PDE12

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PDE12

Official Full Name phosphodiesterase 12
Background Enzyme that cleaves 2,5-phosphodiester bond linking adenosines of the 5-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP
Synonyms PDE12; phosphodiesterase 12; 2,5-phosphodiesterase 12; 2 PDE; 2 phosphodiesterase; DKFZp667B1218; 2-PDE; 2-phosphodiesterase
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PDE12-4245H Recombinant Human PDE12 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Pde12-4741M Recombinant Mouse Pde12 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PDE12-1611H Recombinant Human PDE12, GST-tagged Sf9 Insect Cell GST
    Human PDE12-1714H Recombinant Human PDE12 Mammalian Cell His
    Human PDE12-744H Recombinant Human PDE12 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse PDE12-12546M Recombinant Mouse PDE12 Protein Mammalian Cell His
    Mouse Pde12-305M Recombinant Mouse Pde12 Protein, His-tagged E.coli His
    Rhesus Macaque PDE12-3344R Recombinant Rhesus monkey PDE12 Protein, His-tagged Mammalian Cell His
    Zebrafish PDE12-4280Z Recombinant Zebrafish PDE12 Mammalian Cell His

    PDE12 involved in several pathways and played different roles in them. We selected most pathways PDE12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    PDE12 has several biochemical functions, for example, metal ion binding, poly(A)-specific ribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE12 itself. We selected most functions PDE12 had, and list some proteins which have the same functions with PDE12. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding RNF34A; ANKZF1; SNAI1B; NR2F1B; ZSCAN18; CPSF3; GNAI3; ACAP3B; UNC13C; NUDT1
    poly(A)-specific ribonuclease activity CNOT6; TOE1; CNOT8; PAN2; PDE12; CNOT6L; PARN; CNOT7

    PDE12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE12 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE12.

    UBL4A; BAG6; SGTB; VWA9; SORT1; Rhoa; SIRT4

    Braun, J; Kiltz, U; et al. Emerging drugs for the treatment of axial and peripheral spondyloarthritis. EXPERT OPINION ON EMERGING DRUGS 20:1-14(2015).
    Felquer, MLA; Soriano, ER; et al. New treatment paradigms in psoriatic arthritis: an update on new therapeutics approved by the US Food and Drug Administration. CURRENT OPINION IN RHEUMATOLOGY 27:99-106(2015).

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