odf2
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  • Official Full Name
  • outer dense fiber of sperm tails 2
  • Background
  • The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as Cenexins, encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]
  • Synonyms
  • ODF2; outer dense fiber of sperm tails 2; CT134; ODF84; ODF2/1; ODF2/2; outer dense fiber protein 2; cenexin 1; cancer/testis antigen 134; sperm tail structural protein; outer dense fiber of sperm tails, 84-kD;
Cat.#:ODF2-27389THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ODF2
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Cat.#:ODF2-11073MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ODF2 Protein
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Cat.#:ODF2-2027CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ODF2
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Cat.#:ODF2-3598HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ODF2 293 Cell Lysate
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Involved Pathway

ODF2 involved in several pathways and played different roles in them. We selected most pathways ODF2 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ODF2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Anchoring of the basal body to the plasma membrane
SDCCAG8; TUBB4B; MKS1; TTBK2; PLK4; TCTN3; RPGRIP1L; SSNA1; DCTN1A; CEP97
Assembly of the primary cilium
ODF2B; IFT74; CSNK1D; CLUAP1; MAPRE1A; CDK5RAP2; KIFAP3; TRAF3IP1; TCTEX1D1; TUBG1
Cell Cycle
CSNK2A2; RAD9B; E2F3; BORA; CENPJ; CTDNEP1; TEX12; ANAPC11; ANAPC2; CDT1
Cell Cycle, Mitotic
CDK5RAP2; CLASP1A; SPC25; CSNK2A2; CDT1; TSGA14; CDCA8; CEP78; MIS12; MCM10
Centrosome maturation
CEP76; TUBG1; ODF2B; TUBGCP3; TUBB4A; CEP152; DCTN1; CP110; DCTN2; ACTR1A
G2/M Transition
CEP70; DCTN1A; MYBL2; LIN9; TUBG2; CEP72; TUBG1; ACTR1A; OFD1; CEP76
Loss of Nlp from mitotic centrosomes
CEP135; CEP164; HAUS2; MAPRE1A; PLK4; MAPRE1; CEP63; CEP152; TUBG1; ODF2B
Loss of proteins required for interphase microtubule organizationfrom the centrosome
CKAP5; CEP72; CCP110; NEDD1; SSNA1; CEP152; TUBG1; CEP78; CLASP1A; CEP63

Protein Function

ODF2 has several biochemical functions, for example, Rab GTPase binding, protein binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ODF2 itself. We selected most functions ODF2 had, and list some proteins which have the same functions with ODF2. You can find most of the proteins on our site.
Function
Related Protein
Function Rab GTPase binding
Related Protein SYTL1; STXBP5A; MICALL2; RAB3GAP2; CCDC64B; RPH3A; MICAL1; MYO5B; MYRIP; RABGGTA
Function protein binding
Related Protein RPA3; RRAS2; ZNF295; CTNNA1; KCNG3; SPACA3; IFT88; TBX5; ATP6V1G1; AEN
Function structural molecule activity
Related Protein CLDN10; CRCT1; COPB2; TUBA1C; JAG1; CLDN11A; CLDN2; CLDNH; SEPT5; LELP1

Interacting Protein

ODF2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ODF2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ODF2.
LRRK1; Map3k1

ODF2 Related Articles

Wakle, M; Khole, V; et al. A sperm cytoskeletal protein TSA70 is a novel phosphorylated member of Cenexin/odf2 family. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 354:528-534(2007).
Fitzgerald, CJ; Oko, RJ; et al. Rat Spag5 associates in somatic cells with endoplasmic reticulum and microtubules but in spermatozoa with outer dense fibers. MOLECULAR REPRODUCTION AND DEVELOPMENT 73:92-100(2006).