PARP16

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PARP16

Official Full Name poly (ADP-ribose) polymerase family, member 16
Background Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by theaddition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) toglu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chainpolymers. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes,stroke and cardiovascular disease.
Synonyms PARP16; poly (ADP-ribose) polymerase family, member 16; C15orf30, chromosome 15 open reading frame 30; poly [ADP-ribose] polymerase 16; FLJ20509; FLJ25281; pART15; C15orf30; Chromosome 15 open reading frame 30; EC 2.4.2.30; PAR16_HUMAN; PARP 16; PARP-16; Poly (ADP ribose) polymerase family member 16; Poly [ADP ribose] polymerase 16
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PARP16-4653H Recombinant Human PARP16 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Parp16-4678M Recombinant Mouse Parp16 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PARP16-1129H Recombinant Human PARP16, GST-tagged Wheat Germ GST
    Human PARP16-1532H Recombinant Human PARP16, His-tagged E.coli His
    Human PARP16-3428HCL Recombinant Human PARP16 293 Cell Lysate HEK293 N/A
    Human PARP16-8938H Recombinant Human PARP16 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse PARP16-12372M Recombinant Mouse PARP16 Protein Mammalian Cell His
    Rat PARP16-4277R Recombinant Rat PARP16 Protein Mammalian Cell His
    Zebrafish PARP16-12160Z Recombinant Zebrafish PARP16 Mammalian Cell His

    PARP16 involved in several pathways and played different roles in them. We selected most pathways PARP16 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    PARP16 has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity, kinase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP16 itself. We selected most functions PARP16 had, and list some proteins which have the same functions with PARP16. You can find most of the proteins on our site.

    Function Related Protein
    NAD+ ADP-ribosyltransferase activity PARP8; GIG2E; SIRT4; PARP12A; ART1; GIG2H; TIPARP; PARP3; CHAT1; GIG2I
    kinase binding MIDN; PPP2R5A; JAKMIP1; PER3; TAX1BP1; TRADD; CTNNB1; CEBPA; CHP1; ABI2
    protein binding RXRA; ZC3HAV1; TSKS; SMAD4; PQBP1; TPD52L1; ARSI; KCNE1; PPP2R2A; CTCFL
    protein serine/threonine kinase activator activity MAP2K1; ALS2; FAM20A; LTF; CDK5R1; STRADA; CALM3; CALM1; CAB39; IGF2

    PARP16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP16 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP16.

    FLJ13057; Cyr61; Setd5; MLKL; DOT1L; MRPL1; PCIF1; ZNF644; KLC4

    Qiu, W; Lam, R; et al. Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70:2740-2753(2014).
    Bayraktar, S; Barrera, AMG; et al. USP-11 as a Predictive and Prognostic Factor Following Neoadjuvant Therapy in Women With Breast Cancer. CANCER JOURNAL 19:10-17(2013).

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