-28739THTag:His
Source (Host):Species:Human
Product nameRecombinant Human NR3C1, His-tagged
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Cat.#:NR3C1-8490HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human NR3C1, His-tagged
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Cat.#:Nr3c1-7651MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nr3c1 protein, His-tagged
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Cat.#:Nr3c1-7164RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nr3c1 protein, His-tagged
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Cat.#:Nr3c1-7165RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nr3c1 protein, His & GST-tagged
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Cat.#:NR3C1-3295CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NR3C1
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Cat.#:NR3C1-2867ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NR3C1
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Cat.#:NR3C1-1218HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NR3C1 cell lysate
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Involved Pathway

NR3C1 involved in several pathways and played different roles in them. We selected most pathways NR3C1 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR3C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuroactive ligand-receptor interaction
GLRA1; HTR5AL; P2RY1; TACR1; GHRHR; P2RX4; APLNRA; PTGDR; GABRG3; GRIA1B

Protein Function

NR3C1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, glucocorticoid receptor activity, glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NR3C1 itself. We selected most functions NR3C1 had, and list some proteins which have the same functions with NR3C1. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein NRF1; FOSB; TGIF1; IFI203; ZNF100; DLX4; ZNF395; ZNF713; GCM1; FOXL2
Function glucocorticoid receptor activity
Related Protein NR3C1
Function glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity
Related Protein NR3C1
Function protein binding
Related Protein FRMPD1; CLCNKB; DNM3; ANKRD45; OTUD7B; FANCB; NEFL; C4orf19; PSG5; MECOM
Function steroid binding
Related Protein Ar; HSD3B5; HSD11B2; PAQR5A; ESRRGB; CYP21A1; ESR2B; SERPINA6; ESR1; NR3C1
Function steroid hormone binding
Related Protein ESR2B; ATP1A1; ATP1A3; NR3C1; ATP1A2; GPR30; ESR2A
Function transcription factor activity, sequence-specific DNA binding
Related Protein FOXG1D; VDRB; JUNBB; ZSCAN4C; TBX1; FOXK2; ZNF213; HOXC8A; RERE; MECP2
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein GLI2; TP63; NFATC3; TFAP2C; MITFB; BCL11B; ESR1; EHF; PAX5; HLTF
Function zinc ion binding
Related Protein KDM1B; MICAL1; RPH3A; TRIM65; RNF175; PHF7; ERAP1; ABLIM2; WBP2NL; RNF111

Interacting Protein

NR3C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR3C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR3C1.
HSP90AA1; dexamethasone; HSPA1A; AKT1