PAM Protein, peptidylglycine alpha-amidating monooxygenase


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Official Full Name peptidylglycine alpha-amidating monooxygenase
Background This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known.
Synonyms PAM; peptidylglycine alpha-amidating monooxygenase; peptidyl-glycine alpha-amidating monooxygenase; PAL; peptidyl alpha hydroxyglycine alpha amidating lyase; peptidylglycine alpha hydroxylating monooxygenase; PHM; AMD_HUMAN; Pancreatic peptidylglycine alpha amidating monooxygenase; Peptidyl alpha amidating enzyme; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Peptidylamidoglycolate lyase; Peptidylglycine 2 hydroxylase; Peptidylglycine alpha amidating monooxygenase; OTTHUMP00000158920; OTTHUMP00000158921; OTTHUMP00000158922; OTTHUMP00000158923; OTTHUMP00000222752; OTTHUMP00000227957; peptidylglycine 2-hydroxylase; peptidyl alpha-amidating enzyme; pep
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PAM-1519H Recombinant Human PAM, His-tagged E.coli His
    Human PAM-30777TH Recombinant Human PAM Wheat Germ N/A
    Human PAM-30780TH Recombinant Human PAM Wheat Germ N/A
    Human PAM-3448HCL Recombinant Human PAM 293 Cell Lysate HEK293 N/A
    Human PAM-495H Recombinant Human Peptidylglycine Alpha-Amidating Monooxygenase, His-tagged NS0 His
    Human PAM-559H Recombinant Human PAM Protein, Fc-tagged HEK293 Fc
    Human PAM-560H Recombinant Human PAM Protein, His-tagged HEK293 His
    Rat PAM-4264R Recombinant Rat PAM Protein Mammalian Cell His

    PAM involved in several pathways and played different roles in them. We selected most pathways PAM participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    PAM has several biochemical functions, for example, L-ascorbic acid binding, copper ion binding, peptidylamidoglycolate lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAM itself. We selected most functions PAM had, and list some proteins which have the same functions with PAM. You can find most of the proteins on our site.

    Function Related Protein
    L-ascorbic acid binding PLOD2; PHYH; EGLN1B; LEPRE1; P3H2; LEPREL1; P4HA1A; PLOD3; OGFOD3; EGLN3
    copper ion binding TYRP1; ADNP; ATOX1; PRND; ABHD1; POLR1B; LOXL2B; SLC11A2; TP53; DBH
    peptidylamidoglycolate lyase activity PAM
    peptidylglycine monooxygenase activity PAM
    zinc ion binding ADAM17; TRAF4; PDLIM7; CA5; MORC2; UHRF2; NR1I2; PCGF6; MICAL2; USP13

    PAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAM here. Most of them are supplied by our site. Hope this information will be useful for your research of PAM.


    Mallo, N; Lamas, J; et al. Presence of a plant-like proton-translocating pyrophosphatase in a scuticociliate parasite and its role as a possible drug target. PARASITOLOGY 142:449-462(2015).
    Pone, EJ; Lou, Z; et al. B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: Modulation by BCR and CD40, and relevance to T-independent antibody responses. AUTOIMMUNITY 48:1-12(2015).

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