pcsk5
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  • Official Full Name
  • proprotein convertase subtilisin/kexin type 5
  • Background
  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternate splicing results in two variants encoding distinct isoforms, a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, Jan 2014]
  • Synonyms
  • PCSK5; proprotein convertase subtilisin/kexin type 5; PC5; PC6; PC6A; SPC6; subtilase; protease PC6; prohormone convertase 5; proprotein convertase 6; subtilisin/kexin-like protease PC5;
Cat.#:PCSK5-1480MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse PCSK5 Protein (117-452 aa), His-tagged
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Cat.#:PCSK5-711MTag:His-SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse PCSK5 Protein (117-452 aa), His-SUMO-tagged
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Cat.#:PCSK5-121HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PCSK5, GST-tagged
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Cat.#:PCSK5-122HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PCSK5, His-tagged
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Cat.#:PCSK5-30549THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PCSK5 protein, GST-tagged
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Cat.#:PCSK5-3370HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PCSK5 293 Cell Lysate
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Involved Pathway

PCSK5 involved in several pathways and played different roles in them. We selected most pathways PCSK5 participated on our site, such as NGF processing, Signal Transduction, Signalling by NGF, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NGF processing
NTF7; FURINB; PCSK5; FURINA; PCSK6
Signal Transduction
OTULIN; NOG1; OR52B4; PDK4; SHB; STAM2; STARD13; CNGA1; AMOTL2B; USP15
Signalling by NGF
OMG; PRDM4; RTN4A; LINGO1B; LINGO1; ARHGEF1B; DNAL4A; DNAL4B; AATF; RIT2

Protein Function

PCSK5 has several biochemical functions, for example, peptidase activity, peptide binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK5 itself. We selected most functions PCSK5 had, and list some proteins which have the same functions with PCSK5. You can find most of the proteins on our site.
Function
Related Protein
Function peptidase activity
Related Protein ADAMTS16; MASP1; CAPN1A; ST14A; HE1B; REN; KLK1B5; FOLH1; UFSP2; F9A
Function peptide binding
Related Protein GNRHR4; RNPEP; MAS1; CSNK1D; QRFPR; RPS6KB2; CALR; AVPR2L; HCRTR2; NPFFR1L2
Function protein binding
Related Protein ASGR1; MYH8; MYL2; CEBPB; P2RX4; TDP1; KRTAP10-8; MRTO4; PIH1D2; CRYBA2
Function serine-type endopeptidase activity
Related Protein ELANE; RHBDD2; HPR; TMPRSS11B; CTSH; TPP2; PRSS12; KLK1B3; HTRA1; KLK1B9

Interacting Protein

PCSK5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK5.
NUFIP2; MEOX2; STK16; GLRX3; KRTAP5-9; KRTAP10-7