parp2
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  • Official Full Name
  • poly (ADP-ribose) polymerase 2
  • Background
  • This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.
  • Synonyms
  • PARP2; poly (ADP-ribose) polymerase 2; ADP ribosyltransferase (NAD+; poly(ADP ribose) polymerase) like 2 , ADPRTL2, poly (ADP ribose) polymerase family, member 2; poly [ADP-ribose] polymerase 2; ADP ribosyltransferase like 2; ADPRT 2; ADPRT-2; ADPRT2; ADPRTL 2; ADPRTL 3; ADPRTL2; ADPRTL3; hPARP 2; hPARP-2; hPARP2; NAD(+) ADP ribosyltransferase 2; NAD(+) ADP-ribosyltransferase 2; pADPRT 2; pADPRT-2; pADPRT2; PARP 2; PARP-2; PARP2_HUMAN; Poly (ADP ribose) polymerase family member 2; Poly (ADP ribosyl) transferase like 2; Poly [ADP ribose] synthetase 2; Poly(ADP ribose) synthetase; Poly[ADP-ribose] synthase 2; OTTHUMP00000231900; OTTHUMP00000231902; OTTHUMP00000231904; poly(ADP-ribose) synthetase; poly[ADP-ribose] synthetase 2; poly (ADP-ribosyl) transferase-like 2; poly (ADP-ribose) polymerase family, member 2; ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2
Cat.#:PARP2-157HTag:GST
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human PARP2 Protein, GST-tagged
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Cat.#:PARP2-433HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Poly (ADP-ribose) Polymerase 2, GST-tagged
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Cat.#:PARP2-7559HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PARP2, His-tagged
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Cat.#:PARP2-12373MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PARP2 Protein
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Cat.#:Parp2-453MTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Parp2, His-tagged
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Cat.#:Parp2-613MTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Poly (ADP-ribose) Polymerase Family, Member 2
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Cat.#:Parp2-641MTag:His
Source (Host):Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Parp2, His-tagged
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Cat.#:PARP2-3308RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PARP2 Protein, His-tagged
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Cat.#:PARP2-8014ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PARP2
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Cat.#:Kit-1799Tag:N/A
Source (Host):Species:
Product namePARP2 Chemiluminescent Assay Kit
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Cat.#:Kit-1800Tag:N/A
Source (Host):Species:
Product namePARP2 Colorimetric Assay Kit
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Cat.#:Kit-1801Tag:N/A
Source (Host):Species:
Product namePARP2 Homogeneous Assay Kit
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Involved Pathway

Parp2 involved in several pathways and played different roles in them. We selected most pathways Parp2 participated on our site, such as Base Excision Repair, DNA Damage Recognition in GG-NER, DNA Double-Strand Break Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with Parp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Base Excision Repair
PARP1; NTHL1; xthA; UNG; SMUG1; POLD3; PNKP; HMGB1; APEX1; POLE2
DNA Damage Recognition in GG-NER
PARP1; COPS7B; COPS7A; INO80E; YY1A; COPS8; COPS6; CETN2; DDB1; PARP2
DNA Double-Strand Break Repair
EME1; CHEK2; TIPIN; BABAM1; BRE; PARP1; EYA2; BARD1; PARP2; TDP2B
DNA Repair
CHEK2; WRN; ALKBH2; COPS2; HUS1; TDP2B; MAD2L2; BARD1; COPS8; COPS7A
Dual Incision in GG-NER
DDB1; CHD1L; PARP2; DDB2
Formation of Incision Complex in GG-NER
DDB1; CHD1L; PIAS3; RNF111; DDB2; CETN2; USP45; PARP2
Global Genome Nucleotide Excision Repair (GG-NER)
COPS8; PARP2; INO80B; PIAS3; COPS2; COPS3; USP45; GPS1; ACTR5; INO80C

Protein Function

Parp2 has several biochemical functions, for example, DNA binding, NAD+ ADP-ribosyltransferase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Parp2 itself. We selected most functions Parp2 had, and list some proteins which have the same functions with Parp2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZBTB7A; SCMH1; CHD4A; EME1; SIX3B; ZNF624; AEBP1; DLX2A; ZFP593; DICER1
Function NAD+ ADP-ribosyltransferase activity
Related Protein PARP12; CHAT2; GIG2L; PARP8; ART3; TIPARP; CHAT1; PARP11; TNKS; GIG2E
Function protein binding
Related Protein TERF1; RSPO2; ORM1; KIF18B; KIAA1967; TUBA1C; IKBKG; ARPC4; SH2B1; NIPBL

Interacting Protein

Parp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Parp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Parp2.
FKBP3; STAC; FAM168B; VPS37C; nad+; mgc:39545; NDUFA4; SYNJ2; DFFB; MYO1D; RTN3; IFNA16; PCCA; HMGN2; HIST1H1E; CD58; PTMS